1.8万 件 ・ 関連度順
概要と使いどころ
Find differentially accessible chromatin regions between conditions using DiffBind or DESeq2. Use when comparing chromatin accessibility between treatment groups, cell types, or developmental stages in ATAC-seq experiments.
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Detect transcription factor binding sites through footprinting analysis in ATAC-seq data using TOBIAS. Use when identifying TF occupancy patterns within accessible regions, as TF binding protects DNA from Tn5 cutting.
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Use when the user asks to "run a deliverability pre-flight before I send", "check my SPF/DKIM/DMARC/BIMI", "why am I landing in spam / promotions", or "score my sender reputation and list hygiene"; runs the ONE-TIME pre-send SEND S1 authentication pre-flight and builds the SEND S (Sender-integrity / Deliverability) evidence read — DNS + DMARC-RUA auth, domain/IP reputation, inbox placement, content/link/render, and point-in-time bounce/complaint hygiene — using Pass/Partial/Fail/Unknown/N/A states and scoring only at complete applicable coverage. Not for the recurring hygiene trend — use list-hygiene-monitor; not for final EQS or veto verdicts — use email-quality-auditor; not for segments/suppression lists — use list-segment-builder. 邮件送达率预检/SPF DKIM DMARC认证/发件域声誉
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Set up Apollo.io monitoring and observability. Use when implementing logging, metrics, tracing, and alerting for Apollo integrations. Trigger with phrases like "apollo monitoring", "apollo metrics", "apollo observability", "apollo logging", "apollo alerts".
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Instrument an Algolia integration for actionable availability, latency, freshness, relevance, and event-health signals. Use when defining dashboards, alerts, traces, or service objectives. Trigger with "monitor Algolia", "Algolia metrics", or "search observability".
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Instrument Adobe integrations with redacted structured logs, request/job/activation correlation, service-level indicators, alerts, and evidence retention. Use when the task requires adobe content-safe observability. Trigger with "monitor Adobe API", "Adobe observability", or "App Builder logs".
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Analyze and design idempotency, bounded polling, per-service circuits, durable queues, DLQ/replay, degradation, and reconciliation for Adobe workloads. Use when the task requires adobe async reliability controls. Trigger with "Adobe reliability", "Firefly retry design", or "PDF job recovery".
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Java "Ghost Bits" / Cast Attack playbook (Black Hat Asia 2026). Use when attacking Java services where 16-bit char is silently narrowed to 8-bit byte to bypass WAF/IDS for SQL injection, deserialization RCE, file upload (Webshell), path traversal, CRLF injection, request smuggling, and SMTP injection. Affects Tomcat, Spring, Jetty, Undertow, Vert.x, Jackson, Fastjson, Apache Commons BCEL, Apache HttpClient, Angus Mail, JDK HttpServer, Lettuce, Jodd, XMLWriter and re-enables many "patched" CVEs through WAF bypass.
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Heap exploitation playbook. Use when targeting ptmalloc2/glibc heap vulnerabilities including UAF, double free, overflow, off-by-one/null, and leveraging tcache/fastbin/unsortedbin attacks for arbitrary write or code execution.
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Design habit-forming product loops using the Hook Model (Trigger, Action, Variable Reward, Investment). Use when the user mentions "users arent coming back", "habit formation", "engagement loops", "habit zone", or "the manipulation matrix". Also trigger when designing notification or re-engagement strategies, building streaks or progress systems, or analyzing why users stop after signup. Covers ethics evaluation and onboarding for habits. For friction reduction and B=MAP, see improve-retention. For viral sharing, see contagious.
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Verify a WordPress plugin's Abilities API registrations: enumerate abilities, check that callback behavior matches each annotation's claim (the adversarial readonly-but-writes detection), validate permissions and schemas, and validate audit documents produced by wp-abilities-audit.
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Add file-based observability, tracing, and run analysis to LLM/agent experiments — per-turn transcripts, tool calls and results, reasoning traces, token/cost accounting, per-episode artifacts, plus terminal viewers and a run-comparison report. Platform-agnostic: one small adapter covers OpenAI, Gemini/Vertex, Anthropic, LiteLLM, Tinker, vLLM, or any custom inference stack, and the same tooling then works unchanged. Use this skill whenever the user wants observability, tracing, logging, or run tracking for model experiments; asks why an agent failed a task or wants to replay/debug/diff an episode; wants to compare models, arms, or ablations; wants to instrument a new folder, repo, or platform ("add observability here", "do the same for Tinker/Gemini/OpenAI"); wants to import or tie in existing experiment results so old runs show up alongside new ones; or wants eval runner scripts where many models share one protocol. Reach for this even when they only say "log what the model is doing", "I can't tell what happened in this run", or "set up traces for this experiment".
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End-to-end methodology for reproducing AND patching publicly disclosed, already-fixed vulnerabilities: sourcing the advisory and the fix commit, reading the patch diff, rebuilding a pinned offline lab, building a vulnerable-vs-patched contrast harness with proper controls, minimizing the trigger, designing and validating the fix, and writing it up as a blog post or whitepaper. Use this skill whenever the user wants to reproduce, demonstrate, understand, teach, or write about a known vulnerability or security incident: "reproduce this CVE", "build a repro for", "how did EchoLeak / Log4Shell / the postmark-mcp package actually work", "show me how this exploit worked", "write a blog post about this vulnerability", "set up a lab for CVE-XXXX", "pull the NVD/CVE/OSV details", or "make a PoC I can publish". Use it just as eagerly for the patching half: "how should this be fixed", "is this patch correct", "what would have caught this", "review this security fix", "write a regression test for this CVE", "how do I backport this", or "what's the right fix for this bug class" - even when the user never says the word "reproduce". Reach for it on vague asks like "help me understand this security advisory", "I want to write about this incident", or "can we test whether we were vulnerable" when a disclosed vulnerability is in play. This skill only handles ALREADY-PATCHED, publicly disclosed issues and refuses zero-day discovery, live targets, and weaponization.
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A comprehensive toolbox for computational molecular biology; use it when you need programmatic sequence/structure parsing, batch bioinformatics pipelines, or automated NCBI/BLAST workflows.
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Sequence alignment and alignment file processing with Biopython (Bio.Align/Bio.AlignIO), triggered when you need global/local pairwise alignment, MSA read/write/format conversion, or alignment statistics/filtering.
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Builds clear, executable, and auditable inclusion and exclusion criteria for biomedical and clinical research protocols. Always use this skill when a user needs to translate a target population into operational screening rules tied to chart fields, time windows, tests, procedures, prior therapies, exclusions, and reviewable edge cases. Focus on protocol-stage precision, ambiguity reduction, auditability, and screening reproducibility rather than generic study design advice.
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Generates complete process-related diagnostic biomarker bioinformatics research designs from a user-provided disease context, gene-family or pathway theme, and validation direction. Use when a study centers on process-related genes, DEG and WGCNA integration, machine-learning feature selection, nomogram-based diagnostic modeling, immune infiltration, regulatory-network analysis, and optional external or experimental validation. Covers five study patterns (process-DEG discovery, co-expression-module integration, machine-learning biomarker selection, diagnostic model/nomogram workflow, immune-regulatory interpretation and validation) and always outputs Lite / Standard / Advanced / Publication+ with a recommended primary plan, stepwise workflow, figure plan, validation hierarchy, minimal executable version, publication upgrade path, and strictly verified literature retrieval.
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Generates complete cross-disease shared-biomarker bioinformatics research designs from a user-provided disease pair and validation direction. Always use this skill whenever a user wants to design, plan, or build a multi-dataset study linking two related diseases through shared DEGs, enrichment, PPI hub genes, public validation, regulatory-network analysis, immune infiltration, drug-gene interaction screening, and optional qRT-PCR or cell-line validation. Covers five study patterns (shared-DEG discovery, hub-gene prioritization, regulatory-network interpretation, immune/drug follow-up, bioinformatics-plus-validation) and always outputs four workload configs (Lite / Standard / Advanced / Publication+) with recommended primary plan, step-by-step workflow, figure plan, validation strategy, minimal executable version, publication upgrade path, and a strictly verified reference literature retrieval layer with real references only.
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Generates complete tumor immune-infiltration-guided bulk-transcriptome diagnostic biomarker and machine-learning research designs from a user-provided cancer type and study direction. Always use this skill whenever a user wants to design, plan, or build a tumor bioinformatics study centered on differential expression, immune infiltration estimation, immune-linked module discovery, consensus feature selection, diagnostic modeling, nomogram construction, clinical association, and optional prognostic extension or validation. Covers five study patterns (immune-cell-first diagnostic workflow, immune-module-to-biomarker workflow, consensus-ML biomarker workflow, diagnostic-plus-prognostic hybrid workflow, translational validation workflow) and always outputs four workload configs (Lite / Standard / Advanced / Publication+) with recommended primary plan, step-by-step workflow, figure plan, validation strategy, minimal executable version, publication upgrade path, reference literature pack, and self-critical risk review.
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Generates complete conventional oncology bulk-transcriptome biomarker and hub-gene research designs from a user-provided cancer type and study direction. Always use this skill whenever a user wants to design, plan, or build a tumor bioinformatics study centered on differential expression, prognostic filtering or risk modeling, PPI-based hub-gene prioritization, diagnostic/prognostic evaluation, clinical association, immune infiltration context, methylation context, and optional tissue or cell validation. Covers five study patterns (signature-first prognostic workflow, hub-gene-first biomarker workflow, hybrid signature-to-hub workflow, immune-context biomarker workflow, translational validation workflow) and always outputs four workload configs (Lite / Standard / Advanced / Publication+) with recommended primary plan, step-by-step workflow, figure plan, validation strategy, minimal executable version, publication upgrade path...
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Designs cell-based and animal-based validation plans that translate computational, omics, biomarker, genetic, or clinical findings into experimentally testable validation routes. Always use this skill whenever a user wants to move from an in silico, statistical, or clinical association finding toward wet-lab validation using cell systems, organoid-like systems, xenograft or genetically relevant animal models. It should define the exact claim to test, separate mechanism-testing from association-support and translational-support goals, choose the best-fit model family, specify perturbation strategy, readouts, controls, sequencing of experiments, and four workload configurations (Lite / Standard / Advanced / Publication+) with one recommended primary plan. Never fabricate model availability, reagent availability, species relevance, assay feasibility, phenotype penetrance, expected effect sizes, validation success, or literature references.
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Detects methodological gaps across study design, analysis, validation, bias control, reproducibility, and implementation readiness within a biomedical research area. Use this skill when a user wants to identify what current studies are still methodologically missing, which weaknesses are most consequential, and what upgrade path would produce a stronger next-step study. Always separate design gaps, analysis gaps, validation gaps, and reproducibility gaps. Never treat technical complexity as methodological rigor.
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Use Trivy vulnerability scanner in offline mode to discover security vulnerabilities in dependency files. This skill covers setting up offline scanning, executing Trivy against package lock files, and generating JSON vulnerability reports without requiring internet access.
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Expert performance engineer specializing in modern observability, application optimization, and scalable system performance. Masters OpenTelemetry, distributed tracing, load testing, multi-tier caching, Core Web Vitals, and performance monitoring. Handles end-to-end optimization, real user monitoring, and scalability patterns. Use PROACTIVELY for performance optimization, observability, or scalability challenges.
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