「condition」の検索結果

Constructs and validates polygenic risk scores using LDpred2-auto, SBayesRC, MegaPRS, PRS-CS, PROSPER, MUSSEL, BridgePRS, JointPRS, PRSmix, or PGS Catalog Calculator with ancestry-aware reference panels (HapMap3, UKB-LD), ancestry-conditional calibration, and PRS-RS reporting standards. Use when computing PRS for cohorts, applying absolute-risk transformation, assessing cross-ancestry portability (Martin 2017 / Ding 2023 continuous ancestry), or auditing PRS manuscripts against the 22-item PRS-RS reviewer checklist.

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Computes and interprets treatment effect measures (OR, RR, RD, HR, NNT) with calibrated confidence intervals (Wilson, Newcombe, Miettinen-Nurminen, MOVER, profile likelihood, Bender NNT) and reports marginal vs conditional estimands per FDA 2023 covariate adjustment guidance. Use when reporting treatment effects in confirmatory trials, comparing effect sizes across studies, or constructing forest plots.

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Map nucleosome center positions, occupancy, and fuzziness from ATAC-seq fragment-size patterns using NucleoATAC, ATACseqQC, DANPOS3, or scprinter. Use when characterizing nucleosome organization at promoters and enhancers, calling +1/-1 nucleosomes flanking NFRs, generating V-plots for chromatin structure visualization, or comparing nucleosome positioning between conditions.

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Detect transcription factor binding footprints in ATAC-seq using TOBIAS, HINT-ATAC, Wellington, or scprinter. Use when identifying bound TF sites within accessible regions, correcting Tn5 insertion bias before footprinting, choosing between cleavage-based and aggregate-based footprinters, or comparing differential TF activity between conditions.

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Treats a ctDNA assay as a molecule-counting experiment at the Poisson edge and builds its analytical-validation case the measurement-science way. Covers the genome-equivalent currency (~330 haploid copies/ng), the lambda = input_GE x VAF sampling ceiling (lambda>=3 for ~95% detection), the error-suppression ladder (raw NGS ~1e-3 -> single-strand UMI ~1e-4/1e-5 -> duplex <1e-7), the CLSI EP17 LoB/LoD/LoD95/LoQ framework, the per-locus-vs-panel-integrated LoD distinction that lets bespoke MRD reach ppm, contrived/SEQC2 reference standards, and honest LoD reporting conditioned on input mass + consensus depth + replicate detection rate. Use when stating or trusting a sensitivity claim, designing a dilution-series validation, deciding how many genome equivalents are needed at a target VAF, choosing a single-locus vs panel-integrated LoD, or auditing a "detects 0.1% VAF" claim.

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Analyze TF motif accessibility variability across samples or single cells using chromVAR. Use when identifying TF motifs whose accessibility correlates with conditions, computing per-sample motif z-scores after matched background correction, comparing to ArchR / Signac equivalents, or distinguishing motif-accessibility signal from per-site footprinting.

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Identify differentially accessible chromatin regions across conditions using DiffBind, csaw, DESeq2, or edgeR. Use when comparing ATAC-seq accessibility between treatment groups, choosing between consensus-peak vs sliding-window approaches, picking the correct normalization (full library vs reads-in-peaks), correcting batch with SVA/RUVseq, or interpreting log2FC and FDR thresholds in a chromatin context.

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This skill should be used when the user asks to "create an agent", "add an agent", "write a subagent", "agent frontmatter", "when to use description", "agent examples", "agent tools", "agent colors", "autonomous agent", or needs guidance on agent structure, system prompts, triggering conditions, or agent development best practices for Claude Code plugins.

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This skill determines whether inpatient diabetic patients meet high-risk criteria for CGM initiation using Table 3 factors such as age ≥65 years, BMI ≤27 kg/m², type 1 diabetes, insulin regimen, and specific clinical conditions. It is triggered by clinician questions like "Should I assess this inpatient for CGM initiation based on hypoglycemia risk?" or "Is this patient a candidate for inpatient CGM?"

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Recommends steroidogenesis inhibitors as second-line treatment after transsphenoidal surgery (TSS) in Cushing's disease, as primary therapy for occult or metastatic ectopic ACTH syndrome (EAS), and as adjunctive cortisol reduction in adrenocortical carcinoma. Use when evaluating CS patients post‑TSS, with occult/metastatic EAS, or ACC; triggers include “persistent hypercortisolism after TSS,” “occult EAS,” and “adjunctive for ACC.”

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Recommends confirmatory testing with corticotropin stimulation test in patients presenting with clinical symptoms or signs suggesting PAI (e.g., fatigue, hypotension, hyponatremia, hyperpigmentation) when the patient's condition permits safe testing. Use when a clinician identifies suggestive features and circumstances allow outpatient stimulation testing without imminent need for emergency glucocorticoids.

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Workflow Phase 10 — orchestrator for documentation work. Surveys the diff, routes any page on a documentation surface through `technical-writer`, standalone technical reference through the `documentation` skill, tutorials through `technical-tutorials`, and all other prose body work (inline docs, README updates, user-facing copy) through the `prose` skill (which mandates `humanizer` and conditionally `copywriting`). Verifies completeness and marks phase done.

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Dev-only review of user-facing CLI interface copy in `src/cli/tui/*.js`, `src/cli/*.js` error paths, and `bin/cli.js` help/usage text. Surfaces three failure modes — copy/behavior mismatch, jargon, missing next-action — as a punch list the maintainer addresses before `/grant-commit`. Read-only; no writes to source. Conditionally seeded by `/triage` between `/memory-sync` and `/grant-commit` when the request will touch CLI surfaces.

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Draft or revise English prose for any brief — documentation body, intake problem statements, spec context, RCA summaries, marketing copy, README sections, PR descriptions. Mandatorily invokes `Skill(humanizer)` as the final pass on every draft. Conditionally invokes `copywriting` for persuasive register, `documentation` for reference docs, `technical-tutorials` for tutorials. Used when any phase needs human-readable prose written or rewritten. Composition only — research and register-picking happen in the caller's context.

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Analyze market conditions, geographic opportunities, pricing, consumer behavior, and product validation across Google Maps, Facebook, Instagram, Booking.com, and TripAdvisor.

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Master TypeScript's advanced type system including generics, conditional types, mapped types, template literals, and utility types for building type-safe applications. Use when implementing complex type logic, creating reusable type utilities, or ensuring compile-time type safety in TypeScript projects.

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Find overly complex code: files over 300 lines, functions over 50 lines, deeply nested conditions (4+ levels), and magic numbers. Use for code quality reviews, pre-release checks, or when asked to assess code maintainability.

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Expert-level numerical methods knowledge. Use when working with root finding, numerical integration, numerical differentiation, interpolation, numerical linear algebra, ODEs, PDEs, or optimization algorithms. Also use when the user mentions 'Newton method', 'bisection', 'Runge-Kutta', 'finite difference', 'finite element', 'interpolation', 'numerical integration', 'quadrature', 'iterative solvers', 'condition number', 'round-off error', or 'truncation error'.

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Expert-level optimization knowledge. Use when working with linear programming, convex optimization, nonlinear programming, integer programming, dynamic programming, gradient methods, duality theory, or optimization algorithms. Also use when the user mentions 'linear programming', 'simplex method', 'convex optimization', 'Lagrangian', 'KKT conditions', 'gradient descent', 'Newton method', 'integer programming', 'dynamic programming', 'duality', 'Bellman equation', or 'branch and bound'.

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Walk every branching path and boundary condition in content, report only unhandled edge cases. Orthogonal to adversarial review - method-driven not attitude-driven. Use when you need exhaustive edge-case analysis of code, specs, or diffs.

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Systematic testing methodology for exhaustive branch coverage, edge case identification, and production bug prevention. Use when PR review reveals incomplete test coverage, when tests pass but users report bugs, when code changes break existing features, when verifying all branches and edge cases before merge, when analyzing "it works on my machine" issues, when planning test strategy for new features, or when debugging flaky tests and race conditions.

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Load this skill before implementing a fix for a barrier that may originate in a shared component, design system, renderer, or external dependency rather than this project's own code. Decide whether the responsible fix is local, an existing installed capability, or an upstream contribution before writing a workaround. Absolutely always record any temporary local divergence with an owner and removal condition. Under no circumstances open, comment on, or submit anything in an external project without explicit human approval.

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Analyze, design, write, revise, translate, and review empirical or technical research papers through an evidence-bounded dialectical workflow. Use when Codex must develop a research question, integrate reference papers with a user's ideas, build phenomenon-mechanism-conditions reasoning, design methods or experiments, restructure or edit a manuscript, translate Chinese academic text into restrained English, answer reviewers, or run multi-round peer-review convergence without fabricating evidence.

日本語の概要は準備中です。原文の説明を表示しています。

GStack guard method for strengthening scope boundaries, forbidden actions, stop conditions, and validation gates for an agent or workstream.

日本語の概要は準備中です。原文の説明を表示しています。