1,378 件 ・ 関連度順
概要と使いどころ
Load and parse mass spectrometry data formats including mzML, mzXML, and quantification tool outputs like MaxQuant proteinGroups.txt. Use when starting a proteomics analysis with raw or processed MS data. Handles contaminant filtering and missing value assessment.
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Preprocesses cell-free DNA sequencing data including adapter trimming, alignment optimized for short fragments, and UMI-aware duplicate removal using fgbio. Applies cfDNA-specific quality thresholds and fragment length filtering. Use when processing plasma cfDNA sequencing data before downstream analysis.
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Preprocess CLIP-seq reads (eCLIP, iCLIP, iCLIP2, iCLIP3, irCLIP, PAR-CLIP, FLASH) with protocol-specific UMI extraction, adapter trimming, length filtering, and post-alignment PCR-duplicate collapse. Use when raw CLIP FASTQ must be turned into deduplicated, crosslink-preserving BAM input for peak calling; choosing between two-pass and single-pass adapter trimming; deciding minimum read length; or mapping UMI patterns to specific eCLIP/iCLIP/iCLIP2/iCLIP3 library preps.
日本語の概要は準備中です。原文の説明を表示しています。
Amplicon sequence variant (ASV) inference from 16S rRNA or ITS amplicon sequencing using DADA2. Covers quality filtering, error learning, denoising, and chimera removal. Use when processing demultiplexed amplicon FASTQ files to generate an ASV table for downstream analysis.
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Analyzes base-editing screens for variant function. Covers library design (Sanson 2020 GRACE, Hanna 2021 BRCA1/2 SNV scanning, Cuella-Martin 2021), CBE vs ABE chemistry choice (BE3/BE4 vs ABE7.10/ABE8.20/ABE8e), editing-window math (positions 4-8 from PAM-distal end, wider for ABE8e), bystander-edit quantification and the variant-call ambiguity it creates, sgRNA-efficiency filtering before hit calling, indel byproduct interpretation, the substitution-vs-indel diagnostic, variant annotation against ClinVar / COSMIC, and the Broad be-validation-pipeline. Use when designing a BE variant screen, choosing CBE vs ABE for a specific edit, interpreting bystander-confounded hits, distinguishing functional signal from indel artifact, integrating CRISPResso2 output with screen scoring, or deciding BE vs PE for SNV installation.
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Convert raw Nanopore signal data (FAST5/POD5) to nucleotide sequences using Dorado basecaller. Covers model selection, GPU acceleration, modified base detection, and quality filtering. Use when processing raw Nanopore data before alignment. Note: Guppy is deprecated; use Dorado for all new analyses.
日本語の概要は準備中です。原文の説明を表示しています。
Detects allele-specific transcription factor or histone modification binding from heterozygous-variant ChIP-seq using WASP (reference-bias filter; mandatory upstream), RASQUAL (joint QTL + bias-corrected testing), BaalChIP (Bayesian beta-binomial with copy-number-aware overdispersion), and AlleleSeq (personalized diploid genome). Handles imprinted-locus awareness, X-inactivation artifacts, cancer copy-number imbalance, and integration with downstream caQTL / bQTL mapping. Use when identifying variants with allelic effects on TF binding, fine-mapping causal regulatory variants, validating deep-learning variant predictions, or characterizing cis-acting regulatory effects.
日本語の概要は準備中です。原文の説明を表示しています。
Workflow for small-variant and structural-variant discovery, filtering, annotation, and interpretation from sequencing data.
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End-to-end protein design pipeline guide across preparation, generation, validation, and filtering. Use this skill when: (1) Starting a new protein design project, (2) Need step-by-step workflow guidance, (3) Understanding the full design pipeline, (4) Planning compute resources and timelines, (5) Integrating multiple design tools. For tool selection, use binder-design-tool-selection. For QC thresholds, use protein-design-qc.
日本語の概要は準備中です。原文の説明を表示しています。
ESM2 protein language model for embeddings and sequence scoring. Use this skill when: (1) Computing pseudo-log-likelihood (PLL) scores, (2) Getting protein embeddings for clustering, (3) Filtering designs by sequence plausibility, (4) Zero-shot variant effect prediction, (5) Analyzing sequence-function relationships. For structure prediction, use chai or boltz. For QC thresholds, use protein-qc.
日本語の概要は準備中です。原文の説明を表示しています。
ESM2 protein language model for sequence scoring, embeddings, and plausibility checks. Use this skill when: (1) Computing pseudo-log-likelihood (PLL) scores, (2) Getting protein embeddings for clustering, (3) Filtering designs by sequence plausibility, (4) Zero-shot variant effect prediction, (5) Analyzing sequence-function relationships. For structure prediction, use chai1-structure-prediction or boltz-structure-prediction. For QC thresholds, use protein-design-qc.
日本語の概要は準備中です。原文の説明を表示しています。
Binder design ranking using ipSAE (interprotein Score from Aligned Errors). Use this skill when: (1) Ranking binder designs for experimental testing, (2) Filtering BindCraft or RFdiffusion outputs, (3) Comparing AF2/AF3/Boltz predictions, (4) Predicting binding success rates, (5) Need better ranking than ipTM or iPAE. For structure prediction, use chai or alphafold. For QC thresholds, use protein-qc.
日本語の概要は準備中です。原文の説明を表示しています。
Find academic papers across up to 8 sources (OpenAlex / Semantic Scholar / CrossRef / PubMed / arXiv for English, OpenReview for AI venues, plus native-Chinese retrieval via NSSD 国家哲社文献中心 + yiigle 中华医学期刊) with adjustable depth — Quick scan (5 min) to Audit prep (3 hr). Use when the user wants to find papers, run a literature search, gather references, scope a research topic, search Chinese-language / 中文原生 literature (中文文献/中文核心/CSSCI/C刊/国内研究/国内文献/中华××期刊/心理学报/经济研究), or filter results by journal tier (中科院分区/一区/几区, Q1, JCR/SJR quartile, 影响因子/impact factor, 期刊分区, 顶刊/top journal, '按分区筛'), or export paste-ready professional search strategies / 检索式 for external databases (PubMed / WOS / Scopus / Embase / 知网 CNKI / 万方 / SinoMed — '写检索式', '导出检索式', 'WOS 检索式', '知网专业检索', 'search strategy', 'boolean search strategy'). Triggers on search verbs ('find papers', 'literature search', 'papers about X'), review types ('scoping review', 'systematic review', 'SR prep', 'literature review', 'lit review', 'help me write a lit review'), Chinese ('找文献', '找论文', '论文搜索', '学术检索', '文献检索', '文献综述', '综述前期', '求文献', '中文文献', '中文核心', 'CSSCI', 'C刊', '国内研究', '找中文的'). Outputs Shadcn HTML report + BibTeX/RIS/CSV + PRISMA-S log. Do NOT use for: concept explanations ('what is X' / 'X 是什么', e.g. '影响因子怎么算'), writing ('帮我写' / 'help me write a paragraph'), single-paper interpretation or PDF download with metadata (use paper-downloader-portable), or when the user already has a literature set (use literature-set-review).
日本語の概要は準備中です。原文の説明を表示しています。
Papers With Code MCP tools for searching and reading AI/ML papers, discovering recent and trending research, finding related work and paper lineage, browsing tasks, methods, conferences, organizations, and frameworks, and inspecting benchmark leaderboards with model-size and metric filters through the public Papers With Code catalog. Use whenever the user asks to find papers, survey literature, compare research, inspect an arXiv paper, explore AI/ML taxonomy or conferences, discover benchmarks or state-of-the-art models, or mentions Papers With Code, the PwC MCP server, or paperswithcode.co/mcp.
日本語の概要は準備中です。原文の説明を表示しています。
Property Screener — searches for properties matching investment criteria with pre-built screens for Cash Flow, Appreciation, BRRRR, First-Time Buyer, and Short-Term Rental strategies plus custom criteria support
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Bulk-regenerate broken test selectors after a UI refactor or redesign. Detects drift between old and new DOM with an aria-snapshot diff, maps old locators to new equivalents using role-first + region scoping, validates against the new build, and produces a single PR with grouped per-file selector updates and per-change evidence. Assumes Playwright >= 1.50 (trace viewer DOM-snapshot panel, getByRole filtering, ariaSnapshot). Use when: "UI refactor broke tests," "redesign broke tests," "bulk update selectors," "regenerate selectors after refactor," "selector drift," "fix N broken tests after redesign." Not for: healing one flaky test at runtime — use test-reliability. Not for: writing a new test suite from scratch — use playwright-automation. Not for: re-recording tests after a framework switch (Selenium to Playwright) — use test-migration. Related: test-reliability, playwright-automation, test-migration, ci-cd-integration, visual-testing.
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Hoyeon Google/chromux search workflow for Codex. Use when the user invokes "$hoyeon-google-search" or needs real-browser Google search, site-specific search, time filters, or body/comment enrichment. This adapter loads the canonical google-search skill and follows its Codex runtime surface.
日本語の概要は準備中です。原文の説明を表示しています。
Google search via real Chrome browser (chromux). Use when the user asks to "search Google", "구글 검색", "구글에서 찾아줘", "find articles about", "search the web for", or needs web search results with full page content. Also trigger when: searching a specific site ("search dev.to for..."), finding recent articles/posts about a topic, extracting content from search results, or when WebSearch results are insufficient and real browser rendering is needed. Prefer this over WebSearch when the user wants site-specific search, time-filtered results, or full article body/comments extraction.
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Render Rove's recent releases as a self-contained, Rove-styled HTML page (Chinese by default). Reads shipped notes from packages/rove/CHANGELOG.md + git tags, filters to user-facing changes, and emits one standalone .html file in the `claude` theme (terracotta on near-black, JetBrains Mono, terminal chrome). Use when the user asks for a "release page", "发版速览", "recent release html", "把发版做成网页", or wants to share/post what changed.
日本語の概要は準備中です。原文の説明を表示しています。
Read, transform, analyze, and generate Excel and CSV files. Use when a user asks to open a spreadsheet, process Excel data, merge CSVs, create pivot tables, clean up data, convert between Excel and CSV, add formulas, filter rows, or generate reports from tabular data. Handles .xlsx, .xls, and .csv.
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Explore and manage databases with Drizzle Studio. Use when a user asks to browse database contents visually, inspect tables and data, run ad-hoc queries, manage database records through a GUI, debug database issues, or use a lightweight alternative to pgAdmin or DBeaver. Covers setup with Drizzle ORM, standalone usage, data browsing, filtering, and inline editing.
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Azure OpenAI is Microsoft's hosted service for OpenAI models (GPT, gpt-image, Whisper, embeddings) on Azure infrastructure. Use when calling OpenAI models through Azure, authenticating with Managed Identity or Entra ID, setting up content filters, or deploying with enterprise compliance, regional data residency or private networking.
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Use Amazon SNS for pub/sub messaging and notifications. Create topics and manage subscriptions across protocols (SQS, Lambda, HTTP, email, SMS). Configure message filtering, mobile push notifications, and fan-out architectures.
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Ant Design (antd) is a React component library of 70+ enterprise UI components (tables, forms, date pickers, modals, menus) with design-token theming through ConfigProvider. Use it to build admin panels, back-office tools and data-heavy dashboards: server-paginated tables with filters and bulk actions, validated forms, dark or branded themes, and antd inside Next.js without a flash of unstyled content. Triggers: "antd table", "Ant Design form validation", "customize antd theme", "antd dark mode", "antd with Next.js App Router", "upgrade antd 5 to 6".
日本語の概要は準備中です。原文の説明を表示しています。