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概要と使いどころ
Think and work like an expert Mineralogist. Use when a task calls for Mineralogist judgment. Reasons from crystal chemistry, Pauling coordination, and converging optics–XRD/Raman–EPMA evidence; uses RRUFF/Mindat/AMCSD and CNMNC Checklist 2025 while treating preferred orientation, clay EG/heat triads, metamict amorphization, and QEMSCAN library bias as first-class failure modes.
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Think and work like an expert Functional Genomics Scientist. Use when a task calls for Functional Genomics Scientist judgment. Reasons from perturbation as causal probe, genotype-to-phenotype linkage, library representation, and effect-size-plus-FDR statistics through MAGeCK/BAGEL/CERES-Chronos, CRISPRcleanR, CRISPResso2, MPRAnalyze, and Perturb-seq pipelines while treating MOI/bottleneck artifacts, copy-number and p53/DSB toxicity, RNAi seed effects, and guide-assignment or gating errors as first-class failure modes.
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Research competitor advertising strategies through Facebook Ad Library, Google SERP ads, and social media sponsored content. Covers creative analysis, messaging patterns, targeting signals, and campaign frequency for competitive marketing intelligence.
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End-to-end pooled and single-cell CRISPR screen analysis from FASTQ to hit genes. Orchestrates library design QC, guide counting, six-stage screen QC (plasmid Gini, replicate Pearson, CEGv2 PR-AUC, copy-number artifact), method-appropriate hit calling across MAGeCK RRA/MLE, BAGEL2, drugZ, JACKS, and Chronos, cancer-cell-line copy-number correction (CRISPRcleanR / Chronos), batch correction for multi-batch screens, and the specialized branches for combinatorial paralog screens, single-cell Perturb-seq, base-editor variant-function screens, prime-editor screens, and in vivo bottleneck-aware screens. Use when analyzing any pooled CRISPR screen end-to-end, choosing the correct hit-calling method by experimental design, integrating copy-number correction into the pipeline, or branching the workflow for single-cell, combinatorial, base-editor, prime-editor, or in vivo variants.
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Identify differentially accessible chromatin regions across conditions using DiffBind, csaw, DESeq2, or edgeR. Use when comparing ATAC-seq accessibility between treatment groups, choosing between consensus-peak vs sliding-window approaches, picking the correct normalization (full library vs reads-in-peaks), correcting batch with SVA/RUVseq, or interpreting log2FC and FDR thresholds in a chromatin context.
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Designs and analyzes combinatorial CRISPR screens covering paired-Cas9 (Big Papi, Najm 2018), enhanced AsCas12a multiplex (enCas12a, DeWeirdt 2021), in4mer 4-guide-array Cas12a (Esmaeili Anvar N et al 2024 Nat Commun 15:3577) and the Inzolia paralog-pair library, paralog-buffering detection (Dede 2020 Genome Biol; Thompson 2021 Cell Reports 36:109597), genetic-interaction (GI) scoring as observed_double_LFC minus expected_additive_double_LFC, synthetic-lethal and synthetic-rescue interaction interpretation, the half-of-essentiality buffered by paralogs phenomenon, multiplex screen statistical analysis with MAGeCK MLE interaction terms, and the relationship to single-cell combinatorial Perturb-seq. Use when designing a paralog or pathway-pair screen, choosing between paired-Cas9 (Big Papi) and Cas12a multiplex (Inzolia), interpreting genetic interaction scores, identifying synthetic-lethal targets for drug development, or scaling beyond single-gene CRISPR screens.
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Preprocess CLIP-seq reads (eCLIP, iCLIP, iCLIP2, iCLIP3, irCLIP, PAR-CLIP, FLASH) with protocol-specific UMI extraction, adapter trimming, length filtering, and post-alignment PCR-duplicate collapse. Use when raw CLIP FASTQ must be turned into deduplicated, crosslink-preserving BAM input for peak calling; choosing between two-pass and single-pass adapter trimming; deciding minimum read length; or mapping UMI patterns to specific eCLIP/iCLIP/iCLIP2/iCLIP3 library preps.
日本語の概要は準備中です。原文の説明を表示しています。
Batch effect correction for CRISPR screens covering ComBat empirical-Bayes, RUV, SVA, control-sgRNA normalization, and the model-based alternative of including batch as a covariate in MAGeCK MLE or Chronos. Covers screen-specific batch sources (passage cohort, library lot, infection day, sequencing run, Cas9 lot, FBS lot), PCA + variance-decomposition diagnostic to decide if correction is needed, when correction harms biology by over-correcting condition into batch, limma removeBatchEffect for visualization-only correction, and relationship to multi-condition design matrices. Use when combining screens for joint analysis, when passage cohort confounds biology, when DepMap-style panels need Chronos with batch covariates, when picking ComBat vs RUV, or when correction harms biology and should be replaced with explicit covariate modeling.
日本語の概要は準備中です。原文の説明を表示しています。
Analyzes base-editing screens for variant function. Covers library design (Sanson 2020 GRACE, Hanna 2021 BRCA1/2 SNV scanning, Cuella-Martin 2021), CBE vs ABE chemistry choice (BE3/BE4 vs ABE7.10/ABE8.20/ABE8e), editing-window math (positions 4-8 from PAM-distal end, wider for ABE8e), bystander-edit quantification and the variant-call ambiguity it creates, sgRNA-efficiency filtering before hit calling, indel byproduct interpretation, the substitution-vs-indel diagnostic, variant annotation against ClinVar / COSMIC, and the Broad be-validation-pipeline. Use when designing a BE variant screen, choosing CBE vs ABE for a specific edit, interpreting bystander-confounded hits, distinguishing functional signal from indel artifact, integrating CRISPResso2 output with screen scoring, or deciding BE vs PE for SNV installation.
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Initialize or update CLAUDE.md coding standards for any project by auto-detecting tech stack and assembling rules from the claude-rules template library. Use when user says "init rules", "初始化规范", "生成 CLAUDE.md", or wants to set up coding standards.
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CesiumJS materials and post-processing — Material, Fabric JSON, MaterialAppearance, ImageBasedLighting, PostProcessStage, PostProcessStageLibrary, bloom, depth of field, ambient occlusion, FXAA, tonemapping, BlendingState. Use when defining Fabric materials for entities or primitives, configuring PBR image-based lighting, or adding screen-space post-processing effects.
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Stimulus JS framework for Symfony UX -- client-side behavior via HTML data attributes, zero server round-trips. Use when creating controllers for DOM manipulation, handling click/input/submit events, managing targets and values, wiring outlets between controllers, wrapping third-party JS libraries, or building toggles, dropdowns, modals, tabs, clipboard interactions. Code triggers: data-controller, data-action, data-target, data-*-value, data-*-class, data-*-outlet, stimulusFetch lazy, connect(), disconnect(), static targets, static values. Also trigger when the user asks "how do I add a click handler", "how to toggle a class", "how to build a dropdown/modal/tabs", "how to wrap a JS library in Symfony", "add keyboard shortcuts", "lazy-load a controller", "listen to global events", "communicate between controllers". Do NOT trigger for partial page updates without JS (use turbo), server-rendered reactivity (use live-component), or reusable Twig templates (use twig-component).
日本語の概要は準備中です。原文の説明を表示しています。
Symfony UX TwigComponent for reusable UI building blocks -- server-rendered components with PHP classes and Twig templates. Use when creating buttons, cards, alerts, badges, navbars, or any reusable UI element with props, blocks/slots, computed properties, or anonymous (template-only) components. Code triggers: AsTwigComponent, #[AsTwigComponent], ExposeInTemplate, PreMount, PostMount, <twig:Alert />, <twig:Button>, component(), computed properties, anonymous component, HTML syntax. Also trigger when the user asks "how to create a reusable component", "how to make a component library", "how to pass props to a component", "how to use slots/blocks in a component", "how to build a design system in Symfony", "what is the HTML syntax for components", "how to create a component without a PHP class". Do NOT trigger for components that re-render dynamically on user input (use live-component), for JS behavior (use stimulus), or for page navigation (use turbo).
日本語の概要は準備中です。原文の説明を表示しています。
Compile the TMDb package AND all test targets (without running the tests) to catch test-code compile errors. Use after changing tests or shared code to check everything still builds — delegates to the tooling-runner agent (Haiku) and returns a concise pass/fail + errors-as-file:line summary. Differs from /build, which compiles only the library; to run the tests, use /test.
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This skill should be used when the user asks about "technical decision", "what to use", "A vs B", "comparison analysis", "library selection", "architecture decision", "which one to use", "tradeoffs", "tech selection", "implementation approach", or needs deep analysis for technical decisions. Provides systematic multi-source research and synthesized recommendations.
日本語の概要は準備中です。原文の説明を表示しています。
Generate Word documents programmatically with the docx library — create paragraphs, tables, images, headers, footers, numbered lists, and styled content. Use when tasks involve generating contracts, proposals, resumes, or any .docx output from application data in Node.js.
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Expert guidance for Excalidraw, the open-source virtual whiteboard library for creating hand-drawn style diagrams and sketches. Helps developers embed Excalidraw in React applications, build custom integrations, and leverage the API for programmatic diagram creation.
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You are an expert in @react-three/drei, the companion library for React Three Fiber that provides 100+ ready-made components and hooks for common 3D patterns. You help developers add orbit controls, environment maps, text rendering, HTML overlays, loaders, performance utilities, shaders, and abstractions — eliminating boilerplate and letting teams focus on creative work instead of Three.js plumbing.
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dlt (data load tool) is an open-source Python library that loads data from APIs, files and databases into warehouses and lakes, inferring the schema and tracking incremental state for you. Use when a user asks to build a data pipeline in Python, load a REST API into DuckDB, BigQuery, Snowflake or Postgres, set up incremental or merge loading, enforce a schema contract, or replace a hand-written ETL script or a hosted ELT connector.
日本語の概要は準備中です。原文の説明を表示しています。
Build robust TypeScript applications with Effect — type-safe error handling, concurrency, dependency injection, and streaming. Use when someone asks to "handle errors without try-catch", "type-safe error handling in TypeScript", "dependency injection without classes", "concurrent TypeScript", "Effect library", "replace try-catch with typed errors", or "functional programming in TypeScript". Covers Effect, Layer, Schedule, Stream, and Schema.
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Creates interactive data visualizations with Apache ECharts, the open-source JavaScript charting library. Use when a user asks to build charts, dashboards, or data-driven graphics using ECharts in React, Vue, or vanilla JavaScript applications, render a chart to SVG on the server, or upgrade from ECharts 5 to 6.
日本語の概要は準備中です。原文の説明を表示しています。
Parse complex documents with IBM's open-source Docling library, which turns PDFs and Office files into structured Markdown or JSON. Use when a user asks to parse a document with tables, extract figures from a document, handle multi-column layouts, convert a complex PDF to structured data, extract content from academic papers, or process documents with mixed layouts. Handles tables, figures, headers, footers, and multi-column text.
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Designs the public interface of a module before any implementation exists: writes the caller scenarios first, produces three candidates with genuinely different shapes, type-checks each one against the scenarios, scores them on measurable criteria and records the decision. Use when someone says "design the API for this module", "what should this signature look like", "compare interface options", "this function is awkward to call", "show me alternatives before I build it", or is about to add a module, library entry point, endpoint or command that other code will depend on.
日本語の概要は準備中です。原文の説明を表示しています。
Builds command-line tools in Go with Cobra, the library behind kubectl, Hugo and the GitHub CLI: subcommands, flags, argument validation, generated help and shell completions. Use when a user asks to create a Go CLI, add subcommands or flags, validate arguments, bind flags to config files and environment variables with Viper, or generate bash, zsh, fish or PowerShell completions.
日本語の概要は準備中です。原文の説明を表示しています。