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Comprehensive drug profiling — mechanism, primary/secondary targets, drug interactions, clinical-trial status, adverse events (FAERS), pharmacogenomics, and approval history. Use for full drug investigation reports, 'tell me about drug X' queries, and assembling drug profiles for clinicians, researchers, or regulatory work.
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Assess drug-drug interactions — CYP metabolic interactions (substrate/inhibitor/inducer), transporter (P-gp, BCRP, OATP) effects, pharmacodynamic synergy/antagonism, clinical significance scoring, and management recommendations. Use for polypharmacy review, prescribing decision support, and safety analysis when adding or switching drugs.
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Multi-method binding pocket detection and druggability assessment. Grid-based, fpocket, and P2Rank detection with druggability scoring, visualization, and cross-structure comparison.
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Assigns honest lipid annotation levels, designs class-based internal-standard quantification, and runs lipid-aware differential and enrichment analysis with lipidr, guarding against in-source-fragment phantoms, sn-position over-claims, and invalid cross-class quantification. Use when naming or canonicalizing lipid species (shorthand separators, Goslin), deciding shotgun vs RP vs HILIC LC-MS, picking internal standards (SPLASH/EquiSPLASH), interpreting MS-DIAL/LipidSearch output, or comparing lipid classes. For general feature detection see metabolomics/xcms-preprocessing and metabolomics/msdial-preprocessing; for non-lipid annotation confidence see metabolomics/metabolite-annotation; for normalization/QC see metabolomics/normalization-qc; for multivariate stats see metabolomics/statistical-analysis.
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Experimental data: discover and acquire raw or near-raw measurements, sample-level observations, and reusable datasets from sequencing, transcriptomics, single-cell, perturbation, proteomics, metabolomics, genomics, and structural-biology repositories. Use for study or sample metadata, matrices, reads, spectra, experimental structures, and downloadable research artifacts—not curated database assertions or reference marker collections.
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Performs retrosynthetic planning using AiZynthFinder (MCTS, template-based), Chemformer (template-free transformer), ASKCOS, and emerging RetroSynFormer with explicit handling of route scoring, building-block availability (eMolecules, Enamine, Mcule), forward prediction validation (Molecular Transformer), and disconnection-aware multi-objective search (MO-MCTS). Use when assessing synthetic feasibility of generated or selected molecules, planning multi-step syntheses, building synthesis-aware design pipelines, or screening libraries for retro-route feasibility.
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Builds QSAR / QSPR models using chemprop D-MPNN, MolFormer, Uni-Mol, ChemBERTa, random forest baselines, and Gaussian processes with explicit handling of OECD 5 principles, applicability domain (kNN, leverage, conformal prediction, Mahalanobis), scaffold-balanced splits, ensemble uncertainty, calibration (Platt, isotonic), feature importance (SHAP, atomic attribution), and prospective validation. Use when building target-specific predictive models from in-house bioassay data, ADMET endpoints, or selectivity profiles.
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Predicts ADMET properties using ADMETlab 3.0 (119 endpoints with uncertainty), ADMET-AI, DeepChem MolNet, and chemprop D-MPNN with explicit handling of OECD QSAR principles, applicability domain assessment, calibration, hERG/CYP/AMES gold-standard endpoints, and PAINS / Lipinski / Ro5 / Veber / BBB druglikeness filters. Use when filtering compounds for drug-likeness, prioritizing leads by predicted safety, or building an in-house ADMET QSAR model.
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Biological knowledge: query curated assertions and reference databases for genes, variants, pathways, regulation, cell types, reference atlases, perturbation-derived relationships, phenotypes, therapeutic targets, drugs, interactions, annotations, signatures, compounds, and predicted structures. Use for identifiers, marker sets, gene sets, associations, ontologies, database facts, and cross-database coverage.
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Evaluate an interface from a UX perspective, assessing hierarchy, information architecture, emotional resonance, cognitive load, and overall quality with evidence-linked judgments and actionable feedback. Use when the user wants an overall design or UX review—not when the main need is measurable accessibility/performance diagnosis, or final micro-detail polish.
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Add or refine depth through elevation systems, raised and inset surfaces, layered overlap, and meaningful shadow behavior so interfaces feel structured instead of flat. Use when the user mentions depth, elevation, shadows, layering, flat cards, pressed states, drag feedback, or inset controls.
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Use to process automated PR review feedback (Copilot, Greptile, Codex) and iterate until all AI threads are addressed, checks are green, and the PR is merge-ready. Trigger when the user says "address review feedback", "recycle reviews", or references an automated reviewer.
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Help teams prepare materials for an SCF referral. Use when a team wants to approach a referrer (SCF Pilot, SDF staff, alumni who completed deliverables, ambassador, or ecosystem partner) with a strong package that makes it easy for the referrer to evaluate and endorse them. Covers the referral form fields, what referrers assess, and how to present your project for referral.
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Review Stellar Community Fund (SCF) Build Award applications. Use when evaluating SCF submissions, covering project fit assessment, technical architecture evaluation, team readiness, traction validation, budget analysis, and funding recommendations.
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Stellar smart contract development (Rust, soroban-sdk). Entry point with project setup, contract anatomy, and build/deploy workflow, routing to three companion files in this directory — development.md (storage/TTL, authorization, cross-contract calls, tokens, events, errors, upgrades, fees, troubleshooting), testing.md (unit, fuzz, property, fork, mutation, integration), and security.md (vulnerability classes, checklists, tooling, audits). Use when writing, testing, reviewing, securing, debugging, or shipping Stellar smart contracts, including anything the user calls "Soroban" — Soroban contracts, soroban-sdk, Soroban auth/storage/TTL errors, SEP-41 tokens, or SAC integration from contract code.
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Refresh drift-prone documentation against current code. Reads docs/architecture/freshness-catalog.yml, diffs against the last sweep's upstream/main anchor, regenerates mechanical entries, processes editorial markers, and opens one PR per sweep with a report file.
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Progressively activates todo tests one at a time, updates implementation code until each passes (verified via Wallaby), checks off matching design doc progress, then moves to the next—following the design doc as the single source of truth.
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When the user wants to edit, review, or improve existing marketing copy. Also use when the user mentions 'edit this copy,' 'review my copy,' 'copy feedback,' 'proofread,' 'polish this,' 'make this better,' or 'copy sweep.' This skill provides a systematic approach to editing marketing copy through multiple focused passes.
日本語の概要は準備中です。原文の説明を表示しています。
Assess organizational AI maturity. TRIGGERS - Use when user needs help with ai-maturity-model related tasks.
日本語の概要は準備中です。原文の説明を表示しています。
Design AI ethics frameworks with principles, review processes, and governance. TRIGGERS - Use when user needs help with ai-ethics-framework related tasks.
日本語の概要は準備中です。原文の説明を表示しています。
Audit existing processes for AI automation. TRIGGERS - Use when user needs help with ai-automation-audit related tasks.
日本語の概要は準備中です。原文の説明を表示しています。
Design agency pitch processes. TRIGGERS - Use when user needs help with agency-pitch-process related tasks.
日本語の概要は準備中です。原文の説明を表示しています。
Optimize accounts receivable processes. TRIGGERS - Use when user needs help with accounts-receivable-optimization related tasks.
日本語の概要は準備中です。原文の説明を表示しています。
Design aesthetics consultation processes. TRIGGERS - Use when user needs help with aesthetics-consultation related tasks.
日本語の概要は準備中です。原文の説明を表示しています。