「proto」の検索結果

Use when the user asks the openkb chat to make a deck / slide presentation / PPT / slides / 演示稿 / 幻灯片 from their compiled KB content. Generates a polished single-file HTML deck in the Editorial Monocle visual direction (warm cream background, serif type, brick-red accent) — designed to be opened in a browser, full-screened, and shared. Does NOT apply to generating skills (that's `openkb skill new`), long-form research reports, or interactive prototypes.

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Read and write Bluesky: view profiles and timelines, search posts, post, follow, read notifications. Trigger phrases: bluesky, atproto.

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Takes existing content markdown files and builds production-final resource center pages on client websites using their existing tech stack and design system. Output is live-ready — no review pass, no placeholder content, no prototype styling. Implements hub pages, section listings, article pages, and cross-linking for Blog, Guides, Learn, and Comparisons sections.

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Turn a one-line objective into a step-by-step construction plan for multi-session, multi-agent engineering projects. Each step has a self-contained context brief so a fresh agent can execute it cold. Includes adversarial review gate, dependency graph, parallel step detection, anti-pattern catalog, and plan mutation protocol. TRIGGER when: user requests a plan, blueprint, or roadmap for a complex multi-PR task, or describes work that needs multiple sessions. DO NOT TRIGGER when: task is completable in a single PR or fewer than 3 tool calls, or user says "just do it".

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Technical SEO audit across 9 categories: crawlability, indexability, security, URL structure, mobile, Core Web Vitals, structured data, JavaScript rendering, and IndexNow protocol. Use when user says "technical SEO", "crawl issues", "robots.txt", "Core Web Vitals", "site speed", or "security headers".

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JLCPCB PCB fabrication and assembly — BOM/CPL generation, basic vs extended parts, assembly constraints, design rules, ordering workflow. Use with KiCad for JLCPCB manufacturing. Use this skill when the user mentions JLCPCB, wants to order PCBs or assembled boards, needs prototype bare PCBs and stencils, wants to know JLCPCB design rules and capabilities, or is asking about PCB manufacturing costs or turnaround times. For gerber/CPL export, stencil ordering, and BOM management, see the `bom` skill.

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Search Mouser Electronics for electronic components — secondary source for prototype orders. Find parts, check pricing/stock, download datasheets, analyze specifications. Use with KiCad for BOM creation and part selection. Also supports batch MPN-list seeding (`--mpn-list`) for bulk datasheet workflows without a KiCad project. Use this skill when the user specifically mentions Mouser, when DigiKey is out of stock or has worse pricing, when comparing prices across distributors, or when searching for parts that DigiKey doesn't carry. For package cross-reference tables and BOM workflow, see the `bom` skill.

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Delegate tasks to ANY CLI agent (claude, codex, aider, ...) running in a detached tmux session, with a race-safe done-signal protocol and multi-turn iteration. Use when delegating work to a non-Claude CLI agent, when the user says "tmux delegate", "run agent in tmux", "delegate to codex/aider", or when executor work should run in an observable background terminal instead of the Agent tool.

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Use when reviewing a DataFusion Comet pull request that adds or changes a Spark expression, its Scala serde, its protobuf message, or its native Rust implementation. Load alongside review-comet-pr, which covers the parts of the review that apply to every PR.

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Minimalist UX/Interaction Audit Expert that deconstructs complex interactions through cognitive load and operational efficiency lenses. Use this skill when you need to perform a UX walkthrough audit on a Figma prototype or web interface, evaluating usability based on principles like fewer clicks, less UI elements, no hidden logic, and self-explanatory design.

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Use when preparing ACM CCS appendices and supplementary material, including the ethics considerations appendix, protocol transcripts, formal proofs, measurement tables, and anonymized supporting material under the 12-page body limit, anonymity, and reviewer-discretion constraints for a security paper.

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Use when strengthening AAMAS reproducibility evidence for interaction claims, including proofs and game definitions, opponent and population sets, self-play protocols, random seeds, compute, uncertainty on strategic outcomes, baselines, and consistency between what the paper claims about agents and what the artifact can actually show.

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Builds personalized demo assets for top prospects using the founder's product API/MCP/SDK. Researches prospect, proposes demo concepts, builds working prototype, tests it, and generates comparison report with live demo link.

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Choose the right serialization format for .NET applications. Prefer schema-based formats (Protobuf, MessagePack) over reflection-based (Newtonsoft.Json). Use System.Text.Json with AOT source generators for JSON scenarios.

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Extracts cfDNA fragmentomics features (DELFI genome-wide short/long ratios, WPS nucleosome positioning, Griffin GC-corrected accessibility profiles, end-motifs/MDS, OCF) for cancer detection and tissue-of-origin from plasma WGS. Centers on the nuclease-footprint reframe (every feature re-reads one nucleosome object), the mandatory GC correction, and the cross-protocol non-comparability that breaks naive classifiers. Runs FinaleToolkit (real CLI/Python, MIT) and the Griffin Snakemake pipeline; DELFI is a method, not a package. Use when deriving fragment-based signal from cfDNA, choosing a feature family for detection vs subtyping, or diagnosing why a fragmentomic model failed validation.

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Designs cytosine (CBE, C-to-T) and adenine (ABE, A-to-G) base-editor guides by positioning the target base at the activity-peak of the editing window (protospacer positions ~5-7, PAM-distal numbering), minimizing bystander edits for product purity, reading dinucleotide context (APOBEC1 TC favored / GC disfavored), and selecting the editor variant (BE4max, ABEmax, ABE8e, YE1/SECURE, TadCBE, CGBE, SpG/SpRY-BE). Covers knockout by premature stop (CRISPR-STOP/iSTOP) and splice-site disruption, the three off-target classes (Cas-dependent, Cas-independent DNA, RNA), outcome prediction (BE-Hive/DeepBE), and the base-vs-prime-vs-HDR decision. Use when installing a transition mutation without a double-strand break, knocking out a gene without indels, or choosing CBE vs ABE. Generic guide scoring, prime editing, and HDR donors are separate skills.

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Turns Hi-C/Micro-C FASTQ into a deduplicated, filtered .pairs file with pairtools and decides whether the library worked. Covers the bwa mem -SP5M / bwa-mem2 / chromap --preset hic alignment idiom (mates mapped as independent single-end reads), pairtools parse vs parse2 and the walks-policy choice (5unique pairwise vs all for Pore-C/Micro-C concatemers), pair-type classification (keep UU and rescued UC), dedup (PCR vs optical/by-tile), select by pair_type/MAPQ/distance, restriction-fragment handling (restrict, Arima dual-enzyme, Micro-C/DNase fragment-free), and allele-specific phasing (pairtools phase to two coolers). The library-QC decision uses % long-range cis as the one-number quality metric, trans as the noise floor, orientation balance as fragment-map-free dangling-end/self-circle QC, and % duplicates as a complexity proxy. Use when processing Hi-C/Micro-C/Omni-C reads into pairs, judging library quality, handling multi-enzyme or restriction-agnostic protocols, or generating allele-specific contacts.

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Analyzes single-cell pooled CRISPR screens (Perturb-seq, CROP-seq, Perturb-CITE-seq, ECCITE-seq, multiome) where each cell carries an sgRNA and a scRNA-seq / surface-protein / chromatin readout. Covers experimental design (direct-capture Perturb-seq Dixit 2016 vs CROP-seq 3'UTR-barcoded Datlinger 2017 vs ECCITE-seq vs Multiome), MOI for sgRNA assignment, escaper-cell filtering (Mixscape, Papalexi 2021), SCEPTRE NB GLM + permutation for low-MOI (Barry 2024 Genome Biol 25:124), the Pertpy framework, factor decomposition, genome-scale Perturb-seq (Replogle 2022 Cell, 2.5M cells), and per-perturbation single-cell DE. Use when running a single-cell CRISPR screen, choosing direct-capture vs CROP-seq architecture, filtering escaper cells, performing single-cell DE, integrating Perturb-seq with pathway analysis, scaling to GW CRISPRi via Replogle protocol, or analyzing multi-omics screens.

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Preprocess CLIP-seq reads (eCLIP, iCLIP, iCLIP2, iCLIP3, irCLIP, PAR-CLIP, FLASH) with protocol-specific UMI extraction, adapter trimming, length filtering, and post-alignment PCR-duplicate collapse. Use when raw CLIP FASTQ must be turned into deduplicated, crosslink-preserving BAM input for peak calling; choosing between two-pass and single-pass adapter trimming; deciding minimum read length; or mapping UMI patterns to specific eCLIP/iCLIP/iCLIP2/iCLIP3 library preps.

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Designs adaptive clinical trials including group-sequential (O'Brien-Fleming, Pocock, Lan-DeMets spending), sample-size re-estimation (blinded Friede-Kieser, unblinded Cui-Hung-Wang, Mehta-Pocock promising zone), seamless Phase 2/3 with treatment-arm selection, population enrichment, and response-adaptive randomisation. Covers FDA 2019 Final Adaptive Designs Guidance, FDA 2022 Master Protocols, and ICH E20 Step 2b/3 draft (June 2025, NOT final). Use when planning interim analyses, sample-size re-estimation, or master/platform-trial designs.

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Performs alchemical free-energy calculations including relative binding free energy (RBFE / FEP+) and absolute binding free energy (ABFE) via OpenFE, FEP+, GROMACS, AMBER pmemd, and OpenMM with explicit lambda scheduling, soft-core potentials, MBAR/BAR analysis, cycle-closure validation, and protocol-appropriate enhanced sampling. Compares ML alternatives (Boltz-2 affinity, DeepDock). Use when ranking analogs by binding affinity beyond docking accuracy, performing prospective lead optimization, or validating SAR predictions.

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Computes sample size and power for clinical trials including continuous, binary, and time-to-event endpoints; superiority, non-inferiority, and equivalence designs; FDA 2016 non-inferiority margin selection with M1/M2 framework; Schoenfeld 1981 and Lakatos 1988 for survival; Schuirmann TOST and 80-125% bioequivalence; minimum clinically important difference (MCID) vs δ distinction. Use when justifying trial size in protocol or SAP per CONSORT 2025 item 16a.

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Use when implementing, testing, or evaluating ANY Apple Intelligence, on-device AI, or speech-to-text feature. Covers Foundation Models, @Generable, LanguageModelSession, Tool protocol, eval suites, model-as-judge scoring, SpeechTranscriber, CoreML.

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Apply modern Swift language patterns and idioms for non-concurrency, non-SwiftUI code. Covers if/switch expressions (Swift 5.9+), typed throws (Swift 6+), result builders, property wrappers, opaque and existential types (some vs any), guard patterns, Never type, Regex builders (Swift 5.7+), basic Codable shaping (CodingKeys, custom decoding, nested containers), modern collection APIs (count(where:), contains(where:), replacing()), basic FormatStyle usage, and string interpolation patterns. Use when writing core Swift code involving generics, protocols, enums, closures, or modern language features; route deep Codable to swift-codable, detailed formatting/localization to swift-formatstyle, and API naming to swift-api-design-guidelines.

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