3,813 件 ・ 関連度順
概要と使いどころ
Design and implement scalable API gateways, RESTful APIs, GraphQL endpoints, WebSocket handlers, and microservice communication patterns. Use when creating API routes, designing endpoints, implementing middleware, or setting up service mesh architectures.
日本語の概要は準備中です。原文の説明を表示しています。
Implements missing-data sensitivity analyses for confirmatory clinical trials including MMRM under MAR (with Kenward-Roger correction), reference-based multiple imputation (J2R, CR, CIR, LMCF per Carpenter-Roger 2013), Permutt delta-adjustment / tipping-point analysis, pattern-mixture identifying restrictions (CCMV, NCMV, ACMV), and the Cro vs Bartlett variance debate. Use when handling missing primary or secondary endpoint data in regulatory submissions following NRC 2010 and ICH E9(R1).
日本語の概要は準備中です。原文の説明を表示しています。
Performs logistic regression for clinical trial outcomes (binary, ordinal, multinomial) with marginal-vs-conditional estimand reporting per FDA 2023 covariate adjustment guidance, g-computation/standardisation for marginal effects, modified Poisson for RR, Brant test for proportional odds, Firth penalty for separation, and Hauck-Donner detection. Use when modeling binary or ordinal endpoints in confirmatory or exploratory clinical trials.
日本語の概要は準備中です。原文の説明を表示しています。
Implements multiplicity control for confirmatory clinical trials using graphical procedures (Bretz-Maurer-Hommel), gatekeeping (parallel, serial, mixed), Hochberg/Hommel/Holm with PRDS, and the closed-testing principle (Marcus-Peritz-Gabriel; Goeman 2021 admissibility). Covers FDA Multiple Endpoints Final Guidance (October 2022), graphical procedures via R gMCP, primary + key-secondary + subgroup hierarchies, and FWER vs FDR distinction. Use when designing the multiplicity strategy for confirmatory trials with multiple primary or key secondary endpoints.
日本語の概要は準備中です。原文の説明を表示しています。
Strategic clinical trial design feasibility assessment. Analyzes 6 dimensions (endpoint, population, comparator, effect size, duration, regulatory pathway) using precedent trials and FDA guidance. Produces enrollment projections, endpoint recommendations, and approval-pathway analysis. Use for trial-protocol design, power/sample-size estimation, comparator selection, and FDA submission strategy. Driven by precedent-based reasoning rather than first-principles math.
日本語の概要は準備中です。原文の説明を表示しています。
Analyze nonlinear dynamical systems — phase portraits, fixed points, stability analysis, bifurcation diagrams, Poincare sections, Lyapunov exponents, and chaos detection. Use for any autonomous or non-autonomous ODE system where qualitative behavior matters.
日本語の概要は準備中です。原文の説明を表示しています。
Authors reproducible bioinformatics pipelines with Snakemake - rules wired by output-file pattern, wildcards and expand() for sample fan-out, checkpoints for runtime-unknown outputs, resource/retry escalation, and conda/container software deployment on HPC and cloud. Use when deciding rule-based (Snakemake) vs channel/dataflow (Nextflow) authoring; wiring rules by OUTPUT-file pattern rather than imperative order; using wildcards + expand() for sample fan-out and constraining them to stop silent mis-routing; adding checkpoints when the set of outputs is unknown until a step runs (dynamic DAG); diagnosing why a job reran (or did not) under the mtime-plus-provenance trigger set; escalating memory on retry for OOM-killed jobs; and porting a Snakemake 7 `--cluster`/remote-provider command to the Snakemake 8+ executor-plugin and storage-plugin model (snakemake-executor-plugin-slurm) with `--software-deployment-method`.
日本語の概要は準備中です。原文の説明を表示しています。
Orchestrates an end-to-end CRISPR editing experiment design from target gene to delivery-ready, validatable constructs. Sequences guide design, off-target assessment, edit-modality selection (knockout, base editing, prime editing, HDR knock-in), and template/donor design, with a QC checkpoint at each handoff. Use when designing a complete CRISPR experiment for knockout, point correction, or tagging and the order of operations, the modality decision, and the cross-cutting traps are needed rather than a single step. Defers each step's mechanics to the genome-engineering skills.
日本語の概要は準備中です。原文の説明を表示しています。
Predicts ADMET properties using ADMETlab 3.0 (119 endpoints with uncertainty), ADMET-AI, DeepChem MolNet, and chemprop D-MPNN with explicit handling of OECD QSAR principles, applicability domain assessment, calibration, hERG/CYP/AMES gold-standard endpoints, and PAINS / Lipinski / Ro5 / Veber / BBB druglikeness filters. Use when filtering compounds for drug-likeness, prioritizing leads by predicted safety, or building an in-house ADMET QSAR model.
日本語の概要は準備中です。原文の説明を表示しています。
Creates and edits CARLA Leaderboard route files — placing waypoints and scenario trigger points interactively from the spectator camera (route_creator, scenario_creator), visualising an existing route in the simulator (route_displayer), summarising it as a table (route_summarizer), capturing the current weather in route format (weather_creator), sorting scenarios by route position (scenario_orderer) and converting 1.0-format routes to 2.x (route_bridge). Use when the user asks to "make a new route", "add a scenario to a route", "visualise/debug a route", "see what's in this route file", or "convert old leaderboard routes".
日本語の概要は準備中です。原文の説明を表示しています。
Runs the CARLA Leaderboard evaluator over a set of routes with your agent — routes/routes-subset/repetitions/track selection, checkpoint and live-results endpoints, resume after a crash, recording, and the debug levels — for leaderboard 1.0, 2.0 or 2.1. Preflights the whole stack (version pairing, maps, ports, agent class, sensor budget) before spending hours, and hands the world back in async mode. Use when the user asks to "run the leaderboard", "evaluate my agent", "run routes_training", "resume an evaluation", or "reproduce my submission locally".
日本語の概要は準備中です。原文の説明を表示しています。
TypeDoc (TypeScript API ドキュメントジェネレーター) リファレンス。 typedoc.json、TSDoc タグ、CLI オプション、entryPoints、 テーマ (default / markdown)、プラグイン開発、 TSDoc / JSDoc コメントから HTML / Markdown ドキュメント生成。
Windows アプリ開発 (Fluent Design / WinUI 3) の デザインガイドラインリファレンス。 layout, spacing, alignment, elevation, geometry, breakpoints, Color, Mica, Acrylic, Smoke, Reveal Highlight, materials, typography, Segoe Fluent Icons, app icons, motion, easing, connected animation, page transitions, parallax, reduce motion, NavigationView, TabView, CommandBar, menus, keyboard accelerators, access keys, accessibility, high contrast, RTL, globalization, widgets design。
ZMK Firmware (オープンソースキーボードファームウェア) リファレンス。 Getting Started (hardware, user-setup, customization, zmk-cli)、 Features (bluetooth, split keyboards, encoders, displays, lighting, pointing, studio, low-power)、 Keymaps (keycodes, modifiers, combos, conditional layers)、 Behaviors (タップ・ホールド、レイヤー、マクロ、tap-dance, sticky-key)、 Input Processors、Hardware Integration、Troubleshooting (building, flashing, connection, hardware issues)。
Three.js (WebGL / WebGPU ベース 3D グラフィクスライブラリ) リファレンス。 Scene, PerspectiveCamera, OrthographicCamera, WebGLRenderer, WebGPURenderer、 BufferGeometry, BufferAttribute, Mesh, Group, InstancedMesh, SkinnedMesh、 MeshStandardMaterial, MeshPhysicalMaterial, ShaderMaterial, node-materials (TSL)、 DirectionalLight, PointLight, SpotLight, AmbientLight、 TextureLoader, GLTFLoader, DRACOLoader, FBXLoader、 AnimationMixer, AnimationClip, AnimationAction, KeyframeTrack、 Vector3, Matrix4, Quaternion, Euler, Color, Raycaster, Box3、 OrbitControls, TransformControls, WebXRManager。
Windows アプリ開発 (Windows App SDK / WinRT) の OS 統合 API リファレンス。 DeviceInformation, DeviceWatcher, センサー (Accelerometer, Gyrometer, Compass, OrientationSensor, Pedometer, ActivitySensor), Bluetooth LE, USB, Serial, HID, Battery, HttpClient, StreamSocket, WebSocket, BackgroundDownloader/Uploader, NetworkInformation, PointerInput, KeyboardInput, FocusManager, DragAndDrop, IME/TextInput, Calendar, DateTimeFormatter, CurrencyFormatter, ResourceLoader (多言語化・地域化), PasswordVault, CryptographicBuffer, WindowsHello/Passkeys, WebAuthenticationBroker, Clipboard, DataTransferManager, Launcher, JumpList, TaskbarManager, SecondaryTile, StartupTask, ProtocolActivation。
Ergogen (エルゴノミック自作キーボード設計ツール) リファレンス。 YAML / JSON 設定で points, outlines, cases, pcbs を宣言し SVG / DXF / JSCAD / KiCad を出力。 Anchors, Zones, Adjustments, Preprocessing, Footprints, Traces。 キーレイアウト、ケース設計、PCB 生成。
App Store Connect API (REST) リファレンス。JWT 認証、API キー作成・失効、 Apps, Builds, Bundle IDs, Certificates, Devices, Provisioning Profiles, Users。 TestFlight Beta Groups / Testers / App Review。In-App Purchases, Subscriptions, Subscription Groups, Promotional Offers, App Price Points, Sales Reports。アプリ配布。 Sandbox Testers, User Invitations, Merchant IDs, Pass Type IDs, Bundle ID Capabilities。 Webhooks / Webhook Events / Deliveries、Xcode Cloud (Workflows, Build Runs, Artifacts)、 Alternative Distribution (EU マーケットプレイス / Web Distribution)、 Game Center (Achievements, Leaderboards, Challenges)、Analytics / 診断レポート。
Claude Code (code.claude.com) の CLI 本体リファレンス。 CLAUDE.md memory, settings.json, env-vars, model config, keybindings, statusline, terminal config, cli-reference (-p / --continue / --resume), sessions, checkpointing, worktrees, remote control, channels, deep links, troubleshooting。
Query UniProt's REST API (post-2022 endpoint at rest.uniprot.org) for protein sequences, annotations, GO terms, cross-references, ID mappings, and proteomes. Use when fetching UniProtKB entries, navigating the JSON schema, choosing between UniProtKB/UniRef/UniParc/Proteomes resources, deciding stream vs search endpoint for batch retrieval, running ID-mapping jobs with the async pattern, handling isoform suffixes, or filtering reviewed Swiss-Prot vs auto-annotated TrEMBL. Encodes the legacy URL migration (2022), the new JSON schema layout, and bulk-pull patterns.
日本語の概要は準備中です。原文の説明を表示しています。
Performs logistic regression for clinical trial outcomes (binary, ordinal, multinomial) with marginal-vs-conditional estimand reporting per FDA 2023 covariate adjustment guidance, g-computation/standardisation for marginal effects, modified Poisson for RR, Brant test for proportional odds, Firth penalty for separation, and Hauck-Donner detection. Use when modeling binary or ordinal endpoints in confirmatory or exploratory clinical trials.
日本語の概要は準備中です。原文の説明を表示しています。
Implements missing-data sensitivity analyses for confirmatory clinical trials including MMRM under MAR (with Kenward-Roger correction), reference-based multiple imputation (J2R, CR, CIR, LMCF per Carpenter-Roger 2013), Permutt delta-adjustment / tipping-point analysis, pattern-mixture identifying restrictions (CCMV, NCMV, ACMV), and the Cro vs Bartlett variance debate. Use when handling missing primary or secondary endpoint data in regulatory submissions following NRC 2010 and ICH E9(R1).
日本語の概要は準備中です。原文の説明を表示しています。
Predicts ADMET properties using ADMETlab 3.0 (119 endpoints with uncertainty), ADMET-AI, DeepChem MolNet, and chemprop D-MPNN with explicit handling of OECD QSAR principles, applicability domain assessment, calibration, hERG/CYP/AMES gold-standard endpoints, and PAINS / Lipinski / Ro5 / Veber / BBB druglikeness filters. Use when filtering compounds for drug-likeness, prioritizing leads by predicted safety, or building an in-house ADMET QSAR model.
日本語の概要は準備中です。原文の説明を表示しています。
Implements multiplicity control for confirmatory clinical trials using graphical procedures (Bretz-Maurer-Hommel), gatekeeping (parallel, serial, mixed), Hochberg/Hommel/Holm with PRDS, and the closed-testing principle (Marcus-Peritz-Gabriel; Goeman 2021 admissibility). Covers FDA Multiple Endpoints Final Guidance (October 2022), graphical procedures via R gMCP, primary + key-secondary + subgroup hierarchies, and FWER vs FDR distinction. Use when designing the multiplicity strategy for confirmatory trials with multiple primary or key secondary endpoints.
日本語の概要は準備中です。原文の説明を表示しています。