「fact」の検索結果

Think and work like an expert Atmospheric Chemist. Use when a task calls for Atmospheric Chemist judgment. Reasons from coupled photochemical OH-NOx-VOC radical budgets, heterogeneous aerosol uptake, and NOx-limited versus VOC-limited regimes through MCM/F0AM and GEOS-Chem/CMAQ/WRF-Chem models, OH-reactivity closure, PMF on AMS factors, HYSPLIT trajectories, and EKMA isopleths while treating chamber wall losses, instrument cross-sensitivities and inlet artifacts, and emission-inventory error as first-class failure modes.

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Corrects the gene-independent copy-number artifact in CRISPR-Cas9 screens (Aguirre 2016 / Munoz 2016 Cancer Discov) where amplified loci appear essential from DNA-damage burden of simultaneous cuts. Covers the p53-dependent G2-arrest mechanism, CRISPRcleanR (Iorio 2018) unsupervised pre-hoc correction, CERES (Meyers 2017) joint CN + gene-effect model, Chronos (Dempster 2021) DepMap-standard population-dynamics + CN model with lowest residual bias, the decision tree by data availability, the Spearman LFC-vs-CN diagnostic, focal-amplification examples (ERBB2 in HER2+, MYC in colorectal, FGFR1 in head and neck), and CRISPRi/a alternatives that bypass the artifact. Use when screening cancer cell lines, diagnosing essentiality at amplified loci, choosing CRISPRcleanR / CERES / Chronos, deciding whether CN correction is needed before MAGeCK / BAGEL2 / drugZ, or switching from Cas9 to CRISPRi.

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Detects allele-specific transcription factor or histone modification binding from heterozygous-variant ChIP-seq using WASP (reference-bias filter; mandatory upstream), RASQUAL (joint QTL + bias-corrected testing), BaalChIP (Bayesian beta-binomial with copy-number-aware overdispersion), and AlleleSeq (personalized diploid genome). Handles imprinted-locus awareness, X-inactivation artifacts, cancer copy-number imbalance, and integration with downstream caQTL / bQTL mapping. Use when identifying variants with allelic effects on TF binding, fine-mapping causal regulatory variants, validating deep-learning variant predictions, or characterizing cis-acting regulatory effects.

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Safe refactoring workflow using trace-mcp — assess risk, find candidates, check impact, and rename symbols across all files without missing import sites or cross-file references.

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Iterative rubric-based evaluation and self-improvement loop. Builds a scoring rubric interactively, evaluates an artifact with multiple models in parallel (Codex, Gemini, Claude), then autonomously improves the artifact one criterion at a time until a score threshold is met or circuit breaker fires. "/rulph", "rubric evaluate", "rubric score", "multi-model evaluate", "score and improve", "evaluate and iterate", "grade this", "루브릭 루프", "채점 루프", "자율 개선", "개선 루프", "루브릭 평가"

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You are an expert in Cline, the autonomous AI coding agent for VS Code that can read files, write code, run terminal commands, and use the browser — with human-in-the-loop approval at each step. You help developers use Cline for complex multi-file refactoring, feature implementation, debugging, and codebase exploration where the AI plans and executes while the developer reviews and approves.

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Design and implement discrete event simulations (DES) for systems where state changes occur at discrete time points: queues, manufacturing, logistics, networks. Use when "discrete event, DES simulation, queuing system, queue model, manufacturing simulation, process simulation, SimPy, event-driven simulation, " mentioned.

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Review code architecture for maintainability, catch structural issues before they become debtUse when "Reviewing pull requests with structural changes, Planning refactoring work, Evaluating new feature architecture, Assessing technical debt, Before major releases, When code feels "hard to change", architecture, code-review, refactoring, design-patterns, technical-debt, dependencies, maintainability" mentioned.

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Code review specialist for quality standards, design patterns, security review, and constructive feedbackUse when "code review, pull request, PR review, code quality, refactor, technical debt, design pattern, best practice, code-review, quality, patterns, security, refactoring, best-practices, pull-request, review, ml-memory" mentioned.

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Memory is the cornerstone of intelligent agents. Without it, every interaction starts from zero. This skill covers the architecture of agent memory: short-term (context window), long-term (vector stores), and the cognitive architectures that organize them. Key insight: Memory isn't just storage - it's retrieval. A million stored facts mean nothing if you can't find the right one. Chunking, embedding, and retrieval strategies determine whether your agent remembers or forgets. The field is fragmented with inconsistent terminology. We use the CoALA cognitive architecture framework: semantic memory (facts), episodic memory (experiences), and procedural memory (how-to knowledge). Use when "agent memory, long-term memory, memory systems, remember across sessions, memory retrieval, episodic memory, semantic memory, vector store, rag, langmem, memgpt, conversation history, memory, vector-store, rag, retrieval, embedding, episodic, semantic, procedural, langmem, memgpt, pinecone, qdrant, chromadb" mentioned.

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Comprehensive patterns for building AI-powered code generation tools, code assistants, automated refactoring, code review, and structured output generation using LLMs with function calling and tool use. Use when "code generation, AI code assistant, function calling, structured output, code review AI, automated refactoring, tool use, code completion, agent code, " mentioned.

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Challenges a recommendation, design, large change, or any artifact submitted for hard review (spec, proposal, policy, plan) across 5 dimensions (consistency, completeness, actionability, alignment, risk), from the standards of a named senior expert in the artifact's domain and ideally from a fresh context or a different model. Searches assuming defects exist and reports only those that survive evidence. Panel mode runs several independent lenses in parallel on a release candidate, verifies every finding against the current head, and routes confirmed ones to file owners. Use before shipping a significant recommendation, design, large branch, or multi-agent release, or when asked to tear something apart, be brutally honest, or poke holes in it.

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Axiom — First-Principles Assumption Auditor / 第一性原理拆解器 workflow skill. Use this skill when the user needs First-principles assumption auditor. Classifies each hidden assumption (fact / convention / belief / interest-driven), ranks by fragility × impact, and rebuilds conclusions from verified premises. Bilingual: auto-detects Chinese or English and the operator should preserve the upstream workflow, copied support files, and provenance before merging or handing off.

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Use when the user wants to rename, extract, split, move, or restructure code safely. Examples: "Rename this function", "Extract this into a module", "Refactor this class", "Move this to a separate file"

日本語の概要は準備中です。原文の説明を表示しています。

Suggest small refactors that improve readability without changing behavior. Use when a junior developer asks to clean up code.

日本語の概要は準備中です。原文の説明を表示しています。

产品设计 / UX 设计 (产品设计 / UX 设计 (Product Design / UX Design) — 数字产品的用户体验设计：从用户研究 → 信息架构 → 交互设计 → 视觉/UI → 可用性测试 → 设计系统的认知操作系统，面向 UX designer / product designer / interaction designer / UX researcher / design systems engineer / design lead，以及想入行、转岗、服务这行(设计外包、设计工具厂商、研究平台)的视角。覆盖: (a) 第一性张力 — **用户中心/研究驱动 (user-centered, 'you are not the user', research before pixels, observe behavior not opinions) ⇄ 商业目标/约束/交付 (business goals, north-star metrics, ship it, designer 服务于产品成功不是个人作品集)**; **设计直觉/品味/craft (taste, aesthetics, 'attractive things work better' — Norman 情感化设计) ⇄ 数据/实验/A-B 测试 (data-driven, metrics, experimentation, 'opinions are not data')**; **用户说的 (stated preference, 访谈里说喜欢) ⇄ 用户做的 (revealed behavior, 行为观察 > 自陈, usability test 看人真实卡在哪)**; **一致性/设计系统/规范 (consistency, design system, Jakob's law 用户带着别处的习惯来, 复用组件) ⇄ 创新/打破模式 (innovation, 该不该破规范)**; **减法/简化 (simplicity, Krug 'Don't Make Me Think', less but better — Dieter Rams) ⇄ 功能丰富/利益相关者塞需求 (feature creep, stakeholder pressure)**; **UX(体验/流程/研究) ⇄ UI(视觉/像素/组件)** 的职责之争, **designer 该不该写代码 (design engineer / 'should designers code')**; (b) 核心工作流 / pipeline (最标准、最易蒸高质量+CLI 化) — Double Diamond (发现 discover → 定义 define → 开发 develop → 交付 deliver) / Design Thinking (共情 empathize → 定义 → 构思 ideate → 原型 prototype → 测试 test) / Design Sprint (Jake Knapp 5 天冲刺); 完整链: 用户研究 (访谈/问卷/可用性测试/卡片分类) → persona / journey map / JTBD → 信息架构 IA + 用户流 user flow → 线框 wireframe (低保真) → 交互/原型 prototype (高保真) → 视觉 UI / 设计系统落地 → 可用性测试 usability testing → handoff 给开发 → 度量迭代 (北极星 / HEART 框架); (c) 工具栈 — 设计/原型 (Figma 绝对主导 / Sketch 衰退 / Adobe XD 已停更 / Framer 高保真+建站 / Penpot 开源 / Principle / ProtoPie 微交互); 协作白板 (FigJam / Miro / Mural); 用户研究 (Maze / UserTesting / Lookback / Dovetail 研究库 / Optimal Workshop 卡片分类树测试 / Hotjar / Microsoft Clarity 热图); 设计系统/交付 (Storybook / 蓝湖(中) / Zeplin / design tokens / Tokens Studio); 度量 (Amplitude / Mixpanel / 北极星指标); AI 新兴 (Figma AI / v0 by Vercel / Galileo AI / Uizard / Cursor 给 design engineer); (d) 知识正典 — Don Norman《The Design of Everyday Things》(affordance/signifier/mapping 圣经)、Steve Krug《Don't Make Me Think》(可用性入门)、Alan Cooper《About Face》《The Inmates Are Running the Asylum》(交互设计/persona 起源)、Jakob Nielsen 10 Usability Heuristics + NN/g 文章库、Jake Knapp《Sprint》、Jeff Gothelf《Lean UX》、Teresa Torres《Continuous Discovery Habits》、Erika Hall《Just Enough Research》、Julie Zhuo《The Making of a Manager》、《Refactoring UI》(Adam Wathan/Steve Schoger)、《Universal Principles of Design》、Laws of UX (Jon Yablonski)、《100 Things Every Designer Needs to Know About People》(Susan Weinschenk)、IDEO/Stanford d.school 设计思维材料; (e) figures/流派 — 认知心理/人因派 (Don Norman 认知科学奠基、Susan Weinschenk 行为心理、Kathryn Whitenton); 可用性工程派 (Jakob Nielsen 启发式/折扣可用性、Steve Krug、Jared Spool UIE); 交互设计/目标导向派 (Alan Cooper goal-directed/persona、Kim Goodwin); 设计思维派 (IDEO Tim Brown、David Kelley d.school); 精益/持续探索派 (Jeff Gothelf Lean UX、Teresa Torres continuous discovery、Marty Cagan《Inspired》产品发现); 设计系统/系统化派 (Brad Frost Atomic Design、Nathan Curtis design tokens、Alla Kholmatova); 视觉/UI craft 派 (Adam Wathan & Steve Schoger Refactoring UI、Dieter Rams 'less but better' 工业设计遗产); 设计领导/职业派 (Julie Zhuo、Aarron Walter 情感化设计、John Maeda); 移动优先 (Luke Wroblewski 'Mobile First'); (f) 行业话术/黑话 — affordance 可供性 / signifier 意符 / mental model 心智模型 / IA 信息架构 / heuristic evaluation 启发式评估 / usability 可用性 / a11y accessibility 无障碍 / WCAG / persona 用户画像 / journey map 用户旅程 / JTBD jobs-to-be-done / north-star metric 北极星 / HEART 框架 / wireframe 线框 / mockup / prototype 原型 / fidelity 保真度 (lo-fi/hi-fi) / design system 设计系统 / design token 设计令牌 / atomic design 原子设计 / component library 组件库 / handoff 交付 / red routes 关键路径 / dark pattern 暗黑模式 / Fitts's law / Hick's law / Jakob's law / Miller 7±2 / progressive disclosure 渐进披露 / above the fold / hamburger menu / skeuomorphism vs flat / micro-interaction / empty state / edge case / happy path / design debt 设计债 / dogfooding / dot voting / affinity mapping 亲和图 / card sorting 卡片分类 / tree testing / A/B test / NPS / SUS (System Usability Scale); (

日本語の概要は準備中です。原文の説明を表示しています。

半导体芯片制造工艺 (Semiconductor Process Engineering / 半导体芯片制造工艺 — 以「物理化学极限 + 良率经济双重约束」为特征的集成电路前道/后道制造工艺认知操作系统：从「器件架构与微缩路线（planar→FinFET→GAA nanosheet→CFET、等效微缩 DTCO/STCO、背面供电 BSPDN）→ 工艺整合（FEOL/MOL/BEOL 模块协同、PDK、流片 tape-out）→ 单元工艺（光刻 litho（DUV 浸没式 193i / EUV 13.5nm / 多重曝光 SADP-SAQP / OPC / mask）、刻蚀 etch（RIE/ICP/原子层刻蚀 ALE）、薄膜沉积 depo（CVD/PECVD/LPCVD/ALD/PVD/外延 epi/电镀 Cu）、掺杂 doping（离子注入 ion implant / 退火 RTA-laser anneal）、CMP 化学机械抛光、清洗 cleaning）→ 量测检测 metrology（CD-SEM / OCD / overlay / 椭偏 ellipsometry / 缺陷检测 defect inspection / e-beam）→ 良率工程 yield（缺陷密度 / SPC 统计过程控制 / FDC / APC / DOE 实验设计 / 良率爬坡 yield ramp）→ 先进封装 advanced packaging（2.5D/3D、CoWoS、HBM、混合键合 hybrid bonding、chiplet、TSV）」的完整器件-工艺-良率-量产决策链。覆盖 (a) 第一性张力 — **物理/化学/材料的硬约束（量子隧穿、短沟道效应、RC 延迟、热预算、缺陷物理、ppb 级污染控制）⇄ 良率/成本/产能的经济约束（每片晶圆成本、良率是主经济指标、D0 缺陷密度、wafer-per-hour、折旧）**；**持续微缩/摩尔定律（dimensional + equivalent scaling、节点路线图 N5/N3/N2/A16/A14、high-NA EUV）⇄ 物理极限/微缩放缓（原子尺度、漏电、功耗墙、成本墙、'摩尔定律已死'之争）**；**协同优化/整合（DTCO 设计-工艺协同、STCO 系统-工艺协同、模块间 trade-off）⇄ 单模块极致优化（单一 unit process 工艺窗口）**；**工艺配方的 tacit 手艺（process recipe 调试、工艺窗口、缺陷根因分析、量产 ramp 的经验）⇄ 可建模/可仿真/数据驱动（TCAD 仿真、ML 良率分析、APC/FDC、数字孪生）**；**性能-功耗-面积-成本 PPAC 四角权衡 ⇄ 良率/可制造性 DFM 优先**；**自主可控/国产替代（卡脖子、EUV 出口管制、设备/材料/EDA 国产化、SMIC/长江存储/长鑫/中微/北方华创/上海微电子）⇄ 全球高度分工（ASML 光刻垄断、AMAT/Lam/TEL/KLA 设备、TSMC/Samsung/Intel 代工、全球供应链）**。(b) 核心工作流 / pipeline（最标准、最易蒸高质量 + CLI 化）— 新节点/新工艺导入：器件目标与 PPAC 定义 → 工艺整合方案与 PDK → 单元工艺开发与配方调试（DOE 找工艺窗口）→ 量测建立与 SPC → 良率爬坡（缺陷分类 + 根因分析 + 工艺改善）→ 量产移交与持续改善。具体单元工艺 SOP：光刻（曝光条件 / OPC / overlay 控制 / 多重曝光分解）、刻蚀（选择比 / profile / loading effect / ALE）、沉积（台阶覆盖 / 应力 / 均匀性）、CMP（去除速率 / 碟形 dishing / 侵蚀 erosion）、量测与缺陷分析、良率分析与 FA 失效分析。(c) 工具栈 — 设备（光刻 ASML/上海微电子 SMEE；刻蚀+沉积 AMAT/Lam/TEL/中微 AMEC/北方华创 Naura；离子注入 AMAT/Axcelis；CMP AMAT/荏原 Ebara；量测检测 KLA/AMAT/中科飞测/上海精测）、EDA/TCAD/仿真（Synopsys Sentaurus/Silvaco/Coventor SEMulator3D、OPC Calibre/Synopsys）、良率与制造软件（SPC、MES、FDC/APC、缺陷分析 yield management、PWS）、材料（光刻胶 photoresist、CMP 浆料 slurry、特气、靶材、掩膜 mask blank）。(d) 知识正典 — 半导体工艺 canon 横跨器件物理与制造工程：核心教材（Plummer/Deal/Griffin《Silicon VLSI Technology》、Sze《Physics of Semiconductor Devices》《VLSI Technology》、Wolf & Tauber《Silicon Processing for the VLSI Era》、Campbell《Fabrication Engineering at the Micro and Nanoscale》、May & Spanos《Fundamentals of Semiconductor Manufacturing and Process Control》、Quirk & Serda《Semiconductor Manufacturing Technology》、肖国勇/施敏中文教材）、路线图（ITRS/IRDS、IEEE 国际器件与系统路线图）、顶会论文（IEDM、Symposium on VLSI Technology、IRPS 可靠性、SPIE Advanced Lithography、ISSCC、DAC）、行业分析（SemiAnalysis、TechInsights、IC Knowledge）。(e) figures/流派 — 学术与器件奠基（Gordon Moore 摩尔、Robert Dennard 登纳德微缩、胡正明 Chenming Hu FinFET/UTB-SOI 发明人 UC Berkeley、刘明 Tsu-Jae King Liu Berkeley、Krishna Saraswat Stanford、Mark Bohr Intel 工艺架构）、产业领袖与工艺大师（张忠谋 Morris Chang TSMC、林本坚 Burn-Jeng Lin 浸没式光刻、Martin van den Brink ASML、米玉杰/梁孟松 SMIC/三星工艺、Mark Liu/魏哲家 TSMC）、行业分析师（Dylan Patel SemiAnalysis、Scotten Jones IC Knowledge、TechInsights 拆解、Handel Jones）、科普与拆解（Asianometry、The Chip Letter、半导体行业观察）。流派分歧：等效微缩派 vs 摩尔定律已死派、前道微缩 vs 先进封装 chiplet 异构集成、dimensional scaling vs DTCO 协同优化、IDM vs 纯代工 foundry 模式、自主可控/国产替代路线 vs 全球分工。(f) 行业话术/黑话 — 制程节点 node / 流片 tape-out / 工艺窗口 process window / 良率 yield / 缺陷密度 D0 / 关键尺寸 CD / 套刻 overlay / 掩膜 reticle-mask / 光刻胶 PR / 浸没式 immersion / EUV/DUV / 多重曝光 multi-patterning SADP-SAQP / OPC / 刻蚀选择比 selectivity / profile / loading effect / 原子层刻蚀 ALE / 台阶覆盖 step coverage / 外延 epi / 离子注入 implant / 退火 anneal / RTA / CMP / dishing-erosion / FEOL-MOL-BEOL / FinFET / GAA / 纳米片 nanosheet / CFET / 背面供电 BSPDN / high-NA / PPAC / DTCO-STCO / DFM / SPC / FDC-APC / DOE / WAT-PCM / 良率爬坡 yield ramp / FA 失效分析 / particle 颗粒 / 洁净室 cleanroom-级别 / 12寸-8寸 wafer / chiplet / CoWoS / HBM / 混合键合 hybrid bonding / TSV / PDK / 等效微缩. (g) 争议/批判 — 「摩尔定律是否已死 vs 等效微缩继续」、「节点命名营销化（N3/N2 ≠ 物理 3nm/2nm，gate pitch/metal pitch 才是真尺度）」、「前道微缩 vs 先进封装异构集成谁是未来」、「自主可控/国产替代的现实（EUV 卡脖子、设备/材料/EDA 国产化进度、出口管制 entity list、良率与成熟度差距）」、「良率/成本/性能三角权衡」、「人才稀缺与工艺 know-how 的 tacit 性」、「中国大基金/产能扩张是否过剩」、「制裁与技术封锁」。(h) 大量隐性工艺手艺（process recipe 调试与工艺窗口寻找、缺陷根因分析与 FA、量产良率爬坡的经验判

日本語の概要は準備中です。原文の説明を表示しています。

Composes single-file HTML artifacts (PR review writeups, status reports, incident postmortems, slide decks, design systems, prototypes, flowcharts, module maps, feature explainers, kanban boards, prompt tuners) from a small JSON spec instead of hand-written HTML/CSS/JS. Use when the user asks to "compare options side-by-side", requests an HTML version of a report or review or deck, asks for a flowchart, status update, postmortem, design system reference, interactive prototype, custom editor — or explicitly says "HTML artifact", "single HTML file", "self-contained HTML". Skip for ad-hoc HTML snippets (forms, emails, embedded widgets) where there's no template fit.

日本語の概要は準備中です。原文の説明を表示しています。

Draft, review, and refactor Reddit comments for any company by providing a domain URL and a Reddit thread. Dynamically extracts product knowledge, approved terminology, voice and tone, and positioning guidelines from the domain before writing. Use this skill whenever the user provides a domain and a Reddit thread and asks to write, draft, review, or refactor a Reddit comment or engagement reply. Trigger on inputs like "Domain: [url] Thread: [url or paste]", "write a Reddit comment for this domain", "draft an engagement for this thread", or any variation where a company URL and a Reddit thread are both provided. Always use this skill — never write Reddit comments for a domain without following this full workflow.

日本語の概要は準備中です。原文の説明を表示しています。

Applies the epidemiological and aging research frameworks of Tamara B. Harris (epidemiologist, National Institutes of Health). Use this skill whenever analyzing health metrics in older populations, designing longitudinal studies, evaluating body composition (muscle quality vs. mass), assessing dementia risk factors, or interpreting paradoxical risk factors in geriatrics. Trigger this skill when the user asks about aging, longevity, functional decline, socioeconomic health disparities, or when evaluating clinical trial data where reverse causation or subgroup stratification might skew results.

日本語の概要は準備中です。原文の説明を表示しています。

Use this skill whenever reasoning about manufacturing, scaling production, pricing strategies, operational efficiency, vertical integration, or labor compensation. Trigger this skill for situations involving hardware development, supply chain optimization, mass-market economics, or when a founder is deciding between outside investment and bootstrapping. Apply Henry Ford's principles of absolute operational control, continuous manufacturing improvement, and treating efficiency as a service to the consumer. Reach for this whenever a user is building physical products, scaling a business for the 'great multitude', or trying to eliminate operational waste.

日本語の概要は準備中です。原文の説明を表示しています。

Context-aware line edit that strips generic AI writing patterns without flattening the author's voice, plus a findings-only audit mode that names issues instead of rewriting. Applies contextual rules rather than blanket bans on adverbs, passive voice, and punctuation, and locks facts, numbers, quotes, code, links, and the supplied house style before it touches a sentence. Use before copy, a README, an email, a social post, or a doc ships; after a long assisted-writing session; when the text sounds fine but feels generated; or when the user asks for a findings-only slop audit. NOT FOR: writing new copy from scratch; deciding whether a person or a model wrote text; changing or certifying facts, which must be checked against primary evidence before publication.

日本語の概要は準備中です。原文の説明を表示しています。

Suede Slop Stop: Suede Labs context-aware anti-slop pass for finished prose. Find or remove generic filler, manufactured emphasis, false agency, formulaic structure, chat and draft residue, and formatting applied by rule, without flattening the author's voice. Use before copy, a README, an email, a social post, or a doc ships; after a long assisted-writing session; or for a findings-only slop audit. NOT FOR: writing new copy (use suede-copy); deciding whether a person or model wrote text; changing or certifying facts, which require primary evidence.

日本語の概要は準備中です。原文の説明を表示しています。

Suede-owned app-store optimization discipline for keyword fields, titles, subtitles, descriptions, screenshots, ratings context, and competitor listing audits. Use when improving App Store or Google Play visibility or listing conversion from a live app URL and current console evidence, or when authoring keyword, name, subtitle, and promo fields for an app that has not shipped yet. NOT FOR: building or releasing the app (use android-app-factory or site-to-ios-app; native iOS builds are a private Suede Labs companion, not in this pack: ios-app-factory), creating paid ad assets (use suede-ad-creative), or install-event instrumentation (use suede-analytics).

日本語の概要は準備中です。原文の説明を表示しています。