「search」の検索結果

Build local BLAST databases and run searches using NCBI BLAST+ command-line tools. Use when running >50 queries, building custom databases with -parse_seqids and -taxid, downloading prebuilt NCBI databases via update_blastdb.pl, choosing -task variants (megablast/dc-megablast/blastn/blastn-short), tuning soft/hard masking, scaling threads, or extracting hits with blastdbcmd. Encodes BLAST v5 vs v4 database format, taxonomy filtering, makeblastdb pitfalls.

日本語の概要は準備中です。原文の説明を表示しています。

Runs JACKS (Joint Analysis of CRISPR/Cas9 Knockout Screens; Allen et al 2019 Genome Research) which models per-sgRNA log-fold-change as the product of a treatment-dependent gene-essentiality term and a treatment-independent guide-efficacy term. Covers the Bayesian decomposition math, the hierarchical efficacy prior shared across screens performed with the same library, when JACKS outperforms MAGeCK (multi-screen joint analysis, libraries with broad efficacy variance) and when it does not (single screen, novel libraries with no prior efficacy), library-reuse efficacy transfer, downstream essentiality interpretation, and the 2.5x sample-size reduction enabled by efficacy-aware testing. Use when running multiple screens with the same library, when guide-level noise is suspected to dominate per-gene signal, when reusing published essentiality reference screens for efficacy priors, or when comparing screens performed across cell lines that share library but differ biologically.

日本語の概要は準備中です。原文の説明を表示しています。

Detect distant homologs using profile and structure-aware methods that go beyond standard BLAST. Use when sequence identity falls into the twilight zone (<35% pairwise), when BLAST fails to find homologs that should exist, when working at metagenomic scale (DIAMOND, MMseqs2), or when structure beats sequence (Foldseek). Covers PSI-BLAST (iterative PSSM), jackhmmer (iterative HMM), HHblits/HHsearch (profile-profile), DIAMOND, MMseqs2, and Foldseek (3Di structural alphabet, van Kempen 2024).

日本語の概要は準備中です。原文の説明を表示しています。

Calculates tumor mutational burden from WES/WGS/panel data with Friends of Cancer Research harmonization equations, per-assay calibration (FDA 10/Mb = 7.8 TSO500 = 8.4 OncomineTML), synonymous/indel/germline filtering, hypermutator tiering, blood TMB, and integration with HLA-LOH and neoantigen quality (Luksza 2017 fitness). Use when assessing ICI eligibility under tumor-specific cutoffs (McGrail 2021), comparing tissue vs bTMB, or auditing TMB-H reporting against ESMO 2024 and FDA pembrolizumab pan-tumor 2020.

日本語の概要は準備中です。原文の説明を表示しています。

Performs retrosynthetic planning using AiZynthFinder (MCTS, template-based), Chemformer (template-free transformer), ASKCOS, and emerging RetroSynFormer with explicit handling of route scoring, building-block availability (eMolecules, Enamine, Mcule), forward prediction validation (Molecular Transformer), and disconnection-aware multi-objective search (MO-MCTS). Use when assessing synthetic feasibility of generated or selected molecules, planning multi-step syntheses, building synthesis-aware design pipelines, or screening libraries for retro-route feasibility.

日本語の概要は準備中です。原文の説明を表示しています。

Align protein structures using Foldseek 3Di, TM-align, US-align, DALI, or Foldmason for structural MSA. Predict, score, and superpose backbone coordinates when sequence identity is below the twilight zone or remote-homology detection is required. Use when sequence MSA fails (<25% identity), when the dark proteome is the target, when AlphaFoldDB / ESM Atlas search is needed, or when structural superposition is the goal.

日本語の概要は準備中です。原文の説明を表示しています。

Read this skill before the first step that uses Claude in Chrome, the browser extension whose tools are named mcp__claude-in-chrome__* (also called Chrome, the browser extension, or the external browser) and which acts in the person's real Chrome with their own sign-ins; before those tools are turned on there may be a single enable__mcp__claude-in-chrome tool instead. It covers loading the tools in one ToolSearch call, checking the person's open tabs and working in a new tab, site permissions, GIF recordings, console logs, dialogs to avoid, and when to stop and ask. It is not for the built-in browser (mcp__Claude_Browser__* or mcp__remote-devices__Claude_Browser__* tools), which has its own skill, and it does not decide which browser to use.

日本語の概要は準備中です。原文の説明を表示しています。

docs (editable docs people share and comment on; the default for any document, named as a doc or not: a document, report, proposal, resume, cover letter, letter, contract, policy, form, template, worksheet, essay, handbook, guide, how-to, cheat sheet, SOP or other writing to keep, share, collaborate on, send, submit, print or sign; a doc exports to Word, PDF, Markdown or Google Docs, so needing a file to send, attach, upload, submit or print is no reason to pick Word, and a file nobody asked for is a doc, not Word; a plan, comparison, summary or notes asked in chat stays in chat; a pasted claude.ai artifact link may be a doc: check with docs tools first; Word or another file format named, tracked changes wanted, or a .docx to change or use as a template → that format's skill): making one → if no docs-connector instructions are in context, call its `guide` (topic.instructions) first; then create the doc (headings only, no body) before any search, file read or plan, even with files attached.

日本語の概要は準備中です。原文の説明を表示しています。

Use this skill whenever the user wants to do anything with PDF files. This includes reading or extracting text/tables from PDFs, combining or merging multiple PDFs into one, splitting PDFs apart, rotating pages, adding watermarks, creating new PDFs, filling PDF forms, encrypting/decrypting PDFs, extracting images, and OCR on scanned PDFs to make them searchable. If the user mentions a .pdf file or asks to produce one, use this skill.

日本語の概要は準備中です。原文の説明を表示しています。

Automate Basecamp project management, to-dos, messages, people, and to-do list organization via Rube MCP (Composio). Always search tools first for current schemas.

日本語の概要は準備中です。原文の説明を表示しています。

Automate BambooHR tasks via Rube MCP (Composio): employees, time-off, benefits, dependents, employee updates. Always search tools first for current schemas.

日本語の概要は準備中です。原文の説明を表示しています。

Automate Box operations including file upload/download, content search, folder management, collaboration, metadata queries, and sign requests through Composio's Box toolkit.

日本語の概要は準備中です。原文の説明を表示しています。

Automate Bitbucket repositories, pull requests, branches, issues, and workspace management via Rube MCP (Composio). Always search tools first for current schemas.

日本語の概要は準備中です。原文の説明を表示しています。

Analyze market conditions, geographic opportunities, pricing, consumer behavior, and product validation across Google Maps, Facebook, Instagram, Booking.com, and TripAdvisor.

日本語の概要は準備中です。原文の説明を表示しています。

Automate Asana tasks via Rube MCP (Composio): tasks, projects, sections, teams, workspaces. Always search tools first for current schemas.

日本語の概要は準備中です。原文の説明を表示しています。

Complete App Store Optimization (ASO) toolkit for researching, optimizing, and tracking mobile app performance on Apple App Store and Google Play Store

日本語の概要は準備中です。原文の説明を表示しています。

Astropy is the core Python package for astronomy, providing essential functionality for astronomical research and data analysis.

日本語の概要は準備中です。原文の説明を表示しています。

Optimize content for AI search and LLM citations across AI Overviews, ChatGPT, Perplexity, Claude, Gemini, and similar systems. Use when improving AI visibility, answer engine optimization, or citation readiness.

日本語の概要は準備中です。原文の説明を表示しています。

Automate Airtable tasks via Rube MCP (Composio): records, bases, tables, fields, views. Always search tools first for current schemas.

日本語の概要は準備中です。原文の説明を表示しています。

Automate Amplitude tasks via Rube MCP (Composio): events, user activity, cohorts, user identification. Always search tools first for current schemas.

日本語の概要は準備中です。原文の説明を表示しています。

Automate ActiveCampaign tasks via Rube MCP (Composio): manage contacts, tags, list subscriptions, automation enrollment, and tasks. Always search tools first for current schemas.

日本語の概要は準備中です。原文の説明を表示しています。

Skill for discovering and researching autonomous AI agents, tools, and ecosystems using the AgentFolio directory.

日本語の概要は準備中です。原文の説明を表示しています。

A hybrid memory system that provides persistent, searchable knowledge management for AI agents (Architecture, Patterns, Decisions).

日本語の概要は準備中です。原文の説明を表示しています。

This skill should be used when the user asks to "create AGENTS.md", "update AGENTS.md", "maintain agent docs", "set up CLAUDE.md", or needs to keep agent instructions concise. Enforces research-backed best practices for minimal, high-signal agent documentation.

日本語の概要は準備中です。原文の説明を表示しています。