「chi」の検索結果

Use when opening, merging, or releasing a PR for imp - branching off main, `gh pr create`, enabling auto-merge, writing the PR body or a CHANGELOG entry, cutting a tagged release (version bump + CHANGELOG + tag + GitHub release). Symptoms - "PR stuck BLOCKED", "my last commit didn't land on main", "which check is required", "how do I cut a release", "auto-merge merged too early", "check-release failed", "STALE.md blocks git pull". Do NOT use for build/test mechanics (building-and-testing) or perf measurement / baseline refresh (benchmark-cuda).

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Prerequisites and connection details for attaching to a live Python process with PyFlightProfiler. Read this skill first before using any other PyFlightProfiler command (watch, trace, stack, perf, etc.).

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Trace execution time of Python method invocations in a live process with call stack visualization. Use this to see a hierarchical call tree showing which sub-calls are slow and where time is spent within a function.

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Use when the user wants to contribute a fix or roadmap item back to the Hedgehog project itself (skyf0xx/hedgehog) rather than their own project. Triggers on "let's fix that in Hedgehog", "I want to contribute", "let's pick up a roadmap item", or when `tweaker` offers this at the end of a build and the user says yes. Covers forking/branching, making the change under Hedgehog's own repo rules, committing with Conventional Commits, and opening the PR.

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Implement or modify Python, JavaScript, SCSS, templates, CLI, HTTP, logging, or tests. Use for code changes that require architecture, style, testing, and verification conventions.

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Set up or refine open-source .NET code-quality gates for CI: formatting, `.editorconfig`, SDK analyzers, third-party analyzers, coverage, mutation testing, architecture tests, and security scanning. Use when a .NET repo needs an explicit quality stack in `AGENTS.md`, docs, or pipeline YAML.

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Apply MCAF non-functional-requirements guidance to capture or refine explicit quality attributes such as accessibility, reliability, scalability, maintainability, performance, and compliance. Use when a feature or architecture change needs explicit quality attributes and trade-offs.

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Primary router skill for broad .NET work. Classify the repo by app model and cross-cutting concern first, then switch to the narrowest matching .NET skill instead of staying at a generic layer.

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Builds regime detection models with hidden Markov, threshold, and Bayesian change-point methodologies for strategy adaptation. Use when modeling regime changes, detecting market shifts, or adapting strategies to market conditions.

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Structures investor portal organization with document hierarchy, access permissions, and communication archive management. Use when managing investor portals, organizing LP documentation, or maintaining investor communication records.

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Structures management presentation materials for buyer meetings with business overview, strategy, and financial deep-dives. Use when preparing management presentations, coaching management teams, or organizing buyer meetings.

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Structures technology diligence with architecture review, code quality assessment, scalability analysis, and technical debt evaluation. Use when evaluating startup technology, assessing engineering teams, or reviewing technical infrastructure.

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Structures customer diligence with interview guides, NPS analysis, switching cost assessment, and usage pattern evaluation. Use when conducting customer references, validating product-market fit, or assessing customer satisfaction.

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Evaluates ML applications in investment with feature engineering, model selection, and implementation considerations for alpha generation. Use when evaluating ML for investing, designing ML pipelines, or assessing ML strategy feasibility.

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Evaluates deal protection mechanisms including break-up fees, no-shop clauses, matching rights, and force-the-vote provisions. Use when analyzing deal protections, negotiating break fees, or assessing termination provisions.

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Evaluates competitive advantage sustainability with switching costs, network effects, data assets, and brand strength analysis. Use when assessing competitive moats, analyzing defensibility, or evaluating long-term positioning.

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Perform an adversarial review of the current uncommitted changeset, validating it against project contracts and architectural intent.

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Pythonic wrapper around RDKit with a simplified interface and sensible defaults. Preferred for standard drug discovery work — SMILES/SELFIES/InChI conversion, molecule standardization and sanitization, descriptors, ECFP and other fingerprints, Tanimoto distance matrices, Butina clustering and diverse subset picking, Bemis-Murcko scaffolds and scaffold splits, BRICS/RECAP fragmentation, 3D conformer generation, SDF/CSV/Excel and cloud I/O, and parallel processing via n_jobs. Returns native rdkit.Chem.Mol objects, so it composes with RDKit throughout. Also trigger on datamol, `import datamol as dm`, dm.to_mol, dm.standardize_mol, dm.cluster_mols, or dm.pick_diverse. For advanced control or custom parameters, use the rdkit skill directly.

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Cheminformatics toolkit for fine-grained molecular control. Parse and write SMILES, SDF, MOL and InChI; compute descriptors (MW, LogP, TPSA, QED, Bertz); build fingerprints (Morgan/ECFP, RDKit, MACCS, atom pair, torsion) and score Tanimoto, Dice or cosine similarity; run SMARTS substructure search and reaction SMARTS; generate 2D depictions and ETKDG 3D conformers; extract Murcko scaffolds and canonical hashes; control sanitization and stereochemistry directly. Also trigger on rdkit, Chem.MolFromSmiles, rdFingerprintGenerator, SDMolSupplier, SMARTS query, ETKDG, or FilterCatalog. For standard workflows with a simpler interface use the datamol skill, which wraps RDKit; use rdkit for advanced control, custom sanitization, and specialized algorithms.

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Query the ChEMBL database web services for measured bioactivity data, compound records and calculated properties, targets, assays, mechanisms of action, drug indications and warnings. Use this skill to build curated SAR or QSAR datasets for a target, look compounds up by SMILES, InChIKey, name, or ChEMBL id, run similarity and substructure searches, and check what chemistry is already known against a protein. Also trigger when a query mentions ChEMBL ids (CHEMBL...), pChEMBL values, IC50/Ki/Kd/EC50 retrieval, assay confidence scores, or ebi.ac.uk/chembl.

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Navigate make-on-demand catalogues — ZINC-22 through CartBlanche and Enamine REAL Space — to find compounds that can actually be ordered. Use this skill to look substances up by ZINC identifier or structure, understand tranche partitioning by heavy-atom count and logP, and choose between screening an enumerated subset and searching a combinatorial synthon space with a fragment-growing method such as V-SYNTHES. Also trigger on ZINC22, CartBlanche, Enamine REAL, make-on-demand, tangible library, synthon, tranche, giga-scale enumeration, or ultra-large virtual screening.

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Query the FDA's public openFDA APIs for post-market drug data — FAERS adverse-event reports, Drugs@FDA approval and submission history, Structured Product Labels including boxed warnings, the National Drug Code directory, recall enforcement reports, and drug shortages. Use this skill to check what a regulator has already concluded about a molecule or its class, to date an approval and count its efficacy supplements, to read an approved indication or boxed warning, and to score a drug-event pair for disproportionate reporting with PRR, ROR, and chi-squared. Also trigger on openFDA, api.fda.gov, FAERS, Drugs@FDA, SPL, NDC, pharmacovigilance, boxed warning, adverse event report, drug recall, or safety signal.

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Design small interfering RNA and antisense oligonucleotide sequences against a transcript, and screen them for the failure modes specific to nucleic-acid drugs. Use this skill to tile a target transcript, apply positional and thermodynamic selection rules including duplex asymmetry and nearest-neighbour melting temperature, scan candidates for seed-region complementarity to off-target transcripts, and lay out a chemical modification pattern — gapmer architecture, 2'-O-methyl and 2'-MOE wings, locked nucleic acid, and phosphorothioate placement. Also trigger on siRNA, antisense oligonucleotide, ASO, gapmer, RNase H, seed region, duplex asymmetry, 2'-MOE, locked nucleic acid, phosphorothioate, or GalNAc conjugate.

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Molecular featurization hub with one consistent interface over 100+ featurizers. Fingerprints (ECFP/Morgan, MACCS, atom pair, topological torsion, Avalon, RDKit, ERG), RDKit and Mordred descriptor sets, pharmacophore and 3D shape descriptors, scaffold keys, and pretrained embeddings (ChemBERTa, ChemGPT, MolT5, GIN, Graphormer) through a common transformer API with caching and parallelism. Use this skill to convert SMILES into model-ready feature matrices for QSAR, virtual screening, and molecular ML, and to choose between featurizer families. Also trigger on molfeat, MoleculeTransformer, FPVecTransformer, PretrainedHFTransformer, molfeat model store, or featurizer selection.

日本語の概要は準備中です。原文の説明を表示しています。