「zat」の検索結果

Maps GWAS-implicated loci to candidate effector (causal) genes by integrating variant-to-gene (V2G) features via Open Targets L2G (Mountjoy 2021), MAGMA gene-based association (de Leeuw 2015), FUMA SNP2GENE, cS2G combined SNP-to-gene scores (Gazal 2022), Polygenic Priority Scores (PoPS, Weeks 2023), FLAMES, INQUISIT, DEPICT, and enhancer-gene predictors (ABC, ENCODE-rE2G). Use when narrowing a GWAS lead locus to a candidate causal gene, picking between proximity, eQTL-based, and similarity-based prioritizers, integrating multi-evidence streams (fine-mapping, colocalization, ABC enhancer-gene, distance, chromatin), reconciling discordant L2G vs PoPS calls, prioritizing tissue-specific eQTL evidence, or triangulating across at least three independent lines of evidence for a publication-grade effector-gene nomination.

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Estimate causal effects of an exposure on an outcome from GWAS summary statistics using genetic instruments. Implements IVW (fixed/random), MR-Egger, weighted median/mode, MR-RAPS, CAUSE, GSMR-HEIDI, MR-PRESSO, MVMR, MR-Clust, LCV, and LHC-MR via TwoSampleMR, MendelianRandomization, MR-PRESSO, cause, and lhcMR. Use when testing causal direction between traits, evaluating drug-target effects via cis-pQTL/cis-eQTL, performing multivariable mediation MR, distinguishing causation from correlated horizontal pleiotropy, or producing STROBE-MR-compliant sensitivity batteries.

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Map nucleosome center positions, occupancy, and fuzziness from ATAC-seq fragment-size patterns using NucleoATAC, ATACseqQC, DANPOS3, or scprinter. Use when characterizing nucleosome organization at promoters and enhancers, calling +1/-1 nucleosomes flanking NFRs, generating V-plots for chromatin structure visualization, or comparing nucleosome positioning between conditions.

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Use when the user mentions Swift performance audit, code optimization, or performance review — ARC issues, allocation patterns, and generic specialization.

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Implement, review, or improve data visualizations using Swift Charts. Use when building bar, line, area, point, pie, donut, or iOS 26 3D charts; when adding chart selection, scrolling, annotations, axes, scales, legends, or foregroundStyle grouping; when plotting functions with BarPlot, LinePlot, AreaPlot, PointPlot, Chart3D, or SurfacePlot; or when creating heat maps, Gantt charts, grouped bars, sparklines, threshold lines, or spatial visualizations.

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Integrate Apple Pay payments and Wallet passes using PassKit. Use when adding Apple Pay buttons, creating payment requests, handling payment authorization, adding passes to Wallet, configuring merchant capabilities, managing shipping/contact fields, or working with PKPaymentRequest, PKPaymentAuthorizationController, PKPaymentButton, AddPassToWalletButton, PKPass, PKAddPassesViewController, PKPassLibrary, Wallet pass distribution, or Apple Pay checkout flows for physical goods, real-world services, donations, and eligible recurring payments.

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Implement iOS authentication flows with AuthenticationServices and LocalAuthentication. Use when building Sign in with Apple, passkey/WebAuthn registration or sign-in with ASAuthorizationPlatformPublicKeyCredentialProvider, ASAuthorizationController credential state and revocation handling, ASWebAuthenticationSession OAuth or third-party login, Password AutoFill, identity-token server validation, or local biometric re-authentication with LAContext.

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React and Next.js performance optimization guidelines from Vercel Engineering. This skill should be used when writing, reviewing, or refactoring React/Next.js code to ensure optimal performance patterns. Triggers on tasks involving React components, Next.js pages, data fetching, bundle optimization, or performance improvements.

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Build industrial-grade SCADA/HMI dashboards in MATLAB following industrial-HMI conventions (ISA-101-aligned): gray-field philosophy, alarms at source, write safeguards, fixed-range trends, drill-down layout. Produces a real App Designer app (.mlapp, or plain-text .m+.xml on R2026b+) by handing serialization to the matlab-build-app skill when available, and falls back to a programmatic .m app otherwise. Use when wrapping OPC UA / Modbus / MQTT / OSI PI / PI AF monitoring scripts into a live operator app, building plant overviews, designing operator dashboards, or any time a user asks for a "SCADA dashboard", "HMI", "plant dashboard", "operator screen", or "industrial monitoring app" in MATLAB. Trigger on: SCADA, HMI, industrial dashboard, plant overview, operator screen, uigauge, uilamp, alarm banner, gray-field, ISA-101, OPC UA dashboard, setpoint, write safeguards, alarm visualization, OSIsoft PI, AVEVA PI, PI Server, PI Data Archive, PI AF, PI Asset Framework, piclient, afclient.

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Use when writing, solving, or debugging MATLAB optimization code — formulating problems (optimproblem, optimvar, fcn2optimexpr), selecting and configuring solvers (fmincon, linprog, quadprog, intlinprog, lsqnonlin, ga, surrogateopt, optimoptions), or validating results (exitflag, convergence, constraint violations). Covers problem-based and solver-based approaches, solver tuning, and solution verification.

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Create and customize MATLAB charts and plots. Plot types (line, scatter, bar, histogram, heatmap, surface), axes configuration, annotations, data tips, interactive plots, animation, multiple axes with tiledlayout, colororder, and performance optimization. Works for standalone figures, Live Scripts, and uifigure apps. Use when plotting data, customizing axes, adding annotations or interactivity, animating charts, or arranging multiple axes. Triggers: plot, chart, graph, axes, uiaxes, annotation, data tips, animation, tiledlayout, colororder, heatmap, scatter, figure, visualization, export.

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Generate driving scenes, scenarios, road surfaces, and 3D content from scenariobuilder.* sensor data (GPS, camera, lidar, actor tracks) using Scenario Builder for Automated Driving Toolbox. BUILD, EXPORT, or AUGMENT a virtual scenario/scene/map: ego or actor trajectories, trajectory smoothing, OpenCRG road-surface extraction, 3D asset generation, static-object placement, point-cloud georeferencing + elevation, lane-based ego localization, sensor-fusion tracking, scenario-event extraction (cut-ins, hard brakes, near-misses, ADAS disengagements), or export to RoadRunner, drivingScenario, OpenDRIVE, OpenCRG, OpenSCENARIO, or Unreal Engine. Also: log-to-scenario, scenario harvesting, accident/near-miss reconstruction, SOTIF (ISO 21448) and ISO 26262 scenario coverage, USGS-aerial-lidar augmentation, traffic-sign placement, vision-based vehicle classification for actor assets. NOT for raw-data import or multi-sensor sync/crop/offset/timestamp normalization — route those to matlab-import-driving-data.

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Help users formulate and solve portfolio optimization problems using Financial Toolbox's Portfolio object. Covers mean-variance (Markowitz), maximum Sharpe ratio (tangency), and efficient frontier workflows. Use when users ask about portfolio optimization, Markowitz, efficient frontier, Sharpe ratio, or attempt to use generic solvers (quadprog, fmincon, ga, problem-based optimize) for portfolio problems.

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AWS EC2 virtual machine management — instances, security groups, key pairs, AMIs, EBS volumes, Auto Scaling Groups, Spot Instances, Session Manager, placement groups, and instance lifecycle automation. Trigger on ANY of these, even when EC2 isn't named explicitly: - Launching or provisioning: "spin up a server", "create a VM", "new instance", "run-instances", mention of instance types (t3, m5, c5, r6, g5, p4d, t4g, c7g, etc.) - SSH / connectivity problems: "connection refused", "connection timed out", "permission denied publickey", "can't connect to my instance", "SSH not working" - Instance management: resize, stop, start, terminate, reboot, change instance type - Cost optimization: stop dev instances overnight, save money on EC2, spot vs on-demand, reserved instances - Auto Scaling: ASG, launch template, mixed instances policy, scale to zero, scheduled scaling - Spot Instances: spot fleet, spot interruption, capacity-optimized, price-capacity-optimized - AMIs and backups: create image, custom AMI, EBS snapshot, DLM lifecycle policy, copy AMI - Monitoring: EC2 CPU utilization, CloudWatch metrics for instance, instance status checks, console output - Access methods: Session Manager, EC2 Instance Connect, bastion host, port forwarding - Security: IMDSv2, instance metadata, IAM role on instance, security group rules - User data and bootstrap scripts, cloud-init

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Reduce LLM API and infrastructure costs through model selection, prompt caching, batching, caching, quantization, and self-hosting strategies. Track spend by team and model, set budgets, and implement cost-aware routing.

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Set up metrics collection and visualization with Prometheus and Grafana. Configure scrape targets, create PromQL queries, build dashboards, and implement alerting. Use when implementing monitoring, metrics collection, or visualization for applications and infrastructure.

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Supply Chain Bottleneck Analyzer for Walmart Marketplace sellers. Diagnose cash flow, inventory, WFS costs, and referral fees. Includes comparison with Amazon FBA, lower storage fee optimization, and Walmart Connect ad spend analysis. No API key required for basic analysis.

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Supply Chain Optimization (Lite) - Diagnose bottlenecks and provide cost reduction strategies through conversation

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Supply Chain Bottleneck Analyzer for TikTok Shop sellers. Diagnose cash flow, inventory turnover, affiliate commissions, and return rates. Includes FBT cost analysis, influencer payout optimization, and viral product lifecycle management. No API key required for basic analysis.

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Supply Chain Bottleneck Analyzer for Shopify/DTC stores. Diagnose cash flow, inventory, shipping costs, and customer acquisition efficiency. Includes CAC/LTV analysis, 3PL cost optimization, and ad spend benchmarks. No API key required for basic analysis.

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E-commerce warehouse and inventory optimization advisor. Analyzes inventory health, calculates safety stock and reorder points, performs ABC analysis, evaluates fulfillment costs, and provides actionable recommendations for improving efficiency. Supports all major fulfillment models: Self-fulfillment, Amazon FBA/FBM, Walmart WFS, 3PL, Shopify Fulfillment, TikTok Shop, Dropshipping, and Hybrid setups. No API key required. Use when: (1) reducing stockouts or overstock, (2) calculating safety stock levels, (3) optimizing warehouse costs, (4) improving Amazon IPI score, (5) analyzing inventory KPIs.

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Comprehensive Shopify marketing strategy and execution. SEO optimization, email marketing automation, paid advertising management, conversion rate optimization, and customer retention strategies specifically for DTC Shopify brands. Use when the user asks about Shopify marketing, DTC marketing, Shopify SEO, or Shopify store growth.

日本語の概要は準備中です。原文の説明を表示しています。

Theme speed and UX optimization — Core Web Vitals, Liquid code, image loading, mobile responsiveness

日本語の概要は準備中です。原文の説明を表示しています。

Store speed audit — lazy loading, image compression, app bloat removal, theme code optimization

日本語の概要は準備中です。原文の説明を表示しています。