「chi」の検索結果

Query the ChEMBL database web services for measured bioactivity data, compound records and calculated properties, targets, assays, mechanisms of action, drug indications and warnings. Use this skill to build curated SAR or QSAR datasets for a target, look compounds up by SMILES, InChIKey, name, or ChEMBL id, run similarity and substructure searches, and check what chemistry is already known against a protein. Also trigger when a query mentions ChEMBL ids (CHEMBL...), pChEMBL values, IC50/Ki/Kd/EC50 retrieval, assay confidence scores, or ebi.ac.uk/chembl.

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Cheminformatics toolkit for fine-grained molecular control. Parse and write SMILES, SDF, MOL and InChI; compute descriptors (MW, LogP, TPSA, QED, Bertz); build fingerprints (Morgan/ECFP, RDKit, MACCS, atom pair, torsion) and score Tanimoto, Dice or cosine similarity; run SMARTS substructure search and reaction SMARTS; generate 2D depictions and ETKDG 3D conformers; extract Murcko scaffolds and canonical hashes; control sanitization and stereochemistry directly. Also trigger on rdkit, Chem.MolFromSmiles, rdFingerprintGenerator, SDMolSupplier, SMARTS query, ETKDG, or FilterCatalog. For standard workflows with a simpler interface use the datamol skill, which wraps RDKit; use rdkit for advanced control, custom sanitization, and specialized algorithms.

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Design small interfering RNA and antisense oligonucleotide sequences against a transcript, and screen them for the failure modes specific to nucleic-acid drugs. Use this skill to tile a target transcript, apply positional and thermodynamic selection rules including duplex asymmetry and nearest-neighbour melting temperature, scan candidates for seed-region complementarity to off-target transcripts, and lay out a chemical modification pattern — gapmer architecture, 2'-O-methyl and 2'-MOE wings, locked nucleic acid, and phosphorothioate placement. Also trigger on siRNA, antisense oligonucleotide, ASO, gapmer, RNase H, seed region, duplex asymmetry, 2'-MOE, locked nucleic acid, phosphorothioate, or GalNAc conjugate.

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Pythonic wrapper around RDKit with a simplified interface and sensible defaults. Preferred for standard drug discovery work — SMILES/SELFIES/InChI conversion, molecule standardization and sanitization, descriptors, ECFP and other fingerprints, Tanimoto distance matrices, Butina clustering and diverse subset picking, Bemis-Murcko scaffolds and scaffold splits, BRICS/RECAP fragmentation, 3D conformer generation, SDF/CSV/Excel and cloud I/O, and parallel processing via n_jobs. Returns native rdkit.Chem.Mol objects, so it composes with RDKit throughout. Also trigger on datamol, `import datamol as dm`, dm.to_mol, dm.standardize_mol, dm.cluster_mols, or dm.pick_diverse. For advanced control or custom parameters, use the rdkit skill directly.

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Query the FDA's public openFDA APIs for post-market drug data — FAERS adverse-event reports, Drugs@FDA approval and submission history, Structured Product Labels including boxed warnings, the National Drug Code directory, recall enforcement reports, and drug shortages. Use this skill to check what a regulator has already concluded about a molecule or its class, to date an approval and count its efficacy supplements, to read an approved indication or boxed warning, and to score a drug-event pair for disproportionate reporting with PRR, ROR, and chi-squared. Also trigger on openFDA, api.fda.gov, FAERS, Drugs@FDA, SPL, NDC, pharmacovigilance, boxed warning, adverse event report, drug recall, or safety signal.

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Use when EZ_math_model runs in multi or hybrid mode and has two or more independent subtasks that can be assigned to subagents without shared files, shared state, or dataflow dependencies.

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Phase 1 of 5 — Socratic interview capturing WHAT and WHY; outputs a sprint-sized REQ doc for plan-architecture. Use only when the user asks to run Phase 1, plan requirements, or start the requirements interview — never trigger automatically from a feature description.

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Phase 4 of 5 — implements tasks from TASKS-<N>-<slug>.md (with ARCH-<N>-<slug>.md as architecture-only context) using mode-appropriate verification (tdd, test-after, ui, checklist); pass 'auto' to run without stepping. Use only when the user asks to run Phase 4 or implement tasks from an ARCH doc — never trigger automatically from a coding request.

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Guide Git branching strategies, branch naming, and merge operations. Use when: creating branches, merging, pull requests, Git workflow questions. Keywords: branch, merge, PR, pull request, GitFlow, GitHub Flow, 分支, 合併, 工作流程.

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Use multiple Claude agents to investigate and fix independent problems concurrently

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Execute implementation plan by dispatching fresh subagent for each task, with code review between tasks

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Guide a person through a Coordinate Remote Viewing (CRV) session following the Stargate/SRI protocol. AI acts as the monitor/tasker role, managing protocol progression, catching Analytical Overlay (AOL), and redirecting the viewer through stages I-VI. Use when a person wants to practice CRV and needs a monitor to manage the session protocol, when training a viewer through the staged CRV process, facilitating a structured intuitive perception exercise, or developing non-local awareness skills that complement healing work.

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Register trained models in MLflow Model Registry with version control, implement stage transitions (Staging, Production, Archived) with approval workflows, and manage model lineage with comprehensive metadata and deployment tracking. Use when promoting a trained model from experimentation to production, managing multiple model versions across development stages, implementing approval workflows for governance, rolling back to previous versions, or auditing model changes for compliance.

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Design and execute chaos engineering experiments using Litmus or Chaos Mesh. Test system resilience through controlled fault injection, validate hypothesis-driven tests, and improve failure recovery. Use before major product launches, after architecture changes to validate resilience, during GameDays or disaster recovery drills, to validate assumptions about failure modes, or as part of an SRE maturity program.

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Redact rendered visual artifacts — Mermaid diagrams, SVGs, and HTML dashboards — before public disclosure, using an ordered longest-first mapping table (specific label, then namespace label, then catch-all placeholder) that swaps sensitive identifiers for descriptive stand-ins while preserving structure, node ids, and teaching value. Covers whole-word identifier replacement, node-label-vs-node-id discrimination, re-rendering the derived image from the redacted source, and verifying the result through the redaction gate. Use when a diagram or dashboard built from internal findings must ship to a public mirror without leaking the names behind it.

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Profile and optimize Shiny application performance using profvis, bindCache, memoise, async/promises, debounce/throttle, and ExtendedTask for long-running computations. Use when the app feels slow or unresponsive during user interaction, when server resources are exhausted under concurrent load, when specific operations create bottlenecks, or when preparing an app for production deployment with many concurrent users.

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Apply software pipelining (double-buffering) to a tiled GPU kernel to overlap global memory loads with Tensor Core computation. Covers prologue/loop/epilogue restructuring, LDG-register vs cp.async (LDGSTS) variant selection based on compute/load ratio, shared memory budget verification against architecture-specific occupancy cliffs, and SASS-level verification of load/compute overlap.

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Orchestrate end-to-end machine learning pipelines using Prefect or Airflow with DAG construction, task dependencies, retry logic, scheduling, monitoring, and integration with MLflow, DVC, and feature stores for production ML workflows. Use when automating multi-step ML workflows from data ingestion to deployment, scheduling periodic model retraining, coordinating distributed training tasks, or managing retry logic and failure recovery across pipeline stages.

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Cross-session shared memory for agents. Use at session start to load the persistent bias-log via `mcp__memex__recent_observations`, mid-session to search prior context with `mcp__memex__search`, and immediately when a bias surfaces to log a new `observation` via `mcp__memex__add`. The six-layer reconstruction trail (raw → embedded → indexed → graphed → curated → reflexive) means memex stores facts AND the agent's own reasoning patterns across sessions. Prefer querying memex before re-deriving prior architectural decisions; re-derivation is itself evidence that the trail is incomplete.

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Organize, extract, prune, and verify Claude Code persistent memory files. Covers MEMORY.md as a concise index, topic extraction to dedicated files, staleness detection, accuracy verification against project state, the dual 200-line / 25KB load cap, and reachability of topic files from the index. Use when MEMORY.md is approaching either load cap, after a session produces durable insights worth preserving, when a topic section has grown beyond 10-15 lines and should be extracted, when project state has changed and memory entries may be stale, or before and after rewriting the index so that no topic file loses its only pointer.

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Extract the conceptual essence of a repository as skills, agents, and teams — the project's roles, procedures, and coordination patterns expressed as agentskills.io-standard definitions. Reads an arbitrary codebase and produces generalized definitions that capture WHAT the project does and WHO operates it, without replicating HOW it does it. Use when onboarding to a new codebase and wanting to understand its conceptual architecture, when bootstrapping an agentic system from an existing project, when studying a project's organizational DNA for cross-pollination, or when creating a skill/agent/team library inspired by a reference implementation.

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Sustained neutral pattern recognition across systems without urgency or intervention. Maps naturalist field study methodology to AI reasoning: framing the observation target, witnessing with sustained attention, recording patterns, categorizing findings, generating hypotheses, and archiving a pattern library for future reference. Use when a system's behavior is unclear and action would be premature, when debugging an unknown root cause, when a codebase change needs its effects witnessed before further changes, or when auditing own reasoning patterns for biases or recurring errors.

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Monitor, cap, and recover from context accumulation in agentic systems. Covers per-cycle cost tracking, context window auditing, budget caps with enforcement policies, emergency pruning when approaching limits, and progressive disclosure integration to minimize token spend on routing. Use when running long-lived agent loops (heartbeats, polling, autonomous workflows), when context windows are growing unpredictably between cycles, when API costs spike beyond expected baselines, when designing new agentic workflows that need cost guardrails from the start, or when post-mortem analysis reveals a cost incident caused by context accumulation.

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Optimize Docker build times using layer caching, multi-stage builds, BuildKit features, and dependency-first copy patterns. Applicable to R, Node.js, and Python projects. Use when Docker builds are slow due to repeated package installations, when rebuilds reinstall all dependencies on every code change, when image sizes are unnecessarily large, or when CI/CD pipeline builds are a bottleneck.

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