「summary」の検索結果

Performs gene-level association from GWAS summary statistics via genetically predicted tissue expression using FUSION, PrediXcan, S-PrediXcan, S-MultiXcan, UTMOST, MOSTWAS, kTWAS, EpiXcan, TIGAR-V2, and probabilistic fine-mapping with FOCUS and MA-FOCUS. Use when running TWAS from GWAS sumstats, prioritising candidate causal genes from a GWAS lead locus, picking single-tissue vs cross-tissue models, identifying LD-induced TWAS false positives, choosing ancestry-matched prediction weights, fine-mapping co-regulated TWAS hits, or triangulating TWAS with cis-eQTL Mendelian randomization and colocalization to nominate a causal gene.

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Test whether two or more traits share a causal variant at a locus using Bayesian colocalization (coloc.abf, coloc.susie, HyPrColoc, moloc, eCAVIAR, SMR/HEIDI, PWCoCo, SharePro). Use when integrating GWAS with eQTL/sQTL/pQTL/mQTL, distinguishing shared causal variants from LD-driven coincidence, handling allelic heterogeneity, choosing between single-causal vs multi-causal methods, picking PP.H4 thresholds, running sensitivity over p12, or harmonising summary statistics for colocalization.

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Fits structural equation models to GWAS summary statistics using GenomicSEM (Grotzinger 2019), including common-factor models, confirmatory factor models, ESEM, common-factor GWAS with Q_SNP heterogeneity, multivariate Wald tests, and stratified GenomicSEM partitioned heritability. Reconciles results against MTAG multi-trait analysis. Handles sample overlap via the LDSC sampling-covariance matrix, identifies and resolves Heywood cases, and verifies model fit with CFI / RMSEA. Use when modeling latent genetic architecture across correlated traits, running multivariate GWAS on a shared factor, distinguishing factor-mediated from trait-specific SNP effects, or comparing GenomicSEM common-factor results against MTAG when both depend on accurate sampling covariance.

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Estimate causal effects of an exposure on an outcome from GWAS summary statistics using genetic instruments. Implements IVW (fixed/random), MR-Egger, weighted median/mode, MR-RAPS, CAUSE, GSMR-HEIDI, MR-PRESSO, MVMR, MR-Clust, LCV, and LHC-MR via TwoSampleMR, MendelianRandomization, MR-PRESSO, cause, and lhcMR. Use when testing causal direction between traits, evaluating drug-target effects via cis-pQTL/cis-eQTL, performing multivariable mediation MR, distinguishing causation from correlated horizontal pleiotropy, or producing STROBE-MR-compliant sensitivity batteries.

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Estimates bivariate genetic correlation (rg) between traits from GWAS summary statistics or individual-level genotypes using cross-trait LDSC, HDL, LAVA, rho-HESS, GREML-bivariate, Popcorn, and HDL-L. Use when quantifying shared genetic architecture between two traits, screening MR validity before causal inference, distinguishing global from locus-level rg, estimating trans-ancestry rg, separating partial from full causation via LCV gcp, or producing a STROBE-MR-compliant cross-trait sensitivity battery. Cross-trait LDSC intercept absorbs sample overlap and is NOT a bias; HDL is biased under sample overlap above ~5%. High rg between exposure and outcome motivates CHP-aware MR sensitivity (CAUSE, LHC-MR).

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End-of-week reflection report. Mines your Claude Code transcripts from the last 7 days to produce a self-contained HTML file with (1) the topics/areas you explored, (2) distilled key learnings with live-searched further-reading links, and (3) a token/command/skill/ctx-stack usage summary. Use when the user says "week in review", "weekly review", "what did I learn this week", "my week", or runs /week-in-review.

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Summarize the current pull request including diff, comments, and review status. Use when reviewing a PR, preparing for a review meeting, or getting a quick PR overview.

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Generate an interactive HTML tree visualization of the current project's file structure, with file sizes, color-coded file types, and a sidebar summary. Use when exploring a new repository, understanding project layout, identifying large files, or getting an overview of a codebase.

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Write a pull request description with summary, motivation, and test plan. Use when creating a PR, asked for a PR description, or preparing to submit a pull request.

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Morning startup workflow for daily notes, yesterday summary, agenda, status comments, meeting sections, and daily branch setup. Use when invoked as `$work-start-day` or when the user asks to start the work day.

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Check GitHub Actions CI status for PRs and branches. Use when the user asks "did CI pass", "check status", "what failed", "are checks green", "PR checks", "CI status", "workflow status", "re-run jobs", or wants a quick summary of GitHub Actions runs for a PR or the current branch.

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Synthesise a status, standup, or situation-report from current work state. Trigger when a team member needs a concise summary of where things stand, what is blocked, and what is next.

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Deep analysis of articles/long-form via thinking frameworks (SCQA, mental models, inversion) — 'analyze article', 'deep dive', 'extract insights', URL/text wanting depth not summary.

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Load this skill whenever the project contains charts, graphs, data visualizations, infographics, or any visual representation of data (bar charts, line charts, pie charts, scatter plots, dashboards). Under no circumstances render a chart without a text alternative, data table, or summary. Prioritize conveying the same information through non-visual means.

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[Process] Use when the developer wants something explained or taught, or wants to know HOW TO REVIEW a change — by default the current working tasks + changes in context, or whatever the prompt names (a plan, a subsystem, a decision, a concept, a bug). AI derives WHAT to explain from the prompt and ALWAYS delivers a teacher-and-coach review guide, high level first then detail: what was done, a VISUAL MAP (system flowchart, domain ERD, sequence diagrams), the user stories and business rules with their REAL test-case IDs, a REVIEW PATH naming which files to open first and in what order with an exit criterion per stage, the technical concepts needed to follow it, how it works, why THIS solution, every alternative option with pros/cons, the trade-offs accepted, the blast radius, HOW TO TEST AND DEMO the change, the developer's decision levers, and written challenge prompts that provoke the reader to pressure-test the work. Works at ANY scope — from one line of code to the whole project: it SIZES the target into a scope tier, DECOMPOSES a large one into understanding groups, BREAKS the work into tasks before the first deep read, and ACCUMULATES the report group by group on disk so a huge explanation stays complete instead of thinning out. Writes the full report to a single combined markdown file (plans/reports/understand-*.md) that opens with a detailed summary section — or delivers it in full in chat when Step 3 finds no git-ignored directory for it — and always summarizes it in chat. Regardless of coding level. Never interrogates, never quizzes, never blocks.

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[Testing] Use when you need to run tests locally and analyze the summary report.

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Normalizes and improves the consistency of prospect-list data. Use when the user provides a messy prospect or lead export and wants standardized records, flagged issues, and a cleanup summary.

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Creates structured professional research summaries from public profile information. Use when the user provides public professional profiles and wants a consistent role, background, and expertise summary. Must avoid inferring sensitive personal attributes.

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Research one news topic and save a one-sentence summary each day

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会议纪要整理工作流：汇总指定时间范围内的会议纪要并生成结构化报告。当用户需要整理会议纪要、生成会议周报、回顾一段时间内的会议内容时使用。

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Use this skill any time a .pptx or .potx file is involved in any way — as input, output, or both. This includes: creating slide decks, pitch decks, or presentations; reading, parsing, or extracting text from any .pptx or .potx file (even if the extracted content will be used elsewhere, like in an email or summary); editing, modifying, or updating existing presentations; combining or splitting slide files; working with templates (.potx), layouts, speaker notes, or comments. Trigger whenever the user mentions "deck," "slides," "presentation," or references a .pptx or .potx filename, regardless of what they plan to do with the content afterward. If a .pptx or .potx file needs to be opened, created, or touched, use this skill.

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Show a summary of the current project state including git, tests, and build status

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Auto-generate a professional, client-ready GEO service proposal from audit data. Creates a full proposal in markdown and PDF including executive summary, findings, recommended service packages (Basic/Standard/Premium), pricing, timeline, and terms. Use when user says "proposal", "proposta", "offerta", "preventivo", "generate proposal", or after completing a GEO audit for a prospect.

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Produce a weekly digest of what Ahmad saved in OpenMark over a given time window, clustered by topic. Use whenever Ahmad asks "what did I save this week", "what's new in OpenMark", "last week's saves", "this week's bookmarks", "what happened in my feed", "weekly recap", or any temporal summary of saved content. Faster than full newsletter — output is a scannable digest, not a published post. Triggers on "this week", "last week", "what's new", "weekly digest", "recent saves", "recap".

日本語の概要は準備中です。原文の説明を表示しています。