「validation」の検索結果

Generates complete two-sample Mendelian randomization research designs from a user-provided outcome, exposure or exposure family, and robustness direction. Use when a study centers on summary-statistics causal inference with instrument selection, harmonization, IVW-primary estimation, complementary estimators, sensitivity analyses, optional multivariable upgrades, and conservative evidence interpretation. Covers five study patterns and always outputs Lite / Standard / Advanced / Publication+ with a recommended primary plan, stepwise workflow, figure plan, validation hierarchy, minimal executable version, publication upgrade path, and strictly verified literature retrieval.

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Designs QTL colocalization studies that connect eQTL, pQTL, sQTL, or related molecular QTL signals with GWAS loci. Always use this skill whenever a user wants to plan, scope, or structure a locus-level study asking whether a GWAS association and a molecular QTL association may reflect the same underlying causal signal. Covers locus definition, QTL/GWAS source architecture, ancestry and LD alignment, single-locus vs multi-locus strategy, candidate-gene prioritization, optional fine-mapping, linked MR/SMR follow-up, and functional annotation. Always output four workload configurations (Lite / Standard / Advanced / Publication+) with a recommended primary plan, stepwise workflow, method rationale, evidence hierarchy, figure plan, minimal executable version, and strictly verified literature guidance with no fabricated references. Never equate colocalization with causality proof, mediation proof, or automatic target validation. Always include the mandatory Dataset Disclaimer immediately before any workflow section that mentions datasets, repositories, consortia, or public resources.

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Generates complete bidirectional multi-phenotype Mendelian randomization research designs from a user-provided exposure family and outcome family. Always use this skill whenever a user wants to design, plan, or build a genome-wide causal-inference study based on publicly available GWAS summary statistics, especially when the article logic includes multiple exposures, multiple outcomes or subtypes, bidirectional MR, IV filtering, IVW as the main estimator, weighted median / MR-Egger / MR-PRESSO sensitivity analyses, leave-one-out testing, heterogeneity / pleiotropy checks, and multiple-testing control with FDR. Covers five study patterns (single-family bidirectional MR, multi-phenotype screening MR, subtype-resolved MR, phenome-style bidirectional causal map, mechanism-prioritized MR follow-up) and always outputs four workload configs (Lite / Standard / Advanced / Publication+) with recommended primary plan, step-by-step workflow, figure plan, validation strategy, minimal executable version...

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Use when performing correlation analysis between two variables including Pearson and Spearman correlation methods. Supports command-line parameter input, automatic data format detection, parameter validation, result directory creation, and CSV or TXT format result export.

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Explains why studies on the same biomedical topic reach different or opposing conclusions by auditing differences in population, endpoint definition, sample source, assay or platform, study design, statistical model, adjustment strategy, validation chain, and bias control. It separates true contradiction from apparent contradiction caused by framing or methods. Never fabricate references, PMIDs, DOIs, trial identifiers, dataset details, platform details, study features, or conflict explanations that are not supported by the input.

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Use when performing time-dependent ROC curve analysis for survival data with follow-up time, event status, and a numeric marker. Supports CSV/TXT/TSV/Excel input, `risk_score` as the default marker unless `--marker_col` is provided, parameter validation, standardized output directories, AUC table export, ROC point export, and PDF figure generation.

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Scans the biomarker landscape of a disease area by biomarker type, clinical/research use case, evidence layer, validation status, and maturity level. Use this skill when a user wants a field-level biomarker evidence map rather than a generic literature summary. Always separate exploratory biomarkers from externally validated or clinically embedded biomarkers, and never imply clinical maturity without explicit evidence support.

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Ranks papers by evidence family, methodological quality tier, validation depth, and claim discipline; assigns anchor, context-setting, mechanistic support, or caution citation roles; prevents prestige-based or design-label-based ranking errors.

日本語の概要は準備中です。原文の説明を表示しています。

Use when performing PCA principal component dimensionality reduction on tabular numeric data. Supports command-line parameter input, automatic numeric feature selection, parameter validation, result directory creation, and CSV or TXT format result export.

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Use when building a decision tree model in R and generating feature importance ranking outputs. Supports classification and regression, automatic task detection, parameter validation, model evaluation summaries, and exports of feature-importance tables and figures.

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Use when building a binary classification model from an expression matrix or other omics feature matrix with LASSO logistic regression, cross-validation, and coefficient path visualization. NOT for: multiclass classification, survival/Cox models, or ordinary linear regression.

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Use when selecting predictive genes or other molecular features from bulk expression matrices for binary case-vs-control classification with elastic net logistic regression, including coefficient path and cross-validation plots. Trigger keywords: elastic net, glmnet, feature selection, binary classification, lambda.min, lambda.1se. NOT for: survival/Cox modeling, multiclass outcomes, single-cell data, or non-expression tables.

日本語の概要は準備中です。原文の説明を表示しています。

Use when validating an existing prognostic risk signature on an external bulk expression cohort with survival outcomes, producing risk scores, Kaplan-Meier curves, risk distribution plots, heatmap, and time-dependent ROC curves. NOT for: model training, feature selection, nomogram construction, calibration analysis, or single-cell data.

日本語の概要は準備中です。原文の説明を表示しています。

Calibrates manuscript claim strength so wording matches the actual evidence level, study design, and validation status.

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Use when generating Kaplan-Meier survival curves from tabular survival data containing time, event status, and a precomputed risk group. Supports command-line parameter input, parameter validation, automatic time-unit handling, single-file PDF figure export, and session metadata capture.

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Acknowledges limitations in sample, design, measurement, and validation in a professional way that improves credibility without undermining the whole paper. Use when writing the limitations paragraph of a Discussion section, preparing a grant risk assessment, responding to reviewers about study weaknesses, or framing scope boundaries for a paper. Also triggers on "write my limitations", "how should I address the limitation of", "reviewer said my sample is too small", or "help me word this limitation".

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Add and review preconditions on operations that delete, overwrite, rewrite history, or resolve a caller-supplied name to a filesystem path — refusing instead of warning, placing the guard ahead of the first mutation, structural classification rather than string-prefix matching, name validation plus resolved-path containment as two independent checks, why a guard on the destructive path is invisible to the dry-run, and mutation-testing each half separately. Use when writing or reviewing a `--rebuild`/`--reset`/`--purge` command, a bulk delete, a history rewrite, an `rm -rf`-shaped step, or any code that turns an argument into a file path.

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Review XQUIC harness structure for bloat, duplicated facts, trigger overlap, reference drift, and missing hard checks. Use when changing AGENTS.md, harness specs, pipelines, skills, setup scripts, validation routing, or when asked to audit harness design.

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Fail closed on published draft XQUIC code pull requests before ready-for-review state. Use when asked to pre-review a code PR or move it out of draft; verify current base-to-head code, protocol conformance, validation coverage, adversarial bad cases, hot-path performance, and memory safety in a five-part local report.

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Debug and fix failing GitHub PR checks for xquic. Use when a PR, branch, or commit has failed CI, GitHub Actions, build checks, test checks, or requested validation failures that should be diagnosed from logs before editing.

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Enforce XQUIC test coverage and local validation gates. Use when code, build, or test changes need verification; before commit or pull request; or when asked to build, test, validate, or verify XQUIC. Requires paired happy-path and abnormal-path unit tests, the complete local unit suite, and explicit endpoint coverage or gap reporting for production behavior changes.

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Use when evaluating Jim Simons / Renaissance-style quantitative strategies: many weak signals, statistical validation, signal decay, portfolio construction, execution cost, and model risk.

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Use when evaluating crypto charts through an Hsaka-style technical lens: market structure, trend, invalidation, leverage discipline, and narrative-aware timing.

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Use when evaluating US stocks through Serenity / @aleabitoreddit's AI and semiconductor supply-chain lens: upstream chokepoints, photonics/CPO bottlenecks, hyperscaler capex, institutional rotation, dilution risk, and thesis validation.

日本語の概要は準備中です。原文の説明を表示しています。