「sat」の検索結果

Estimates time-scaled phylogenies, molecular-clock rates, effective reproduction number R_e, and population dynamics from dated pathogen genomes using TreeTime (maximum-likelihood) and BEAST2 (Bayesian; strict/relaxed clocks; coalescent, Bayesian-Skyline, Skygrid, Birth-Death-Skyline, and sampled-ancestor priors; structured coalescent via MASCOT). Covers root-to-tip clock QC via TempEst, date-randomisation tests, recombination masking via Gubbins/ClonalFrameML before clock inference for recombining bacteria, BDSKY origin-vs-rootHeight pitfalls, sampling-bias correction, multi-chain convergence diagnostics, and reconciling phylodynamic R_e with case-based R_t. Use when dating outbreak origins, estimating substitution rates, inferring R_e through time, building time-calibrated Nextstrain Augur trees, choosing between strict and relaxed clocks, fitting Birth-Death-Skyline models, diagnosing temporal-signal failure, running MASCOT for structured-population analyses, or using UShER for pandemic-scale placement.

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Quality control for flow, spectral, and mass cytometry - time-based anomaly cleaning (flowAI, flowCut, PeacoQC, flowClean), margin/boundary event removal, signal-drift detection, dead-cell exclusion, CyTOF Gaussian/DNA/event-length checks, instrument calibration/standardization (MESF, CS&T, peak-2), and batch-level outlier flagging. Use when assessing acquisition quality, choosing a cleaning tool, ordering QC relative to compensation, deciding margin removal before density-based steps, or flagging problematic samples before clustering or differential analysis.

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Designs and analyzes pooled prime-editor (PE) screens for installing precise genetic variants without bystander confounding. Covers pegRNA design with PRIDICT and PRIDICT2 for predicting per-pegRNA editing efficiency, pegRNA architecture (spacer + scaffold + PBS + RTT), PE2/PE3/PE3b/PEmax variants, MOSAIC in situ saturation mutagenesis, the PRIME pooled-screen methodology (Ren 2023; ~3,699 ClinVar variant screens), chromatin context as a major locus-level determinant of PE efficiency, scaffold-incorporation and indel byproduct quantification with CRISPResso2, and the cross-modal validation strategy of PE + base-editor screens for variant function. Use when designing a pegRNA library for variant installation, choosing between BE and PE for a specific edit, predicting pegRNA efficiency before library synthesis, analyzing PE screen output, distinguishing intended-edit from scaffold-incorporation, or scaling PE screens to thousands of variants.

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Analyzes base-editing screens for variant function. Covers library design (Hanna 2021 ClinVar-scale CBE screen benchmarked on BRCA1/2, Cuella-Martin 2021 DDR saturation), CBE vs ABE chemistry choice (BE3/BE4 vs ABE7.10/ABE8.20/ABE8e), editing-window math (positions 4-8 from PAM-distal end; 4-7 for ABE7.10), bystander-edit quantification and the variant-call ambiguity it creates, sgRNA-efficiency filtering before hit calling, indel byproduct interpretation, the substitution-vs-indel diagnostic, variant annotation against ClinVar / COSMIC, and the Broad be-validation-pipeline. Use when designing a BE variant screen, choosing CBE vs ABE for a specific edit, interpreting bystander-confounded hits, distinguishing functional signal from indel artifact, integrating CRISPResso2 output with screen scoring, or deciding BE vs PE for SNV installation.

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Align preprocessed CLIP-seq reads (eCLIP, iCLIP, iCLIP2, PAR-CLIP) to genome with STAR or bowtie2 using crosslink-preserving parameters, choosing between unique-mapper-only and multi-mapper-aware alignment for repeat-binding RBPs, deciding STAR vs HISAT2 memory trade-offs, and applying ENCODE-compatible filters. Use when turning preprocessed CLIP FASTQ into a deduplicated, MAPQ-filtered BAM ready for peak calling or crosslink-site detection.

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Designs Bayesian clinical trials including Phase I dose-finding (BOIN, CRM, EWOC, mTPI-2), meta-analytic-predictive (MAP) priors with robust mixtures for external data borrowing, EXNEX for basket trials, hierarchical models for safety AE (Berry-Berry), Bayesian platform trials (I-SPY 2, GBM AGILE, REMAP-CAP), and posterior probability stopping rules. Covers FDA Bayesian Devices Guidance (2010), FDA Bayesian Methodology in Drugs Draft (January 2026), BOIN Fit-for-Purpose qualification (December 2021), and Project Optimus dose-optimisation. Use when designing dose-finding studies, platform trials, or sensitivity analyses with informative priors.

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Calls microsatellite instability from WES/WGS/targeted-panel with MSIsensor, MSIsensor-pro, MSIsensor-ct (panel-aware), mSINGS, and MANTIS for FDA pembrolizumab MSI-H pan-tumor / Lynch syndrome / dMMR ICI biomarker. Use when stratifying ICI eligibility (Le 2015), pairing MSI with TMB-H (Sha 2020 / Salem 2018), screening Lynch syndrome (universal IHC + MSI), or distinguishing MSI-H tumors from POLE-exo hypermutator with overlapping signatures.

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Designs adaptive clinical trials including group-sequential (O'Brien-Fleming, Pocock, Lan-DeMets spending), sample-size re-estimation (blinded Friede-Kieser, unblinded Cui-Hung-Wang, Mehta-Pocock promising zone), seamless Phase 2/3 with treatment-arm selection, population enrichment, and response-adaptive randomisation. Covers FDA 2019 Final Adaptive Designs Guidance, FDA 2022 Master Protocols, and ICH E20 Step 2b/3 draft (June 2025, NOT final). Use when planning interim analyses, sample-size re-estimation, or master/platform-trial designs.

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Performs logistic regression for clinical trial outcomes (binary, ordinal, multinomial) with marginal-vs-conditional estimand reporting per FDA 2023 covariate adjustment guidance, g-computation/standardisation for marginal effects, modified Poisson for RR, Brant test for proportional odds, Firth penalty for separation, and Hauck-Donner detection. Use when modeling binary or ordinal endpoints in confirmatory or exploratory clinical trials.

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Estimates bivariate genetic correlation (rg) between traits from GWAS summary statistics or individual-level genotypes using cross-trait LDSC, HDL, LAVA, rho-HESS, GREML-bivariate, Popcorn, and HDL-L. Use when quantifying shared genetic architecture between two traits, screening MR validity before causal inference, distinguishing global from locus-level rg, estimating trans-ancestry rg, separating partial from full causation via LCV gcp, or producing a STROBE-MR-compliant cross-trait sensitivity battery. Cross-trait LDSC intercept absorbs sample overlap and is NOT a bias; HDL is biased under sample overlap above ~5%. High rg between exposure and outcome motivates CHP-aware MR sensitivity (CAUSE, LHC-MR).

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Estimate causal effects of an exposure on an outcome from GWAS summary statistics using genetic instruments. Implements IVW (fixed/random), MR-Egger, weighted median/mode, MR-RAPS, CAUSE, GSMR-HEIDI, MR-PRESSO, MVMR, MR-Clust, LCV, and LHC-MR via TwoSampleMR, MendelianRandomization, MR-PRESSO, cause, and lhcMR. Use when testing causal direction between traits, evaluating drug-target effects via cis-pQTL/cis-eQTL, performing multivariable mediation MR, distinguishing causation from correlated horizontal pleiotropy, or producing STROBE-MR-compliant sensitivity batteries.

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Assesses RNA-seq data quality specifically for alternative splicing analysis. QC layers include experimental design audit (library prep, read length, depth, replicates), STAR 2-pass cohort-style alignment, junction saturation curves and discovery plateau detection, novel-vs-known junction ratio diagnostics, junction-overhang distribution, splice-site strength scoring (MaxEntScan intrinsic + SpliceAI context-aware), strandedness verification, GENCODE basic vs comprehensive choice, and rRNA contamination screening. Splicing analysis is more demanding than DGE on read length, depth, library prep, alignment strategy, and annotation choice — failures silently bias PSI estimates and inflate novel-junction false positives. Use when evaluating data suitability for splicing analysis, troubleshooting low event detection, or designing sequencing experiments where AS is a primary endpoint.

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Conversational search runtime: send messages, keep sessions consistent, and verify retrieval behavior and responses.

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Drives a multi-turn conversation with a LiveKit agent running locally to see what it does. Use when the user says "test my agent", "try my agent", "does this work", "why did it call that tool", "it says the wrong thing when I ask X", "test this change", or whenever you have edited an agent and need to check how it behaves. Wraps `lk agent debugger`: start the agent in text mode, send turns, read the tool calls, handoffs, errors and logs behind each reply, and restart after an edit. It runs without audio or a LiveKit room at one LLM call per turn, so it is the preferred way for a coding agent to live-test during development, and the default when the user says "test" without naming unit tests or simulations.

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Deploys and operates a LiveKit agent in production: shipping a version to LiveKit Cloud and rolling it back, secrets and configuration, the worker process model and prewarming, safe async inside worker processes, provider timeouts and degradation, graceful shutdown, SDK upgrades, and observability. Use when the user says "deploy my agent", "roll back the deployment", "tail the agent logs", "the first call after a restart is slow", "attached to a different loop / event loop is closed", "prewarm the VAD", "shut down without dropping calls", "upgrade livekit-agents safely", "correlate logs by session", or is changing an agent codebase that is already live. Not for designing the agent (building-livekit-agents) or reproducing one bad conversation locally (debugging-livekit-agents).

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Runs LiveKit agent simulations and acts on the results. Use when the user says "run my simulations", "regression test my agent before deploying", "run the scenarios", "use lk agent simulate", "did my agent pass", "why did this scenario fail", "run simulations in CI", "test the audio pipeline", "check turn-taking and interruptions", or wants to check whole-conversation behavior before shipping. Covers text and audio mode and what each catches, running against a local or deployed agent, degraded-audio flags, automating a pre-release run, and triaging failures with list, view and export. For writing the scenarios use writing-livekit-scenarios. Not the default for a bare "test my agent", which goes to debugging-livekit-agents. Use this skill when the user names simulations, scenarios, a run, CI, or shipping.

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Export conversation MATLAB code to a clean, runnable .m script. Use when asked to save or export session work. TRIGGER: user asks to save, export, or generate a script from the current session's MATLAB code. Also when asked for a reproducible script or clean version of what was run.

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Design and analyze electrically large antenna structures using MATLAB Antenna Toolbox. Covers reflector antennas (parabolic, Cassegrain, Gregorian, offset, corner, cylindrical, spherical, custom STL), reflectarrays and reconfigurable intelligent surfaces (RIS), antennas installed on platforms (vehicles, aircraft, ships, satellites), and radar cross section (RCS) analysis. Includes solver selection (MoM-PO, PO, MoM, FMM), mesh control, and GPU acceleration. Use when the user wants to design a dish/reflector antenna, reflectarray, analyze an antenna on a platform, or compute RCS.

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Patterns for using blockedImage to process large images, harness parallel compute for image processing, and write custom adapters. Use when writing code that creates, processes, or visualizes blockedImage objects, when implementing images.blocked.Adapter subclasses, or when a user needs help with large image data. Always use this skill when working with TIFF,GeoTIFF, .svs, .ndpi, .czi or other WSI, satellite imagery or microscopy volume image formats.

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Work with hyperspectral and multispectral images in MATLAB. Covers reading/writing (ENVI, NITF, TIFF, Sentinel-2, Landsat, ASTER), ECOSTRESS spectral libraries, processing (calibration, atmospheric correction, denoising, sharpening, dimensionality reduction, endmember extraction, unmixing, target/anomaly detection, spectral indices, segmentation), labeling (Spectral Image Labeler app, ground truth objects, automation algorithms), and deep learning (pixel classification CNNs, unmixing autoencoders, transfer learning). Use when reading, writing, processing, analyzing, classifying, labeling, or applying deep learning to hyperspectral or multispectral images.

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Design and operationalize SRE dashboards that surface reliability, latency, error, saturation, and capacity signals across services. Use when building observability views for SLOs, incident response, and executive reliability reporting.

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Verify claims, quotations, citations and references against live primary sources, and produce a reproducible audit record instead of an assertion. Use when asked to: check whether a quotation, verse, statistic, date, attribution or citation is accurate; verify references before publishing a report, thesis, article, slide deck or legal filing; confirm a text against an authoritative database; cross-check a claim across independent sources; build a citation register or verification appendix; find out whether two datasets agree; detect a misattributed or fabricated quotation; or audit a document's existing citations. Source-agnostic by design, with working providers for REST/JSON APIs, scraped HTML, bulk corpora, bibliographic catalogues (OpenLibrary), DOI resolution (Crossref) and reference works (Wikipedia) -- including scriptural tiers (Qur'an.com, sunnah.com and an independent hadith corpus) with full diacritic handling for Arabic, Hebrew, Greek and any script with optional marks. Covers content-addressed matching when sources disagree on numbering, graded match verdicts, byte-level integrity checks, published-string verification, and a catalogue of silent failure modes (identifier divergence, mojibake, scraper blocking, false-positive keyword rules, missing glyphs, unreliable PDF text layers).

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Supply Chain Optimization (Lite) - Diagnose bottlenecks and provide cost reduction strategies through conversation

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Customer service on TikTok Shop — response time, dispute resolution, auto-replies, buyer satisfaction

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