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概要と使いどころ
Suite of tools for creating elaborate, multi-component claude.ai HTML artifacts using modern frontend web technologies (React, Tailwind CSS, shadcn/ui). Use for complex artifacts requiring state management, routing, or shadcn/ui components - not for simple single-file HTML/JSX artifacts.
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Toolkit for interacting with and testing local web applications using Playwright. Supports verifying frontend functionality, debugging UI behavior, capturing browser screenshots, and viewing browser logs.
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Inspects PostHog Visual Review (VR) runs that gate PR merges with screenshot regression checks. Use when the user mentions "visual review", "VR", "snapshot diff", "screenshot test", "storybook regression", "playwright snapshot", asks why a PR is blocked or what changed visually, wants to triage the VR backlog, decide whether a snapshot diff is real vs flaky, or check whether a story has been changing across runs. Also invoke when a PR has a failing `visual-review` status check, when a PR comment mentions "Visual review", or when the user is on a branch with an open VR run.
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Deploy and manage projects on Vercel using token-based authentication. Use when working with Vercel CLI using access tokens rather than interactive login — e.g. "deploy to vercel", "set up vercel", "add environment variables to vercel".
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Required reading before writing any HogQL/SQL or calling execute-sql against PostHog. Use whenever the user wants to search, find, or do complex aggregations PostHog entities (insights, dashboards, cohorts, feature flags, experiments, surveys, hog flows, data warehouse, persons, etc.) and query analytics data (trends, funnels, retention, lifecycle, paths, stickiness, web analytics, error tracking, logs, sessions, LLM traces). Covers HogQL syntax differences from ClickHouse SQL, system table schemas (system.*), available functions, query examples, and the schema-discovery workflow.
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Build a throwaway prototype to flesh out a design — a runnable terminal app for state/business-logic questions, or several radically different UI variations toggleable from one route.
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When GitHub Actions fails, fetch failing job logs and assign each failing job to a separate subagent that fixes its slice of the problem in parallel. Use for multi-job CI failures where jobs are independent.
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Find feature flags that were soft-deleted in the active project within a recent time window. Use when the user asks "what flags were deleted in the last N days", "show me recently deleted feature flags", "who deleted flag X", "audit recent flag deletions", or anything similar. Handles the non-obvious gotcha that system.feature_flags exposes the deleted boolean but does not expose a deletion timestamp — the actual deleted-at time lives in the per-flag activity log and must be cross-referenced.
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Debug the signals pipeline locally end-to-end. Covers emitting test signals from fixtures, monitoring Temporal workflows via the REST API, reading sandbox agent logs from object storage, inspecting Docker sandbox containers, and diagnosing common failures (stale ClickHouse embeddings, agentsh network denials, inactivity timeouts). Use when a signal isn't reaching the inbox, a signal-report-summary workflow fails, or a sandbox task run times out.
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Build and sharpen a project's domain model. Use when the user wants to pin down domain terminology or a ubiquitous language, record an architectural decision, or when another skill needs to maintain the domain model.
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Investigates distributed application performance using PostHog APM (OpenTelemetry span) data via MCP. Use when the user asks about service traces, slow HTTP/database spans, error spans, trace IDs, or span attributes — not AI observability traces or product logs. Uses posthog:query-apm-spans, posthog:apm-trace-get, posthog:apm-services-list, posthog:apm-attributes-list, and posthog:apm-attribute-values-list.
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Designs genomics experiments so technical nuisance variation (batch, lane, plate, flow cell, operator, reagent lot, processing day) is balanced against the biological variable of interest and therefore estimable rather than confounded, using constrained sample-to-batch assignment (designit, OSAT), the confounder/mediator/collider distinction, and the principle that no post-hoc correction recovers a fully confounded design. Covers detecting hidden batches with surrogate variable analysis, a decision table for downstream correction (ComBat-seq, RUVSeq, SVA) whose execution is deferred to differential-expression/batch-correction, and reproducibility metadata. Use when assigning samples to sequencing batches/lanes/plates, avoiding batch-condition confounding, deciding whether a design is salvageable by correction, choosing a correction method, or estimating the number of hidden batches. For the experimental unit, randomization, and blocking concepts see experimental-design/randomization-blocking.
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Statistical modeling — linear/logistic/ordinal/Poisson regression, ANOVA, Kruskal-Wallis, chi-square, Mann-Whitney, Cox survival, spline fits (R `ns()`), odds ratios, Cohen's d, F-statistic, p-value computation. Specializes in clinical-trial AE analysis (SDTM DM/AE), severity ordinal regression, and per-feature stat workflows.
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Designs Bayesian clinical trials including Phase I dose-finding (BOIN, CRM, EWOC, mTPI-2), meta-analytic-predictive (MAP) priors with robust mixtures for external data borrowing, EXNEX for basket trials, hierarchical models for safety AE (Berry-Berry), Bayesian platform trials (I-SPY 2, GBM AGILE, REMAP-CAP), and posterior probability stopping rules. Covers FDA Bayesian Devices Guidance (2010), FDA Bayesian Methodology in Drugs Draft (January 2026), BOIN Fit-for-Purpose qualification (December 2021), and Project Optimus dose-optimisation. Use when designing dose-finding studies, platform trials, or sensitivity analyses with informative priors.
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Mendelian randomization (MR) causal inference — does an exposure, risk factor, or biomarker CAUSALLY affect a disease/outcome, using genetic variants as instrumental variables (IEU OpenGWAS / EpiGraphDB MR-EvE). Use this whenever the user asks if X causes Y, whether an observational association is actually causal or just correlation, if a biomarker/trait is a causal risk factor, wants to triangulate epidemiology against genetic evidence, or mentions Mendelian randomization, instrumental-variable analysis, two-sample MR, or genetic causal evidence — even if they never say "MR" (e.g. "is LDL cholesterol actually causal for heart disease?", "does BMI cause type 2 diabetes or just correlate?", "is CRP a causal driver of stroke?"). Covers trait-label resolution, MR effect direction/magnitude, instrument quality (MOE score), method agreement (IVW vs MR-Egger vs weighted median), bidirectional MR for reverse causation, and distinguishing causation from genetic correlation. Not for plain GWAS association lookups (use the GWAS skills) or fitting your own instruments from raw summary statistics.
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Structures biological experiments so inference is valid by construction, covering Fisher's principles (randomization, replication, local control), the experimental-vs-observational unit distinction and pseudoreplication (Hurlbert 1984; Lazic 2018), randomization mechanics (complete, restricted, stratified, rerandomization, run-order), blocking layouts (randomized complete block, Latin square, incomplete block), factorial designs and interactions, and the split-plot/nested error strata hidden inside multi-batch genomics. Use when deciding the experimental unit and what counts as a replicate, planning randomization and run order, choosing a blocked/factorial/split-plot/nested layout, avoiding pseudoreplication in cell-culture or animal studies, or specifying the random-effects structure of the analysis model. For assigning samples to sequencing batches/lanes/plates and batch-effect correction see experimental-design/batch-design; for regulated clinical-trial randomization see clinical-biostatistics.
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Package agent-generated scientific code, figures, tables, data, logs, and conclusions into a navigable workspace result with stable paths and a concise manifest. Use near the end of computational tasks.
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Rigorous methodology for evaluating ML models on established benchmarks. Covers proper train/val/test splits, baseline verification from original papers, exact metric formula discrepancies, data-leak detection checklist, multi-seed robustness, and honest reporting templates. Use when claiming to beat published baselines, writing methods papers, or auditing existing results.
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Build training datasets for LLM specialization from production data, frontier model distillation, and synthetic bootstrapping. Use when formatting production logs into SFT data, distilling from frontier APIs, or preparing data for fine-tuning. Covers JSONL formatting, data quality validation, deduplication, and train/eval splitting.
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Builds diagnostic and prognostic classifiers on omics feature matrices with regularized logistic regression, random forest, and gradient-boosted trees, handling the p>>n regime, batch shortcut learning, class imbalance, and probability calibration. Use when building a classifier from expression, methylation, or variant data, choosing an algorithm for high-dimensional small-n data, or diagnosing a suspiciously perfect AUC. For unbiased evaluation see machine-learning/model-validation; for feature selection see machine-learning/biomarker-discovery; for time-to-event outcomes see machine-learning/survival-analysis.
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Explains ML predictions on omics data with SHAP, LIME, and permutation importance, handling the correlated-feature trap, the conditional-vs-interventional Shapley choice, and the attribution-is-not-causation boundary. Use when interpreting an omics classifier, debugging shortcut/batch learning, or deciding whether an attribution ranking can be trusted as biology. For validated feature selection see machine-learning/biomarker-discovery; explanations are not a selection method.
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Builds and validates predictive time-to-event models on clinical and omics data with penalized Cox, random survival forests, gradient-boosted and deep survival models, and prediction-grade evaluation (Uno's C, time-dependent AUC, integrated Brier, calibration, competing risks). Use when building an individualized risk predictor or prognostic omics signature, choosing a survival model, or evaluating one beyond the C-index. For Kaplan-Meier, log-rank, and classical Cox hazard-ratio inference in a trial see clinical-biostatistics/survival-analysis.
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Process-based discrete-event simulation framework in Python. Use this skill when building simulations of systems with processes, queues, resources, and time-based events such as manufacturing systems, service operations, network traffic, logistics, or any system where entities interact with shared resources over time.
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Orchestrates an end-to-end MeRIP-seq / m6A-seq analysis from raw FASTQ to differential m6A peak calls and metagene plots, chaining fastp adapter trimming, STAR splice-aware alignment (NO deduplication for non-UMI MeRIP), deepTools replicate-concordance + IP-enrichment QC, PreSeq saturation curves, exomePeak2 (transcript-aware Poisson GLM) peak calling, optional MACS3 broad-peak cross-check, DRACH motif confirmation as a sanity check (NOT a per-peak filter), exomePeak2 differential calling via the four-BAM-vector interface (bam_ip + bam_input control; bam_treated_ip + bam_treated_input treatment), ChIPseeker annotation, and the canonical Guitar metagene with stop-codon enrichment as the biological QC anchor. Use when running a complete MeRIP analysis from raw reads, when chaining the constituent epitranscriptomics skills (merip-preprocessing -> m6a-peak-calling -> m6a-differential -> modification-visualization), or when wrapping the pipeline in Snakemake / Nextflow.
日本語の概要は準備中です。原文の説明を表示しています。