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概要と使いどころ
Scan an iOS/macOS Xcode project for common App Store rejection patterns before submission. Use when preparing an app for App Store review, after receiving a rejection from Apple, or when auditing metadata, subscriptions, privacy manifests, entitlements, or design compliance. Integrates with the asc CLI for metadata inspection.
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Use when closing out a feature, tidying developing/ documentation, or asked to check docs health — runs the lifecycle linter and applies the README deletion rules.
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Use when the user requests React Doctor or a React code-health audit, or when a concrete React diagnostic question would benefit from its scan. Not a default step after React changes or before committing.
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This skill helps Claude write secure web applications. Use this when working on any web application or when a user requests a scan or audit to ensure security best practices are followed.
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Review code for security problems; scan for vulnerabilities, secrets, dependency and prompt risks. Use when: asked whether code is safe to ship, even one small handler.
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Codex-native multi-keyword Amazon opportunity scan using LaunchFast MCP. Use when the user wants to research 1-10 keywords, compare niches, or decide whether a product idea is a GO, INVESTIGATE, or PASS. Requires the LaunchFast MCP tool `research_products`.
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Register a deferred decision in the debt registry. Trigger by judgment, not a marker scan, whenever a future reader would ask "why this way?": an unmade decision, stub, loosened type, bypassed check, swallowed error, a default picked "for now", or a TODO/FIXME/HACK/XXX marker. Trigger immediately whenever you defer work, or when the user invokes $add. Over-register freely; the developer drops with "drop A", "drop A,C", or "drop all".
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Use when reviewing a DataFusion Comet pull request that crosses the JVM/native boundary, touching Arrow C Data or C Stream interface code, batch export and import, CometExecIterator, ScanExec, NativeUtil, CometVector subclasses, or jni_api. Load alongside review-comet-pr.
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Shared loop-engineering reference for COG skills - the agent loop, deterministic verifiers, termination conditions, in-loop context management, and named patterns. Invoke when designing or debugging a skill that iterates (search-verify-retry, scan-until-dry, fetch-retry-gate).
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Deterministic pre-publish scan that refuses AI-slop tells in anything about to be written, published, or sent: files, artifacts, slide titles, table headers, diagram labels, chat messages, commit messages. Use before publishing or sending any deliverable, in CI, or wired as a Claude Code hook so the check runs without being remembered. The editorial counterpart is no-ai-slop, which rewrites; this one blocks.
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Discover all customers of a given company by scanning websites, case studies, review sites, press, social media, job postings, and more. Use when you need competitive intelligence on who a company sells to.
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Scan support tickets, Slack channels, NPS scores, and usage patterns to flag accounts showing early churn indicators. Produces a weekly risk scorecard with severity tiers, root cause hypotheses, and suggested save plays per account. Designed for seed/Series A teams where the founder or a single CSM manages all accounts manually.
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Scan an AgentMail inbox for newsletter signals using configurable keyword campaigns. Extracts matched keywords, context snippets, and company mentions from incoming emails. Use for monitoring accounting industry newsletters for buying signals like acquisitions, migrations, and staffing news.
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Detect buying signals across TAM companies and watchlist personas. Three-phase architecture: (1) free diff-based signals from existing data (headcount growth, tech stack changes, funding rounds), (2) Apify-powered signals (job postings, LinkedIn content analysis, profile changes), and (3) post-processing with dedup, scoring, and lead status updates. Writes signals to Supabase signals table for downstream activation.
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Generate a personal voice guide for X (Twitter) and/or LinkedIn by scanning a user's past posts and iteratively refining with sample-and-feedback loops. Produces a structured markdown voice guide that sibling skills (create-x-content, create-linkedin-content) consume to draft in-voice posts. Different from brand-voice-extractor, which analyses company blogs/landing pages — this skill is for personal social voice.
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Use when asked to run Design Error Detection (quick defect scan), find design errors in a Simulink model, perform root cause analysis on DED findings, fix division-by-zero, overflow, dead logic or out-of-bounds defects detected by SLDV, or diagnose why missing coverage cannot be achieved (dead logic blocking coverage objectives). Do NOT use for requirement verification, test generation, Inf/NaN detection, active logic analysis, or coverage measurement.
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Guidelines for making .NET libraries and applications trimming-safe and Native AOT compatible. Covers the trimming/AOT model, the MSBuild properties that enable analysis (IsTrimmable, IsAotCompatible, PublishTrimmed, PublishAot), the trimming attributes (RequiresUnreferencedCode, RequiresDynamicCode, DynamicallyAccessedMembers, UnconditionalSuppressMessage), IL2xxx/IL3xxx warning codes, and a pattern playbook: source generators and UnsafeAccessor, generated-interception diagnostic suppressors, intentional runtime scanning boundaries, trimming-safe islands and feature switches, migration analyzers, and temporary warning-approval baselines. Use when introducing trimming/AOT support, resolving IL2xxx/IL3xxx warnings, or making reflection-heavy code trimming-safe in C# / .NET codebases. For System.Text.Json AOT scenarios, see also the serialization skill.
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Predict peptide-MHC class I binding and natural presentation with MHCflurry, NetMHCpan-4.1, and MixMHCpred to nominate candidate CD8 T-cell epitopes. Covers the binding-affinity (BA) vs eluted-ligand (EL/presentation) distinction, why %Rank beats raw nM for cross-allele work, the MS abundance bias that misranks low-expression neoantigens, allele-coverage inequity, and length bias. Use when scanning a protein or peptide set for class I epitopes, scoring neoantigen candidates, or choosing a binding predictor. For CD4/HLA class II see mhc-class-ii-prediction.
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Detects somatic mutations in circulating tumor DNA, treating low-VAF detection as a signal-versus-noise problem set by error suppression and molecules sampled, not by the choice of caller. Distinguishes de novo CALLING (scanning a panel for unknown variants, bounded by per-locus error and multiple testing) from tumor-informed DETECTION (tracking a pre-specified variant set, where panel integration reaches single-ppm). Covers VarDict and Mutect2 for de novo calling, UMI-aware callers, and a pysam-based known-variant VAF tracker, with matched-WBC subtraction as the mandatory defense against clonal hematopoiesis (the dominant false positive). Use when calling or tracking tumor mutations from plasma cfDNA, setting a VAF threshold, or deciding whether a low-VAF call is tumor versus CHIP.
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Reads, inspects, and writes Flow Cytometry Standard (FCS) files from conventional, spectral, and mass cytometry (CyTOF), and parses FlowJo/Cytobank/Diva workspaces. Covers FCS 2.0/3.0/3.1/3.2 internals ($PnE linear-vs-log, $DATATYPE, $SPILLOVER vs SPILL vs $COMP, $TIMESTEP), channel/parameter metadata, the silent linearize/truncate defaults, and R (flowCore, flowWorkspace, CytoML) plus Python (FlowKit, readfcs) readers. Use when loading flow or mass cytometry data, mapping detector channels to antibodies, extracting the event matrix, choosing a reader, or bridging FCS to the scanpy/AnnData ecosystem before preprocessing.
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Stores and operates on sparse expression matrices for single-cell and large bulk RNA-seq, covering dgCMatrix/dgRMatrix/dgTMatrix when-each-is-fast, the dgCMatrix (CSC, R) <-> CSR (Python) implicit transpose, AnnData (cells-rows) <-> SingleCellExperiment (cells-cols) orientation flip, HDF5/h5ad vs Zarr cloud-native shift, HDF5SummarizedExperiment + DelayedArray for out-of-memory bulk, scanpy backed mode for large h5ad, the ~10-15% density crossover where dense beats sparse, 10X format proliferation (MTX vs CellRanger H5 vs h5ad), the dense-conversion memory blow-up, and Dask + Zarr for consortium-scale matrices. Use when choosing sparse format, working with single-cell-sized matrices, importing/exporting 10X, debugging R/Python interop transposes, processing matrices too large for RAM, or building cloud-native pipelines.
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Normalizes and transforms RNA-seq count matrices for DE, visualization, clustering, and ML. Covers between-sample (TMM, TMMwsp, RLE/median-of-ratios, upper quartile), within-sample (TPM, FPKM/RPKM), variance-stabilizing (VST, rlog, log-CPM), GC-content correction (cqn, EDASeq), and single-cell (scran deconvolution, scanpy normalize_total). Encodes the composition-bias rationale, the "most genes not DE" assumption and its catastrophic failure modes (MYC amplification, apoptosis, viral host shutoff, prokaryotic stress), the "lengthScaledTPM is not TPM" naming trap, the "TPM is not for DE" rule, the blind=TRUE vs FALSE decision, ERCC spike-in normalization (SBN), and the single-cell zero-inflation breakdown of TMM/RLE. Use when choosing or applying normalization, debugging shifted-MA-plot diagnostics, handling zero-heavy single-cell data, or correcting GC bias.
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Detect positive (diversifying / episodic / pervasive) selection using codon dN/dS frameworks. Implements PAML codeml site models (M0/M1a/M2a/M7/M8/M8a), branch models, branch-site model A (Zhang 2005), and HyPhy methods (BUSTED, BUSTED-S, BUSTED-MH, BUSTED-PH, MEME, FEL, FUBAR, aBSREL, SLAC, RELAX, GARD, FUBAR-MH). Includes McDonald-Kreitman framework (asymptotic alpha, impMKT, polyDFE, DFE-alpha, GRAPES) for within-species + divergence inference, RERconverge for trait-correlated rate shifts, CSUBST for convergent substitution, and PhyloAcc for accelerated noncoding evolution. Use when testing adaptive evolution at codons, branches, or full gene; running GARD recombination pre-screen; controlling alignment-error and gBGC false positives; reconciling PAML vs HyPhy results; or performing genome-scale selection scans.
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Identify direct miRNA-target interactions from AGO HITS-CLIP, AGO-CLEAR-CLIP (chimeric reads), HEAP (Halo-Ago2 mouse), chimeric eCLIP / miR-eCLIP (deep miRNA-target profiling), or CLASH using chimeric-read processing pipelines, seed-pairing analysis, and 3' auxiliary pairing rules. Use when distinguishing direct miRNA targets from indirect, integrating CLIP-derived target maps with TargetScan / miRDB / DIANA predictions, applying canonical 7mer-8mer seed matching with 3' UTR context, or recovering miRNA-mRNA chimeras at scale.
日本語の概要は準備中です。原文の説明を表示しています。