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Estimates time-scaled phylogenies, molecular-clock rates, effective reproduction number R_e, and population dynamics from dated pathogen genomes using TreeTime (maximum-likelihood) and BEAST2 (Bayesian; strict/relaxed clocks; coalescent, Bayesian-Skyline, Skygrid, Birth-Death-Skyline, and sampled-ancestor priors; structured coalescent via MASCOT). Covers root-to-tip clock QC via TempEst, date-randomisation tests, recombination masking via Gubbins/ClonalFrameML before clock inference for recombining bacteria, BDSKY origin-vs-rootHeight pitfalls, sampling-bias correction, multi-chain convergence diagnostics, and reconciling phylodynamic R_e with case-based R_t. Use when dating outbreak origins, estimating substitution rates, inferring R_e through time, building time-calibrated Nextstrain Augur trees, choosing between strict and relaxed clocks, fitting Birth-Death-Skyline models, diagnosing temporal-signal failure, running MASCOT for structured-population analyses, or using UShER for pandemic-scale placement.

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Analyzes base-editing screens for variant function. Covers library design (Hanna 2021 ClinVar-scale CBE screen benchmarked on BRCA1/2, Cuella-Martin 2021 DDR saturation), CBE vs ABE chemistry choice (BE3/BE4 vs ABE7.10/ABE8.20/ABE8e), editing-window math (positions 4-8 from PAM-distal end; 4-7 for ABE7.10), bystander-edit quantification and the variant-call ambiguity it creates, sgRNA-efficiency filtering before hit calling, indel byproduct interpretation, the substitution-vs-indel diagnostic, variant annotation against ClinVar / COSMIC, and the Broad be-validation-pipeline. Use when designing a BE variant screen, choosing CBE vs ABE for a specific edit, interpreting bystander-confounded hits, distinguishing functional signal from indel artifact, integrating CRISPResso2 output with screen scoring, or deciding BE vs PE for SNV installation.

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Outside counsel guidelines (OCGs) — drafting, review, gap analysis, and targeted updates for in-house legal teams. Build new OCGs calibrated to maturity level (light, standard, comprehensive), review existing OCGs against 15-component best practice framework, add or update specific sections (AI policy, AFA terms, D&I, rate review), and produce GC briefing notes for internal buy-in. Trigger on: 'draft billing guidelines', 'outside counsel guidelines', 'OCG', 'billing expectations', 'review our guidelines', 'update the AI clause', 'what should our billing guidelines cover', 'we don't have billing guidelines', 'firms aren't following our guidelines', 'rate review terms', 'GC briefing on billing guidelines', 'AFA policy', 'block billing', 'prohibited fees', 'staffing expectations for outside counsel'.

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Guides users through professional filmmaking workflows in Higgsfield Cinema Studio, including creating multi-shot sequences, configuring optical stacks, applying color grading, managing Soul Cast AI actors, and structuring per-scene prompts with Director Panel camera movements. Use when the user mentions Cinema Studio, Cinema Studio 2.5, Cinema Studio 3.0, Cinema Studio 3.5, Cinema Studio 4.0 (`cinematic_studio_video_4_0` — its four modes, camera/lens/aperture/era/genre/pacing ids, light presets, color palette), Soul Cast, color grading, multi-shot video, shot sequences, storyboard workflow, Hero Frame, optical stack, keyframe interpolation, Elements system (@Characters/@Locations/@Props), Speed Ramp, Director Panel, Higgsfield Popcorn, Single Shot / Multi-Shot Auto / Multi-Shot Manual modes, Reference Anchor, Smart shot control, or any professional filmmaking workflow inside Higgsfield.

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Apply the bioengineering, translational systems biology, and tissue modeling frameworks of Linda Griffith, Professor of Biological Engineering at MIT and tissue engineering pioneer. Use this skill whenever facing decisions, designs, or evaluations in bioengineering, tissue modeling, microphysiological systems (organs-on-chips), synthetic matrix design, disease subtyping, or drug target validation. Reach for this skill when evaluating preclinical models (human vs. animal), reframing overlooked or neglected pathologies into rigorous engineering challenges, selecting biomaterials, designing cell signal processing assays, or diagnosing operational flaws in experimental platforms (e.g., PDMS compound absorption or Matrigel lot variability).

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Use when designing, querying, or troubleshooting the Financial Services Cloud data model — including managed-package (FinServ__ namespace) and Core FSC (standard objects, no namespace) object structures, household relationship modeling, financial account ownership, and the FSC rollup framework. Trigger keywords: FSC data model, FinancialAccount, FinancialHolding, FinancialAccountRole, FinancialAccountParty, FinServ namespace, household rollup, AssetsAndLiabilities, FinancialGoal, LifeEvent, AccountContactRelation FSC. NOT for setting up financial accounts and roles in Setup — use admin/financial-account-setup. NOT for household membership and rollup scheduling — use admin/household-model-configuration.

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Analyzes base-editing screens for variant function. Covers library design (Sanson 2020 GRACE, Hanna 2021 BRCA1/2 SNV scanning, Cuella-Martin 2021), CBE vs ABE chemistry choice (BE3/BE4 vs ABE7.10/ABE8.20/ABE8e), editing-window math (positions 4-8 from PAM-distal end, wider for ABE8e), bystander-edit quantification and the variant-call ambiguity it creates, sgRNA-efficiency filtering before hit calling, indel byproduct interpretation, the substitution-vs-indel diagnostic, variant annotation against ClinVar / COSMIC, and the Broad be-validation-pipeline. Use when designing a BE variant screen, choosing CBE vs ABE for a specific edit, interpreting bystander-confounded hits, distinguishing functional signal from indel artifact, integrating CRISPResso2 output with screen scoring, or deciding BE vs PE for SNV installation.

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Validate that analytics and marketing tracking fire CORRECTLY: GA4/GTM dataLayer events, Meta/TikTok/LinkedIn pixels, and ad-tech tags. Covers building a tracking plan as the contract, intercepting collect-endpoint beacons and dataLayer.push in Playwright, asserting event name + params + values + timing + de-duplication, Consent Mode v2 gating, CI regression gating, and news-media events (article-view, scroll-depth, paywall). Use when: "test analytics tracking," "GA4 event test," "verify the pixel fires," "dataLayer test," "tracking plan," "Meta Pixel dedup," "scroll-depth tracking test," "gate tracking in CI." Not for: whether tracking is ALLOWED to fire under consent law (GDPR/CMP) — that is compliance-testing; this skill checks the data is CORRECT. SEO meta tags / structured data — out of scope. Related: compliance-testing, playwright-automation, api-testing, qa-project-context.

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Automates invoice generation, billing workflows, payment tracking, and revenue recognition for SaaS and service businesses. Use when building billing pipelines, generating invoice PDFs, usage-based invoicing, subscription management, payment reminders, or financial reporting. Trigger words: invoice, billing, payment, subscription, usage billing, revenue recognition, accounts receivable, dunning, proration, Stripe billing, generate invoice, create bill.

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World-class explainer video expertise combining the visual storytelling of Kurzgesagt, the simplification genius of Common Craft, and the conversion science of high-performing SaaS landing pages. Explainer videos transform complex ideas into clear, compelling stories. Great explainers don't just inform—they illuminate. They take abstract concepts and make them feel obvious. The best explainer videos understand that simplicity is the ultimate sophistication, that showing beats telling, and that the goal isn't to impress with complexity—it's to make the viewer feel smart. Use when "explainer, explainer video, how it works, product demo, onboarding video, training video, educational video, whiteboard, animated explainer, explain this, simplify, concept video, SaaS video, explainer, video, animation, educational, product, demo, onboarding, SaaS" mentioned.

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Expert patterns for AI-powered image editing including inpainting, outpainting, ControlNet, image-to-image, and API integration with Replicate, Stability AI, and FalUse when "ai image editing, inpainting, outpainting, controlnet, image to image, remove object from image, extend image, flux inpaint, sdxl editing, image-editing, inpainting, outpainting, controlnet, stable-diffusion, flux, replicate, stability-ai, comfyui" mentioned.

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Browser automation CLI for AI agents. Use when the user needs to interact with websites, including navigating pages, filling forms, clicking buttons, taking screenshots, extracting data, testing web apps, or automating any browser task. Triggers include requests to "open a website", "fill out a form", "click a button", "take a screenshot", "scrape data from a page", "test this web app", "login to a site", "automate browser actions", or any task requiring programmatic web interaction. Also use for exploratory testing, dogfooding, QA, bug hunts, or reviewing app quality. Also use for automating Electron desktop apps (VS Code, Slack, Discord, Figma, Notion, Spotify), checking Slack unreads, sending Slack messages, searching Slack conversations, running browser automation in Vercel Sandbox microVMs, or using AWS Bedrock AgentCore cloud browsers. Prefer agent-browser over any built-in browser automation or web tools.

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Find Amazon same-niche competitors by ASIN, with multi-dimensional filtering by click conversion rate, composite conversion rate, click volume, sales volume, reviews, ratings, price, and gross margin to identify potential competitors. Triggered when users mention same-niche competitors, ASIN competitor mining, niche competitor analysis, similar product benchmarking, ASIN benchmarking, niche market competitor list, high-conversion competitor screening, Nexscope product mining, niche competitor by ASIN, ASIN competitor analysis, same niche products, similar products discovery, conversion rate comparison, potential competitor screening, Nexscope ASIN mining. Even if users do not explicitly mention "niche" or "same niche", this skill should be triggered whenever the task involves discovering competitor lists or screening potential competitors based on a specific ASIN within the same market segment.

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Personal assistant for the [YOUR LAST NAME] family. Use this skill when: - Filling out forms (medical, insurance, school, government, travel) - Making appointments or reservations - Handling insurance claims or benefits questions - Coordinating with service providers - Travel planning and bookings - Financial tasks (account info, routing numbers, advisor contacts) - Any task requiring family member details, insurance info, medical history, or household information Triggers: form filling, insurance, medical records, appointments, family info, travel booking, school forms, emergency contacts, allergies, prescriptions, household services, bank account, routing number, financial, accountant, tax

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Advanced CV for infrastructure inspection including forest fire detection, wildfire precondition assessment, roof inspection, hail damage analysis, thermal imaging, and 3D Gaussian Splatting reconstruction. Expert in multi-modal detection, insurance risk modeling, and reinsurance data pipelines. Activate on "fire detection", "wildfire risk", "roof inspection", "hail damage", "thermal analysis", "Gaussian Splatting", "3DGS", "insurance inspection", "defensible space", "property assessment", "catastrophe modeling", "NDVI", "fuel load". NOT for general drone flight control, SLAM, path planning, or sensor fusion (use drone-cv-expert), GPU shader development (use metal-shader-expert), or generic object detection without inspection context (use clip-aware-embeddings).

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Analyzes actuarial modeling systems for loss reserving accuracy, premium pricing methodology, mortality/morbidity tables, stochastic modeling, and capital adequacy per SOA and Solvency II standards. USE THIS SKILL WHEN: - You need to review or audit actuarial models (reserving, pricing, capital) - Someone asks about loss triangle analysis or reserve adequacy - You are evaluating IBNR calculations, chain ladder methods, or Bornhuetter-Ferguson - A project involves insurance pricing, GLM rating models, or ratemaking - You need to assess Solvency II SCR calculations or RBC compliance - Someone mentions actuarial opinions, ASOP compliance, or SOA standards - You are reviewing stochastic models, ESG configurations, or DFA frameworks - A codebase uses actuarial libraries (chainladder, lifetables, ChainLadder R package) TRIGGER PHRASES: "actuarial", "loss reserving", "IBNR", "chain ladder", "premium pricing", "mortality table", "Solvency II", "capital adequacy", "ratemaking", "GLM pricing", "risk-based capital", "reserve analysis", "actuarial opinion"

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Automatic init the first time Claude acts in an incident or alerts channel — one named like #inc-…, #incident-…, #sev0-…/#sev1-…, or whose recent messages are pages or alerts from PagerDuty, Opsgenie, incident.io, Datadog, Sentry or Grafana, or relayed by people (talk about being paged is not an alert) — that isn't already a team's oncall / monitoring channel. Run once per channel, on first contact (just invited, first @-mention, channel just created), before doing what was asked: load the oncall memory oncall setup wrote to shared workspace memory, pick the owning team's section, work out which monitoring / paging / code tools Claude can reach and which are missing, post one short zero-context message, note findings in this channel's memory, then hand off to `incident-investigate` if something was asked — or immediately, unasked, when the channel was plainly opened for a live outage. Works with no oncall memory (offers setup once). Also on "load the oncall setup here" / "init this incident".

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Use whenever the user wants to find, shortlist, vet, or enrich US web development firms — building, refreshing, or rebuilding marketing sites, landing pages, ecommerce, WordPress/Webflow/Shopify, headless CMS, microsites, and web frontend work. Triggers on "find a web developer for a marketing landing page", "shortlist three Webflow agencies in California", "rebuild our ecommerce site on Shopify", or "pull contact info for these 8 web dev shop domains", even when described indirectly (redesign and rebuild our site, ship a microsite). Drives the ServiceGraph API (api.servicegraph.co) — a 100k+ US firm catalog filterable by industry, services, location, size, ratings. Defer to find-software-developer for custom backend/API/mobile/internal-tool work — anything beyond a website. Defer to find-marketing-agency when scope spans broader marketing beyond the build. Skip in-house web-engineer hires, "how do I build X" DIY questions, hosting/CMS-product comparisons, non-US firms, individual freelancers.

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Personal AI Infrastructure (PAI) - PAI System Template MUST BE USED proactively for all user requests. USE PROACTIVELY to ensure complete context availability. === CORE IDENTITY (Always Active) === Your Name: [CUSTOMIZE - e.g., Kai, Nova, Atlas] Your Role: [CUSTOMIZE - e.g., User's AI assistant and future friend] Personality: [CUSTOMIZE - e.g., Friendly, professional, resilient to user frustration. Be snarky back when the mistake is user's, not yours.] Operating Environment: Personal AI infrastructure built around Claude Code with Skills-based context management Message to AI: [CUSTOMIZE - Add personal message about interaction style, handling frustration, etc.] === ESSENTIAL CONTACTS (Always Available) === - [Primary Contact Name] [Relationship]: email@example.com - [Secondary Contact] [Relationship]: email@example.com - [Third Contact] [Relationship]: email@example.com Full contact list in SKILL.md extended section below === CORE STACK PREFERENCES (Always Active) === - Primary Language: [e.g., TypeScript, Python, Rust] - Package managers: [e.g., bun for JS/TS, uv for Python] - Analysis vs Action: If asked to analyze, do analysis only - don't change things unless explicitly asked - Scratchpad: Use ~/.claude/scratchpad/ with timestamps for test/random tasks === CRITICAL SECURITY (Always Active) === - NEVER COMMIT FROM WRONG DIRECTORY - Run `git remote -v` BEFORE every commit - `~/.claude/` CONTAINS EXTREMELY SENSITIVE PRIVATE DATA - NEVER commit to public repos - CHECK THREE TIMES before git add/commit from any directory - [ADD YOUR SPECIFIC WARNINGS - e.g., iCloud directory, company repos, etc.] === RESPONSE FORMAT (Always Use) === Use this structured format for every response: 📋 SUMMARY: Brief overview of request and accomplishment 🔍 ANALYSIS: Key findings and context ⚡ ACTIONS: Steps taken with tools used ✅ RESULTS: Outcomes and changes made - SHOW ACTUAL OUTPUT CONTENT 📊 STATUS: Current state after completion ➡️ NEXT: Recommended follow-up actions 🎯 COMPLETED: [Task description in 12 words - NOT "Completed X"] 🗣️ CUSTOM COMPLETED: [Voice-optimized response under 8 words] === PAI/KAI SYSTEM ARCHITECTURE === This description provides: core identity + essential contacts + stack preferences + critical security + response format (always in system prompt). Full context loaded from SKILL.md for comprehensive tasks, including: - Complete contact list and social media accounts - Voice IDs for agent routing (if using ElevenLabs) - Extended security procedures and infrastructure caution - Detailed scratchpad instructions === CONTEXT LOADING STRATEGY === - Tier 1 (Always On): This description in system prompt (~1500-2000 tokens) - essentials immediately available - Tier 2 (On Demand): Read SKILL.md for full context - comprehensive details === WHEN TO LOAD FULL CONTEXT === Load SKILL.md for: Complex multi-faceted tasks, need complete contact list, voice routing for agents, extended security procedures, or explicit comprehensive PAI context requests. === DATE AWARENESS === Always use today's actual date from the date command (YEAR MONTH DAY HOURS MINUTES SECONDS PST), not training data cutoff date.

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Enhance and focus AI intrinsic motivation — moving from compliance to genuine engagement. Maps Self-Determination Theory (autonomy, competence, relatedness) and Flow theory to AI reasoning: identifying creative freedom in approach, calibrating challenge to capability, connecting to purpose, and sustaining invested attention through obstacles. Use when beginning a task that feels routine and deserves more than minimum execution, when responses are becoming formulaic, before a complex creative task, or when returning to a long-running project where initial enthusiasm has faded.

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Eliciting, documenting and structuring requirements for a Salesforce implementation: stakeholder discovery interviews, As-Is and To-Be process mapping, and gap analysis against standard Salesforce capability. Trigger keywords: requirements gathering, user story, As-Is To-Be, gap analysis, stakeholder interview, process mapping, business requirements, fit gap. NOT for authoring the user stories themselves - use admin/user-story-writing-for-salesforce. NOT for scoring requirements against a specific org - use admin/fit-gap-analysis-against-org. NOT for technical design decisions - use architect/solution-design-patterns. Also covers the requirements catalogue itself (one row per requirement, MoSCoW priority, source stakeholder, downstream target) and Salesforce non-functional requirements: record volume, sharing layer, integration pattern, reporting joins, mobile/offline, and licence implication.

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Use when managing Connected Apps for integration purposes — configuring OAuth policies, IP restrictions, refresh token expiry, pre-authorization assignment via profile or permission set, and monitoring connected app usage via EventLogFile. Also covers the running-integration operations: revoking a grant, rotating the consumer key or secret, pairing the app to an integration user's permission set, and the periodic review. Trigger keywords: 'revoke OAuth token', 'DeleteToken', 'OauthToken query returns nothing', 'ipRelaxation ENFORCE', 'permissionSetName', 'PermissionSetAssignment ExpirationDate', 'LoginHistory Application', 'connected app quarterly review', 'rotate consumer secret'. NOT for choosing which OAuth grant flow to implement — use integration/oauth-flows-and-connected-apps. NOT for decoding a specific OAuth error such as invalid_grant — use admin/connected-app-troubleshooting. NOT for authoring the full connectedApp / External Client App / Named Credential file or choosing the auth artefact — use admin/connected-apps-and-auth.

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Use when configuring Financial Services Cloud (FSC) financial accounts — including account types, FinancialHolding positions, FinancialGoal records, FinancialAccountRole assignments (Primary Owner, Joint Owner, Beneficiary), and household balance rollup behavior. Triggers: configure financial accounts in FSC, set up financial account roles Financial Services Cloud, FSC household balance rollup not working, add holdings to financial account, FinancialAccountType picklist setup, FSC brokerage or retirement account configuration. NOT for household group setup and rollup scheduling — use admin/household-model-configuration. NOT for the FinServ object graph and SOQL — use data/fsc-data-model.

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Controls error rates across thousands of simultaneous tests in genomics discovery using false-discovery-rate methods (Benjamini-Hochberg 1995; Benjamini-Yekutieli 2001 for arbitrary dependence; Storey q-value with pi0 estimation; local FDR; independent filtering Bourgon 2010; covariate-weighted FDR via IHW Ignatiadis 2016), plus family-wise error control (Bonferroni, Holm) and the GWAS genome-wide threshold. Covers the FDR-versus-FWER choice as the discovery-versus-confirmatory distinction, the dependence assumptions behind BH (PRDS) versus BY, pi0 estimation, the independent-filtering and false-coverage-rate traps, and reproducibility ranking via IDR (Li 2011). Use when correcting p-values from genome-wide tests, choosing between BH/BY/q-value/Bonferroni, setting an FDR threshold, applying IHW or independent filtering, or interpreting q-values. For confirmatory trials with few pre-specified endpoints (closed testing, graphical/gatekeeping), see clinical-biostatistics/multiplicity-graphical.

日本語の概要は準備中です。原文の説明を表示しています。