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Analyzes chemical libraries by scaffold using Bemis-Murcko scaffolds, generic frameworks, cyclic skeletons, matched molecular pair (MMP) analysis via mmpdb, R-group decomposition, Free-Wilson analysis, scaffold hopping, and chemotype-aware ML train/test splits. Use when identifying chemotype clusters in a library, deriving SAR transformation rules, decomposing series into R-groups, performing scaffold-balanced QSAR splits, or planning analog campaigns.

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Designs and validates quantitative targeted metabolomics assays (MRM/SRM on triple-quadrupole, PRM on high-resolution instruments) to report absolute concentrations. Covers the internal-standard strategy (external cal -> global IS -> standard addition -> stable-isotope-labeled IS), weighted calibration judged by back-calculated %RE not R-squared, ion-ratio quantifier/qualifier confirmation, matrix-effect/recovery characterization, and ICH M10 method validation. Use when quantifying a closed panel of known metabolites with units, building or validating an LC-MS/MS assay, choosing an IS or calibration weighting, or judging whether a reported concentration is trustworthy. For untargeted feature detection see metabolomics/xcms-preprocessing; for group statistics see metabolomics/statistical-analysis; for flux/MID/tracing see metabolomics/isotope-tracing.

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Predicts ADMET properties using ADMETlab 3.0 (119 endpoints with uncertainty), ADMET-AI, DeepChem MolNet, and chemprop D-MPNN with explicit handling of OECD QSAR principles, applicability domain assessment, calibration, hERG/CYP/AMES gold-standard endpoints, and PAINS / Lipinski / Ro5 / Veber / BBB druglikeness filters. Use when filtering compounds for drug-likeness, prioritizing leads by predicted safety, or building an in-house ADMET QSAR model.

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Searches molecular libraries for substructure matches using SMARTS patterns with explicit handling of recursive SMARTS, ring membership, aromaticity dialect, vector binding, atom map indices, and reactive/PAINS/REOS/Brenk/Aldridge filter catalogs. Use when filtering compounds by pharmacophore features, functional groups, scaffold matches, or screening for assay-interference / structural alerts.

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Programmatic untargeted LC-MS feature extraction in R with the modern xcms 4.x MsExperiment/XcmsExperiment API, taking raw mzML to a feature table via CentWave peak detection, retention-time alignment, peak-density correspondence, gap-filling, CAMERA redundancy collapse, and built-in QC feature filtering. Use when converting centroided LC-MS runs into a features-by-samples matrix and deciding centWave/grouping/alignment parameters. For drift correction and QC/CV filtering execution see metabolomics/normalization-qc; for metabolite identification see metabolomics/metabolite-annotation; for the MS-DIAL GUI alternative with MS2Dec deconvolution see metabolomics/msdial-preprocessing; for downstream statistics see metabolomics/statistical-analysis.

日本語の概要は準備中です。原文の説明を表示しています。

Map the competitive landscape for a Stellar project idea. Use when a user says "who are my competitors on Stellar", "competitive analysis Stellar", "what already exists in this space on Stellar", "show me similar Stellar projects", "is anyone else building this on Stellar", or "map the Stellar landscape for X". Queries the 728-project LumenLoop ecosystem database and Electric Capital developer activity to rank competitors by SCF funding history and repo activity.

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Benchmark stellar-build skills to measure quality and the lift from optimization. Use when the user says "bench my skills", "bench-skills", "benchmark skills", "did optimization help", "measure my skills", "stellar-loop bench", or wants to quantify whether /optimize-skills actually improved things. Held-out eval prompts scored by an LLM judge, reproducible with fixed seeds. Fully local.

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Meta-skill — browse and discover all installed stellar.new skills. Use when a user says "what skills do I have", "show me available skills", "what can I do", "find a skill for X", "which skill should I use", "help me navigate", "what does stellar.new do", or "where do I start". Lists skills by journey phase, surfaces the SKILL_ROUTER trigger phrases, and recommends the next skill given current context.

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Continue working on an OpenSpec change by creating the next artifact. Use when the user wants to progress their change, create the next artifact, or continue their workflow.

日本語の概要は準備中です。原文の説明を表示しています。

Start a new OpenSpec change using the experimental artifact workflow. Use when the user wants to create a new feature, fix, or modification with a structured step-by-step approach.

日本語の概要は準備中です。原文の説明を表示しています。

Continues Charted Coding work for a PR by routing to scaffold, red, or green based on design doc progress. Use when resuming work on a PR, continuing TDD after a break, or when the user invokes charted continue with a design doc and PR number.

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Interviews the user section by section to collaboratively produce design documents. Use when creating a design doc, starting feature design, or when the user invokes the design command.

日本語の概要は準備中です。原文の説明を表示しています。

Progressively activates todo tests one at a time, updates implementation code until each passes (verified via Wallaby), checks off matching design doc progress, then moves to the next—following the design doc as the single source of truth.

日本語の概要は準備中です。原文の説明を表示しています。

Generate Conventional Commits spec git commits (auto-separate by feature)

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When the user needs marketing ideas, inspiration, or strategies for their SaaS or software product. Also use when the user asks for 'marketing ideas,' 'growth ideas,' 'how to market,' 'marketing strategies,' 'marketing tactics,' 'ways to promote,' or 'ideas to grow.' This skill provides 139 proven marketing approaches organized by category.

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Extract applicant details from rental application PDFs and generate a side-by-side XLSX for comparing income, employment, and move-in dates.

日本語の概要は準備中です。原文の説明を表示しています。

Compress an image to fit within a specific file size in bytes using quality-first compression.

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Gets a custom map into CARLA on UE 5.8 — the four distinct routes and which one to pick — via Util/Tools/Import.py for FBX+OpenDRIVE assets into a source build, CARLA_MAPS_TO_COOK to ship a map inside a package, or client.generate_opendrive_world() for an OpenDRIVE-only map at runtime with no build at all. Covers where imported assets land, why an imported map cannot be loaded from a package by name, and the four capabilities the UE4 skill has that ue58 lacks — standalone asset packages, their installer, semantic-material tagging, and a pedestrian navmesh that is generated but silently skipped. Use when the user asks to "import a map", "add a custom map", "load my .xodr", "package my own town", or "create a standalone map package".

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Controls the traffic-light actors on a running CARLA server — set a light green/red/yellow/off, freeze all lights (optionally all-green), set phase timing (green/yellow/red durations), and reset to the normal cycle. Target all lights, one by id, all in a junction, or the nearest. Use when the user asks to "make the light red", "freeze all lights green", "change the light timing", "turn the traffic lights off", or "reset the lights". This is the light actors, not the Traffic Manager (that's control-traffic).

日本語の概要は準備中です。原文の説明を表示しています。

Downloads CARLA so nothing has to be fetched by hand — an official release package for any published version (resolved live from the GitHub releases, with AdditionalMaps), the rolling nightly Dev build, a shallow source checkout of a branch or tag, or the carlasim/carla Docker image. Reports exactly what was obtained and where, plus the environment variables the other skills read. Use when the user asks to "download CARLA", "get CARLA 0.9.16", "install CARLA", "clone the carla repo", "fetch the latest CARLA", or has no CARLA at all yet.

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Answers "can CARLA do X here, and is there a vetted procedure for it" before you promise anything, and detects client/server/tree version skew — a support matrix over the whole collection (covered by a skill / works but undocumented / present but untested / broken or removed), an index of the features that are verified BROKEN on 0.10.0 (gbuffers crash the server, map layers do nothing, Landmark.waypoint is None, standalone asset packages are gone), and a probe that reports what this machine's build flags and running server actually offer. Use when the user asks whether CARLA supports something, when a feature has no skill, when a UE4 tutorial's steps do not exist, or before improvising a procedure.

日本語の概要は準備中です。原文の説明を表示しています。

Installs the CARLA Autonomous Driving Leaderboard (leaderboard.carla.org) at a chosen version — 1.0, 2.0 or 2.1 — together with the exact scenario_runner branch and CARLA build each one requires, then wires the four-root PYTHONPATH and verifies the whole stack imports. Detects which version an existing checkout is by reading its code, not its branch name. Use when the user asks to "install the leaderboard", "set up the CARLA challenge", "evaluate my driving agent", "reproduce my leaderboard score", or names a leaderboard version.

日本語の概要は準備中です。原文の説明を表示しています。

Visualises and validates a map's pedestrian navigation mesh by sampling walkable locations (get_random_location_from_navigation) and drawing them as debug points. Use when the user asks to "show/visualise the pedestrian navmesh", "check walkable areas", "validate pedestrian navigation after a map import", or "why won't my walkers move". Confirms the navmesh loaded and how far it covers.

日本語の概要は準備中です。原文の説明を表示しています。

Installs the CARLA Python client (the `carla` package) into a chosen interpreter so the other python-api skills work — from a wheel bundled with your release or checkout, from PyPI (`pip install carla==X.Y.Z`), or by putting an older release's .egg on PYTHONPATH. Detects what is already present, picks the source that matches your simulator's version, pins numpy<2, and verifies `import carla` plus the client/server version match. Use when the user asks to "install the CARLA Python API", "pip install carla", "set up the carla python package", or when a skill reports "cannot import carla".

日本語の概要は準備中です。原文の説明を表示しています。