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Turns an answer into a one-page visual HTML explainer: the model writes a short Markdown draft and the bundled CLI builds one page. Use it proactively and liberally, without being asked, whenever a page would help the reader more than plain text, even if plain text would also work: any explanation of how something works or how parts relate (flow, request path, architecture, code or folder structure, state machine, lifecycle, history); any comparison, trade-off or decision with pros and cons; any diagnosis, review or investigation, especially with several causes or findings to rank; any answer with a table, a numbered or ranked list, steps, branches or several sections; or when the user says "I don't get it / draw it / explain visually / 讲讲原理 / 没看懂 / 画个图". When in doubt, use it: a page is quick and cheap to make. Also for explainer videos ("make a video", "做个视频") and for changing its settings. Skip only for small talk, a trivial one-line answer, or when the user asks for plain text.

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Create text-driven visuals in Markdown: charts, diagrams, cards, architecture and page layouts. Charts and analytical views (bar, line, pie, heatmap, correlation, regression); reliability and operations (latency, incident, throughput, cycle time, OKR, standup, on-call); product and finance (funnel, retention, revenue, budget); process and workflow (approval, BPMN); software design and behaviour (class, state machine, sequence, C4); dependencies and impact (dependency graph, ER, causality); system architecture as HTML (layer stack, wings, zones, topology, service catalogue, request paths); infrastructure (cloud, Kubernetes, ETL, network, security, IAM, compliance); governance and people (ArchiMate, org chart, hiring); knowledge and planning (mind map, roadmap, Gantt, migration); documents (comparison, SWOT, memo, policy, catalogue, case study). Use when a document needs a diagram, chart or card. Figures render live. Not for slide decks or math notation. Not recommended: mermaid / canvas / drawio / dot.

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Build a contribution schedule and calculate a supplied price-path cost basis without predicting returns. Use when the user asks to dollar-cost averaging with AlphaGBM. Use the bundled Python runner; never silently replace real results with demos.

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Analyzes genetic variant effects on gene expression (RNA-seq), chromatin accessibility (DNASE), histone marks (ChIP), and transcription factors using the AlphaGenome API. Use when the user asks about non-coding variant effects, pathogenicity, clinical significance, disease associations, functional effects, gene expression changes, splicing disruption, or regulatory effects in promoters and enhancers. Also use for resolving biological terms to tissue/cell-type ontologies (UBERON/CL) or analyzing variants in chr:pos:ref>alt format.

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Query the STRING database for protein-protein interactions (PPIs), functional enrichment, and homology. Use when the user asks about interactions between specific proteins, interaction evidence, confidence scores, protein interaction partners, or pathway enrichments.

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Checks whether the uv Python package manager is installed and installs it if missing. Ensures uv is on PATH. Use when another skill requires uv as a prerequisite.

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Comet preset path: Bug fix / hotfix. Skip brainstorming, directly open → build → verify → archive. Applicable for behavior fixes, scenarios not involving new capability design.

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Comet preset path: Non-bug small changes (tweak). Skip brainstorming and full plan, directly open → lightweight build → light verify → archive. Applicable for copy, configuration, documentation or prompt local optimization.

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Apply IRQL graph functions to KQL or IRQL query results for Kusto Explorer visualization. Generates Lift_To_Graph mappings and composes Graph_Render_View, Graph_Fold_By_Property, Extract_Node_*, Enrich_Node_*, and Enrich_Graph_* calls. Accepts a supplied query or limited basic natural-language source request; it is not a general natural-language-to-KQL/IRQL skill. WHEN: Lift_To_Graph, Graph_Render_View, Graph_Fold_By_Property, IRQL graph enrichment, graph mapping for existing query results, icon-decorated graph, fold graph nodes. Use azure-kusto-graph for native make-graph analysis, graph-match, shortest paths, components, or persistent graphs.

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Gene Ontology over-representation analysis using clusterProfiler enrichGO. Use when identifying biological functions enriched in a gene list from differential expression or other analyses. Supports all three ontologies (BP, MF, CC), multiple ID types, and customizable statistical thresholds.

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Visualize enrichment results using enrichplot package functions. Use when creating publication-quality figures from clusterProfiler results. Covers dotplot, barplot, cnetplot, emapplot, gseaplot2, ridgeplot, and treeplot.

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Gene Set Enrichment Analysis using clusterProfiler gseGO and gseKEGG. Use when analyzing ranked gene lists to find coordinated expression changes in gene sets without arbitrary significance cutoffs. Detects subtle but coordinated expression changes.

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Profile functional potential of metagenomes using HUMAnN3 and similar tools. Use when obtaining pathway abundances, gene family counts, or functional annotations from metagenomic data.

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Perform multi-locus sequence typing (MLST), core genome MLST, and SNP-based strain typing for bacterial isolate characterization using mlst and chewBBACA. Use when identifying strain types, tracking outbreak clones, or characterizing bacterial isolates.

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Infer pathogen transmission networks and identify likely transmission pairs using TransPhylo and outbreak reconstruction algorithms. Estimate who-infected-whom from genomic and epidemiological data. Use when investigating outbreak transmission chains or identifying superspreaders.

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Annotate CNVs with genes, pathways, and clinical significance. Use when interpreting CNV calls or identifying affected genes from copy number analysis.

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MAGeCK (Model-based Analysis of Genome-wide CRISPR-Cas9 Knockout) for pooled CRISPR screen analysis. Covers count normalization, gene ranking, and pathway analysis. Use when identifying essential genes, drug targets, or resistance mechanisms from dropout or enrichment screens.

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Assign pathogen lineages and track variants using Nextclade and pangolin for viral surveillance. Monitor variant prevalence and identify emerging variants of concern. Use when classifying viral sequences, tracking lineage dynamics, or monitoring for variants of concern.

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Filter and prioritize variants by pathogenicity, population frequency, and clinical evidence for rare disease analysis. Use when identifying candidate disease-causing variants from exome or genome sequencing.

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Query ClinVar for variant pathogenicity classifications, review status, and disease associations via REST API or local VCF. Use when determining clinical significance of variants for diagnostic or research purposes.

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Decompose genetic effects into direct and indirect paths through mediating variables using the mediation R package. Tests whether gene expression, methylation, or other molecular phenotypes mediate the effect of genetic variants on disease. Use when testing whether a molecular phenotype mediates the genotype-to-phenotype relationship.

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Query BindingDB for measured drug-target binding affinities (Ki, Kd, IC50, EC50). Search by target (UniProt ID), compound (SMILES/name), or pathogen. Essential for drug discovery, lead optimization, polypharmacology analysis, and structure-activity relationship (SAR) studies.

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Fetch dependency source code to give AI agents deeper implementation context. Use when the agent needs to understand how a library works internally, read source code for a package, fetch implementation details for a dependency, or explore how an npm/PyPI/crates.io package is built. Triggers include "fetch source for", "read the source of", "how does X work internally", "get the implementation of", "opensrc path", or any task requiring access to dependency source code beyond types and docs.

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Screen S&P 500 stocks for Mark Minervini's Volatility Contraction Pattern (VCP) and detect historical VCPs in a single ticker's price path. Identifies Stage 2 uptrend stocks forming tight bases with contracting volatility near breakout pivot points; in historical single-ticker mode walks a multi-year history and emits every VCP that formed with forward-outcome stats (breakout / stop-hit / timeout). Use when user requests VCP screening, Minervini-style setups, tight base patterns, volatility contraction breakout candidates, Stage 2 momentum stock scanning, or historical VCP pattern study on a specific ticker (e.g. FIX, TSLA).

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