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Converts an audited medical research gap into a complete, structured, gap-traceable study design. Always use this skill whenever a user already has one or more candidate research gaps and wants to transform them into an executable biomedical research plan rather than re-run broad topic ideation. Covers six gap-to-design patterns (evidence-completion, mechanism-resolution, cell-state/context-mapping, translation-bridge, causality-upgrade, population/stage-specific) and always outputs one recommended primary protocol, a gap-to-design dependency map, step-by-step workflow, figure plan, validation strategy, minimal executable version, publication upgrade path, and verified design-support literature rules. Never fabricate references. Preserve claim-evidence discipline and do not replace a topic-specific gap with a generic workflow.

日本語の概要は準備中です。原文の説明を表示しています。

Create beautiful visual art in .png and .pdf documents using design philosophy. You should use this skill when the user asks to create a poster, piece of art, design, or other static piece. Create original visual designs, never copying existing artists' work to avoid copyright violations.

日本語の概要は準備中です。原文の説明を表示しています。

Parallel design review by 6 specialist agents (PM, Architect, Designer, Security Design, UX, CTO) with mandatory unanimous approval.

日本語の概要は準備中です。原文の説明を表示しています。

Create beautiful visual art in .png and .pdf documents using design philosophy. You should use this skill when the user asks to create a poster, piece of art, design, or other static piece. Create original visual designs, never copying existing artists' work to avoid copyright violations.

日本語の概要は準備中です。原文の説明を表示しています。

Build scalable design systems with Tailwind CSS, design tokens, component libraries, and responsive patterns. Use when creating component libraries, implementing design systems, or standardizing UI patterns.

日本語の概要は準備中です。原文の説明を表示しています。

Master REST and GraphQL API design principles to build intuitive, scalable, and maintainable APIs that delight developers. Use when designing new APIs, reviewing API specifications, or establishing API design standards.

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Map this token system to or from any external design system (Material Design 3, Apple HIG, Fluent, Carbon, Ant, shadcn/ui, Radix, Chakra, Mantine, Bootstrap…) — adopt their look, build on their stack, or migrate between systems. Use when the user mentions interop, migration, or a specific design-system/component-library bridge.

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Design a UI component spec to the house quality bar — anatomy, variants, sizes, the 8 states, token mapping, and accessibility. Use when the user wants to design or document a component (button, input, tabs, toast, combobox, date picker, modal, etc.) at the spec level before or alongside code. For generating framework code, use design-code.

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End-to-end user research assistant — qualitative and quantitative. Use this skill whenever the user mentions user research, user interviews, discussion guides, interview guides, research plans, qualitative research, quantitative research, user surveys, survey design, usability studies, participant recruitment, research synthesis, interview transcripts, research reports, running studies with AI, or explicitly mentions Cookiy AI. Also trigger when users want to talk to customers, conduct discovery research, create a study or survey, analyze interview data, run AI-moderated interviews, or collect survey responses. Covers the full lifecycle: planning studies, creating discussion guides, running AI-moderated interviews (real or synthetic) via Cookiy, designing and distributing surveys, and synthesizing results into reports.

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Design, improve, and review interfaces for websites, apps, dashboards, and components: explore distinct design directions, compare styles side by side, and refine visual hierarchy against real screenshots. Delivers comparison pages, design notes, mockups, or working interfaces. Use for new interface design, style comparison, visual polish, screenshot recreation, or interface review. Not for business logic, APIs, builds, or code cleanup without visible UI changes. If oil-ui-pro is installed, use oil-ui-pro instead. 设计、改进和评审网站、App、后台与组件的界面，完成设计方向探索、多风格同屏比较、视觉层级和基于实际画面的迭代；按请求交付对比页、设计说明、设计稿或可运行界面。当用户需要新界面设计、比较不同设计风格、视觉精修、截图还原或界面评审时使用。只负责设计判断，组件归属、数据流、状态正确性和测试等代码实现质量不在范围内。不用于纯业务逻辑、接口、构建部署、无界面行为变化的代码整理、单独绘制普通插画或操作现有网站。已安装 oil-ui-pro 时交给 oil-ui-pro。

日本語の概要は準備中です。原文の説明を表示しています。

Batch-generate and compare visual design directions so a user can choose the style they actually want. Use when the user says they cannot describe an abstract visual style, asks for many style options, wants to choose from generated UI/design-system images, rejects outputs as too colorful/too dead/too generic, or needs an existing UI/design system evolved without discarding current assets.

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Present a design to a client so they can make a decision rather than react to a picture — the brief restated, the moves explained against it, the options with their trade-offs, and a specific decision requested. Use when asked to present a design to a client, prepare a design review meeting, present concept options, or when a client keeps changing their mind after sign-off. Produces the presentation structure, the brief-to-design traceability, the options with honest trade-offs, the cost and programme position, and the decision record that makes sign-off stick.

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Backend infrastructure for a project via Cohesivity (cohesivity.ai). Provisions Postgres, Redis, object storage, vector database, hosting, auth, realtime, email inbox, and AI model APIs through one HTTP API. No account or API keys required to start. Trigger phrases: cohesivity, provision backend, need a database, need hosting, need storage, deploy backend, on-the-fly infrastructure.

日本語の概要は準備中です。原文の説明を表示しています。

AI design specialist skill with DESIGN.md management, anti-pattern enforcement, optional Stitch MCP integration, and component library guidance. Covers typography, color systems, motion design (motion/react, GSAP, Three.js), responsive-first layouts, and accessibility (WCAG 2.2).

日本語の概要は準備中です。原文の説明を表示しています。

Define or review a visual system, DESIGN.md, or redesign direction. Use for typography, layout, color, motion, and interaction design decisions.

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Database specialist for SQL, NoSQL, and vector database modeling, schema design, normalization, indexing, transactions, integrity, concurrency control, backup, capacity planning, data standards, anti-pattern review, and compliance-aware database design. Use for database, schema, ERD, table design, document model, vector index design, RAG retrieval architecture, migration, query tuning, glossary, capacity estimation, backup strategy, database anti-pattern remediation work, and ISO 27001, ISO 27002, or ISO 22301-aware database recommendations.

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Anti-slop frontend skill for landing pages, portfolios, and redesigns. The agent reads the brief, infers the right design direction, and ships interfaces that do not look templated. Real design systems when applicable, audit-first on redesigns, strict pre-flight check.

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Designs donor/repair templates for precise CRISPR knock-ins -- choosing the format (ssODN, long-ssDNA/Easi-CRISPR, dsDNA/plasmid, AAV6), sizing homology arms, placing the cut within ~10 bp of the edit, and adding a mandatory codon-checked blocking (PAM/seed) mutation so the edited allele is not re-cut. Frames the HDR-vs-NHEJ-vs-MMEJ pathway competition, the MMEJ (PITCh) and homology-independent (HITI/HMEJ) alternatives for post-mitotic cells, ssODN strand/asymmetry choice, phosphorothioate end-protection, and ranked HDR enhancers. Use when designing a donor for a point mutation, epitope/fluorophore tag, allele replacement, or knock-in, or when HDR efficiency is low. Guide design and base/prime editing are separate skills.

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Structures biological experiments so inference is valid by construction, covering Fisher's principles (randomization, replication, local control), the experimental-vs-observational unit distinction and pseudoreplication (Hurlbert 1984; Lazic 2018), randomization mechanics (complete, restricted, stratified, rerandomization, run-order), blocking layouts (randomized complete block, Latin square, incomplete block), factorial designs and interactions, and the split-plot/nested error strata hidden inside multi-batch genomics. Use when deciding the experimental unit and what counts as a replicate, planning randomization and run order, choosing a blocked/factorial/split-plot/nested layout, avoiding pseudoreplication in cell-culture or animal studies, or specifying the random-effects structure of the analysis model. For assigning samples to sequencing batches/lanes/plates and batch-effect correction see experimental-design/batch-design; for regulated clinical-trial randomization see clinical-biostatistics.

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Aligns sample metadata with count matrices and constructs design matrices for downstream DE, handling the alphabetical-reference-level trap (relevel BEFORE DESeq), LRT reduced-model rules, the interaction-term resultsNames trap, continuous-covariate scaling and splines, repeated measures via duplicateCorrelation or dream, high-cardinality categorical pseudo-singular designs, sample swap detection via XIST/RPS4Y1 expression and somalier/NGSCheckMate genotypes, SABV (sex-as-biological-variable) mandate, Simpson's-paradox collapsing of technical replicates, and the `~ 0 + group` parameterization for clean contrasts. Use when building a design matrix, troubleshooting reversed fold-change direction, encoding paired or repeated-measures designs, detecting sample swaps, deciding sex-as-covariate, or aggregating technical replicates.

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Analyzes CRISPR drug-modifier (chemogenomic) screens with drugZ (Colic et al. 2019 Genome Med), a bidirectional Z-score method that identifies synthetic-lethal sensitizing genes and resistance-conferring suppressor genes from vehicle vs drug comparisons. Covers vehicle-anchored design (not Day-0), the bidirectional Z math giving greater sensitivity to small-effect hits than MAGeCK / STARS / edgeR / RIGER on drug screens, per-gene sumZ and normZ, synth (sensitizer) vs supp (suppressor) FDR, multi-dose handling, integration with control sgRNAs, and comparison with MAGeCK MLE with dose covariate. Use when running a drug-modifier CRISPR screen, identifying sensitizing or resistance genes for a drug candidate, choosing drugZ vs MAGeCK MLE for chemogenomic analysis, troubleshooting low-effect drug screens where MAGeCK lacks sensitivity, or designing a drug-screen layout (vehicle vs drug arms).

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Designs novel molecules using REINVENT 4 (de novo, scaffold decoration, linker design, R-group, molecular optimization), MolMIM, Diffusion-based generators (DiGress, DiffSMol), and JT-VAE with explicit handling of multi-parameter optimization (MPO), goal-directed scoring functions, transfer/reinforcement/curriculum learning, synthetic accessibility scoring, and chemical space exploration vs exploitation. Use when designing new chemical matter against a target, decorating a scaffold, linking fragments, or optimizing a hit for multiple ADMET / activity properties simultaneously.

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Designs adaptive clinical trials including group-sequential (O'Brien-Fleming, Pocock, Lan-DeMets spending), sample-size re-estimation (blinded Friede-Kieser, unblinded Cui-Hung-Wang, Mehta-Pocock promising zone), seamless Phase 2/3 with treatment-arm selection, population enrichment, and response-adaptive randomisation. Covers FDA 2019 Final Adaptive Designs Guidance, FDA 2022 Master Protocols, and ICH E20 Step 2b/3 draft (June 2025, NOT final). Use when planning interim analyses, sample-size re-estimation, or master/platform-trial designs.

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Use when the user mentions window resizing support, resizable-window readiness, iPhone Mirroring compatibility, iPhone Duo readiness, scene-lifecycle migration checking, or preparing an app for the 27-cycle resizing model.

日本語の概要は準備中です。原文の説明を表示しています。