「defi」の検索結果

Quantify homologous recombination deficiency (HRD) from tumor copy number using the three genomic-scar metrics — loss of heterozygosity (LOH), large-scale state transitions (LST), and telomeric allelic imbalance (TAI) — with scarHRD, and via the whole-genome HRDetect and CHORD models. Covers the genomic instability score, the PARP-inhibitor clinical context, whole-genome-doubling correction, and the scar-versus-state distinction. Use when computing an HRD score for PARP-inhibitor eligibility, deriving LOH/LST/TAI scars from allele-specific copy number, deciding between scar-based and mutational-signature HRD methods, or interpreting an HRD result in a BRCA-reverted or low-purity tumor.

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Prepares statistical reports for clinical trials following CONSORT 2025, SPIRIT 2025, ICH E9(R1) estimands, and FDA 2023 covariate adjustment guidance. Covers Table 1 generation, analysis populations (ITT/FAS/PP/Safety), the 5 ICH E9(R1) intercurrent-event strategies, MMRM under MAR (mmrm), reference-based MI (rbmi J2R/CR/CIR), Permutt tipping-point sensitivity, and Rubin's-rules vs frequentist variance debate. Use when preparing regulatory submissions, defining estimands, or implementing missing-data sensitivity analyses.

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Reads, validates, and prepares CDISC SDTM and ADaM clinical trial data for analysis. Covers SDTM domain joins (DM, AE, EX, VS, LB, DS), ADaM architecture (ADSL, BDS, OCCDS, ADTTE) with traceability, treatment-emergent AE conventions, baseline derivation, SUPPQUAL/NSV handling, Define-XML 2.1, and Pinnacle 21 / CORE validation. Use when working with clinical trial datasets in CDISC SDTM/ADaM format, preparing analysis-ready data, or validating for regulatory submission.

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Annotates ChIP-seq peaks to genomic features, nearest genes, ENCODE candidate cis-regulatory elements (cCREs), and regulatory domains. Uses ChIPseeker (R), HOMER annotatePeaks.pl (CLI), pyranges (Python), GREAT/rGREAT (regulatory domain gene-set enrichment), ChIP-Enrich (locus-length-adjusted), ENCODE SCREEN cCRE classification (PLS/pELS/dELS/CA-CTCF/CA-H3K4me3), and ENCODE-rE2G for cell-type-specific enhancer-gene linking. Handles nearest-TSS vs host-gene ambiguity, promoter window definition, and feature priority. Use when assigning genomic context to peaks, linking enhancer peaks to target genes, classifying peaks against ENCODE cCRE registry, or running gene-set enrichment on peak-associated genes.

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Implement, review, or improve data persistence using SwiftData. Use when defining @Model classes with @Attribute, @Relationship, @Transient, #Unique, or #Index; when querying with @Query, #Predicate, FetchDescriptor, or SortDescriptor; when configuring ModelContainer and ModelContext for SwiftUI or background work with @ModelActor; when planning schema migrations with VersionedSchema and SchemaMigrationPlan; when setting up CloudKit sync with ModelConfiguration; or when coexisting with or migrating from Core Data.

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Discover and configure Bluetooth and Wi-Fi accessories using AccessorySetupKit. Use when presenting a privacy-preserving accessory picker, defining discovery descriptors for BLE or Wi-Fi devices, handling accessory session events, migrating from CoreBluetooth permission-based scanning, or setting up accessories without requiring broad Bluetooth permissions.

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Design, validate, and plan a startup from scratch. Covers market research, competitive analysis, business model, brand identity, product definition, financial projections, and validation experiments. Trigger when the user has a startup idea to explore, wants to validate a business concept, needs a business plan or lean canvas, asks for market sizing or competitive landscape, wants brand positioning or go-to-market strategy, or says anything like "I have an idea for..." or "is this idea worth pursuing". Also handles resuming from a previous checkpoint.

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Build and validate experimental WebMCP tools for an existing web page. Use when an agent needs to expose a site's real workflows as page tools, create webmcp.init.js, define deterministic checks, or compare WebMCP with accessibility-tree automation.

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Import Gerber, ODB++, Allegro .brd, .mcm files for PCB boards and IC packages. Inspect nets, layers, shapes, and stackups. TRIGGER: user asks to import, read, or open a PCB layout file. Gerber files use gerberRead or PCBReader; ODB++, Allegro .brd, .mcm, and native formats use pcbFileRead. Also when inspecting nets, layers, components, or stackups from an imported board. Invoke BEFORE writing import code — the query API (cadnet, cadnetList, componentList) is specialized. SKIP: EM analysis or S-parameter extraction (use matlab-analyze-em), PDN/IR-drop analysis (use matlab-analyze-pcb-pdn), building custom geometry (use matlab-assemble-pcb-layout), material/stackup definition only (use matlab-manage-pcb-material).

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Microstrip, stripline, CPW, differential pairs, and crosstalk analysis for impedance-controlled PCB interconnects. TRIGGER: user asks to design or analyze a transmission line (microstrip, stripline, CPW, coplanar, differential pair), extract RLGC or per-unit-length parameters, compute trace impedance, analyze a PCB trace cross-section, or perform crosstalk/coupling analysis. Invoke BEFORE writing code — preferred over RF Toolbox analytical functions (txlineMicrostrip, txlineStripline, txlineCPW). SKIP: EM simulation/S-parameter extraction of an existing component (use matlab-analyze-em), material/stackup definition only (use matlab-manage-pcb-material), building custom non-catalog geometry (use matlab-assemble-pcb-layout), optimization sweeps (use matlab-optimize-pcb-design).

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Dielectric substrates, metal conductors, multi-layer stackups, and loss models (FR4, Rogers, Teflon) for RF PCB simulation. TRIGGER: user asks to set up a substrate, define dielectric properties, create a stackup, select a PCB material (FR4, Rogers, Teflon, etc.), or configure metal conductors. Invoke BEFORE writing dielectric() or metal() code — the API for named vs custom materials differs significantly. SKIP: PCB layout assembly (use matlab-assemble-pcb-layout), transmission line design (use matlab-design-pcb-transmission-line), EM analysis (use matlab-analyze-em), importing a PCB file (use matlab-read-pcb-layout).

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Set up worker environment and per-worker state for parallel pools. Use when code needs paths, environment variables, database connections, loaded libraries, or expensive objects available on workers before parfor/parfeval runs. Teaches parallel.pool.Constant, parfevalOnAll, and parpool name-value pairs. Also use when refactoring existing code that uses spmd for side-effect setup (an anti-pattern). Triggers: worker setup, pool constant, per-worker state, non-serializable, loadlibrary on workers, database connection parfor, addpath workers, spmd before parfor, worker environment, reduce parfor overhead, parfor setup, resource creation in parallel loop, cannot serialize error, undefined function or variable on workers error, load data per worker, reduce data transfer, parallelize setup, improve parallel code.

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Build custom PCB structures with pcbComponent, shapes, Boolean ops, feeds, and multi-layer stackups for non-catalog geometries. TRIGGER: user asks to build, modify, or customize a pcbComponent — add/remove shapes, edit polygons, place feeds, add metal layers, cut slots, or create non-catalog RF structures. Also when modifying geometry of an existing catalog-designed component (e.g., adding pads, removing elements, editing vertices). Invoke BEFORE writing pcbComponent code — layer/shape/feed API is non-obvious. SKIP: designing catalog components like filters/couplers/txlines (use the specific matlab-design-pcb-* skill), material/stackup definition only (use matlab-manage-pcb-material), EM analysis (use matlab-analyze-em), importing PCB files (use matlab-read-pcb-layout).

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Turn raw MATLAB code into a published .mltbx toolbox — full pipeline from scope definition through packaging and release. Drives 8 phases with human checkpoints, enforcing ordering and dependencies. Use when asked to package, create a toolbox, or run the files-to-package pipeline.

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Convert Lanelet2 maps (.osm) to RoadRunner HD Map (.rrhd) format using MATLAB. Use when converting Lanelet2 maps into RoadRunner Scene Builder, building driving scenes from open-source map data, or transforming road network definitions for simulation.

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Programmatically author RoadRunner scenarios from MATLAB using roadrunnerAPI. Use when adding actors, creating routes, building scenario logic (phases, conditions, actions), placing vehicles/pedestrians, defining cut-in/crossing/ follow scenarios, or any programmatic scenario creation in RoadRunner. Triggers on: roadrunnerAPI, scenario authoring, add actor, create route, phase logic, cut-in scenario, pedestrian crossing, scenario from MATLAB.

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AWS ECS container orchestration for running Docker containers. Use when deploying containerized applications, configuring task definitions, setting up services, managing clusters, or troubleshooting container issues.

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Deploy containers on ECS and Fargate. Configure task definitions, services, and load balancing. Use when running containerized workloads on AWS.

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Define and run multi-container Docker applications using Docker Compose. Create compose files, manage service dependencies, configure networks and volumes, and orchestrate local development environments. Use when setting up multi-service applications or development environments.

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[Deprecated] This is the required documentation for agents operating on the CloudBase Relational Database through MCP. It defines the canonical SQL management flow with `queryMysqlDatabase`, `manageMysqlDatabase`, `queryPermissions`, and `managePermissions`, including destroy flow, async status checks, safe query execution, schema initialization, and permission updates. MySQL provisioning is no longer available through MCP; new environments should use PostgreSQL — see postgresql-development skill instead.

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Scan Express.js source files to discover all API route definitions.

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Review a business plan from the perspective of the named target customer. Asks: would they actually pay this price for this solution today? Outputs a verdict with one of four modes — PAY NOW / PAY WITH FRICTION / WOULDN'T PAY / WRONG ICP. Use when the user has a defined ICP and pricing and wants to stress-test whether the value prop survives contact with reality. Triggered by: 'customer review', 'would they pay', 'pricing reality check', '客户视角', '会付费吗'.

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Define, validate, run, resume, and audit repo-local multi-step automations with current `asc workflow` and `.asc/workflow.json`, including step outputs and safe release/TestFlight workflows.

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Define and check simple service-level objectives for Claude Code from Agent Monitor data — session completion rate, tool success rate (PostToolUse/PreToolUse), and error rate (APIError/total) — then compare each to its target and report the error budget remaining. Use when reporting reliability or when someone asks "are we meeting our SLOs?".

日本語の概要は準備中です。原文の説明を表示しています。