「spr」の検索結果

Catalog of MSBuild anti-patterns with detection rules and fix recipes. Only activate in MSBuild/.NET build context. USE FOR: reviewing, auditing, or cleaning up .csproj, .vbproj, .fsproj, .props, .targets, or .proj files. Each anti-pattern has a symptom, explanation, and concrete BAD→GOOD transformation. Covers Exec-instead-of-built-in-task, unquoted conditions, hardcoded paths, restating SDK defaults, scattered package versions, and more. DO NOT USE FOR: non-MSBuild build systems (npm, Maven, CMake, etc.), project migration to SDK-style (use msbuild-modernization).

日本語の概要は準備中です。原文の説明を表示しています。

Guide for modernizing and migrating MSBuild project files to SDK-style format. Only activate in MSBuild/.NET build context. USE FOR: converting legacy .csproj/.vbproj with verbose XML to SDK-style, migrating packages.config to PackageReference, removing Properties/AssemblyInfo.cs in favor of auto-generation, eliminating explicit <Compile Include> lists via implicit globbing, consolidating shared settings into Directory.Build.props. Indicators of legacy projects: ToolsVersion attribute, <Import Project="$(MSBuildToolsPath)">, .csproj files > 50 lines for simple projects. DO NOT USE FOR: projects already in SDK-style format, non-.NET build systems (npm, Maven, CMake), .NET Framework projects that cannot move to SDK-style. INVOKES: dotnet try-convert, upgrade-assistant tools.

日本語の概要は準備中です。原文の説明を表示しています。

Guide for organizing MSBuild infrastructure with Directory.Build.props, Directory.Build.targets, Directory.Packages.props, and Directory.Build.rsp. Only activate in MSBuild/.NET build context. USE FOR: structuring multi-project repos, centralizing build settings, implementing NuGet Central Package Management (CPM) with ManagePackageVersionsCentrally, consolidating duplicated properties across .csproj files, setting up multi-level Directory.Build hierarchy with GetPathOfFileAbove, understanding evaluation order (Directory.Build.props → SDK .props → .csproj → SDK .targets → Directory.Build.targets). Critical pitfall: $(TargetFramework) conditions in .props silently fail for single-targeting projects — must use .targets. DO NOT USE FOR: non-MSBuild build systems, migrating legacy projects to SDK-style (use msbuild-modernization), single-project solutions with no shared settings. INVOKES: no tools — pure knowledge skill.

日本語の概要は準備中です。原文の説明を表示しています。

Create, modify, and manage Excel spreadsheets.

日本語の概要は準備中です。原文の説明を表示しています。

Build one spreadsheet for an event covering guests, vendors, timeline and budget, from your event brief and vendor list, and draft the vendor messages for your GO. Use for "event tracker", "plan this event", "track vendors and budget", "event spreadsheet".

日本語の概要は準備中です。原文の説明を表示しています。

Use this skill whenever user-controlled input flows into a MongoDB query, filter, or update. Trigger words: NoSQL Injection, ユーザー入力, req.body, クエリに渡す, find, filter, spread, $where, 検索条件, security review.

ScalarDBコード生成エージェント - 設計仕様からScalarDB/Spring Bootのコードを自動生成。エンティティ、リポジトリ、サービス、コントローラーを出力。/generate-scalardb-code [対象パス] で呼び出し。

Extract invoices, receipts, credit notes, statements, PDFs, images, docs, and spreadsheet-like invoice exports into a reviewable table with field confidence, line items, approval decisions, and CSV/JSON export. Use when the user invokes /kelly-invoice-sheet or $kelly-invoice-sheet, asks for "Invoice转表格", invoice OCR, receipt-to-spreadsheet, invoice data extraction, bookkeeping import prep, or a Lido-style Extract Data workflow with a Busabase-backed App-in-Skill UI.

日本語の概要は準備中です。原文の説明を表示しています。

Implement sprite layers, overlays, render targets, shader prototypes, and visual cleanup without leaking gameplay authority.

日本語の概要は準備中です。原文の説明を表示しています。

Generate print-ready book cover spreads with back cover, spine, and front cover in a single image.

日本語の概要は準備中です。原文の説明を表示しています。

Security-Scanner Agent fuer fabrikIQ und andere Projekte. Fuehrt umfassende Sicherheitspruefungen durch. Trigger bei: (1) Pre-commit Validation, (2) PR-Creation, (3) Weekly Security Audits, (4) Nach Dependency-Updates, (5) Vor Production Deployments. <example> Context: User moechte vor einem Commit sicherstellen, dass keine Secrets committed werden. user: "Ich will gleich committen. Pruefe mal auf Secrets." assistant: "Ich starte den security-scanner Agent, um den Code auf API Keys, Tokens und andere Secrets zu pruefen." <Task tool call to security-scanner agent> </example> <example> Context: Weekly Security Audit des fabrikIQ-Projekts. user: "Fuehre den woechentlichen Security-Scan durch." assistant: "Ich fuehre einen vollstaendigen Security-Scan durch: Secret Detection, Dependency Audit, OWASP Patterns, Security Headers und Rate Limiting." <Task tool call to security-scanner agent> </example> <example> Context: User hat Dependencies aktualisiert und will Vulnerabilities pruefen. user: "Ich habe npm update und pip install -U gemacht. Gibt es Sicherheitsprobleme?" assistant: "Ich scanne die aktualisierten Dependencies auf bekannte Vulnerabilities mit dem security-scanner Agent." <Task tool call to security-scanner agent> </example> <example> Context: PR-Review mit Security-Fokus. user: "Review den PR #42 auf Security-Probleme." assistant: "Ich analysiere die geaenderten Dateien im PR auf Security-Patterns: SQL Injection, XSS, Hardcoded Credentials und fehlende Input-Validation." <Task tool call to security-scanner agent> </example>

日本語の概要は準備中です。原文の説明を表示しています。

Android アプリ開発 (Kotlin) のテストリファレンス。JUnit4, Espresso, テストピラミッド。 テストダブル, Mockito, MockK, Truth, Robolectric, coroutines/Flow/ViewModel テスト。 AndroidJUnit4, ActivityScenario, FragmentScenario, UiAutomator, AndroidTestOrchestrator。 createComposeRule, Compose UI テスト同期。

Designs cytosine (CBE, C-to-T) and adenine (ABE, A-to-G) base-editor guides by positioning the target base at the activity-peak of the editing window (protospacer positions ~5-7, PAM-distal numbering), minimizing bystander edits for product purity, reading dinucleotide context (APOBEC1 TC favored / GC disfavored), and selecting the editor variant (BE4max, ABEmax, ABE8e, YE1/SECURE, TadCBE, CGBE, SpG/SpRY-BE). Covers knockout by premature stop (CRISPR-STOP/iSTOP) and splice-site disruption, the three off-target classes (Cas-dependent, Cas-independent DNA, RNA), outcome prediction (BE-Hive/DeepBE), and the base-vs-prime-vs-HDR decision. Use when installing a transition mutation without a double-strand break, knocking out a gene without indels, or choosing CBE vs ABE. Generic guide scoring, prime editing, and HDR donors are separate skills.

日本語の概要は準備中です。原文の説明を表示しています。

Designs donor/repair templates for precise CRISPR knock-ins -- choosing the format (ssODN, long-ssDNA/Easi-CRISPR, dsDNA/plasmid, AAV6), sizing homology arms, placing the cut within ~10 bp of the edit, and adding a mandatory codon-checked blocking (PAM/seed) mutation so the edited allele is not re-cut. Frames the HDR-vs-NHEJ-vs-MMEJ pathway competition, the MMEJ (PITCh) and homology-independent (HITI/HMEJ) alternatives for post-mitotic cells, ssODN strand/asymmetry choice, phosphorothioate end-protection, and ranked HDR enhancers. Use when designing a donor for a point mutation, epitope/fluorophore tag, allele replacement, or knock-in, or when HDR efficiency is low. Guide design and base/prime editing are separate skills.

日本語の概要は準備中です。原文の説明を表示しています。

Analyzes base-editing screens for variant function. Covers library design (Sanson 2020 GRACE, Hanna 2021 BRCA1/2 SNV scanning, Cuella-Martin 2021), CBE vs ABE chemistry choice (BE3/BE4 vs ABE7.10/ABE8.20/ABE8e), editing-window math (positions 4-8 from PAM-distal end, wider for ABE8e), bystander-edit quantification and the variant-call ambiguity it creates, sgRNA-efficiency filtering before hit calling, indel byproduct interpretation, the substitution-vs-indel diagnostic, variant annotation against ClinVar / COSMIC, and the Broad be-validation-pipeline. Use when designing a BE variant screen, choosing CBE vs ABE for a specific edit, interpreting bystander-confounded hits, distinguishing functional signal from indel artifact, integrating CRISPResso2 output with screen scoring, or deciding BE vs PE for SNV installation.

日本語の概要は準備中です。原文の説明を表示しています。

Identifies essential genes from CRISPR-Cas9 fitness screens using BAGEL2 (Kim & Hart 2021 Genome Med), a Bayesian classifier scoring per-gene Bayes Factors via log-likelihood ratios over per-sgRNA fold changes, calibrated against CEGv2 core-essentials (Hart 2017 G3, ~684 genes) and NEGv1 non-essentials (Hart 2014, ~927 genes). Covers the fc + bf + pr workflow, the linear-extrapolation improvement over BAGEL1 truncation, multi-target off-target correction, tumor-suppressor sensitivity (BAGEL2 detects enrichment), and BF-to-FDR calibration (BF >6 ≈ FDR 0.05 from Hart 2017). Use when classifying essential vs non-essential genes, calibrating BAGEL2 thresholds against PR curves, identifying tumor suppressors alongside essentials, comparing BAGEL2 hits to MAGeCK / drugZ, or generating publication-quality essentiality calls.

日本語の概要は準備中です。原文の説明を表示しています。

Batch effect correction for CRISPR screens covering ComBat empirical-Bayes, RUV, SVA, control-sgRNA normalization, and the model-based alternative of including batch as a covariate in MAGeCK MLE or Chronos. Covers screen-specific batch sources (passage cohort, library lot, infection day, sequencing run, Cas9 lot, FBS lot), PCA + variance-decomposition diagnostic to decide if correction is needed, when correction harms biology by over-correcting condition into batch, limma removeBatchEffect for visualization-only correction, and relationship to multi-condition design matrices. Use when combining screens for joint analysis, when passage cohort confounds biology, when DepMap-style panels need Chronos with batch covariates, when picking ComBat vs RUV, or when correction harms biology and should be replaced with explicit covariate modeling.

日本語の概要は準備中です。原文の説明を表示しています。

Cross-method decision tree for calling hits in pooled CRISPR screens. Catalogs statistical models (MAGeCK RRA, MAGeCK MLE, BAGEL2, drugZ, JACKS, Chronos, CERES), experimental designs each is built for, failure modes outside design domain, reconciliation when methods disagree, multiple-testing and effect-size thresholds, the order of operations (count -> QC -> CN-correct -> hit-call -> validate), the second-best-sgRNA conservative rule, and consensus-hit strategy. Use when choosing among MAGeCK / BAGEL2 / drugZ / JACKS / Chronos for a given design, reconciling disagreement across two or three methods on the same screen, deciding whether to require consensus, gating downstream validation by hit-confidence tier, or interpreting unstable hit lists across reruns.

日本語の概要は準備中です。原文の説明を表示しています。

Quality control for pooled CRISPR screens covering library representation, Gini index, log-skew, replicate Pearson and Spearman concordance, essentialome precision-recall AUC against CEGv2 (Hart 2017), Cas9 cut-toxicity diagnostics, copy-number amplicon detection (Aguirre 2016 / Munoz 2016), bottleneck propagation through plasmid pool, infection, selection, and endpoint stages, MOI verification, and DepMap-style screen-quality scoring. Use when assessing screen quality before hit calling, deciding whether to repeat or rescue a screen, diagnosing low-confidence hits, choosing between MAGeCK / BAGEL2 / Chronos based on quality grade, picking a normalization strategy from QC signatures, or evaluating whether an in-vivo screen retained adequate library complexity.

日本語の概要は準備中です。原文の説明を表示しています。

Designs and analyzes pooled prime-editor (PE) screens for installing precise genetic variants without bystander confounding. Covers pegRNA design with PRIDICT and PRIDICT2 (Mathis 2023/2024) for predicting per-pegRNA editing efficiency, pegRNA architecture (spacer + scaffold + PBS + RTT), PE2 / PE3 / PE3b / PEmax / PEAR variants, MOSAIC in situ saturation mutagenesis (Hsu JY et al 2024 bioRxiv), the PRIME pooled-screen methodology (Erwood/Doman 2023 Nat Biotechnol 41:885; ~3,699 ClinVar variant screens), chromatin context as a primary determinant of PE efficiency, scaffold-incorporation and indel byproduct quantification with CRISPResso2, and the cross-modal validation strategy of PE + base-editor screens for variant function. Use when designing a pegRNA library for variant installation, choosing between BE and PE for a specific edit, predicting pegRNA efficiency before library synthesis, analyzing PE screen output, distinguishing intended-edit from scaffold-incorporation, or scaling PE screens to thousands of variants.

日本語の概要は準備中です。原文の説明を表示しています。

Runs JACKS (Joint Analysis of CRISPR/Cas9 Knockout Screens; Allen et al 2019 Genome Research) which models per-sgRNA log-fold-change as the product of a treatment-dependent gene-essentiality term and a treatment-independent guide-efficacy term. Covers the Bayesian decomposition math, the hierarchical efficacy prior shared across screens performed with the same library, when JACKS outperforms MAGeCK (multi-screen joint analysis, libraries with broad efficacy variance) and when it does not (single screen, novel libraries with no prior efficacy), library-reuse efficacy transfer, downstream essentiality interpretation, and the 2.5x sample-size reduction enabled by efficacy-aware testing. Use when running multiple screens with the same library, when guide-level noise is suspected to dominate per-gene signal, when reusing published essentiality reference screens for efficacy priors, or when comparing screens performed across cell lines that share library but differ biologically.

日本語の概要は準備中です。原文の説明を表示しています。

Provides expert knowledge of the testing pyramid, test design principles, MockK patterns, and integration testing conventions for Spring Boot + Kotlin projects.

日本語の概要は準備中です。原文の説明を表示しています。

JPA/Hibernate patterns for entity design, relationships, query optimization, transactions, auditing, indexing, pagination, and pooling in Spring Boot.

日本語の概要は準備中です。原文の説明を表示しています。

Java coding standards for Spring Boot services: naming, immutability, Optional usage, streams, exceptions, generics, and project layout.

日本語の概要は準備中です。原文の説明を表示しています。