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Analyzes pooled CRISPR screens with MAGeCK (Li et al 2014), covering count generation (mageck count), the RRA two-condition workflow (mageck test using alpha-RRA over per-sgRNA negative-binomial p-values), the MLE multi-condition workflow (mageck mle with explicit design matrix and beta-score output), normalization choice (median vs total vs control-sgRNA vs spike-in), sgRNA efficiency injection, paired-sample testing, time-course design, drug-screen versus dropout-screen design matrices, MAGeCKFlute and MAGeCK-VISPR downstream visualization, and decision logic for when to use MAGeCK vs JACKS / BAGEL2 / drugZ / Chronos. Use when running a fresh CRISPR screen analysis, picking RRA vs MLE for the experimental design, choosing a normalization method from QC signatures, debugging MLE convergence failure or NaN beta scores, comparing MAGeCK output across tools, or building a batch-aware multi-cell-line / multi-condition MLE design matrix.

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Build and analyze pangenomes for prokaryotes (Panaroo, PPanGGOLiN, PEPPAN, GET_HOMOLOGUES, anvi'o pangenomics) and eukaryotes (Minigraph-Cactus, PGGB, vg pangenome graphs). Implement Tettelin core/accessory/cloud genome decomposition (Tettelin 2005), Heap's law open/closed pangenome modeling, gene presence/absence GWAS (Scoary, pyseer), pangenome graph variant calling (vg, PanGenie), and structural-variation graph indexing. Use when assembling species- or genus-level pan-gene catalogs, separating core from accessory/shell/cloud genes, testing gene-content associations with phenotypes, building pangenome graphs from haplotype-resolved assemblies, calling SVs from pangenome graphs, or selecting between bacterial-pangenome and eukaryotic-pangenome workflows.

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Quantify homologous recombination deficiency (HRD) from tumor copy number using the three genomic-scar metrics — loss of heterozygosity (LOH), large-scale state transitions (LST), and telomeric allelic imbalance (TAI) — with scarHRD, and via the whole-genome HRDetect and CHORD models. Covers the genomic instability score, the PARP-inhibitor clinical context, whole-genome-doubling correction, and the scar-versus-state distinction. Use when computing an HRD score for PARP-inhibitor eligibility, deriving LOH/LST/TAI scars from allele-specific copy number, deciding between scar-based and mutational-signature HRD methods, or interpreting an HRD result in a BRCA-reverted or low-purity tumor.

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Maps GWAS-implicated loci to candidate effector (causal) genes by integrating variant-to-gene (V2G) features via Open Targets L2G (Mountjoy 2021), MAGMA gene-based association (de Leeuw 2015), FUMA SNP2GENE, cS2G combined SNP-to-gene scores (Gazal 2022), Polygenic Priority Scores (PoPS, Weeks 2023), FLAMES, INQUISIT, DEPICT, and enhancer-gene predictors (ABC, ENCODE-rE2G). Use when narrowing a GWAS lead locus to a candidate causal gene, picking between proximity, eQTL-based, and similarity-based prioritizers, integrating multi-evidence streams (fine-mapping, colocalization, ABC enhancer-gene, distance, chromatin), reconciling discordant L2G vs PoPS calls, prioritizing tissue-specific eQTL evidence, or triangulating across at least three independent lines of evidence for a publication-grade effector-gene nomination.

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Use this skill when the user asks about DataQ — FMCSA's data review system at dataqs.fmcsa.dot.gov — for disputing inspection violations, crash records, or other entries that appear in a carrier's CSA / SMS score. Covers Request for Data Review (RDR) process, success rates, common dispute grounds, what evidence to attach, timeline expectations, and how successful disputes reduce BSI (BASIC Severity Indicator) scores. Cite 49 CFR 392.7 and the FMCSA DataQs User Guide.

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Validates agent outputs against schemas and quality criteria, scores confidence, detects hallucinations, monitors convergence, decides when to iterate, and synthesizes actionable feedback. Use when checking if a node's output is acceptable, scoring confidence, detecting fabricated content, deciding whether to re-execute, or generating improvement feedback. Activate on "validate output", "check quality", "confidence score", "hallucination check", "should we iterate", "improvement feedback". NOT for executing DAGs (use dag-runtime), planning DAGs (use dag-planner), or matching skills (use dag-skills-matcher).

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Technical SEO audit across 9 categories: crawlability, indexability, security, URL structure, mobile, Core Web Vitals, structured data, JavaScript rendering, and IndexNow protocol. Use when user says "technical SEO", "crawl issues", "robots.txt", "Core Web Vitals", "site speed", or "security headers".

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Comprehensive SEO analysis for any website or business type. Full site audits, single-page analysis, technical SEO (crawlability, indexability, Core Web Vitals with INP), schema markup, content quality (E-E-A-T), image optimization, sitemap analysis, and GEO for AI Overviews/ChatGPT/Perplexity. Industry detection for SaaS, e-commerce, local, publishers, agencies. Triggers on: SEO, audit, schema, Core Web Vitals, sitemap, E-E-A-T, AI Overviews, GEO, technical SEO, content quality, page speed.

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C++ Core Guidelines（isocpp.github.io）に基づくC++コーディング規約。モダンで安全かつイディオマティックなプラクティスを強制するために、C++コードの記述、レビュー、リファクタリング時に使用。

Находит точную причину повторного падения процессов сервера 1С в Linux: SIGABRT, технологический журнал, core dump, GDB, C++-исключения и проверка причины. Используйте, когда rphost, ragent или rmngr исчезает, становится zombie, завершается сигналом 6 или оставляет core.

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Adds comprehensive accessibility testing to CI/CD pipelines using axe-core Playwright integration or pa11y-ci. Automatically generates markdown reports for pull requests showing WCAG violations with severity levels, affected elements, and remediation guidance. This skill should be used when implementing accessibility CI checks, adding a11y tests to pipelines, generating accessibility reports, enforcing WCAG compliance, automating accessibility scans, or setting up PR accessibility gates. Trigger terms include a11y ci, accessibility pipeline, wcag ci, axe-core ci, pa11y ci, accessibility reports, a11y automation, accessibility gate, compliance check.

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Comprehensive WCAG accessibility auditing with multi-tool testing (axe-core + pa11y + Lighthouse), TRUE PARALLEL execution with Promise.allSettled, graceful degradation, retry with backoff, context-aware remediation, learning integration, and video accessibility. Uses 3-tier browser cascade: Vibium → agent-browser → Playwright+Stealth.

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Govern Power Automate flows and Power Apps at scale using the FlowStudio MCP cached store. Classify flows by business impact, detect orphaned resources, audit connector usage, enforce compliance standards, manage notification rules, and compute governance scores — all without Dataverse or the CoE Starter Kit. Load this skill when asked to: tag or classify flows, set business impact, assign ownership, detect orphans, audit connectors, check compliance, compute archive scores, manage notification rules, run a governance review, generate a compliance report, offboard a maker, or any task that involves writing governance metadata to flows. Requires a FlowStudio for Teams or MCP Pro+ subscription — see https://mcp.flowstudio.app

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Get best practices for Entity Framework Core

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Containerize an ASP.NET Core project by creating Dockerfile and .dockerfile files customized for the project.

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Connect to 163/126/yeah.net (Coremail) email via IMAP, read inbox, search emails, and send emails via SMTP. Activate when user asks to check email, read mail, send email, or monitor inbox on 163/126/yeah.net accounts. Handles the Coremail-specific IMAP ID command requirement that causes "Unsafe Login" errors in standard clients.

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Skill for ef-core-best-practices tasks.

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Specialized skill for containerized database testing using Testcontainers. Use when testing real database behavior, using SQL Server/PostgreSQL/MySQL containers, testing EF Core/Dapper. Covers container startup, database migrations, test isolation, container sharing. Keywords: testcontainers, container testing, database testing, MsSqlContainer, PostgreSqlContainer, MySqlContainer, EF Core testing, Dapper testing, Testcontainers.MsSql, Testcontainers.PostgreSql, GetConnectionString, IAsyncLifetime, CollectionFixture

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Complete guide for ASP.NET Core Web API integration testing. Use when performing integration testing on Web API endpoints or validating ProblemDetails error format. Covers WebApplicationFactory, IExceptionHandler, Testcontainers multi-container orchestration, Flurl URL construction, and AwesomeAssertions HTTP validation. Keywords: webapi integration testing, WebApplicationFactory, asp.net core integration test, webapi integration test, IExceptionHandler, ProblemDetails, ValidationProblemDetails, AwesomeAssertions, Flurl, Respawn, Be201Created, Be400BadRequest, multi-container testing, Collection Fixture, global exception handling

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Specialized skill for ASP.NET Core integration testing. Use when testing Web API endpoints, HTTP request/response, middleware, and dependency injection. Covers WebApplicationFactory, TestServer, HttpClient testing, in-memory database configuration. Keywords: integration testing, web api testing, WebApplicationFactory, TestServer, HttpClient testing, controller testing, endpoint testing, RESTful API testing, Microsoft.AspNetCore.Mvc.Testing, CreateClient, ConfigureWebHost, AwesomeAssertions.Web, Be200Ok, Be404NotFound, middleware testing, dependency injection testing

日本語の概要は準備中です。原文の説明を表示しています。

EF Core, DbContext, AsNoTracking, query splitting.

日本語の概要は準備中です。原文の説明を表示しています。

Designs EF Core data layer architecture. Read/write split, aggregate boundaries, N+1 governance.

日本語の概要は準備中です。原文の説明を表示しています。

Creates complete AEM components with dialog, HTL template, Sling Model, unit tests, and clientlibs. Supports extending Core Components and project components. When a Figma design URL is provided, fetches the design via Figma MCP (get_design_context) and translates it into pixel-perfect HTL, CSS, and JS. Follows Adobe Experience League best practices for AEM Cloud Service and 6.5. Use this skill whenever the user mentions creating, building, generating, or scaffolding an AEM component, or mentions component types like teaser, card, hero, banner, accordion, tabs, carousel, list, navigation, breadcrumb, or any custom AEM component. Also trigger when the user wants to extend a Core Component, create a component dialog, add a Sling Model, or convert a Figma design into an AEM component.

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Systematically improves Largest Contentful Paint (LCP), Interaction to Next Paint (INP), and Cumulative Layout Shift (CLS) with prioritized fixes and verification. Use for "Core Web Vitals", "performance", "LCP", "INP", or "CLS".

日本語の概要は準備中です。原文の説明を表示しています。