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Runs JACKS (Joint Analysis of CRISPR/Cas9 Knockout Screens; Allen et al 2019 Genome Research) which models per-sgRNA log-fold-change as the product of a treatment-dependent gene-essentiality term and a treatment-independent guide-efficacy term. Covers the Bayesian decomposition math, the hierarchical efficacy prior shared across screens performed with the same library, when JACKS outperforms MAGeCK (multi-screen joint analysis, libraries with broad efficacy variance) and when it does not (single screen, novel libraries with no prior efficacy), library-reuse efficacy transfer, downstream essentiality interpretation, and the 2.5x sample-size reduction enabled by efficacy-aware testing. Use when running multiple screens with the same library, when guide-level noise is suspected to dominate per-gene signal, when reusing published essentiality reference screens for efficacy priors, or when comparing screens performed across cell lines that share library but differ biologically.

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Test whether two or more traits share a causal variant at a locus using Bayesian colocalization (coloc.abf, coloc.susie, HyPrColoc, moloc, eCAVIAR, SMR/HEIDI, PWCoCo, SharePro). Use when integrating GWAS with eQTL/sQTL/pQTL/mQTL, distinguishing shared causal variants from LD-driven coincidence, handling allelic heterogeneity, choosing between single-causal vs multi-causal methods, picking PP.H4 thresholds, running sensitivity over p12, or harmonising summary statistics for colocalization.

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Deep competitive intelligence for any market. Analyzes competitors' products, pricing, customer sentiment, GTM strategy, and growth signals using real web data. Produces battle cards, pricing landscape, and feature matrix. Use when the user wants to understand their competitive landscape, analyze competitors, compare products in a market, or research who they're competing against. Triggers for "who are my competitors", "competitive analysis", "competitor research", "battle cards", "pricing comparison", "competitor pricing", "market players", "competitive intelligence", "competitive landscape", "who else is in this space", "competitive moat", or any request to profile, compare, or map competitors in a category. Works standalone — no prior startup-design session needed.

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Shared SearchCLI setup: install, authenticate, run doctor, and verify the local environment.

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Discover and choose Cloudflare products for apps, APIs, AI agents, storage, networking, and security. Use for architecture and product selection, including when the user describes a need without naming a Cloudflare product; then find the relevant skill or documentation.

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Design, configure, troubleshoot, or review Cloudflare One Zero Trust and SASE deployments. Use cloudflare-one-migrations for migration planning from other vendors.

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Migrate Cloudflare Sandbox apps from stable @cloudflare/sandbox to @cloudflare/sandbox@next (SDK 1.0 preview). Use sandbox-next for apps already on the preview.

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Discover, configure, and connect to Arduino boards from MATLAB using the Arduino Support Package. Use this skill when the user wants to set up an Arduino board, connect to Arduino hardware, find connected boards, scan serial ports, configure Arduino libraries, or any task that requires an Arduino connection as a prerequisite (e.g., blink LED, read sensor, read digital pin, read analog pin, write pin, plot sensor data, scan I2C, use ultrasonic sensor, control servo, read temperature, read voltage, data logging from hardware). Triggers on: arduino, board setup, COM port, serial port, hardware connection, Arduino Nano, Arduino Uno, Arduino Mega, Arduino Micro, Grove, sensor setup, I2C scan, ultrasonic, servo, readDigitalPin, writeDigitalPin, readVoltage, writePWMVoltage, temperature sensor, air pressure, pin read, pin write, analog input.

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Deploy AI models to embedded hardware using MathWorks tools (MATLAB, Simulink, Embedded Coder). Covers two workflow patterns: (1) MathWorks-native or imported models rebuilt as dlnetwork for lean hardware, (2) direct C/C++ code generation from PyTorch and LiteRT models. Both patterns support all targets (Cortex-M/A/R, x86, GPU). Trigger when: user wants to deploy AI to embedded targets; generate C/CUDA from neural networks; compress AI models for MCU; integrate AI in Simulink for system-level simulation; import PyTorch/ONNX/TensorFlow models for embedded deployment; optimize AI for resource-constrained hardware; or use loadPyTorchExportedProgram, loadLiteRTModel, importNetworkFromPyTorch, importNetworkFromONNX, importNetworkFromTensorFlow, importNetworkFromKeras, dlquantizer, exportNetworkToSimulink, or Embedded Coder with AI models.

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Use this skill to classify tabular data end-to-end in MATLAB — load a dataset, prepare and clean it, select promising classifiers, train them, and compare accuracies with cross-validation, holdout, or hyperparameter optimization plus statistical tests. TRIGGER when: user asks to classify tabular data, pick classifiers for a dataset, compare classifier accuracy, run cross-validation or a holdout evaluation, or find the best model with statistical uncertainty. DO NOT TRIGGER when: user has non-tabular inputs (images, sequences, time series), wants a regression model, is training a specific neural network architecture (use matlab-train-network), or wants cost-sensitive learning or an arbitrary class-prior vector (this skill only supports the built-in uniform-prior toggle for imbalanced data).

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Build and deploy edge functions with Cloudflare Workers and Wrangler. Use for APIs, cron jobs, and edge middleware.

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E-commerce warehouse and inventory optimization advisor. Analyzes inventory health, calculates safety stock and reorder points, performs ABC analysis, evaluates fulfillment costs, and provides actionable recommendations for improving efficiency. Supports all major fulfillment models: Self-fulfillment, Amazon FBA/FBM, Walmart WFS, 3PL, Shopify Fulfillment, TikTok Shop, Dropshipping, and Hybrid setups. No API key required. Use when: (1) reducing stockouts or overstock, (2) calculating safety stock levels, (3) optimizing warehouse costs, (4) improving Amazon IPI score, (5) analyzing inventory KPIs.

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Hit the Cloudflare REST API directly for operations that wrangler and MCP can't handle well. Bulk DNS, custom hostnames, email routing, cache purge, WAF rules, redirect rules, zone settings, Worker routes, D1 cross-database queries, R2 bulk operations, KV bulk read/write, Vectorize queries, Queues, and fleet-wide resource audits. Produces curl commands or scripts. Triggers: 'cloudflare api', 'bulk dns', 'custom hostname', 'email routing', 'cache purge', 'waf rule', 'd1 query', 'r2 bucket', 'kv bulk', 'vectorize query', 'audit resources', 'fleet operation'.

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Scaffold and deploy Cloudflare Workers with Hono routing, Vite plugin, and Static Assets. Describe project, scaffold structure, configure bindings, deploy. Use whenever the user wants to create a Worker project, set up Hono on Cloudflare, configure D1 / R2 / KV / Queues bindings, or troubleshoot Worker export syntax, API route conflicts, HMR issues, or deployment failures.

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Build a full-stack TanStack Start app on Cloudflare Workers from scratch — SSR, file-based routing, server functions, D1+Drizzle, better-auth, Tailwind v4+shadcn/ui. Use whenever the user mentions TanStack Start, asks to scaffold a full-stack Cloudflare app with SSR, wants an SSR dashboard, or asks for a React 19 + Cloudflare Workers app with file-based routing and server functions — even if they don't name TanStack Start specifically. No template repo — Claude generates every file fresh per project.

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Compare UX patterns across multiple reference apps using pattern libraries produced by ux-extract. Reads 2+ pattern-library.md files, walks them category by category, identifies where apps converge (strong signal), where they diverge (genuine design choice), what's unique to one app, and what's absent across the set. Produces an opinionated comparison document with recommendations for a new build. No browser needed — pure markdown analysis. Trigger with 'compare UX patterns', 'how do top apps handle X', 'ux comparison', 'pattern comparison across reference apps'.

日本語の概要は準備中です。原文の説明を表示しています。

When the user wants to optimize brand search for a company with multiple domains (e.g. parent company.com vs product.ai). Ensure the parent/company domain ranks first for brand queries. Also use when the user mentions "brand search," "multi-domain SEO," "company domain first," "parent vs product domain," "hub-spoke domain," "brand SERP control," or "differentiate company and product domains." For domain structure, use domain-architecture.

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Deprecated compatibility entry for Careers Page construction. This page is now maintained in Pagina; install and use page-builder to build a new Careers Page.

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Deprecated compatibility entry for Social Share construction. This component is now maintained in Bricks; install and use component-builder to build a new Social Share.

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Assemble the final `.ppmplugin` binary bundle for a PAM native extension and verify its contents. First **reconciles** the manifest's declared `entrypoints` against the binaries actually staged — if the manifest declares a platform with no built binary it gates (build it / ship without it / stop) rather than shipping a broken bundle. Then re-runs the plugin's upload-compatibility checks on the reconciled manifest, zips the manifest plus whichever of `android/<PascalName>Plugin.dex` and `ios/<PascalName>Plugin.framework/` are present into `ppmplugin/<name>.ppmplugin`, and verifies the archive layout with `jar tf` (exactly the manifest + the shipped binaries — nothing missing, nothing extra). Output: a statically verified `.ppmplugin` file on disk. Prereqs: `jar` (JDK). Run after /generate-ppmplugin-manifest and the build skill(s).

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Capture a human-approved UI design lesson as a privacy-minimized local StyleSeed candidate, review it, and prepare an opt-in share package without transmitting project code, prompts, screenshots, or brand data. Use when a person asks StyleSeed to remember, learn from, generalize, review, or prepare a reusable rule from an accepted design correction.

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Expert CIS Controls v8 (CIS Top 18) advisor — implementation group scoping (IG1/IG2/IG3), control gap assessments, safeguard-level guidance, asset inventory, software inventory, data protection, secure configuration, account management, access control, continuous vulnerability management, audit log management, email and web browser protections, malware defenses, network infrastructure management, network monitoring and defense, application software security, incident response, penetration testing, and CIS Controls mapping to NIST CSF, ISO 27001, SOC 2, and CMMC. Use for any question about CIS Controls, CIS Benchmarks, Implementation Groups, or prioritized cyber hygiene for any organization size.

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This skill should be used when the user asks to "optimize Snowflake queries", "analyze Snowflake SQL performance", "size Snowflake warehouses", "review Snowflake data models", or "troubleshoot Snowflake cost issues".

日本語の概要は準備中です。原文の説明を表示しています。

Calculate share of voice by script vs competitors in search, social and AI. "what's our share of voice"

日本語の概要は準備中です。原文の説明を表示しています。