「sam」の検索結果

Answers a business question with data without fooling yourself — framing the question so an answer would change something, choosing the right comparison, checking the data before trusting it, recognizing the traps that produce confident wrong answers (aggregation reversals, survivorship, regression to the mean, multiple comparisons), and reporting uncertainty honestly. Use this to run an analysis, review one before acting on it, or work out why two people looking at the same data reached opposite conclusions.

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Designs, runs, and reads A/B tests and growth experiments — hypothesis, sample size, duration, and honest interpretation. Use this to plan a test, judge whether a result is real, build an experimentation program, decide what to test next, or diagnose why tests keep producing inconclusive or non-replicating results.

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Decides where capital and attention go across business lines, products, and markets — what to fund, hold, harvest, or exit, and on what evidence. Use this to allocate budget across businesses, evaluate whether a product line should continue, decide whether to exit one, structure a portfolio review, or when several initiatives compete for the same limited investment.

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Spawn N parallel candidates at the same task, pick a base, graft the strongest parts of the losers into it. Use for /arena, 'arena this', 'throw it in the arena', or when one attempt at a non-trivial artifact would lock in the wrong shape.

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Apply when introducing a new internal API while old callers still exist. Migrate callers and delete the old API in the same wave instead of preserving compatibility layers.

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Apply when you catch yourself writing the same instruction a second time, or notice a recurring correction. Encode the rule as a lint, metadata flag, runtime check, or script instead of more text.

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Apply when designing commands, lifecycle steps, or processing loops that run amid crashes, restarts, and retries. Converge to the same end state regardless of partial prior runs.

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Apply when concurrent actors might write to the same file, branch, key, or state object. Eliminate the sharing first; serialize structurally only when one shared writer is a real invariant.

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Apply when two or more fixes that share one premise have failed the same gate. Take a census of which actors hold the imbalance before the next fix, then question the premise instead of writing another fix that assumes it.

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Generate forest plots for meta-analysis of continuous data. Input a CSV file containing study names, means, standard deviations, and sample sizes for experimental and control groups. Output forest plot PNG and data table CSV.

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Generate meta-analysis forest plots for binary classification data. Input is a CSV file containing study names, event counts and sample sizes for experimental and control groups. Output includes forest plot PNG and data table CSV.

日本語の概要は準備中です。原文の説明を表示しています。

Generate standardized figure legends for scientific figures and charts; use when preparing publication-ready legends that summarize design, variables, sample size, and key statistical notes.

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Designs a realistic, execution-aware biomedical study version under explicit constraints of samples, time, budget, data access, lab capacity, team skill, and validation resources. Always use this skill when the user has a real study idea, a candidate route, or a partially framed project but cannot assume ideal conditions. If critical feasibility inputs are missing, first clarify what resources are currently available, what resources may be obtainable, and what resources are realistically unavailable. Do not invent access, capabilities, collaborations, or validation resources. Focus first on feasibility-constrained study framing, route narrowing, dependency control, and minimum viable study design.

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Compares multiple study-route options for the same biomedical research question and recommends one primary plan, while explicitly explaining why alternative routes are secondary, premature, weaker, or dependency-heavy. Always use this skill when the user already has a reasonably defined question but is unsure which main study route should anchor the project. Focus on plan comparison, route selection, dependency awareness, and primary-plan justification rather than full protocol drafting.

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Designs complete research plans that integrate clinical variables with multi-omics data from a user-provided biomedical direction. Always use this skill whenever a user wants to design, scope, or structure a study that combines clinical variables with transcriptomics, proteomics, metabolomics, epigenomics, or related omics layers for mechanism interpretation, biomarker development, risk stratification, treatment-response analysis, or translational use. It should define the clinical use case, alignment across data layers, feature-reduction and fusion logic, modeling route, mechanism-interpretation layer, validation ladder, and four workload configurations (Lite / Standard / Advanced / Publication+). Never fabricate datasets, accession numbers, sample counts, metadata completeness, platform coverage, literature references, PMIDs, DOIs, or validation status. Always include the mandatory Dataset Disclaimer immediately before any workflow section that mentions datasets or public resources.

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Designs retrospective or prospective clinical cohort study protocols for biomedical and clinical research. Always use this skill when the user needs a cohort-based study plan rather than a general study idea, evidence summary, or mechanistic experiment design. Focus on cohort appropriateness, enrollment logic, baseline time-zero definition, follow-up structure, endpoint definition, variable collection, confounding control, and a coherent primary statistical analysis line. Do not invent data availability, follow-up completeness, outcome ascertainment quality, sample size adequacy, or causal interpretability.

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Generates complete Mendelian randomization study designs from a user-provided exposure and outcome direction. Always use this skill whenever a user wants to design, plan, or build a Mendelian randomization study — even if phrased as "help me write a paper on X", "design an MR study for Y", or "I want to test whether A causally affects B using GWAS". Covers core two-sample MR design, optional bidirectional follow-up, optional multivariable MR, IV selection logic, ancestry alignment, harmonization, IVW as the default primary estimator, weighted median / MR-Egger / MR-PRESSO / leave-one-out sensitivity analyses, Steiger directionality, heterogeneity / pleiotropy checks, and explicit claim-boundary control. Always outputs four workload configs (Lite / Standard / Advanced / Publication+) with a recommended primary plan, stepwise workflow, method rationale, validation ladder, figure plan, minimal executable version, and strictly verified literature guidance with no fabricated references.

日本語の概要は準備中です。原文の説明を表示しています。

Designs QTL colocalization studies that connect eQTL, pQTL, sQTL, or related molecular QTL signals with GWAS loci. Always use this skill whenever a user wants to plan, scope, or structure a locus-level study asking whether a GWAS association and a molecular QTL association may reflect the same underlying causal signal. Covers locus definition, QTL/GWAS source architecture, ancestry and LD alignment, single-locus vs multi-locus strategy, candidate-gene prioritization, optional fine-mapping, linked MR/SMR follow-up, and functional annotation. Always output four workload configurations (Lite / Standard / Advanced / Publication+) with a recommended primary plan, stepwise workflow, method rationale, evidence hierarchy, figure plan, minimal executable version, and strictly verified literature guidance with no fabricated references. Never equate colocalization with causality proof, mediation proof, or automatic target validation. Always include the mandatory Dataset Disclaimer immediately before any workflow section that mentions datasets, repositories, consortia, or public resources.

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Use when performing correlation analysis between two variables including Pearson and Spearman correlation methods. Supports command-line parameter input, automatic data format detection, parameter validation, result directory creation, and CSV or TXT format result export.

日本語の概要は準備中です。原文の説明を表示しています。

Quickly judges whether a biomedical paper is worth deep reading by screening for question fit, design quality, sample adequacy, methodological novelty, and reproducibility value.

日本語の概要は準備中です。原文の説明を表示しています。

Use when building a weighted gene co-expression network from a bulk expression matrix and a sample group file, filtering variable genes by MAD, identifying co-expression modules with WGCNA, correlating modules with traits, and exporting module-level plots and gene tables. NOT for single-cell RNA-seq, differential expression testing, methylation analysis, or datasets that are too small for WGCNA after quality control.

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Designs complete integrated research plans for bulk transcriptomics, proteomics, metabolomics, and related omics from a user-provided biomedical direction. Always use this skill whenever a user wants to design, scope, or structure a bulk multi-omics or single-omics-plus-clinical study — including disease-focused, mechanism-focused, biomarker-focused, stratification-oriented, or translational projects. It should define the research question, choose the best-fit study pattern, recommend example datasets as reference candidates only, specify the core analysis modules and method choices, propose a validation ladder, and output four workload configurations (Lite / Standard / Advanced / Publication+). Never fabricate datasets, accession numbers, sample counts, metadata completeness, cohort availability, assay coverage, literature references, PMIDs, DOIs, or validation status. Always include the mandatory Dataset Disclaimer immediately before any workflow section that mentions datasets or public resources.

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Assesses whether study results are trustworthy by auditing design integrity, sample structure, statistical handling, bias control, validation chain, and claim discipline. It identifies where results are robust, fragile, overfit, under-validated, or overclaimed. Always separate reported findings from reliability judgment. Never fabricate references, PMIDs, DOIs, trial identifiers, study features, or validation claims.

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Use when identifying stable sample subtypes from bulk expression matrices with ConsensusClusterPlus, including PAC-based model selection and consensus matrix/CDF visualization. NOT for: differential expression analysis, single-cell clustering workflows, or non-expression tables.

日本語の概要は準備中です。原文の説明を表示しています。