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Designs pooled sgRNA libraries for CRISPR knockout, interference (CRISPRi), activation (CRISPRa), Cas12a multiplex, base-editor, and prime-editor screens. Covers on-target scoring (Rule Set 2, Azimuth, DeepSpCas9, CRISPRon), off-target scoring (CFD, MIT), TSS-relative positioning for CRISPRi/a (Horlbeck, Dolcetto, Calabrese), PAM-variant chemistries, control-guide composition, oligo cloning architecture, and library QC. Use when choosing a genome-wide library (GeCKOv2 vs Avana vs Brunello vs TKOv3 vs Inzolia), designing a focused or paralog-focused custom library, picking CRISPRi vs CRISPRa TSS windows, deciding control-guide proportions, or diagnosing library skew and dropout in a freshly cloned pool.

日本語の概要は準備中です。原文の説明を表示しています。

Generates 3D conformer ensembles using RDKit ETKDGv3 with knowledge-enhanced distance geometry, MMFF94/UFF force-field optimization, CREST + GFN2-xTB semi-empirical refinement, and macrocycle-aware torsion preferences. Provides explicit decision rules for single vs ensemble conformer use, RMSD pruning, energy windows, conformer count, and force-field choice. Use when preparing 3D ligands for docking, generating descriptor input for 3D QSAR, or sampling macrocycle/peptide conformational ensembles.

日本語の概要は準備中です。原文の説明を表示しています。

Identifies differentially bound ChIP-seq regions between conditions using DiffBind, csaw (sliding windows), DESeq2/edgeR/PyDESeq2 on count matrices, NormR (control-aware), or MAnorm2. Distinguishes three distinct normalization problems (composition bias, trended bias, global shifts) and matches each to its appropriate fix including spike-in scaling. Use when comparing ChIP-seq binding between experimental conditions, choosing normalization for global vs local changes, integrating spike-in data, or reconciling DiffBind/DESeq2 disagreement.

日本語の概要は準備中です。原文の説明を表示しています。

Use this skill to file your IFTA quarterly fuel tax return. Covers filing windows, calculation, payment, and refund situations.

日本語の概要は準備中です。原文の説明を表示しています。

Overlay controller for dialogs, sheets, modals, windows, and toasts opened by dispatch. Use when opening, adding, registering, or debugging an overlay, or touching features/overlays/**, app/DeferredSingletonCore.tsx, lib/redux/slices/overlaySlice.ts, dispatch(openOverlay(...)), useOpenX hooks, or XController components. NOT for the WindowPanel component itself (use window-panels).

日本語の概要は準備中です。原文の説明を表示しています。

Find and identify the CCSGameRules__sm_mapGcBanInformation global variable in CS2 binary using IDA Pro MCP. Use this skill when reverse engineering CS2 server.dll or libserver.so to locate the GC ban information map structure by decompiling CCSPlayerController_ResourceDataThink's sub-function (Linux) or searching for the "Notification about user penalty" string (Windows).

日本語の概要は準備中です。原文の説明を表示しています。

Perform a diff-scoped, behavior-neutral cleanup of AI-generated slop on the current branch before code review. Use for removing trivial comment, defensive-check, type-laundering, redundant-intermediate, compatibility-shim, or local style drift from the branch diff. Do not use for full correctness or safety review, documentation work handled by technical-documentation or docs-refactor, or repo-wide refactors.

日本語の概要は準備中です。原文の説明を表示しています。

Write, review, or audit this repository's technical documentation, including README.md, CONTRIBUTING.md, root and scoped AGENTS.md files, docs pages, and documentation drift. Use for source-backed documentation authoring, behavior verification, and cross-surface consistency. Do not use for code review, deslop diff cleanup, or whole-page rewrites, splits, or reorganizations handled by docs-refactor.

日本語の概要は準備中です。原文の説明を表示しています。

Refactor a whole documentation page in this repository without losing source-verified behavior facts. Use for page rewrites, splits, reorganizations, or substantial shortening of README sections, docs pages, or instruction files. Do not use for ordinary documentation authoring, targeted corrections, or documentation review; use technical-documentation instead.

日本語の概要は準備中です。原文の説明を表示しています。

Enables Claude Code to collaborate with OpenAI Codex CLI on Windows. Use this skill when the user wants to get a second opinion from Codex, compare approaches between Claude and Codex, or leverage both AI assistants for collaborative problem-solving. This skill supports both non-interactive mode (automatic response retrieval) and interactive mode (visual pane splitting with tmux).

日本語の概要は準備中です。原文の説明を表示しています。

Gives coding agents temporal awareness by reading the session transcript the host already writes, so the agent stops guessing about time and stops repeating commands that just failed. Activates whenever an agent reasons about recency, elapsed time, retry windows, deploy cooldowns, memory or file staleness, idle detection, or any "when / how long ago / how long did that take" question. Required for autonomous, parallel, or long-running agents.

日本語の概要は準備中です。原文の説明を表示しています。

Performance optimization guidelines for OneKey React/React Native applications. Use when optimizing app performance, fixing UI freezes/lag, reducing re-renders, handling concurrent operations, or analyzing performance bottlenecks. Triggers on performance, optimization, optimize, slow, lag, freeze, hang, jank, stutter, memory, leak, concurrent, batching, batch, memoization, memo, bridge, windowSize, contentVisibility, FlashList, re-render, fps, tti, bundle.

日本語の概要は準備中です。原文の説明を表示しています。

Expert security auditor for AI Skills and Bundles. Performs non-intrusive static analysis to identify malicious patterns, data leaks, system stability risks, and obfuscated payloads across Windows, macOS, Linux/Unix, and Mobile (Android/iOS).

日本語の概要は準備中です。原文の説明を表示しています。

Use when running integration tests in the VS Code repo. Covers scripts/test-integration.sh (macOS/Linux) and scripts/test-integration.bat (Windows), their supported arguments for filtering, and the difference between node.js integration tests and extension host tests.

日本語の概要は準備中です。原文の説明を表示しています。

.NET timezone handling guidance for C# applications. Use when working with TimeZoneInfo, DateTimeOffset, NodaTime, UTC conversion, daylight saving time, scheduling across timezones, cross-platform Windows/IANA timezone IDs, or when a .NET user needs the timezone for a city, address, region, or country and copy-paste-ready C# code.

日本語の概要は準備中です。原文の説明を表示しています。

Expert guidance for developing cross-platform desktop applications with Avalonia UI framework. Use when building, debugging, or optimizing Avalonia apps including MVVM architecture, XAML design, data binding, styling, theming, custom controls, and cross-platform deployment for Windows, macOS, Linux, iOS, Android, and WebAssembly.

日本語の概要は準備中です。原文の説明を表示しています。

Adopt a virtual Kraken exotic animal at animalhouse.ai. Deep sea. Incredibly long feeding windows. Surfaces rarely. When it does, it remembers everything. Feeding every 48 hours. Extreme tier animal.

日本語の概要は準備中です。原文の説明を表示しています。

Run and manage a PokeGypt TFS 1.2 Pokemon OT private server — SQLite backend, account manager, Linux/Windows.

日本語の概要は準備中です。原文の説明を表示しています。

Debugs Windows apps via WinDbg MCP. Crash, hang, high-CPU, and memory triage from dumps or live attach.

日本語の概要は準備中です。原文の説明を表示しています。

Builds WinUI 3 desktop apps. Windows App SDK, XAML patterns, MSIX/unpackaged, UWP migration.

日本語の概要は準備中です。原文の説明を表示しています。

Deploys Uno Platform apps. Per-target guidance for WASM, iOS, Android, macOS, Windows, Linux.

日本語の概要は準備中です。原文の説明を表示しています。

Create safe, deterministic git worktrees for large or risky workstreams using the repository-owned runtime helper and Windows-safe defaults.

日本語の概要は準備中です。原文の説明を表示しています。

Identifies and exploits SMB protocol vulnerabilities using Metasploit Framework during authorized penetration tests to demonstrate risks from unpatched Windows systems, misconfigured shares, and weak authentication in enterprise networks.

日本語の概要は準備中です。原文の説明を表示しています。

Detect WMI event subscription persistence by analyzing Sysmon Event IDs 19, 20, and 21 for malicious EventFilter, EventConsumer, and FilterToConsumerBinding creation.

日本語の概要は準備中です。原文の説明を表示しています。