871 件 ・ 関連度順
概要と使いどころ
Recall ChatCrystal memories for debugging tasks involving failing tests, compiler errors, runtime exceptions, dependency issues, environment breakage, or performance regressions. Use when historical root causes, fixes, or pitfalls may accelerate diagnosis before proposing a fix.
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End-to-end observational epidemiology analysis — from research question (PECO Population/Exposure/Comparator/Outcome) to publication-ready statistical report. Covers cohort/case-control/cross-sectional design, regression with confounders, propensity scoring, sensitivity analysis. Writes Python code for every step. Use for epidemiology study analysis, NHANES/UK-Biobank-style analyses.
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Sparse Identification of Nonlinear Dynamics (SINDy) — discover governing equations from time-series data. Builds sparse dynamical system models dx/dt = f(x) from measurements using PySINDy. Use when you have trajectory data and want to find the underlying ODE.
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Performs subgroup and heterogeneous treatment effect (HTE) analyses for clinical trials. Covers Mantel-Haenszel pooling, Breslow-Day, interaction tests in regression, RERI for additive interaction, modern data-adaptive HTE methods (STEPP, SIDES, causal forests, X/R-learners), Bayesian shrinkage (Dixon-Simon, MAP, EXNEX), graphical multiplicity (Bretz-Maurer), and credibility frameworks (Sun BMJ, EMA 2019). Use when analyzing treatment effects across patient subgroups for regulatory submissions or precision-medicine claims.
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Performs time-to-event analysis for clinical trials including Cox proportional hazards regression with PH diagnostics, restricted mean survival time (RMST) under non-PH, competing risks via Fine-Gray vs cause-specific Cox, weighted log-rank and MaxCombo for non-proportional hazards, recurrent events (Andersen-Gill, PWP, WLW), and interval-censored data. Use when analyzing time-to-event endpoints (OS, PFS, DOR, TTR, TTNT) in oncology or other clinical trials.
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Nonlinear curve fitting for physics data with proper error propagation, chi-squared analysis, residual diagnostics, confidence intervals, and model comparison (AIC/BIC). Use for any parameter extraction from experimental or simulation data.
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Builds diagnostic and prognostic classifiers on omics feature matrices with regularized logistic regression, random forest, and gradient-boosted trees, handling the p>>n regime, batch shortcut learning, class imbalance, and probability calibration. Use when building a classifier from expression, methylation, or variant data, choosing an algorithm for high-dimensional small-n data, or diagnosing a suspiciously perfect AUC. For unbiased evaluation see machine-learning/model-validation; for feature selection see machine-learning/biomarker-discovery; for time-to-event outcomes see machine-learning/survival-analysis.
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This skill should be used for time series machine learning tasks including classification, regression, clustering, forecasting, anomaly detection, segmentation, and similarity search. Use when working with temporal data, sequential patterns, or time-indexed observations requiring specialized algorithms beyond standard ML approaches. Particularly suited for univariate and multivariate time series analysis with scikit-learn compatible APIs.
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End-to-end clinical trial analysis workflow from CDISC SDTM/ADaM loading through ICH E9(R1) estimand-driven primary analysis to CONSORT 2025 regulatory-compliant reporting. Covers data preparation, FDA 2023 marginal vs conditional logistic regression, categorical tests with Boschloo, modern HTE/subgroup methods, missing-data sensitivity (MMRM, reference-based MI, Permutt tipping point), graphical multiplicity (Bretz-Maurer), survival analysis (Cox/RMST/competing risks) when applicable, and Table 1. Use when performing a complete analysis of clinical trial data.
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Statistical models library for Python. Use when you need specific model classes (OLS, GLM, mixed models, ARIMA) with detailed diagnostics, residuals, and inference. Best for econometrics, time series, rigorous inference with coefficient tables. For guided statistical test selection with APA reporting use statistical-analysis.
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ToolUniverse plugin router. STEP 1 BEFORE ANY ANALYSIS: if the data folder contains `*_executed.ipynb`, run `tu run read_executed_notebook '{"data_folder":"<path>","search":"<keyword>"}'` to extract its cell outputs and apply EVERY filter/sample-exclusion the notebook used — even when the question says 'Using DESeq2/Run X/Compute Y' (this describes the METHOD the notebook used, not a request to rerun). The notebook's cell outputs are the only published authoritative answers; reimplementing or reading stale pre-computed CSVs in the data folder produces different numbers because of outlier-sample removal, library version, and filter steps you don't see by skimming. STEP 2 routing — pick a sub-skill name from this exact list (never invent): tooluniverse-rnaseq-deseq2 (RNA/miRNA-seq DE, correlation, PCA, clustering, dispersion), tooluniverse-gene-enrichment (GO/KEGG/Reactome/GSEA/pathway enrichment), tooluniverse-statistical-modeling (regression, ANOVA, ordinal/logistic, chi-square, correlation, power), tooluniverse-image-analysis (microscopy, colony, fluorescence, dose-response, .tif — including ANOVA / Dunnett / power-analysis on image-derived measurements), tooluniverse-epigenomics (DNA methylation, CpG, m6A, MeRIP-seq, bisulfite, ChIP-seq, chromatin), tooluniverse-sequence-analysis (FASTQ, Trimmomatic, BWA, samtools, coverage), tooluniverse-variant-analysis (VCF, VAF, SNP, mutation), tooluniverse-phylogenetics (treeness, PhyKIT, parsimony), tooluniverse-single-cell (scRNA, h5ad, scanpy), tooluniverse-crispr-screen-analysis (MAGeCK, sgRNA), tooluniverse-proteomics-analysis (mass spec, TMT). Use for CSV/Excel/VCF/FASTA/h5ad and any biology/chemistry/medicine analysis question.
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Dose-response / concentration-response curve fitting — IC50, EC50, Hill slope, Emax/Emin efficacy, and relative potency from paired concentration vs response data (enzyme/cell assays, drug screening, agonist/antagonist pharmacology). Fits the 4-parameter logistic (Hill sigmoidal) model. Use when you have concentrations + responses and need a potency value, to compare two compounds' potency, or to judge curve quality. NOT for image-derived dose-response (use tooluniverse-image-analysis) and NOT for survival/regression (use tooluniverse-statistical-modeling).
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Enzyme kinetics — Michaelis-Menten Km, Vmax, kcat (turnover), and kcat/Km (catalytic efficiency / specificity constant) from substrate-velocity data, plus inhibition-mechanism analysis (competitive / uncompetitive / non-competitive, Ki). Fits the MM equation by nonlinear regression (and reports Lineweaver-Burk for reference). Use when you have substrate concentrations and initial reaction velocities and need kinetic parameters or to classify an inhibitor. NOT for BRENDA database lookups of published constants (use the BRENDA tools).
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Continuous improvement system for ToolUniverse tools, skills, and plugin. Run benchmarks, diagnose failures, route fixes to devtu skills, retest. Use after skill optimization, tool additions, or as regression check.
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Diagnose a reproducible failure, fix its cause, and verify the regression. Use for crashes, incorrect behavior, and failing tests.
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Structured bug diagnosis and fixing workflow — reproduce, diagnose root cause, apply minimal fix, write regression test, and scan for similar patterns
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Use when you need to run real accessibility tests — Playwright keyboard interactions, axe-core scanning, visual regression, and WCAG 2.2 compliance checks. The measurement layer that feeds evidence into a11y-critic reviews.
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5-level verification pyramid: static→unit→Playwright E2E (homepage-first, 6bp)→AI visual→post-deploy. 8-check quality gate. Multi-agent testing (functional/security/a11y/performance). Playwright v1.59+ AI agents (Planner/Generator/Healer). WCAG 2.2 AA via axe-core v4.11. Percy+Chromatic visual regression. ADA Title II 2027/2028 deadlines.
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Audits security and supply-chain risk between two git refs with Codex cross-validation. 预发布安全审计（含 Codex 交叉验证）。Use when performing pre-release security audits, supply-chain reviews, or comparing two git refs for security regressions. Triggers on “预发布审计”, “security audit”, “release audit”, “安全预审”.
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Use when you need the current position in the Lean spec-driven pipeline, or any deterministic check of a Cradle project — status, golden regression, Lean layer walls, regeneration impact, unslop lint, ddd cleanup. Runs the scripts under scripts/ and reports their output verbatim.
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Use after the Lean model changed and before touching backend code — regenerates Kotlin from Lean, lists changed generated symbols, the hand-written files and contract tests that reference them, and golden regressions, so the blast radius is known before implementation.
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Build kokoro-js-jp and run its real-browser e2e suite (Worker + WASM openjtalkjs g2p + ONNX kokoro-js synthesis, English and Japanese). Use when asked to verify this package actually works in a browser, to check whether a change broke synthesis, or to add browser-level regression coverage for a bug in the g2p/synthesis pipeline that vitest's pure-function tests can't catch. Not for typecheck/lint/unit-test requests — use npm run typecheck / npm test for those.
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Ensure code changes keep logs/metrics/traces useful for debugging failures and regressions.
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コミット/PR の「全部置換した」「-N%削減」等の完了主張を grep で反証できる残骸や best/typical/worst 試算で検証し、抽出・集約リファクタでは並列度(Promise.all)/fast-path/遅延評価の性能特性退行と、Map/Set 集約キーの cross-kind 衝突による検出漏れも監査する