「pair」の検索結果

Molecular featurization hub with one consistent interface over 100+ featurizers. Fingerprints (ECFP/Morgan, MACCS, atom pair, topological torsion, Avalon, RDKit, ERG), RDKit and Mordred descriptor sets, pharmacophore and 3D shape descriptors, scaffold keys, and pretrained embeddings (ChemBERTa, ChemGPT, MolT5, GIN, Graphormer) through a common transformer API with caching and parallelism. Use this skill to convert SMILES into model-ready feature matrices for QSAR, virtual screening, and molecular ML, and to choose between featurizer families. Also trigger on molfeat, MoleculeTransformer, FPVecTransformer, PretrainedHFTransformer, molfeat model store, or featurizer selection.

日本語の概要は準備中です。原文の説明を表示しています。

Query the FDA's public openFDA APIs for post-market drug data — FAERS adverse-event reports, Drugs@FDA approval and submission history, Structured Product Labels including boxed warnings, the National Drug Code directory, recall enforcement reports, and drug shortages. Use this skill to check what a regulator has already concluded about a molecule or its class, to date an approval and count its efficacy supplements, to read an approved indication or boxed warning, and to score a drug-event pair for disproportionate reporting with PRR, ROR, and chi-squared. Also trigger on openFDA, api.fda.gov, FAERS, Drugs@FDA, SPL, NDC, pharmacovigilance, boxed warning, adverse event report, drug recall, or safety signal.

日本語の概要は準備中です。原文の説明を表示しています。

Cheminformatics toolkit for fine-grained molecular control. Parse and write SMILES, SDF, MOL and InChI; compute descriptors (MW, LogP, TPSA, QED, Bertz); build fingerprints (Morgan/ECFP, RDKit, MACCS, atom pair, torsion) and score Tanimoto, Dice or cosine similarity; run SMARTS substructure search and reaction SMARTS; generate 2D depictions and ETKDG 3D conformers; extract Murcko scaffolds and canonical hashes; control sanitization and stereochemistry directly. Also trigger on rdkit, Chem.MolFromSmiles, rdFingerprintGenerator, SDMolSupplier, SMARTS query, ETKDG, or FilterCatalog. For standard workflows with a simpler interface use the datamol skill, which wraps RDKit; use rdkit for advanced control, custom sanitization, and specialized algorithms.

日本語の概要は準備中です。原文の説明を表示しています。

Number antibody variable domains, annotate CDRs, and assess developability from sequence. Use this skill to apply IMGT, Kabat, Chothia, Martin, or AHo numbering with ANARCI, delimit CDRs and framework regions, scan for chemical liabilities (N-glycosylation sequons, deamidation NG, isomerisation DG, oxidation, unpaired cysteine, fragmentation), compute pI, net charge, extinction coefficient and hydrophobicity, and plan humanisation by CDR grafting. Also trigger on antibody, nanobody, VHH, scFv, Fab, CDR, framework, ANARCI, abnumber, IgBLAST, OAS, SAbDab, humanization, Vernier residues, or developability.

日本語の概要は準備中です。原文の説明を表示しています。

Use when a non-designer needs to audit a UI, generate a design spec (spacing, type scale, color tokens, grids), or build brand foundations (logo systems, palette and type pairing, brand guidelines). Covers the visual layer, UX/perceptual critique, and brand identity. For implementing the design in code (React/HTML/CSS), use frontend-design.

日本語の概要は準備中です。原文の説明を表示しています。

Find and fix broken internal links, dead external URLs, stale imports, missing cross-references, and orphaned files. Ensures all project references remain valid and up-to-date. Use when documentation contains broken internal links, external URLs return 404 errors, import statements reference moved or deleted modules, cross-references between files are out of sync, or files exist but are never referenced anywhere in the project. Also use in index mode for a directory of markdown notes with a designated index, such as an agent-memory store, where an orphan is a file the index does not link to.

日本語の概要は準備中です。原文の説明を表示しています。

Export and optimize 3D models for FDM/SLA printing including STL/3MF export, mesh integrity verification, wall thickness checking, support generation, and slicing. Use when exporting from CAD or modeling software for 3D printing, verifying STL/3MF files are printable before slicing, troubleshooting models that fail to slice correctly, optimizing part orientation for strength or surface finish, or converting between model formats while preserving printability.

日本語の概要は準備中です。原文の説明を表示しています。

Create a new SKILL.md file following the Agent Skills open standard (agentskills.io). Covers frontmatter schema, section structure, writing effective procedures with Expected/On failure pairs, validation checklists, cross-referencing, and registry integration. Use when codifying a repeatable procedure for agents, adding a new capability to the skills library, converting a guide or runbook into agent-consumable format, or standardizing a workflow across projects or teams.

日本語の概要は準備中です。原文の説明を表示しています。

Build reusable Shiny modules with proper namespace isolation using NS(). Covers module UI/server pairs, reactive return values, inter-module communication, and nested module composition. Use when extracting a reusable component from a growing Shiny app, building a UI widget used in multiple places, encapsulating complex reactive logic behind a clean interface, or composing larger applications from smaller, testable units.

日本語の概要は準備中です。原文の説明を表示しています。

Spring Data JPA entity design, repository patterns, query methods, JPQL, Flyway/Liquibase migrations, and N+1 avoidance. Apply on Spring Boot projects with spring-boot-starter-data-jpa. Pairs with spring-boot-plugin:spring-conventions and java-foundation:java-conventions. Use this skill to: - Design JPA entities with proper annotations, ID strategy, and lazy loading. - Write JpaRepository interfaces with derived query methods and JPQL @Query. - Avoid N+1 queries using @EntityGraph or JOIN FETCH. - Manage schema evolution with Flyway or Liquibase. - Project query results with Spring Data Projections and DTOs. Do NOT use this skill for: - Service or controller patterns — see spring-boot-plugin:spring-conventions. - Build tool setup — see java-foundation:build-tooling. - Test slices (@DataJpaTest) — see java-foundation:jvm-testing.

日本語の概要は準備中です。原文の説明を表示しています。

This skill should be used when analyzing weekly price charts for stocks, stock indices, cryptocurrencies, or forex pairs. Use this skill when the user provides chart images and requests technical analysis, trend identification, support/resistance levels, scenario planning, or probability assessments based purely on chart data without consideration of news or fundamental factors.

日本語の概要は準備中です。原文の説明を表示しています。

Use when asked to find duplication, check consistency, establish or repair SSOT, consolidate facts, or when the user says "consolidate this" or "ssotize this". Not for remote or irreversible changes.

日本語の概要は準備中です。原文の説明を表示しています。

Use when the user runs /toolchain-health and wants a trustworthy green/yellow/red verdict on the installed toolchain with ranked repairs. Not for tasks that require source or remote-system changes.

日本語の概要は準備中です。原文の説明を表示しています。

Use when a human explicitly invokes a watcher cycle for an open pull request that must be watched until mergeable or blocked. Not for merge, force-push, or work outside the invoked cycle.

日本語の概要は準備中です。原文の説明を表示しています。

Use when landing a queue of open PRs: gate each PR, sweep its review feedback to root cause, then merge, repair, hold, or close it. Human-only.

日本語の概要は準備中です。原文の説明を表示しています。

Use when a repository needs Git safety controls: guard destructive commands, set up gitignore or fix gitignore when untracked files keep appearing, or install or repair a repository-local pre-commit hook from project gates, including package-manager-native commit-time checks. Not for remote, credential, publish, deploy, or irreversible changes.

日本語の概要は準備中です。原文の説明を表示しています。

Use when asked to optimize code, make a path faster, make this as fast as possible, reduce allocations, repair a regression, profile a target, grill every inefficiency, or run a subsystem or repo-wide performance campaign against a measured floor; when a performance requirement, slowness report, Core Web Vitals miss, or profiling evidence identifies a bottleneck; or for an "extremely optimize" performance campaign, optimizing suspected hot paths without waiting for benchmarks, or estimating hot and complexity-neutral cold paths while refusing complexity theater. Not for remote, credential, publish, deploy, or irreversible changes.

日本語の概要は準備中です。原文の説明を表示しています。

Use when a request names a working principle (subtract before you add, idempotent operations, never block on the human) or asks which principle applies. Not for running a repair: use strike-the-root.

日本語の概要は準備中です。原文の説明を表示しています。

Use when a human says "overhaul", "rebuild this subsystem", or "rewrite it from scratch". Not for thin-slice features: use incremental-implementation. Not for root-cause repair: use strike-the-root.

日本語の概要は準備中です。原文の説明を表示しています。

Assess one bounded Proto UI Adapter question without changing repository or external state. Use for new-Adapter research, target compatibility, catalog readiness, reviewed Module support or omission evidence, Host Capability fidelity, lifecycle translation, dependency risk, or implementation readiness. Do not catalog, implement, repair, or approve the Adapter slice.

日本語の概要は準備中です。原文の説明を表示しています。

Repair one independently verified Proto UI maintenance finding when governing authority or an explicit product decision fixes the expected result. Use for the bounded remediation and its evidence packet before independent review.

日本語の概要は準備中です。原文の説明を表示しています。

Diagnose one bounded Proto UI Actions or CI failure from an exact workflow run and revision, then route the exact repair, validation, or recheck transition. Use to locate the owning failure and distinguish infrastructure from change failures. This leaf remains read-only.

日本語の概要は準備中です。原文の説明を表示しています。

Freeze one eligible Proto UI autonomous-maintenance candidate into a bounded mission packet and lease. Use before observation when a current request or governed queue supplies scope, oracle, baseline, capability, risk, budget, completion, and stop conditions. Do not observe, verify, repair, or invent a mission.

日本語の概要は準備中です。原文の説明を表示しています。

Apply one exact-target reversible Proto UI Issue, pull-request, review-thread, or Actions collaboration update and return a verified receipt. Use for governed title/body or label repair, update-branch, ready-for-review, review requests, fixed-thread resolution, bounded status comments, and exact-run CI recheck. Do not submit a review disposition, merge, close, publish, release, or change privileged repository settings.

日本語の概要は準備中です。原文の説明を表示しています。