chroma
無料Embedding database for RAG and semantic search.
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概要と使いどころ
Embedding database for RAG and semantic search.
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Notion API + ntn CLI: pages, databases, markdown, Workers.
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Artificial intelligence-based personalised learning in education: a ... — 18. Nov. 2025 · Thoroughly
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Sifa 1 , Fabian Küch 6 , Andreas Herten 4 , René Jäkel 3 , Georg Rehm 5 , Stefan Kesselheim 4 , Joac
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Autonomously improve a real artifact (code, training recipe, agent harness, data pipeline, prompt) against an objective and an evaluator, using Hypothesis Tree Refinement (HTR) from the Arbor paper. Use this whenever someone wants to iteratively optimize something over many experiments without overfitting — e.g. "get my model's eval score up", "improve this agent/harness", "tune this pipeline", "beat the baseline on this benchmark", "run a search over approaches and keep the best", "do an MLE-bench / Kaggle-style optimization", or any long-horizon "make this artifact better and don't just memorize the dev set" task. Trigger it even when the user doesn't say "Arbor" or "hypothesis tree" but describes repeated experiment-and-evaluate loops, branching exploration of competing ideas, or worries about a dev/test gap. Runs Claude itself as the coordinator with subagent executors in isolated git worktrees; for the standalone `arbor` CLI tool see references/arbor-upstream.md.
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Plan, execute, and document validation, verification, and transfer of analytical procedures under the governing framework - ICH Q2(R2) and Q14, USP <1220>/<1225>/<1226>, ICH M10 bioanalytical, CLSI EP, or ISO/IEC 17025. Use for HPLC, LC-MS/MS, GC, CE, ICP-MS, dissolution, qNMR, qPCR, NIR, and ligand binding or cell-based assays whenever the question is whether a procedure is fit for its intended purpose. Triggers include "method validation", "analytical method validation", "AMV", "validation protocol", "acceptance criteria", "linearity", "reportable range", "accuracy and precision", "repeatability", "intermediate precision", "recovery", "LOD", "LOQ", "detection limit", "quantitation limit", "specificity", "robustness", "method transfer", "method comparison", "Deming", "Passing-Bablok", "Bland-Altman", "equivalence testing", "OOS investigation", "ICH Q2", "Q2(R2)", "Q14", "USP 1225", "ICH M10", "incurred sample reanalysis", "ISR", "CLSI EP", and any request to show that an assay works.
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Retrieve and analyze AlphaFold predicted structures for a protein. Use when the user provides a specific UniProt Accession ID and wants structural confidence metrics (pLDDT), domain boundary analysis, or disorder assessment. Do not use if the user only has a protein name, gene name, or amino acid sequence — ask for a UniProt ID first.
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Search and retrieve preprints from arXiv via the Atom API. Use this skill when searching for papers in physics, mathematics, computer science, quantitative biology, quantitative finance, statistics, electrical engineering, or economics by keywords, authors, arXiv IDs, date ranges, or categories.
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AiZynthFinder retrosynthetic route planning (CASP) from AstraZeneca Molecular AI. Monte Carlo tree search guided by a template-based neural expansion policy recursively disconnects a target SMILES until precursors are found in a purchasable stock. Covers config.yml (v4 format), aizynthcli batch screening, the AiZynthFinder/AiZynthExpander Python API, one-step disconnections, custom stocks via smiles2stock, scorers, Retro*/breadth-first/DFPN search alternatives, and reading output.json.gz / trees.json. Use for synthesis route planning, synthesizability screening, and building-block/precursor search. For reaction barriers use neb-irc-activation-energy; for 2D reaction scheme drawing use rdkit-chemdraw-cdxml.
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Regression testing strategies for AI-assisted development. Sandbox-mode API testing without database dependencies, automated bug-check workflows, and patterns to catch AI blind spots where the same model writes and reviews code.
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Access AlphaFold DB's 200M+ predicted structures by UniProt ID. Download PDB/mmCIF, analyze pLDDT/PAE, bulk-fetch proteomes via Google Cloud. For experimental structures use PDB; for prediction use ColabFold or ESMFold.
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Access AlphaFold's 200M+ AI-predicted protein structures. Retrieve structures by UniProt ID, download PDB/mmCIF files, analyze confidence metrics (pLDDT, PAE), for drug discovery and structural biology.
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RED-GREEN-REFACTOR for process documentation - baseline without skill, write addressing failures, iterate closing loopholes
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Dispatch to the right problem-solving technique based on how you're stuck
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Deploy and manage projects on Vercel using token-based authentication. Use when working with Vercel CLI using access tokens rather than interactive login — e.g. "deploy to vercel", "set up vercel", "add environment variables to vercel".
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Create detailed implementation plans with bite-sized tasks for engineers with zero codebase context
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NVIDIA RAG Blueprint deployment, configuration, troubleshooting, and shutdown guidance for Docker, Helm, and library-based RAG stacks.
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Repository-grounded threat modeling that enumerates trust boundaries, assets, attacker capabilities, abuse paths, and mitigations, and writes a concise Markdown threat model. Trigger only when the user explicitly asks to threat model a codebase or path, enumerate threats/abuse paths, or perform AppSec threat modeling. Do not trigger for general architecture summaries, code review, or non-security design work.
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NVIDIA RAG Blueprint evaluation guidance for measuring retrieval and answer quality with stable datasets, baselines, and reproducible scoring workflows.
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Perform a read-only, defect-first review of a specified code change and return every actionable finding. Use when another agent delegates review of uncommitted changes, a base-branch diff, a commit, or custom review instructions.
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Use when you need to resolve an in-progress git merge/rebase conflict.
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Analyze git repositories to build a security ownership topology (people-to-file), compute bus factor and sensitive-code ownership, and export CSV/JSON for graph databases and visualization. Trigger only when the user explicitly wants a security-oriented ownership or bus-factor analysis grounded in git history (for example: orphaned sensitive code, security maintainers, CODEOWNERS reality checks for risk, sensitive hotspots, or ownership clusters). Do not trigger for general maintainer lists or non-security ownership questions.
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Evaluate recommender system quality for the CSX4207 Vinyl Record Store. Use whenever you must compute or report recommender metrics (Precision@k, Recall@k, HitRate@k, MRR, MAP@k, NDCG@k, coverage, diversity, novelty, serendipity, personalization), design an evaluation protocol/split, run a baseline comparison, or write the evaluation section of a course deliverable. Covers formulas, JavaScript reference implementations, and the reporting checklist.
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Add authentication and user management to a Netlify site with @netlify/identity — signup/login/logout, OAuth social login (Google/GitHub/GitLab/Bitbucket), server-side user verification in Functions, role-based access control (RBAC), admin user management, and Identity event hooks. Use when adding a login/signup flow, "add social login", gating content by user role, protecting a function or page behind auth, assigning roles at signup, customizing auth emails, or handling OAuth/confirmation/recovery callbacks. Not for locking an entire site to a company/team — that is netlify-access-control.
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