「cer」の検索結果

Builds QSAR / QSPR models using chemprop D-MPNN, MolFormer, Uni-Mol, ChemBERTa, random forest baselines, and Gaussian processes with explicit handling of OECD 5 principles, applicability domain (kNN, leverage, conformal prediction, Mahalanobis), scaffold-balanced splits, ensemble uncertainty, calibration (Platt, isotonic), feature importance (SHAP, atomic attribution), and prospective validation. Use when building target-specific predictive models from in-house bioassay data, ADMET endpoints, or selectivity profiles.

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Detects allele-specific transcription factor or histone modification binding from heterozygous-variant ChIP-seq using WASP (reference-bias filter; mandatory upstream), RASQUAL (joint QTL + bias-corrected testing), BaalChIP (Bayesian beta-binomial with copy-number-aware overdispersion), and AlleleSeq (personalized diploid genome). Handles imprinted-locus awareness, X-inactivation artifacts, cancer copy-number imbalance, and integration with downstream caQTL / bQTL mapping. Use when identifying variants with allelic effects on TF binding, fine-mapping causal regulatory variants, validating deep-learning variant predictions, or characterizing cis-acting regulatory effects.

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Applies ACMG/AMP 2015 framework with ClinGen SVI specifications, Tavtigian 2018/2020 Bayesian point system, Abou Tayoun 2018 PVS1 decision tree, Pejaver 2022 and Bergquist 2025 calibrated PP3/BP4 thresholds for REVEL/BayesDel/AlphaMissense, Brnich 2020 PS3/BS3 OddsPath, Walker 2023 SpliceAI splicing framework, and AMP/ASCO/CAP 2017 tumor tiers. Use when classifying germline variants P / LP / VUS / LB / B, applying VCEP-specific CSpec rules, computing Whiffin BS1, or assigning cancer Tier I-IV per Li 2017.

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Predicts ADMET properties using ADMETlab 3.0 (119 platform features, including 77 prediction models with modeled-endpoint uncertainty), ADMET-AI, DeepChem MolNet, and chemprop D-MPNN with explicit handling of OECD QSAR principles, applicability domain assessment, calibration, hERG/CYP/AMES endpoints, and PAINS / Lipinski / Ro5 / Veber / BBB druglikeness filters. Use when filtering compounds for drug-likeness, prioritizing leads by predicted safety, or building an in-house ADMET QSAR model.

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Analyzes differential transcript usage (DTU) and isoform switches with functional consequence prediction (NMD via 50nt rule, ORF disruption, protein domain loss/gain, signal peptide changes, IDR alterations, coding-potential shifts). Tools include IsoformSwitchAnalyzeR v2 (auto-selects satuRn for >5 reps else DEXSeq), the manual DRIMSeq -> DEXSeq/satuRn -> stageR DTU pipeline, and fishpond/swish for inferential-uncertainty-aware DTE. Distinguishes DTU from DGE and DTE; integrates external annotators (CPC2, Pfam, SignalP, IUPred2A or DeepTMHMM). Use when investigating how splicing differences alter protein function or trigger NMD-mediated degradation.

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Analyzes alternative splicing from PacBio Iso-Seq (HiFi, Kinnex/MAS-Iso-seq) and Oxford Nanopore (direct cDNA, direct RNA, R10.4.1+) long-read RNA-seq with full-isoform resolution. Tools include FLAIR (correct/collapse/quantify/diffSplice for PacBio + ONT), IsoQuant (de-novo or annotation-guided isoform discovery 2024 SOTA), Bambu (annotation-aware Bayesian discovery + quantification with Novel Discovery Rate), SQANTI3 (isoform classification: FSM/ISM/NIC/NNC + artifact flags), rMATS-long (event calling on long-read isoforms), and minimap2 (-ax splice:hq for HiFi; -ax splice -k14 for ONT cDNA; add -uf only for direct RNA or stranded cDNA preps). Solves microexon detection, recursive splicing, complex multi-exon isoforms, and DTU without transcript-quantification uncertainty. Use when short-read AS limitations (anchor length, complex isoforms, microexons, recursive splicing, transcript ambiguity) demand full-isoform resolution.

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Map nucleosome center positions, occupancy, and fuzziness from ATAC-seq fragment-size patterns using NucleoATAC, ATACseqQC, DANPOS3, or scprinter. Use when characterizing nucleosome organization at promoters and enhancers, calling +1/-1 nucleosomes flanking NFRs, generating V-plots for chromatin structure visualization, or comparing nucleosome positioning between conditions.

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Trim PCR primers from aligned reads in amplicon-panel BAMs using samtools ampliconclip. Use when processing SARS-CoV-2 ARTIC, hereditary cancer panels, ctDNA hot-spot panels, or any amplicon assay where primer-derived bases would falsely confirm reference at primer footprints.

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Use when accepting ANY real-world payment — Apple Pay, Wallet passes, Tap to Pay, Orders in Wallet. NOT in-app purchase / digital content (use axiom-integration). Covers entitlements, certs, signing, App Review payment rules.

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Use when storing credentials securely, encrypting data, implementing passkeys, securing AI/agentic features against prompt injection, code signing, or managing certificates and provisioning profiles.

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Use when the user mentions SwiftUI architecture review, separation of concerns, testability issues, or "logic in view" problems.

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Use when working with iOS/macOS Keychain Services (SecItem queries, kSecClass, OSStatus errors), biometric authentication (LAContext, Face ID, Touch ID), CryptoKit (AES-GCM, ChaChaPoly, ECDSA, ECDH, HPKE, ML-KEM), Secure Enclave, secure credential storage (OAuth tokens, API keys), certificate pinning (SecTrust, SPKI), keychain sharing across apps/extensions, migrating secrets from UserDefaults or plists, or OWASP MASVS/MASTG mobile compliance on Apple platforms.

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Implement, review, or improve SwiftUI Liquid Glass effects for iOS 26+. Covers glassEffect modifier, GlassEffectContainer, glass button styles, glass toolbar/tab bar, static status badges vs interactive controls, morphing transitions, tinting, interactive glass, ToolbarSpacer, scrollEdgeEffectStyle, backgroundExtensionEffect, and availability gating. Use when asked about Liquid Glass, glass buttons, glassEffect, GlassEffectTransition, glassEffectID, glassEffectUnion, scroll edge effects, or adopting iOS 26 design.

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Create, read, and manage calendar events and reminders using EventKit and EventKitUI. Use when adding events to the user's calendar, creating reminders, setting recurrence rules, requesting calendar or reminders access, presenting event editors, choosing calendars, handling alarms, observing calendar changes, or working with EKEventStore, EKEvent, EKReminder, EKCalendar, EKRecurrenceRule, EKEventEditViewController, EKCalendarChooser, or EventKitUI views.

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Access security tokens and smart cards using CryptoTokenKit. Use when building TKTokenDriver or TKSmartCardTokenDriver extensions, communicating with smart cards via TKSmartCard/TKSmartCardSlotManager, using iOS 26+ NFC smart-card sessions, registering smart cards, querying token-backed keychain items with kSecAttrTokenID, monitoring TKTokenWatcher, or configuring certificate-based smart-card authentication.

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This skill should be used when user asks to "deploy to Hetzner", "create Hetzner server", "manage Hetzner Cloud", "hcloud CLI", or works with Hetzner Cloud infrastructure including servers, networks, firewalls, load balancers, DNS zones, and volumes.

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Configure, simulate, debug, and analyze radarDataGenerator within radarScenario. Use for: interactively building radar detection scenarios from datasheets or performance requirements; diagnosing missed detections and configuration errors; interpreting sensor spherical, body, and scenario-frame outputs; deriving ReferenceRange from hardware specs via link budget; scan mode configuration (mechanical, electronic/AESA, hybrid); and validating simulation results against analytical predictions.

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Use this skill to classify tabular data end-to-end in MATLAB — load a dataset, prepare and clean it, select promising classifiers, train them, and compare accuracies with cross-validation, holdout, or hyperparameter optimization plus statistical tests. TRIGGER when: user asks to classify tabular data, pick classifiers for a dataset, compare classifier accuracy, run cross-validation or a holdout evaluation, or find the best model with statistical uncertainty. DO NOT TRIGGER when: user has non-tabular inputs (images, sequences, time series), wants a regression model, is training a specific neural network architecture (use matlab-train-network), or wants cost-sensitive learning or an arbitrary class-prior vector (this skill only supports the built-in uniform-prior toggle for imbalanced data).

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Manage secrets and PKI with HashiCorp Vault. Configure secret engines, authentication methods, and policies. Use when implementing centralized secrets management, dynamic credentials, or certificate management.

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Manage secrets and certificates in Azure Key Vault. Configure access policies, integrate with Azure services, and implement secure secret management. Use when managing secrets in Azure environments.

日本語の概要は準備中です。原文の説明を表示しています。

Configure load balancers and traffic distribution. Implement health checks and SSL termination. Use when distributing traffic across servers.

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Implement SOC 2 Trust Services Criteria. Configure security, availability, and processing integrity controls. Use when achieving SOC 2 certification.

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Supply Chain Bottleneck Analyzer for TikTok Shop sellers. Diagnose cash flow, inventory turnover, affiliate commissions, and return rates. Includes FBT cost analysis, influencer payout optimization, and viral product lifecycle management. No API key required for basic analysis.

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TikTok Shop brand protection toolkit. Detect unauthorized sellers, counterfeit products, and affiliate abuse. Includes TikTok IP Protection reporting, influencer misuse detection, and complaint templates. No API key required.

日本語の概要は準備中です。原文の説明を表示しています。