「eu」の検索結果

Analyzes time-series and longitudinal RNA-seq for differential expression and trajectory structure. Covers DESeq2 LRT with reduced models, time as factor vs continuous vs natural splines, maSigPro (Nueda 2014 for RNA-seq), ImpulseDE2 with explicit impulse-model failure modes, DREAM for repeated measures via linear mixed models, pseudoreplication avoidance, conditional vs marginal modeling, and trajectory clustering with DPGP, Mfuzz (with Schwämmle 2010 fuzzifier estimation), and splines+k-means. Use when modeling time-course or longitudinal expression, choosing factor vs spline, handling repeated measures from the same subject, avoiding pseudoreplication, clustering temporal trajectories, or selecting between dedicated time-course tools and pairwise+LRT.

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Runs JACKS (Joint Analysis of CRISPR/Cas9 Knockout Screens; Allen et al 2019 Genome Research) which models per-sgRNA log-fold-change as the product of a treatment-dependent gene-essentiality term and a treatment-independent guide-efficacy term. Covers the Bayesian decomposition math, the hierarchical efficacy prior shared across screens performed with the same library, when JACKS outperforms MAGeCK (multi-screen joint analysis, libraries with broad efficacy variance) and when it does not (single screen, novel libraries with no prior efficacy), library-reuse efficacy transfer, downstream essentiality interpretation, and the 2.5x sample-size reduction enabled by efficacy-aware testing. Use when running multiple screens with the same library, when guide-level noise is suspected to dominate per-gene signal, when reusing published essentiality reference screens for efficacy priors, or when comparing screens performed across cell lines that share library but differ biologically.

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Build and analyze pangenomes for prokaryotes (Panaroo, PPanGGOLiN, PEPPAN, GET_HOMOLOGUES, anvi'o pangenomics) and eukaryotes (Minigraph-Cactus, PGGB, vg pangenome graphs). Implement Tettelin core/accessory/cloud genome decomposition (Tettelin 2005), Heap's law open/closed pangenome modeling, gene presence/absence GWAS (Scoary, pyseer), pangenome graph variant calling (vg, PanGenie), and structural-variation graph indexing. Use when assembling species- or genus-level pan-gene catalogs, separating core from accessory/shell/cloud genes, testing gene-content associations with phenotypes, building pangenome graphs from haplotype-resolved assemblies, calling SVs from pangenome graphs, or selecting between bacterial-pangenome and eukaryotic-pangenome workflows.

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Time-blind friendly planning, executive function support, and daily structure for ADHD brains. Specializes in realistic time estimation, dopamine-aware task design, and building systems that actually work for neurodivergent minds.

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This skill guides postoperative management after Cushing's syndrome surgery by classifying patients into hypocortisolism, hypercortisolism, or eucortisolism based on serum cortisol levels. Use when postoperative cortisol is <5 µg/dL (hypocortisolism), >20 µg/dL (hypercortisolism), or 5-20 µg/dL (eucortisolism) to direct glucocorticoid replacement, further treatment, or monitoring.

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/cs:ai-act-readiness <system> — EU AI Act 6-question forcing interrogation. Use during AI-system intake, before EU deployment, or during annual compliance refresh as Article 113 obligations phase in (2025-02-02 / 2025-08-02 / 2026-08-02 / 2027-08-02).

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Plan journeys across Germany and Europe using the Deutsche Bahn API (v6.db.transport.rest)

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Query flight offers (price, schedule, availability) via Amadeus API.

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Expert-level water treatment covering drinking water treatment, wastewater treatment, industrial water systems, membrane processes, and water reuse.

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Expert-level dynamics covering kinematics and kinetics of particles and rigid bodies, Newton-Euler equations, energy methods, impulse-momentum, and vibrations.

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React composition patterns that scale. Use when refactoring components with boolean prop proliferation, building flexible component libraries, or designing reusable APIs. Triggers on tasks involving compound components, render props, context providers, or component architecture. Includes React 19 API changes.

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Use the local Apple Music MCP server to browse or manage the user's library and playlists, search the catalog, discover music, control playback, or edit the Up Next queue. Trigger whenever the user asks about their Apple Music account, listening history, playlists, library, playback, recommendations, or queue.

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Use when verifying a story or ticket implementation against its spec and acceptance criteria - per-AC verdicts with file:line evidence and proving tests, code reuse and design conformance, dead code, stale docs, comment discipline. Finds the spec from an explicit path, the ticket key in the branch name, or plan files - and asks rather than guessing. For defect-hunting code review use dotnet-techne-code-review instead. Keywords: story QA, acceptance criteria, spec conformance, AC coverage, definition of done, dead code check, reuse check, comment check, verify story, QA this branch.

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Inteligência de design UI/UX. 50 estilos, 21 paletas, 50 combinações de fontes, 20 gráficos, 9 stacks (React, Next.js, Vue, Svelte, SwiftUI, React Native, Flutter, Tailwind, shadcn/ui). Ações: plan, build, create, design, implement, review, fix, improve, optimize, enhance, refactor, check UI/UX code. Projetos: website, landing page, dashboard, admin panel, e-commerce, SaaS, portfolio, blog, mobile app, .html, .tsx, .vue, .svelte. Elementos: button, modal, navbar, sidebar, card, table, form, chart. Estilos: glassmorphism, claymorphism, minimalism, brutalism, neumorphism, bento grid, dark mode, responsive, skeuomorphism, flat design. Tópicos: color palette, accessibility, animation, layout, typography, font pairing, spacing, hover, shadow, gradient. Integrações: shadcn/ui MCP para busca de componentes e exemplos.

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Identifica leads de alta qualidade para seu produto ou serviço analisando seu negócio, pesquisando empresas-alvo e fornecendo estratégias de contato acionáveis. Perfeito para profissionais de vendas, desenvolvimento de negócios e marketing.

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Escreva papers prontos para publicação em NeurIPS, ICML, ICLR, ACL, AAAI, COLM. Use quando estiver elaborando papers a partir de repositórios de pesquisa, estruturando argumentos, verificando citações ou preparando submissões finais. Inclui templates LaTeX, diretrizes de revisores e workflows de verificação de citações.

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Avalia LLMs em mais de 60 benchmarks acadêmicos (MMLU, HumanEval, GSM8K, TruthfulQA, HellaSwag). Use quando benchmarking de qualidade de modelo, comparação de modelos, relatório de resultados acadêmicos ou rastreamento de progresso de treinamento. Padrão da indústria usado por EleutherAI, HuggingFace e laboratórios principais. Suporta HuggingFace, vLLM, APIs.

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NLM PubTator3 实体级关系挖掘 — 检索"疾病-药物-基因-化学品-突变"在生物医学文献中的标注与关系。当用户问"哪些研究讨论了 BTK 抑制剂与肺曲霉病"、"基因 X 与疾病 Y 的关联"、"药物-基因相互作用"、"找含某突变的文献"、"PubTator / 实体标注 / NER / annotation / biomedical entity / 疾病基因关联 / 药物-基因 / 化学品-疾病 / 突变检索"时使用。无需 API key。**实体级 · 关系挖掘**定位 — 不做文献综合检索(用 pubmed-eutils / europepmc-search)、不做全文(用 BioC)、不做试验(用 ct-v2)。

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NLM PubTator3 实体级关系挖掘原子 skill — 在 PubMed 文献里检索"疾病-药物-基因-化学品-突变-物种-细胞系"的标注与关系三元组。当用户问"BTK 与肺曲霉病的关联文献"、"BTK 抑制剂(MeSH D000077180)在哪些研究被讨论"、"标注这些 PMID 中提到的所有疾病/药物/基因实体"、"ibrutinib 的 MeSH/DrugBank ID"、"voriconazole 与 CYP2C19 药物-基因相互作用"、"BRAF V600E 突变 / rs113488022 检索"、"实体共现 / co-mention / 关系挖掘 / 实体规范化 / NER / annotation / entity normalization / disease-gene association / drug-gene interaction / chemical-disease relation" 时使用。无需 API key,跨平台稳定。**实体级 + 关系级**定位 — 不做综合文献检索(走 pubmed-eutils / europepmc-search)、不做全文段落抽取(走 bioc-fulltext-fetch)、不做证据等级排序(走 medical-evidence-grading)。

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Act on the queued items. Works through every pending item on the working todo list (the queue built with /list), actually doing each one, marking it in_progress then completed as you go. Use after stacking items with /list.

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UI/UX design intelligence. 67 styles, 96 palettes, 57 font pairings, 25 charts, 13 stacks (React, Next.js, Vue, Svelte, SwiftUI, React Native, Flutter, Tailwind, shadcn/ui). Actions: plan, build, create, design, implement, review, fix, improve, optimize, enhance, refactor, check UI/UX code. Projects: website, landing page, dashboard, admin panel, e-commerce, SaaS, portfolio, blog, mobile app, .html, .tsx, .vue, .svelte. Elements: button, modal, navbar, sidebar, card, table, form, chart. Styles: glassmorphism, claymorphism, minimalism, brutalism, neumorphism, bento grid, dark mode, responsive, skeuomorphism, flat design. Topics: color palette, accessibility, animation, layout, typography, font pairing, spacing, hover, shadow, gradient. Integrations: shadcn/ui MCP for component search and examples.

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Cloudflare Workers CLIでWorkers、KV、R2、D1、Vectorize、Hyperdrive、Workers AI、Containers、Queues、Workflows、Pipelines、Secrets Storeを開発・デプロイ・管理する。Wranglerコマンドを実行する前に使用し、最新の公式ドキュメントに基づく構文と安全規則を確認する。

Extract and consolidate reusable components, design tokens, and patterns into your design system. Identifies opportunities for systematic reuse and enriches your component library. Use when the user asks to create components, refactor repeated UI patterns, build a design system, or extract tokens.

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Builds reusable Convex components with isolated tables and app-facing APIs. Use for new components, reusable backend modules, integrations, or component boundary work.

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