「machine」の検索結果

Builds and validates predictive time-to-event models on clinical and omics data with penalized Cox, random survival forests, gradient-boosted and deep survival models, and prediction-grade evaluation (Uno's C, time-dependent AUC, integrated Brier, calibration, competing risks). Use when building an individualized risk predictor or prognostic omics signature, choosing a survival model, or evaluating one beyond the C-index. For Kaplan-Meier, log-rank, and classical Cox hazard-ratio inference in a trial see clinical-biostatistics/survival-analysis.

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Scalable data processing for ML workloads. Streaming execution across CPU/GPU, supports Parquet/CSV/JSON/images. Integrates with Ray Train, PyTorch, TensorFlow. Scales from single machine to 100s of nodes. Use for batch inference, data preprocessing, multi-modal data loading, or distributed ETL pipelines.

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Chains a somatic (tumor-normal) SNV/indel and structural-variant pipeline end to end with GATK Mutect2 (or Strelka2), wiring the somatic-specific machinery - panel-of-normals and gnomAD germline-resource priors, GetPileupSummaries/CalculateContamination, and LearnReadOrientationModel FFPE/oxoG orientation-bias filtering fed into FilterMutectCalls. Use when calling somatic mutations from a tumor-normal pair (or tumor-only with PoN caveats), deciding which artifact filter removes which class of false positive, reasoning about VAF/purity/ploidy and clonal-vs-subclonal detection, adding somatic SV/CNV or TMB/MSI/signatures, or routing variants to AMP/ASCO/CAP tier and oncogenicity interpretation (never germline ACMG).

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Distributed computing for larger-than-RAM pandas/NumPy workflows. Use when you need to scale existing pandas/NumPy code beyond memory or across clusters. Best for parallel file processing, distributed ML, integration with existing pandas code. For out-of-core analytics on single machine use vaex; for in-memory speed use polars.

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Use this skill for processing and analyzing large tabular datasets (billions of rows) that exceed available RAM. Vaex excels at out-of-core DataFrame operations, lazy evaluation, fast aggregations, efficient visualization of big data, and machine learning on large datasets. Apply when users need to work with large CSV/HDF5/Arrow/Parquet files, perform fast statistics on massive datasets, create visualizations of big data, or build ML pipelines that do not fit in memory.

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Maps query single-cell data onto reference atlases and transfers cell-type labels using scArches surgery (scVI/scANVI), Symphony, Azimuth, CellTypist, scPoli, popV, and foundation models, with explicit out-of-distribution and label-transfer uncertainty. Use when annotating new single-cell datasets against a pre-trained reference, deciding which mapping method fits, or judging whether transferred labels are trustworthy. For de novo clustering and manual annotation see single-cell/cell-annotation; for batch integration without a reference see single-cell/batch-integration.

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Install or update ToolUniverse in Claude Science — create the conda env, install the tooluniverse pip package, and (re)build the tooluniverse-research skill by fetching the current workflow library from GitHub. Use for first-time setup, upgrading the ToolUniverse version, refreshing the bundled workflows after an upstream release, or reinstalling on a new machine.

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This skill should be used for time series machine learning tasks including classification, regression, clustering, forecasting, anomaly detection, segmentation, and similarity search. Use when working with temporal data, sequential patterns, or time-indexed observations requiring specialized algorithms beyond standard ML approaches. Particularly suited for univariate and multivariate time series analysis with scikit-learn compatible APIs.

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Model interpretability and explainability using SHAP (SHapley Additive exPlanations). Use this skill when explaining machine learning model predictions, computing feature importance, generating SHAP plots (waterfall, beeswarm, bar, scatter, force, heatmap), debugging models, analyzing model bias or fairness, comparing models, or implementing explainable AI. Works with tree-based models (XGBoost, LightGBM, Random Forest), deep learning (TensorFlow, PyTorch), linear models, and any black-box model.

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High-performance toolkit for genomic interval analysis in Rust with Python bindings. Use when working with genomic regions, BED files, coverage tracks, overlap detection, tokenization for ML models, or fragment analysis in computational genomics and machine learning applications.

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Reads and summarises ScenarioRunner output — the criteria pass/fail tables from --output/--file, the machine-readable --json and --junit result files, and the criteria JSON written alongside a --record recording — and runs the metrics module (metrics_manager.py) to compute custom measurements over a recorded run offline, without the simulator. Use when the user asks "did the scenario pass", "why did it fail", "summarise these results", "compare these runs", or wants distance/speed/lane metrics from a recording.

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Answers "can CARLA do X here, and is there a vetted procedure for it" before you promise anything, and detects client/server/tree version skew — a support matrix over the whole collection (covered by a skill / works but undocumented / present but untested / broken or removed), an index of the features that are verified BROKEN on 0.10.0 (gbuffers crash the server, map layers do nothing, Landmark.waypoint is None, standalone asset packages are gone), and a probe that reports what this machine's build flags and running server actually offer. Use when the user asks whether CARLA supports something, when a feature has no skill, when a UE4 tutorial's steps do not exist, or before improvising a procedure.

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Read a liarjs fingerprint report and attribute each failing check to the component that produced it - what the check id measures, whether the signal comes from the launch configuration, the page-modifying layer, the network path or the machine image, and which failures are inherent to headless or datacenter environments. Use when a fingerprint scan came back with a low score, or when a check id such as webdriver, worker-consistency, gpu-triad, native-integrity or tz needs explaining.

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Map N6-methyladenosine (m6A) RNA modifications at single-nucleotide resolution using miCLIP (Linder 2015), miCLIP2 + m6Aboost machine learning (Kortel 2021), GLORI (Liu 2023, antibody-free chemical conversion), DART-seq (Meyer 2019, APOBEC1-YTH fusion), m6Anet (nanopore direct RNA), or MeRIP-seq with calibration. Use when distinguishing antibody-based from antibody-free m6A detection methods, applying the DRACH motif constraint, reconciling cross-method disagreements (DART 44% in DRACH vs GLORI), or detecting m6Am at the cap.

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Azure Machine Learning SDK v2 for Python. Use for ML workspaces, jobs, models, datasets, compute, and pipelines.

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AI and machine learning workflow covering LLM application development, RAG implementation, agent architecture, ML pipelines, and AI-powered features.

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Set up gbrain for this coding agent: install the CLI, initialize a local PGLite or Supabase brain, register MCP, capture per-remote trust policy. One command from zero to "gbrain is running, and this agent can call it." Use when: "setup gbrain", "connect gbrain", "start gbrain", "install gbrain", "configure gbrain for this machine". (gstack)

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Guides type-driven design in Rust. Use when encoding invariants in types, applying newtype pattern, implementing type state machines, using PhantomData, or making invalid states unrepresentable.

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Triage issues through a state machine driven by triage roles. Use when user wants to create an issue, triage issues, review incoming bugs or feature requests, prepare issues for an AFK agent, or manage issue workflow.

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Build a throwaway prototype to flesh out a design before committing to it. Routes between two branches — a runnable terminal app for state/business-logic questions, or several radically different UI variations toggleable from one route. Use when the user wants to prototype, sanity-check a data model or state machine, mock up a UI, explore design options, or says "prototype this", "let me play with it", "try a few designs".

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Generate Mermaid diagrams from code, architecture, or concepts. Use when you need to visualize code flow, system architecture, data relationships, state machines, sequences, class structures, or any other diagrammable concept.

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Use when you need to visually interact with a GUI — test buttons, fill forms, verify visual layouts, fuzz web pages, automate user flows, take screenshots, or perform end-to-end QA on any application. Works on cloud VMs, Docker containers, local machines, and sandboxes. Install: pip install cua.

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Turn a rough idea into a fully approved design before any code is written. Load when the user wants to brainstorm, explore ideas, design a feature, think through approaches, plan a new capability, or figure out what to build. Also triggers on "let's think through", "help me design", "explore options", "what's the best approach for", "I have an idea for", "before we build", or any request to design something before implementation. Enforces a hard gate: no code, no implementation until user approves a design. For executable feature specs (FRs, NFRs, ACs as Given/When/Then), route to `feature-spec` instead — brainstorming owns approach and architecture, not machine-readable requirements.

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Write the executable feature specification — the WHAT and WHY artifact that agents and reviewers treat as source of truth. Owns both /specify and /clarify modes. Load when the user asks to write a feature spec, write a specification, write an executable spec, define functional requirements, capture acceptance criteria as Given/When/Then, or when the spec-driven-development orchestrator routes here. Also triggers on "feature spec", "executable spec", "/specify", "/clarify", "write the spec for this feature", "specification for", "spec-driven", "machine-readable spec". Output: docs/specs/YYYY-MM-DD-<slug>-feature-spec.md. Hard gate: cannot Approve while [NEEDS CLARIFICATION] markers remain.

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