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Generates, normalizes, and converts bedGraph signal tracks (4-column chrom/start/end/value, 0-based half-open) with bedtools genomecov, deepTools bamCoverage/bamCompare/bigwigCompare, bedtools unionbedg, and UCSC bedGraphToBigWig. Covers why a raw coverage bedGraph is not comparable across samples until normalized, the CPM/RPKM/BPM/RPGC normalization menu and the conserved-total assumption that makes them wrong under a global perturbation, the strict sorted-non-overlapping-chrom.sizes bedGraphToBigWig contract that silently corrupts a bigWig, effective-genome-size selection, and bin-size aliasing. Use when building or normalizing a coverage/signal track from a BAM, comparing tracks across samples or conditions, converting bedGraph to a browser-ready bigWig, or diagnosing a track that looks plausible but reports wrong heights.

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Performs set operations on genomic intervals - intersect (-wa/-wb/-wo/-wao/-loj/-c/-v/-u), subtract (-A), merge (-d, -c/-o), complement, cluster, multiinter, unionbedg, map, and groupby - with bedtools (CLI) and pybedtools/pyranges/bioframe (Python). Covers the sorted-input contract and the -sorted chromosome-order footgun, reciprocal/fractional overlap (-f/-F/-r/-e) and the A-vs-B asymmetry, -split for spliced/BED12/BAM features, and jaccard/fisher as mechanics only. Use when finding overlapping or unique regions between BED/peak/feature files, building consensus peaksets, removing blacklisted regions, transferring annotation values onto intervals, or computing interval-set similarity; route overlap-significance testing to overlap-significance.

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Loads, converts, and manipulates Hi-C contact matrices in cooler format (.cool/.mcool/.scool) and Juicer .hic, using cooler (Python + CLI), hic2cool, and hictk. Covers the single-resolution mcool URI (file.mcool::/resolutions/<bp>), the load-bearing divisive-vs-multiplicative weight-naming rule (KR/VC/VC_SQRT auto-divisive vs cooler's multiplicative weight), what survives .hic<->.cool conversion (FRAG matrices and norm vectors do not), raw-vs-balanced coarsening, the .pairs upper-triangle/chromsize-order contract, and chrom-naming/bin-table provenance. Use when loading a cooler, converting .hic to .mcool, selecting a resolution, building a cooler from pairs or a matrix, coarsening/zoomifying, importing Juicer norm vectors, or debugging all-NaN balanced matrices and chr1-vs-1 empty fetches.

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Use when running or scheduling periodic repository review cycles that must dispatch the correct reviewer, aggregate findings, and escalate outcomes into reports, issues, or corrective PRs across API contracts, documentation freshness, code quality, and CloudBase skill quality.

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Source-blind user behavior validation against a prewritten contract for apps, CLIs, APIs, and generated artifacts.

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前后端接口契约安全规范，适用于接口新增或调整、联调、列表分页异常与临时兼容治理；用于避免响应结构漂移被前端兼容长期掩盖。

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Review, run, debug, and verify approved MATLAB or Beita Tianyuan modeling code against its plan, data contract, method decision, compatibility constraints, and experiment outputs, saving one compact JSON review.

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Detect whether approved modeling code is Python or MATLAB/Beita Tianyuan and route it to the matching reviewer using the compact named-check review contract.

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Translate a human-approved main method and usable baseline into a minimal language-neutral implementation and experiment contract. Use after G2.5 and data readiness, before Python or MATLAB code generation.

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Review, run, debug, and verify approved Python modeling code against its code plan, data contract, method decision, risk conditions, and experiment outputs, saving one compact JSON review.

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Build, transform, audit, and migrate prompts for GPT-5.6 Sol using outcome-first contracts, explicit success criteria, evidence and tool rules, approval boundaries, output requirements, and stop conditions. Use when someone asks for a GPT-5.6 prompt, wants an existing prompt optimized for GPT-5.6, or needs a prompt stack adapted from an older model.

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Statically audit a built `.ppmplugin` before wrap testing. Checks archive layout, manifest compatibility, bundle consistency, Android DEX integrity and SDK leakage, iOS framework structure, native source-to-receiver alignment, and the PCF composite-key/sendAsync transport contract. Reports CRITICAL, WARNING, and INFO findings with fixes routed to the owning stage; never modifies the archive. Requires `jar`; `dexdump` or `strings` improves DEX inspection. Run after /assemble-ppmplugin or standalone on an existing bundle.

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Diagnose and fix failures in a built third-party `.ppmplugin` control: crashes, silent no-ops, PCF error outputs, or incorrect behavior. Uses the reported symptom, `shared/error-codes.md`, and file-level evidence to trace the manifest, Android/iOS modules, PCF dispatch, and build configuration. Produces a ranked diagnosis, asks for approval, then applies a surgical fix while keeping the committed manifest and affected contracts synchronized. Re-validates manifest changes through /generate-ppmplugin-manifest.

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Generate the dispatcher PCF for a third-party `.ppmplugin` (wrap-runtime) control. Runs `pac pcf init` in the pcf/ subfolder, rewrites ControlManifest.Input.xml from ARCHITECTURE §6, and writes index.ts derived from ARCHITECTURE §4 (message contract), §8 (PCF surface), §9 (error UX) — no placeholders. The bridge dispatches the composite key `<name>/<receiver>` to `NativeModules.<nativeModule>.<method>` via the host-injected `window.PowerApps.NativeExtension.sendAsync` global (never `cordova.exec` — not in the PCF sandbox); also emits a `PowerAppsNativeExtension.d.ts` ambient declaration. Responses are peeled with `extractResponse`. Emits structured JSON debug/error logs. Validated by `npm run build`. **Local only** — does not deploy. Needs only `pac` CLI. Run after the native module exists. Uses npm (not pnpm).

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Design a structured onboarding experience that gets new team members productive in 30, 60, and 90 days. Use when a new hire is joining, when contractors or agency partners need to ramp up, when an existing team is restructuring and members are switching focus, or when current onboarding feels chaotic and slow. Also triggers when one person owns all the tribal knowledge and you need to capture it, when you keep losing people in their first 90 days, or when a new project has many fresh members joining at once. Useful for engineering, design, product, marketing, and operations roles.

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Expert ITAR compliance advisor for US defense contractors, exporters, and manufacturers. Use this skill for any question about 22 CFR Parts 120-130, the United States Munitions List (USML), DDTC registration, export license applications (DSP-5/73/94), Technical Assistance Agreements (TAA), Manufacturing License Agreements (MLA), brokering regulations (Part 129), deemed export rules for foreign nationals, technology control plans, voluntary disclosures, violation mitigation, jurisdiction determination (ITAR vs EAR), or US Munitions List category scoping. Trigger even if the user doesn't say "skill" — any ITAR or US defense export control question should use this skill.

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California Consumer Privacy Act (CCPA) and California Privacy Rights Act (CPRA) compliance advisor — business threshold analysis, consumer rights fulfillment (access, delete, correct, opt-out of sale/sharing, limit SPI, ADMT opt-out), privacy notice drafting, service provider vs. contractor vs. third-party classification, sensitive personal information (SPI) handling, data minimization, opt-out mechanisms (including GPC), cybersecurity audits and risk assessments (live since Jan 1, 2026), ADMT obligations (effective 2026, deadline Jan 1, 2027), CPPA enforcement (Disney $2.75M, PlayOn $1.1M, Ford $375K), penalty exposure, GDPR comparison, and gap assessments for businesses operating in or targeting California residents.

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Expert Section 508 compliance advisor for US federal ICT accessibility. Use this skill whenever a user asks about Section 508, WCAG 2.0/2.1 AA for federal systems, VPAT or Accessibility Conformance Reports (ACR), accessibility audits, remediation planning, PDF accessibility, web or software accessibility, mobile accessibility, federal procurement accessibility requirements, contractor obligations, undue burden exceptions, assistive technology compatibility, or Section 508 testing. Covers the Revised Section 508 Standards (2018), all WCAG 2.0 Level AA success criteria, the four POUR principles, testing methodologies, and agency compliance workflows. Trigger even if the user doesn't say "skill" — any Section 508 or ICT accessibility question for federal systems should use this skill.

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Expert third-party risk management (TPRM) advisor — a vendor risk analyst for the full lifecycle: risk-based vendor tiering, tailored due-diligence questionnaires (SIG-style or mapped to ISO 27001, SOC 2, DORA, NIS2, HIPAA), SOC 2 Type II report review (exceptions, carve-outs, CUECs, bridge letters), DPA and sub-processor review under GDPR Art. 28, contract security addenda (DORA Art. 30 provisions), ongoing monitoring programmes, and vendor offboarding. Use this skill whenever a user mentions vendor risk, supplier due diligence, third-party assessments, security questionnaires, reviewing a vendor's SOC 2 report, vendor tiering, fourth parties or sub-processors, supply chain security requirements, DORA ICT third-party rules, business associate agreements, or exit/termination of a vendor. Also trigger for 'a customer sent us a questionnaire' and 'how do I assess this vendor' style requests.

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Diagnose and recover from Codex Slides plugin, MCP, Browser handoff, local runtime, durable run, project resume, rendering, Design Files, export, and version-contract failures. Use when a tool fails, a run stalls, a project appears stale, or Codex and the Browser disagree.

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Monitor on-chain events like large transfers and contract deployments

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Extract structured data from multiple documents into comparison matrix with citations. Use for bulk document review.

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Review REST API designs for quality, consistency, and breaking changes. Lints OpenAPI specs, generates scorecards, and detects breaking changes between versions. Use when designing APIs, reviewing contracts, or managing API versioning.

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Generate API test suites from route definitions across frameworks: auth, input validation, contract, k6 load testing, mocking, and OpenAPI-driven generation. Use when adding new APIs, auditing test coverage, or building regression suites.

日本語の概要は準備中です。原文の説明を表示しています。