Nonlinear curve fitting for physics data with proper error propagation, chi-squared analysis, residual diagnostics, confidence intervals, and model comparison (AIC/BIC). Use for any parameter extraction from experimental or simulation data.
日本語の概要は準備中です。原文の説明を表示しています。
huang-sh/DeepScience☆ 42026年7月15日 更新
Builds diagnostic and prognostic classifiers on omics feature matrices with regularized logistic regression, random forest, and gradient-boosted trees, handling the p>>n regime, batch shortcut learning, class imbalance, and probability calibration. Use when building a classifier from expression, methylation, or variant data, choosing an algorithm for high-dimensional small-n data, or diagnosing a suspiciously perfect AUC. For unbiased evaluation see machine-learning/model-validation; for feature selection see machine-learning/biomarker-discovery; for time-to-event outcomes see machine-learning/survival-analysis.
日本語の概要は準備中です。原文の説明を表示しています。
huang-sh/DeepScience☆ 42026年7月15日 更新
Statistical models library for Python. Use when you need specific model classes (OLS, GLM, mixed models, ARIMA) with detailed diagnostics, residuals, and inference. Best for econometrics, time series, rigorous inference with coefficient tables. For guided statistical test selection with APA reporting use statistical-analysis.
日本語の概要は準備中です。原文の説明を表示しています。
huang-sh/DeepScience☆ 42026年7月15日 更新
ToolUniverse plugin router. STEP 1 BEFORE ANY ANALYSIS: if the data folder contains `*_executed.ipynb`, run `tu run read_executed_notebook '{"data_folder":"<path>","search":"<keyword>"}'` to extract its cell outputs and apply EVERY filter/sample-exclusion the notebook used — even when the question says 'Using DESeq2/Run X/Compute Y' (this describes the METHOD the notebook used, not a request to rerun). The notebook's cell outputs are the only published authoritative answers; reimplementing or reading stale pre-computed CSVs in the data folder produces different numbers because of outlier-sample removal, library version, and filter steps you don't see by skimming. STEP 2 routing — pick a sub-skill name from this exact list (never invent): tooluniverse-rnaseq-deseq2 (RNA/miRNA-seq DE, correlation, PCA, clustering, dispersion), tooluniverse-gene-enrichment (GO/KEGG/Reactome/GSEA/pathway enrichment), tooluniverse-statistical-modeling (regression, ANOVA, ordinal/logistic, chi-square, correlation, power), tooluniverse-image-analysis (microscopy, colony, fluorescence, dose-response, .tif — including ANOVA / Dunnett / power-analysis on image-derived measurements), tooluniverse-epigenomics (DNA methylation, CpG, m6A, MeRIP-seq, bisulfite, ChIP-seq, chromatin), tooluniverse-sequence-analysis (FASTQ, Trimmomatic, BWA, samtools, coverage), tooluniverse-variant-analysis (VCF, VAF, SNP, mutation), tooluniverse-phylogenetics (treeness, PhyKIT, parsimony), tooluniverse-single-cell (scRNA, h5ad, scanpy), tooluniverse-crispr-screen-analysis (MAGeCK, sgRNA), tooluniverse-proteomics-analysis (mass spec, TMT). Use for CSV/Excel/VCF/FASTA/h5ad and any biology/chemistry/medicine analysis question.
日本語の概要は準備中です。原文の説明を表示しています。
huang-sh/DeepScience☆ 42026年7月15日 更新
End-to-end clinical trial analysis workflow from CDISC SDTM/ADaM loading through ICH E9(R1) estimand-driven primary analysis to CONSORT 2025 regulatory-compliant reporting. Covers data preparation, FDA 2023 marginal vs conditional logistic regression, categorical tests with Boschloo, modern HTE/subgroup methods, missing-data sensitivity (MMRM, reference-based MI, Permutt tipping point), graphical multiplicity (Bretz-Maurer), survival analysis (Cox/RMST/competing risks) when applicable, and Table 1. Use when performing a complete analysis of clinical trial data.
日本語の概要は準備中です。原文の説明を表示しています。
huang-sh/DeepScience☆ 42026年7月15日 更新
This skill should be used for time series machine learning tasks including classification, regression, clustering, forecasting, anomaly detection, segmentation, and similarity search. Use when working with temporal data, sequential patterns, or time-indexed observations requiring specialized algorithms beyond standard ML approaches. Particularly suited for univariate and multivariate time series analysis with scikit-learn compatible APIs.
日本語の概要は準備中です。原文の説明を表示しています。
huang-sh/DeepScience☆ 42026年7月15日 更新
Continuous improvement system for ToolUniverse tools, skills, and plugin. Run benchmarks, diagnose failures, route fixes to devtu skills, retest. Use after skill optimization, tool additions, or as regression check.
日本語の概要は準備中です。原文の説明を表示しています。
huang-sh/DeepScience☆ 42026年7月15日 更新
Enzyme kinetics — Michaelis-Menten Km, Vmax, kcat (turnover), and kcat/Km (catalytic efficiency / specificity constant) from substrate-velocity data, plus inhibition-mechanism analysis (competitive / uncompetitive / non-competitive, Ki). Fits the MM equation by nonlinear regression (and reports Lineweaver-Burk for reference). Use when you have substrate concentrations and initial reaction velocities and need kinetic parameters or to classify an inhibitor. NOT for BRENDA database lookups of published constants (use the BRENDA tools).
日本語の概要は準備中です。原文の説明を表示しています。
huang-sh/DeepScience☆ 42026年7月15日 更新
Dose-response / concentration-response curve fitting — IC50, EC50, Hill slope, Emax/Emin efficacy, and relative potency from paired concentration vs response data (enzyme/cell assays, drug screening, agonist/antagonist pharmacology). Fits the 4-parameter logistic (Hill sigmoidal) model. Use when you have concentrations + responses and need a potency value, to compare two compounds' potency, or to judge curve quality. NOT for image-derived dose-response (use tooluniverse-image-analysis) and NOT for survival/regression (use tooluniverse-statistical-modeling).
日本語の概要は準備中です。原文の説明を表示しています。
huang-sh/DeepScience☆ 42026年7月15日 更新
Structured bug diagnosis and fixing workflow — reproduce, diagnose root cause, apply minimal fix, write regression test, and scan for similar patterns
日本語の概要は準備中です。原文の説明を表示しています。
gracefullight/pkgs☆ 42026年10月2日 更新
Diagnose a reproducible failure, fix its cause, and verify the regression. Use for crashes, incorrect behavior, and failing tests.
日本語の概要は準備中です。原文の説明を表示しています。
gracefullight/pkgs☆ 42026年10月2日 更新
Use when you need to run real accessibility tests — Playwright keyboard interactions, axe-core scanning, visual regression, and WCAG 2.2 compliance checks. The measurement layer that feeds evidence into a11y-critic reviews.
日本語の概要は準備中です。原文の説明を表示しています。
aibot88/sec_skill_store☆ 42026年5月27日 更新
Audits security and supply-chain risk between two git refs with Codex cross-validation. 预发布安全审计(含 Codex 交叉验证)。Use when performing pre-release security audits, supply-chain reviews, or comparing two git refs for security regressions. Triggers on “预发布审计”, “security audit”, “release audit”, “安全预审”.
日本語の概要は準備中です。原文の説明を表示しています。
aibot88/sec_skill_store☆ 42026年5月27日 更新
5-level verification pyramid: static→unit→Playwright E2E (homepage-first, 6bp)→AI visual→post-deploy. 8-check quality gate. Multi-agent testing (functional/security/a11y/performance). Playwright v1.59+ AI agents (Planner/Generator/Healer). WCAG 2.2 AA via axe-core v4.11. Percy+Chromatic visual regression. ADA Title II 2027/2028 deadlines.
日本語の概要は準備中です。原文の説明を表示しています。
aibot88/sec_skill_store☆ 42026年5月27日 更新
Use when you need the current position in the Lean spec-driven pipeline, or any deterministic check of a Cradle project — status, golden regression, Lean layer walls, regeneration impact, unslop lint, ddd cleanup. Runs the scripts under scripts/ and reports their output verbatim.
日本語の概要は準備中です。原文の説明を表示しています。
asuka1975/cradle☆ 42026年10月1日 更新
Use after the Lean model changed and before touching backend code — regenerates Kotlin from Lean, lists changed generated symbols, the hand-written files and contract tests that reference them, and golden regressions, so the blast radius is known before implementation.
日本語の概要は準備中です。原文の説明を表示しています。
asuka1975/cradle☆ 42026年10月1日 更新
Build kokoro-js-jp and run its real-browser e2e suite (Worker + WASM openjtalkjs g2p + ONNX kokoro-js synthesis, English and Japanese). Use when asked to verify this package actually works in a browser, to check whether a change broke synthesis, or to add browser-level regression coverage for a bug in the g2p/synthesis pipeline that vitest's pure-function tests can't catch. Not for typecheck/lint/unit-test requests — use npm run typecheck / npm test for those.
日本語の概要は準備中です。原文の説明を表示しています。
nerosui/kokoro-js-jp☆ 42026年9月10日 更新
コミット/PR の「全部置換した」「-N%削減」等の完了主張を grep で反証できる残骸や best/typical/worst 試算で検証し、抽出・集約リファクタでは並列度(Promise.all)/fast-path/遅延評価の性能特性退行と、Map/Set 集約キーの cross-kind 衝突による検出漏れも監査する
s977043/river-review☆ 42026年10月12日 更新
Ensure code changes keep logs/metrics/traces useful for debugging failures and regressions.
日本語の概要は準備中です。原文の説明を表示しています。
s977043/river-review☆ 42026年10月12日 更新
Performs subgroup and heterogeneous treatment effect (HTE) analyses for clinical trials. Covers Mantel-Haenszel pooling, Breslow-Day, interaction tests in regression, RERI for additive interaction, modern data-adaptive HTE methods (STEPP, SIDES, causal forests, X/R-learners), Bayesian shrinkage (Dixon-Simon, MAP, EXNEX), graphical multiplicity (Bretz-Maurer), and credibility frameworks (Sun BMJ, EMA 2019). Use when analyzing treatment effects across patient subgroups for regulatory submissions or precision-medicine claims.
日本語の概要は準備中です。原文の説明を表示しています。
peacezha/TRACE☆ 32026年10月11日 更新
Performs time-to-event analysis for clinical trials including Cox proportional hazards regression with PH diagnostics, restricted mean survival time (RMST) under non-PH, competing risks via Fine-Gray vs cause-specific Cox, weighted log-rank and MaxCombo for non-proportional hazards, recurrent events (Andersen-Gill, PWP, WLW), and interval-censored data. Use when analyzing time-to-event endpoints (OS, PFS, DOR, TTR, TTNT) in oncology or other clinical trials.
日本語の概要は準備中です。原文の説明を表示しています。
peacezha/TRACE☆ 32026年10月11日 更新
Evaluate deliverable quality — scorecard, outcome tracking, regression checklist, and aggregate stats.
日本語の概要は準備中です。原文の説明を表示しています。
lgzarturo/springboot-course☆ 32026年10月12日 更新
Iteratively detects and auto-fixes technical debt in a codebase using three quality criteria from debt-analysis references: conditional branch simplification, encapsulation, and separation of concerns. Applies fixes directly to code, runs existing tests to verify no regressions, re-analyzes, and loops until all high-severity issues are resolved or max iterations (5) reached. Use this skill when you want to automatically improve code quality with real code changes, reduce technical debt systematically, or clean up code to meet quality standards. Trigger on phrases like "fix technical debt", "clean up code quality", "refactor and fix issues", "improve code quality automatically", "apply debt fixes", "fix code problems", "eliminate debt".
日本語の概要は準備中です。原文の説明を表示しています。
ac2393921/long-running-harness☆ 32026年5月13日 更新
Find root cause of errors, crashes, regressions, failing tests before any fix. Not for code review or new features.
日本語の概要は準備中です。原文の説明を表示しています。
sebastianbreguel/dotfiles☆ 32026年10月8日 更新