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概要と使いどころ
Filter and select sequences by criteria (length, ID, GC content, patterns) using Biopython. Use when subsetting sequences, removing unwanted records, or selecting by specific criteria.
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Detect transcription factor binding footprints in ATAC-seq using TOBIAS, HINT-ATAC, Wellington, or scprinter. Use when identifying bound TF sites within accessible regions, correcting Tn5 insertion bias before footprinting, choosing between cleavage-based and aggregate-based footprinters, or comparing differential TF activity between conditions.
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Detect contamination and assess genome quality using CheckM, CheckM2, GTDB-Tk, and GUNC for metagenome-assembled genomes and isolate assemblies. Use when checking assemblies for contamination.
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Preprocesses cell-free DNA sequencing data including adapter trimming, alignment optimized for short fragments, and UMI-aware duplicate removal using fgbio. Applies cfDNA-specific quality thresholds and fragment length filtering. Use when processing plasma cfDNA sequencing data before downstream analysis.
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Comprehensive quality control for CLIP-seq libraries (eCLIP, iCLIP, iCLIP2, PAR-CLIP) covering library complexity (preseq), FRiP, IDR replicate reproducibility, read-distribution metagene, SMInput vs IgG control rationale, rRNA / snoRNA contamination, fragment-length distribution, and ENCODE-compliance thresholds. Use when assessing whether a CLIP library passed, deciding lenient vs stringent peak thresholds, comparing replicates with IDR rescue and self-consistency ratios, or distinguishing failed IP from over-amplified library.
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Review SDS-PAGE or protein purification gel images using DNA sequence, protein sequence, base-pair length, expected protein size, and lane labels. Use when the user wants to judge whether a gel ran well, whether the main band matches the expected product, or whether there may be impurities, degradation, aggregation, or low expression.
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Use for all frontend and web UI tasks by default to apply a business-agnostic desktop web visual style system with medium-strength guardrails; if an existing design system is present, follow it first and use this skill only as a style harmonizer.
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Validate that analytics and marketing tracking fire CORRECTLY: GA4/GTM dataLayer events, Meta/TikTok/LinkedIn pixels, and ad-tech tags. Covers building a tracking plan as the contract, intercepting collect-endpoint beacons and dataLayer.push in Playwright, asserting event name + params + values + timing + de-duplication, Consent Mode v2 gating, CI regression gating, and news-media events (article-view, scroll-depth, paywall). Use when: "test analytics tracking," "GA4 event test," "verify the pixel fires," "dataLayer test," "tracking plan," "Meta Pixel dedup," "scroll-depth tracking test," "gate tracking in CI." Not for: whether tracking is ALLOWED to fire under consent law (GDPR/CMP) — that is compliance-testing; this skill checks the data is CORRECT. SEO meta tags / structured data — out of scope. Related: compliance-testing, playwright-automation, api-testing, qa-project-context.
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Construct a high-conversion offer using Alex Hormozi's value equation and Grand Slam Offer mechanics during PRD v0.9 Go-to-Market. Triggers on requests to design the offer, set up the pitch, build bonuses or guarantees, or when user asks "how do we package this?", "what's the offer?", "build a grand slam offer", "Hormozi", "$100M offers", "guarantee", "bonus stack". Outputs GTM-* entries with Type=Offer / Type=Guarantee and BR-PRICING-* updates.
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Audit how AI search engines (ChatGPT, Perplexity, Google AI Overviews, Claude) describe and recommend your product, then propose fixes. Triggers on requests to audit AI search visibility, improve AEO/GEO, check ChatGPT/Perplexity coverage, or when user asks "do we show up in AI search?", "AEO audit", "generative engine optimization", "AI discoverability", "how does ChatGPT describe us?", "Perplexity ranking". Outputs GTM-AEO-* entries and a Coverage Matrix.
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Classify product approach into one of six types (Clone, Unbundle, Undercut, Slice, Wrapper, Innovation) based on competitive landscape. Triggers on PRD v0.2 work after competitive analysis, or when user asks "what type of product should we build?", "should we clone or innovate?", "is this a fast-follow opportunity?", "how should we position against competitors?", "clone vs undercut", "unbundle vs slice", or requests help choosing product strategy. Outputs BR- entries for product type classification and inherited GTM constraints.
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Build a Hacker News + Reddit launch playbook for developer-tools and community-led products during PRD v0.9 Go-to-Market. Triggers on requests to plan HN/Reddit launch, "Show HN" post, community launch, or when user asks "HN launch", "Show HN", "Reddit launch", "launch on /r/SaaS", "Product Hunt vs HN", "community launch", "developer launch". Outputs GTM-* with Type=Channel-HN / Type=Channel-Reddit entries with timing, title, story angle, and engagement plan.
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Build customer case studies as marketing and chasm-crossing reference assets during PRD v1.0 Market Adoption. Triggers on requests to build case studies, produce customer stories, create reference content, or when user asks "build a case study", "customer story", "reference account", "case study interview", "before/after story", "social proof page", "logo wall". Outputs CFD-CASE-* evidence entries, GTM-CASE-* marketing assets, and updates ADO-REF-* with story status.
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Allocate launch channels using the Owned / Rented / Borrowed (ORB) framework during PRD v0.9 Go-to-Market. Triggers on requests to pick launch channels, distribute the offer, build a channel portfolio, or when user asks "where do we launch?", "what channels?", "ORB", "owned vs rented vs borrowed", "channel allocation", "channel mix", "Corey Haines launch". Outputs GTM-* entries with Type=Channel, a channel-mix matrix, and a launch sequence.
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Define product positioning using April Dunford's 5-step framework during PRD v0.9 Go-to-Market. Triggers on requests to position the product, define category, frame against competitors, or when user asks "what category are we?", "how do we position?", "Dunford positioning", "obviously awesome", "market frame of reference", "positioning statement". Outputs GTM-* entries with Type=Positioning and BR-POS-* positioning rules.
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Generate "X vs Y" and "Alternative to X" SEO/CRO pages targeting competitive search intent during PRD v0.9 Go-to-Market. Triggers on requests to build comparison pages, target competitive search traffic, or when user asks "build alternatives pages", "X vs Y page", "competitor comparison page", "we're better than X page", "capture branded search", "competitive SEO". Outputs SCR-ALT-* page specs and GTM-* channel entries.
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Design the changelog as a distribution surface bridging engineering releases (DEP-/FEA-) to marketing channels (GTM-) during PRD v0.8 Deployment & Ops. Triggers on requests to set up a changelog system, publish releases, or when user asks "how should we publish releases?", "changelog as marketing", "release notes", "Stripe-style changelog", "what to do with our release notes", "ship and tell". Outputs MON-CHG-* changelog entries and per-channel formats.
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Systematically harvest short testimonials from customers via NPS, milestones, post-purchase, and email during PRD v1.0 Market Adoption. Triggers on requests to collect testimonials, set up social proof harvest, gather customer quotes, or when user asks "how do we get testimonials?", "social proof harvest", "NPS responses", "testimonial wall", "customer quotes", "post-purchase survey", "milestone follow-up". Outputs CFD-TST-* testimonial entries and GTM-TST-* placement assets.
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Edit-Pass für bestehenden deutschen Text: Register/Rhythmus messen, belegtreu redigieren, Naturalness prüfen, KI-Schreibmuster/KI-Tells auditieren und entfernen; deutschen Text humanisieren; German AI Text Humanizer.
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Ember.js is an opinionated JavaScript framework for large single-page web apps, built on convention over configuration: Glimmer components, tracked state, nested routing, services, Ember Data (WarpDrive) and the ember-cli build tool. Use when someone asks to "build an Ember app", "create an Ember component or route", "upgrade Ember", "use Ember Data", or "convert Ember templates to .gjs/.gts".
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World-class explainer video expertise combining the visual storytelling of Kurzgesagt, the simplification genius of Common Craft, and the conversion science of high-performing SaaS landing pages. Explainer videos transform complex ideas into clear, compelling stories. Great explainers don't just inform—they illuminate. They take abstract concepts and make them feel obvious. The best explainer videos understand that simplicity is the ultimate sophistication, that showing beats telling, and that the goal isn't to impress with complexity—it's to make the viewer feel smart. Use when "explainer, explainer video, how it works, product demo, onboarding video, training video, educational video, whiteboard, animated explainer, explain this, simplify, concept video, SaaS video, explainer, video, animation, educational, product, demo, onboarding, SaaS" mentioned.
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The art of reviewing code that improves both the codebase and the developer - sharing knowledge, maintaining standards, and building cultureUse when "code review, PR review, pull request, merge request, review comments, LGTM, review feedback, approve PR, request changes, review checklist, code quality, review standards, code-review, pull-request, PR, quality, standards, feedback, collaboration, mentoring" mentioned.
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World-class color theory expertise combining the scientific precision of Josef Albers' "Interaction of Color," the systematic thinking of color systems from Pantone and RAL, and the perceptual psychology insights from researchers like Bevil Conway. Color is not just aesthetics - it's communication, emotion, and usability compressed into wavelengths. Great color work is invisible when done right. Users don't notice "nice colors" - they notice when they can't read text, when buttons don't look clickable, when errors don't feel urgent, or when the interface feels "off" without knowing why. Color theory is the science of making the right thing feel obvious. Use when "color theory, color palette, color scheme, color harmony, complementary colors, analogous colors, contrast ratio, dark mode colors, light mode, color tokens, semantic colors, color accessibility, color blindness, color psychology, color system, brand colors, data visualization colors, color, design, accessibility, contrast, dark-mode, theming, tokens, wcag, palette, harmony" mentioned.
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Expert in brutally honest, self-deprecating marketing that converts. Covers transparent messaging, vulnerability as strategy, "we're not for everyone" positioning, and turning weaknesses into strengths. Knows when honesty builds trust and when it backfires. Use when "anti-marketing, honest marketing, brutally honest, we're not for everyone, transparent, no bullshit, self-deprecating marketing, " mentioned.
日本語の概要は準備中です。原文の説明を表示しています。