pytdc
無料Therapeutics Data Commons. AI-ready drug discovery datasets (ADME, toxicity, DTI), benchmarks, scaffold splits, molecular oracles, for therapeutic ML and pharmacological prediction.
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Therapeutics Data Commons. AI-ready drug discovery datasets (ADME, toxicity, DTI), benchmarks, scaffold splits, molecular oracles, for therapeutic ML and pharmacological prediction.
日本語の概要は準備中です。原文の説明を表示しています。
Implement EUI sessions, shared state and messages, server lifecycle, and client presentation.
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Extract structured fields from steuerbescheid documents.
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Extract structured fields from umsatzsteuervoranmeldung documents.
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Extract structured fields from steuererklaerung documents.
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Extract structured fields from lohnsteuerbescheinigung documents.
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Windows アプリ開発 (Win32 / WPF / WinForms 相互運用) の相互運用・近代化リファレンス。 Win32 API, CreateWindowExW, WNDPROC, メッセージループ, COM (IUnknown, CoCreateInstance, ComPtr), CsWin32, windows-rs, C++/WinRT (winrt::com_ptr, IAsyncOperation, IDL, ABI 相互運用), C#/WinRT (cswinrt, ComWrappers, AOT/trimming, WindowNative), XAML Islands (DesktopWindowXamlSource, DesktopChildSiteBridge, WindowsXamlManager), WPF/WinForms 相互運用 (HwndHost, HwndSource, WindowsFormsHost, ElementHost), UWP から Windows App SDK / WinUI 3 への 移行 (namespace mapping, AppWindow, DispatcherQueue, .NET Upgrade Assistant)。
Three.js (WebGL / WebGPU ベース 3D グラフィクスライブラリ) リファレンス。 Scene, PerspectiveCamera, OrthographicCamera, WebGLRenderer, WebGPURenderer、 BufferGeometry, BufferAttribute, Mesh, Group, InstancedMesh, SkinnedMesh、 MeshStandardMaterial, MeshPhysicalMaterial, ShaderMaterial, node-materials (TSL)、 DirectionalLight, PointLight, SpotLight, AmbientLight、 TextureLoader, GLTFLoader, DRACOLoader, FBXLoader、 AnimationMixer, AnimationClip, AnimationAction, KeyframeTrack、 Vector3, Matrix4, Quaternion, Euler, Color, Raycaster, Box3、 OrbitControls, TransformControls, WebXRManager。
Upstash サーバーレスデータプラットフォームリファレンス。 @upstash/redis — REST API、pipelining、transactions、JSON、Search、グローバルレプリケーション。 @upstash/ratelimit — Fixed Window、Sliding Window、Token Bucket、limit、blockUntilReady。 QStash — publishJSON、schedules、queues、DLQ、URL Groups、callbacks、flow-control。 @upstash/vector — upsert、query、ANN、hybrid index、sparse index、embedding models、namespace。 Rust 製ローカル vector DB エンジン fandhe-db とは別(こちらはマネージド SaaS の JS SDK)。 @upstash/workflow — durable execution、serve、context.run/sleep/call/invoke、waitForEvent、parallel steps、agents。 Upstash Search — search、upsert、fetch、range、filtering、reranking、algorithm、@upstash/search。 Upstash Box — サンドボックス、agent、filesystem、git、browser(CDP/AI actions/recordings)、network policy、snapshots、schedules。
Proxmox VE (PVE) ハイパーバイザーリファレンス。KVM/QEMU 仮想マシン、LXC コンテナ、 クラスター構築・HA・SDN・Ceph・ZFS・ストレージ管理。 qm, pct, pvecm, pvesm, pveceph, pvesh, pveum, vzdump, pveam, pvesr, ha-manager CLI。 REST API、設定ファイル (qm.conf, pct.conf, datacenter.cfg)、バックグラウンドサービス一覧。
Apple オンデバイス機械学習フレームワークリファレンス。 Core ML / Create ML / Vision / Natural Language / Speech。 MLModel, MLModelConfiguration, MLMultiArray, MLComputeUnits, MLImageClassifier, MLTextClassifier, MLDataTable, VNImageRequestHandler, VNRecognizeTextRequest, VNCoreMLRequest, NLTagger, NLLanguageRecognizer, NLEmbedding, SFSpeechRecognizer, SFSpeechAudioBufferRecognitionRequest, SFTranscription。
App Store Connect API (REST) リファレンス。JWT 認証、API キー作成・失効、 Apps, Builds, Bundle IDs, Certificates, Devices, Provisioning Profiles, Users。 TestFlight Beta Groups / Testers / App Review。In-App Purchases, Subscriptions, Subscription Groups, Promotional Offers, App Price Points, Sales Reports。アプリ配布。 Sandbox Testers, User Invitations, Merchant IDs, Pass Type IDs, Bundle ID Capabilities。 Webhooks / Webhook Events / Deliveries、Xcode Cloud (Workflows, Build Runs, Artifacts)、 Alternative Distribution (EU マーケットプレイス / Web Distribution)、 Game Center (Achievements, Leaderboards, Challenges)、Analytics / 診断レポート。
Apple グラフィックスフレームワークリファレンス。 Metal, Core Animation, Core Graphics, Core Image, SpriteKit, SceneKit。 MTLDevice, MTKView, MTLBuffer, MTLTexture, Metal 4 (MTL4CommandQueue, MTL4CommandBuffer, MTL4ArgumentTable), CALayer, CABasicAnimation, CADisplayLink, CAMetalDisplayLink, CAMetalDrawable, CGContext, CGPath, CGImage, CIFilter, CIContext, CIImage, CIRAWFilter, CIWarpKernel, CIBlendKernel, SKScene, SKSpriteNode, SKAction, SCNNode, SCNGeometry, SCNMaterial。
Compare cell-type composition and spatial features across conditions in IMC/MIBI cohorts with the patient as the experimental unit, covering pseudoreplication, per-patient aggregation, mixed models, compositional (Dirichlet/scCODA) differential abundance, diffcyt, per-image-to-patient spatial differential testing (SpaceANOVA), batch covariates, and FDR. Use when testing whether a cell type or spatial niche differs between groups, avoiding cell-level pseudoreplication, choosing a differential-abundance method, or correctly powering an IMC cohort comparison.
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Detects focal chromatin loops (point interactions / corner-dots) in balanced Hi-C and Micro-C contact maps and aggregates/validates a loop set. Covers de-novo calling with cooltools dots (HiCCUPS-style 4-background local enrichment with lambda-chunked FDR), chromosight (template-correlation), and Mustache (scale-space blob detection); aggregate peak analysis (APA) via cooltools pileup for confirmation; the depth/resolution prerequisite (de-novo needs ~5-10kb resolution = hundreds of millions to billions of valid pairs); consensus across callers and convergent-CTCF support as validation; and differential loops via union anchors plus chromosight quantify. Use when calling chromatin loops or dots from a cooler, deciding whether a map is deep enough to call de-novo vs running APA on known CTCF/cohesin anchors, building an aggregate peak pileup, comparing loops across conditions, or validating loop calls. For HiChIP/PLAC-seq/PCHi-C protein-anchored data use FitHiChIP/MAPS, not dots.
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Structures biological experiments so inference is valid by construction, covering Fisher's principles (randomization, replication, local control), the experimental-vs-observational unit distinction and pseudoreplication (Hurlbert 1984; Lazic 2018), randomization mechanics (complete, restricted, stratified, rerandomization, run-order), blocking layouts (randomized complete block, Latin square, incomplete block), factorial designs and interactions, and the split-plot/nested error strata hidden inside multi-batch genomics. Use when deciding the experimental unit and what counts as a replicate, planning randomization and run order, choosing a blocked/factorial/split-plot/nested layout, avoiding pseudoreplication in cell-culture or animal studies, or specifying the random-effects structure of the analysis model. For assigning samples to sequencing batches/lanes/plates and batch-effect correction see experimental-design/batch-design; for regulated clinical-trial randomization see clinical-biostatistics.
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Analyzes time-series and longitudinal RNA-seq for differential expression and trajectory structure. Covers DESeq2 LRT with reduced models, time as factor vs continuous vs natural splines, maSigPro (Nueda 2014 for RNA-seq), ImpulseDE2 with explicit impulse-model failure modes, DREAM for repeated measures via linear mixed models, pseudoreplication avoidance, conditional vs marginal modeling, and trajectory clustering with DPGP, Mfuzz (with Schwämmle 2010 fuzzifier estimation), and splines+k-means. Use when modeling time-course or longitudinal expression, choosing factor vs spline, handling repeated measures from the same subject, avoiding pseudoreplication, clustering temporal trajectories, or selecting between dedicated time-course tools and pairwise+LRT.
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Runs JACKS (Joint Analysis of CRISPR/Cas9 Knockout Screens; Allen et al 2019 Genome Research) which models per-sgRNA log-fold-change as the product of a treatment-dependent gene-essentiality term and a treatment-independent guide-efficacy term. Covers the Bayesian decomposition math, the hierarchical efficacy prior shared across screens performed with the same library, when JACKS outperforms MAGeCK (multi-screen joint analysis, libraries with broad efficacy variance) and when it does not (single screen, novel libraries with no prior efficacy), library-reuse efficacy transfer, downstream essentiality interpretation, and the 2.5x sample-size reduction enabled by efficacy-aware testing. Use when running multiple screens with the same library, when guide-level noise is suspected to dominate per-gene signal, when reusing published essentiality reference screens for efficacy priors, or when comparing screens performed across cell lines that share library but differ biologically.
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Build and analyze pangenomes for prokaryotes (Panaroo, PPanGGOLiN, PEPPAN, GET_HOMOLOGUES, anvi'o pangenomics) and eukaryotes (Minigraph-Cactus, PGGB, vg pangenome graphs). Implement Tettelin core/accessory/cloud genome decomposition (Tettelin 2005), Heap's law open/closed pangenome modeling, gene presence/absence GWAS (Scoary, pyseer), pangenome graph variant calling (vg, PanGenie), and structural-variation graph indexing. Use when assembling species- or genus-level pan-gene catalogs, separating core from accessory/shell/cloud genes, testing gene-content associations with phenotypes, building pangenome graphs from haplotype-resolved assemblies, calling SVs from pangenome graphs, or selecting between bacterial-pangenome and eukaryotic-pangenome workflows.
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Build and configure Laravel 10+ applications, including creating Eloquent models and relationships, implementing Sanctum authentication, configuring Horizon queues, designing RESTful APIs with API resources, and building reactive interfaces with Livewire. Use when creating Laravel models, setting up queue workers, implementing Sanctum auth flows, building Livewire components, optimising Eloquent queries, or writing Pest/PHPUnit tests for Laravel features.
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Extract and consolidate reusable components, design tokens, and patterns into your design system. Identifies opportunities for systematic reuse and enriches your component library. Use when the user asks to create components, refactor repeated UI patterns, build a design system, or extract tokens.
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Builds reusable Convex components with isolated tables and app-facing APIs. Use for new components, reusable backend modules, integrations, or component boundary work.
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openreel-storyboardのMiniMax H3 queueをCLIで検証・生成・監視・復旧する。既存runのstatus、resume、cancelにも使う。
Train and deploy neural networks in distributed E2B sandboxes with Flow Nexus
日本語の概要は準備中です。原文の説明を表示しています。