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Build and deploy full-stack web and mobile apps with AWS Amplify Gen2 (TypeScript code-first). Covers auth (Cognito), data (AppSync/DynamoDB), storage (S3), functions, APIs, and AI (Amplify AI Kit with Bedrock). Supports React, Next.js, Vue, Angular, React Native, Flutter, Swift, and Android. Always use this skill for Amplify Gen2 topics — even for questions you think you know — it contains validated, version-specific patterns that prevent common mistakes. TRIGGER when: user mentions Amplify Gen2; project has amplify/ directory or amplify_outputs; code imports @aws-amplify packages; user asks about defineBackend, defineAuth, defineData, defineStorage, defineFunction, or npx ampx. SKIP: Amplify Gen1 (amplify CLI v6), standalone SAM/CDK without Amplify (use aws-serverless), direct Bedrock without Amplify AI Kit (use bedrock).

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Runs SQL analytics on SageMaker Catalog asset metadata tables exported as Apache Iceberg in S3 Tables. Covers governance queries, asset growth tracking, ownership audits, time-travel over catalog state, and metadata quality analysis. Applies when querying catalog inventory, finding assets without descriptions, comparing catalog snapshots, or auditing data ownership. Trigger phrases: catalog inventory SQL, how many assets, assets without descriptions, asset growth over time, who owns this data, catalog governance, data quality audit, catalog analytics.

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Identifies translationally meaningful paths for bioinformatics findings by mapping omics or computational discoveries to diagnosis, stratification, prognosis, treatment-response, monitoring, or target-nomination use cases, while auditing bridge evidence, assayability, and validation burden. Use this skill when a user wants to know whether a bioinformatics finding can be framed as a stronger translational topic without overclaiming clinical relevance. Always separate statistical signal from translational value, and never imply clinical utility, targetability, or validation depth without explicit evidence support.

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Use when correcting batch effects in merged bulk expression matrices with sample-level batch metadata while preserving biological group structure and generating before-and-after QC plots. NOT for: single-cell integration, raw FASTQ processing, differential expression without batch labels, or datasets without biological groups.

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Draw cloud architecture diagrams for AWS, Azure or GCP with the official provider icon sets, using TerraVision. Use whenever the user asks to draw, diagram, sketch or visualize a system on AWS, Azure or Google Cloud, or one built from their services (Lambda, DynamoDB, S3, EC2, EKS, RDS, API Gateway, Azure Functions, App Service, AKS, Cosmos DB, Cloud Run, GKE, BigQuery and the like), even if they never say 'cloud', 'diagram' or a tool name; also for a diagram of Terraform code. Prefer it over Mermaid, PlantUML, hand-written SVG or ASCII, which cannot use the official icons or VPC/subnet grouping. Not for diagrams that are not cloud infrastructure: sequence diagrams, flowcharts, class or ER diagrams, code or module structure, org charts, on-premises-only networks; use Mermaid or similar for those. Works with or without Terraform: with Terraform code the diagram comes from terraform plan; without it, write a small JSON graph and render it.

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Produce a polished local talking-head or narrated screen-recording rough cut without a cloud editor. Use when Codex must clean Chinese or mixed Chinese-English speech, correct product terminology before semantic editing, compress pauses without making speech breathless, preserve source resolution and frame rate, normalize dialogue loudness, generate final-audio subtitle artifacts, or benchmark local output against ChatCut/video-use/chengfeng/AI剪口播.

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Fine-tune models on Microsoft Foundry using SFT (supervised), DPO (preference), or RFT (reinforcement with graders). Covers dataset preparation, training job submission, deployment, and evaluation. USE FOR: fine-tune, SFT, DPO, RFT, training data, grader, distillation, fine-tuned model, training job, large file upload, calibrate grader, deploy fine-tuned model, evaluate fine-tuned model. DO NOT USE FOR: general model deployment without fine-tuning (use deploy-model), agent creation (use agents), prompt optimization without training (use prompt-optimizer).

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Negotiate a car purchase without getting played — know the real target price, handle the dealership tactics, and keep the financing and add-ons from eating your savings. Use when asked to help me negotiate a car, buy a car without getting ripped off, what should I pay for this car, or dealership negotiation tips. Produces a target-price approach (research the out-the-door price), the dealer tactics to expect and counters, guidance on separating price/trade/financing, the add-ons to decline, and a walk-away plan — flagging to verify current pricing and rates.

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Set up the essentials in the right order after moving to a new country — the ID/registration, bank account, phone, address, and social/tax number that unlock each other — so you don't get stuck in the chicken-and-egg loops that trap newcomers. Use when someone says 'I just moved to a new country', 'what do I do first after arriving', 'set up my life in [country]', or 'I can't open a bank account without an address but can't rent without a bank'. Produces a sequenced arrival checklist with dependencies and the official offices for each. Routes to official sources; rules are local.

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Design the archive layer that keeps current workspaces lean without losing history — what moves, when, to where, findable-by-search, with the project-close ritual that makes archiving automatic instead of aspirational. Use when asked set up an archiving system, our workspace is drowning in old projects, when should things get archived, or make history findable without cluttering today. Produces the archive triggers, the destination structure, the findability rules, and the close-out ritual.

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Think clearly about whether bankruptcy is the right move, or whether another path fits better — without shame and without a sales pitch. Use when asked should I file for bankruptcy, is bankruptcy my best option, alternatives to bankruptcy, or what happens if I file. Produces an honest read on whether your situation is the kind bankruptcy actually helps, the main types and what each does (and doesn't) discharge, the real trade-offs (what you keep, the credit impact and its recovery, what's not dischargeable), the alternatives to weigh first (negotiation, debt management, doing nothing on time-barred debt), and a strong push to consult a bankruptcy attorney. Not legal advice.

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Search DigiKey for electronic components and download datasheets — primary source for prototype orders and the preferred API method for fetching datasheets. Find parts by keyword or MPN, check pricing/stock, download datasheets via API, analyze specifications. Sync and maintain a local datasheets directory — extract components from schematics, download missing datasheets, keep them up to date. Also supports batch MPN-list seeding (`--mpn-list`) for bulk workflows without a KiCad project. Use when the user asks about electronic components, part specs, datasheets, pricing, stock, footprints, or needs to download a datasheet — even without mentioning "DigiKey". Also for "sync datasheets", "download datasheets for my board/project", or mentions a datasheets directory. DigiKey is the default distributor for prototyping. For BOM workflows, see the bom skill.

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Use when a vulnerability or security report arrives for triage, when assessing a CVE/RCE/OGNL/injection claim against the code, or when drafting a reply to a security researcher — to research the claim from source without trusting the reporter and without fabricating your own facts.

日本語の概要は準備中です。原文の説明を表示しています。

Search DigiKey for electronic components and download datasheets — primary source for prototype orders and the preferred API method for fetching datasheets. Find parts by keyword or MPN, check pricing/stock, download datasheets via API, analyze specifications. Sync and maintain a local datasheets directory — extract components from schematics, download missing datasheets, keep them up to date. Also supports batch MPN-list seeding (`--mpn-list`) for bulk workflows without a KiCad project. Use when the user asks about electronic components, part specs, datasheets, pricing, stock, footprints, or needs to download a datasheet — even without mentioning "DigiKey". Also for "sync datasheets", "download datasheets for my board/project", or mentions a datasheets directory. DigiKey is the default distributor for prototyping. For BOM workflows, see the bom skill.

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Configures Simulink simulations non-destructively using SimulationInput objects — parameter overrides without modifying the model, batch sweeps via parsim, custom input signals via Dataset, and simulation data retrieval via logsout. Use when running sim()/parsim() with setVariable, setBlockParameter, setExternalInput, or when performing parameter sweeps and multi-run analysis. Not needed for one-shot simulations without configuration.

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Designs cytosine (CBE, C-to-T) and adenine (ABE, A-to-G) base-editor guides by positioning the target base at the activity-peak of the editing window (protospacer positions ~5-7, PAM-distal numbering), minimizing bystander edits for product purity, reading dinucleotide context (APOBEC1 TC favored / GC disfavored), and selecting the editor variant (BE4max, ABEmax, ABE8e, YE1/SECURE, TadCBE, CGBE, SpG/SpRY-BE). Covers knockout by premature stop (CRISPR-STOP/iSTOP) and splice-site disruption, the three off-target classes (Cas-dependent, Cas-independent DNA, RNA), outcome prediction (BE-Hive/DeepBE), and the base-vs-prime-vs-HDR decision. Use when installing a transition mutation without a double-strand break, knocking out a gene without indels, or choosing CBE vs ABE. Generic guide scoring, prime editing, and HDR donors are separate skills.

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Profiles RNA-binding protein targets without antibody or UV crosslinking using STAMP (APOBEC1-RBP fusion, C-to-U editing), scSTAMP (single-cell), TRIBE/HyperTRIBE (ADAR-RBP, A-to-I editing), DART-seq (APOBEC1-YTH for m6A), or Bullseye/SAILOR edit-site detection pipelines. Use when antibody is unavailable or specificity is doubtful, when single-cell RBP profiling is needed (scSTAMP), or when in vivo RBP profiling without UV is preferred.

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Drives a multi-turn conversation with a LiveKit agent running locally to see what it does. Use when the user says "test my agent", "try my agent", "does this work", "why did it call that tool", "it says the wrong thing when I ask X", "test this change", or whenever you have edited an agent and need to check how it behaves. Wraps `lk agent debugger`: start the agent in text mode, send turns, read the tool calls, handoffs, errors and logs behind each reply, and restart after an edit. It runs without audio or a LiveKit room at one LLM call per turn, so it is the preferred way for a coding agent to live-test during development, and the default when the user says "test" without naming unit tests or simulations.

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Customize Kubernetes manifests without templating using Kustomize. Create base configurations with environment overlays, manage configuration variants, and patch resources declaratively. Use when managing Kubernetes configurations across multiple environments without Helm.

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Optimize RF PCB dimensions for bandwidth, return loss, or area via patternsearch and surrogateopt with constraints. TRIGGER: user asks to optimize an RF PCB component for performance (bandwidth, return loss, insertion loss, area) or apply constraints to a design. Invoke BEFORE writing optimization code — RF PCB Toolbox has a built-in optimize() function that differs from generic fmincon/ga approaches. SKIP: designing a component from scratch without an optimization objective (use the specific matlab-design-pcb-* skill), EM analysis without optimization (use matlab-analyze-em), material/stackup setup only (use matlab-manage-pcb-material).

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Read BEFORE optimizing any MATLAB code for speed. Without this workflow, agents commonly optimize the wrong target, fabricate speedup claims without measurement, or introduce regressions. Guides the 7-step workflow: baseline, profile, identify, optimize, measure, verify, report.

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Use this skill when you develop, design, build, deploy, debug, migrate, or troubleshoot CloudBase (腾讯云开发, 云开发, TCB, 微信云开发) projects — Web, 微信小程序, 小程序, uni-app, mobile (iOS, Android, Flutter, React Native). Covers UI (页面, 界面, 表单, dashboard, prototype, 原型); auth (登录, 注册, OAuth, publishable key); databases (NoSQL 文档数据库, MySQL 关系型数据库, PostgreSQL/CloudBase PG, app.rdb(), queryPgDatabase/managePgDatabase, CRUD, security rules); 云函数/cloud functions (serverless, scf_bootstrap); CloudRun (云托管, Dockerfile); 云存储; built-in AI (内置大模型, AI 对话, streaming, 流式输出, 图片生成, generateText, streamText, createModel, generateImage, TokenHub, Hunyuan, DeepSeek, GLM, Kimi, Token Credits 资源包, 小程序成长计划); third-party/custom model onboarding (第三方大模型接入, 大模型调用, LLM API); AI agent (智能体, AG-UI, LangGraph); ops troubleshooting (巡检, 诊断, 日志); spec workflow (需求文档, 技术方案, requirements, tasks.md). Do NOT use for non-CloudBase projects, pure frontend without CloudBase, or self-hosted backends without CloudBase.

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Evaluate ecommerce price candidates using unit economics, historical observations, elasticity analysis, scenario modeling, and controlled experiments. Use when a seller asks what price to test, how price changes could affect contribution or revenue, how to estimate elasticity, how to optimize a bundle or tier, or how to design a price experiment across Amazon, Shopify, TikTok Shop, Walmart, eBay, or other channels. Do not claim a proven optimal price without sufficient clean data, and do not change live prices without explicit authorization.

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Push the current working tree directly to a GitHub PR whose head lives on a **fork**, without creating a new branch and without pushing to `origin` (which is usually the upstream). Invoke when the user says things like "push straight to PR

日本語の概要は準備中です。原文の説明を表示しています。