「tfs」の検索結果

Simulate transcription factor perturbation effects on cell state in silico with CellOracle and Dynamo, and predict transcriptional responses to genetic perturbations with GEARS, scGen, and CPA. Covers the direction-not-magnitude principle, local-linear validity, the GRN/velocity error it inherits, baseline discipline (mean and additive baselines), and the validation gap. Use when predicting TF knockout or overexpression effects, ranking driver TFs for fate transitions, or planning perturbation experiments. For GRN construction see multiomics-grn; for experimental Perturb-seq see single-cell/perturb-seq.

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Identifies super-enhancers from H3K27ac, MED1, or BRD4 ChIP-seq using ROSE, ROSE2, LILY, HOMER -style super, and ENCODE dELS cross-referencing. Handles peak stitching parameters, ranking choices, hockey-stick inflection, marker choice (H3K27ac vs MED1/BRD4), and cross-condition comparison with spike-in normalization. Constructs core regulatory circuitry (Saint-Andre 2016) from SE-encoded TFs. Use when identifying cell-identity / cancer-associated regulatory domains, comparing super-enhancers between conditions, identifying master transcription factor networks, or predicting BET-inhibitor responsiveness.

日本語の概要は準備中です。原文の説明を表示しています。

Simulate transcription factor perturbation effects on cell state in silico with CellOracle and Dynamo, and predict transcriptional responses to genetic perturbations with GEARS, scGen, and CPA. Covers the direction-not-magnitude principle, local-linear validity, the GRN/velocity error it inherits, baseline discipline (mean and additive baselines), and the validation gap. Use when predicting TF knockout or overexpression effects, ranking driver TFs for fate transitions, or planning perturbation experiments. For GRN construction see multiomics-grn; for experimental Perturb-seq see single-cell/perturb-seq.

日本語の概要は準備中です。原文の説明を表示しています。

Identifies super-enhancers from H3K27ac, MED1, or BRD4 ChIP-seq using ROSE, ROSE2, LILY, HOMER -style super, and ENCODE dELS cross-referencing. Handles peak stitching parameters, ranking choices, hockey-stick inflection, marker choice (H3K27ac vs MED1/BRD4), and cross-condition comparison with spike-in normalization. Constructs core regulatory circuitry (Saint-Andre 2016) from SE-encoded TFs. Use when identifying cell-identity / cancer-associated regulatory domains, comparing super-enhancers between conditions, identifying master transcription factor networks, or predicting BET-inhibitor responsiveness.

日本語の概要は準備中です。原文の説明を表示しています。

Track stocks, ETFs, indices, crypto (where available), and FX pairs with caching + provider fallbacks.

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Anti-forensics and evidence destruction techniques for red team operators conducting authorized engagements. Covers log clearing on Windows (wevtutil, Clear-EventLog, ETW provider patching) and Linux (journal truncation, utmp/wtmp binary editing, syslog manipulation), timestamp manipulation via Timestomp and SetMACE to defeat timeline analysis, filesystem-level anti-forensics including NTFS Alternate Data Streams for payload hiding and secure deletion with sdelete/shred, memory artifact removal to counter live forensics, disk artifact manipulation targeting MFT entries and USN journal records, network forensics evasion through encrypted C2 channels and DNS-over-HTTPS tunneling, and anti-VM/sandbox detection to avoid dynamic analysis environments. Tools: Timestomp, wevtutil, sdelete, shred, MimiPenguin, Invoke-Phant0m. Aligns to MITRE ATT&CK T1070 (Indicator Removal), T1027 (Obfuscated Files or Information), T1497 (Virtualization/Sandbox Evasion). Each technique includes the forensic artifact it targets, t...

日本語の概要は準備中です。原文の説明を表示しています。