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概要と使いどころ
Generate novel drug-like molecules using the GenMol NIM microservice. Use for de novo generation, scaffold decoration, motif extension, lead optimization, SAFE notation, QED or LogP ranking, hosted NVIDIA API calls, or local Docker deployment. GenMol takes SAFE notation in the smiles field, not ordinary SMILES.
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LP, MILP, QP — concepts, problem-text parsing, and formulation patterns (parameters, constraints, decisions, objective). Concepts only; no API.
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LP, MILP, and QP (beta) with cuOpt — Python, C, and CLI. Use when the user is solving LP, MILP, or QP with any cuOpt interface.
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Troubleshoot Golang programs systematically - find and fix the root cause. Use when encountering bugs, crashes, deadlocks, races, or unexpected behavior in Go code. Covers debugging methodology, common Go pitfalls, test-driven debugging, pprof setup and capture, Delve, race detection, GODEBUG tracing, and production debugging. Start here for any 'something is wrong' situation. Not for interpreting profiles or benchmarking (→ See `samber/cc-skills-golang@golang-benchmark` skill), applying optimization patterns (→ See `samber/cc-skills-golang@golang-performance` skill), or designing new code (→ See `samber/cc-skills-golang@golang-safety` skill for defensive coding, `samber/cc-skills-golang@golang-concurrency` skill for concurrency design).
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Golang data structures — slices (internals, capacity growth, preallocation, slices package), maps (internals, hash buckets, maps package), arrays, container/list/heap/ring, strings.Builder vs bytes.Buffer, generic collections, pointers (unsafe.Pointer, weak.Pointer), and copy semantics. Use when choosing or optimizing Go data structures, implementing generic containers, using container/ packages, unsafe or weak pointers, or questioning slice/map internals. Not for applying optimization patterns once profiling has identified a bottleneck (→ See `samber/cc-skills-golang@golang-performance` skill).
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Golang benchmarking, profiling, and performance measurement. Use when writing, running, or comparing Go benchmarks, profiling hot paths with pprof, interpreting CPU/memory/trace profiles, analyzing results with benchstat, setting up CI benchmark regression detection, or investigating production performance with Prometheus runtime metrics. Also use when the developer needs deep analysis on a specific performance indicator - this skill provides the measurement methodology, while `samber/cc-skills-golang@golang-performance` provides the optimization patterns.
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Comet preset path: Non-bug small changes (tweak). Skip brainstorming and full plan, directly open → lightweight build → light verify → archive. Applicable for copy, configuration, documentation or prompt local optimization.
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Diagnose Day-2 AKS GPU and KAITO incidents using profile-aware, read-only evidence. WHEN: 'Insufficient nvidia.com/gpu', GPU pod Pending, model-load OOM, DCGM/VRAM, KAITO Workspace not ready, or GPU autoscaling. DO NOT USE FOR: setup (airunway-aks-setup), non-GPU incidents (aks-troubleshooting), standalone VM quota (azure-quotas), or generic cost (cost-analysis or cost-optimization from the optional azure-cost plugin).
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Fine-tune models on Microsoft Foundry using SFT (supervised), DPO (preference), or RFT (reinforcement with graders). Covers dataset preparation, training job submission, deployment, and evaluation. USE FOR: fine-tune, SFT, DPO, RFT, training data, grader, distillation, fine-tuned model, training job, large file upload, calibrate grader, deploy fine-tuned model, evaluate fine-tuned model. DO NOT USE FOR: general model deployment without fine-tuning (use deploy-model), agent creation (use agents), prompt optimization without training (use prompt-optimizer).
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End-to-end orchestrator: from a business idea, app idea, or existing app to running Azure deployment with cost estimates and pre-deploy approval. Analyzes your app, auto-detects the right Azure services, scaffolds infrastructure code, and deploys — tailored to your app, not a template. Handles moving existing apps to Azure without rewriting or with minimal changes. WHEN: bring your app to Azure, plan my app, cost to run, is my code ready to deploy, deploy my app to the cloud, deploy all my services, what Azure services do I need, plan my Azure deployment, deploy my new app to Azure, one-click deploy, I have an app and want it on Azure, migrate my app to Azure, help me get started, build an app, no code yet, starter project. DO NOT USE FOR: use azd for deployment(use azure-deploy), optimizing existing costs (use cost-optimization), code readiness checks only (use azure-app-onboard-prereq).
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Optimize existing Azure resources and analyze Reservations or Savings Plans. WHEN: "optimize Azure costs", "reduce cloud spending", "rightsize resources", "find idle resources", "orphaned disk", "deleted VM still charged", "public IP still charging", "reservation utilization", "Savings Plan coverage", "commitment recommendation", "why is pay-as-you-go still charged". DO NOT USE FOR: cost spikes, forecasts, pricing estimates, budgets, or governance.
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Design guides for cytosine and adenine base editing using editing window optimization and BE-Hive outcome prediction. Select optimal positions for C-to-T or A-to-G conversions without double-strand breaks. Use when designing base editor experiments for precise nucleotide changes.
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Query BindingDB for measured drug-target binding affinities (Ki, Kd, IC50, EC50). Search by target (UniProt ID), compound (SMILES/name), or pathogen. Essential for drug discovery, lead optimization, polypharmacology analysis, and structure-activity relationship (SAR) studies.
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End-to-end binder design using BindCraft hallucination. Use this skill when: (1) Designing protein binders with built-in AF2 validation, (2) Running production-quality binder campaigns, (3) Using different design protocols (fast, default, slow), (4) Need joint backbone and sequence optimization, (5) Want high experimental success rate. For backbone-only generation, use rfdiffusion. For QC thresholds, use protein-qc. For tool selection guidance, use binder-design.
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Cloud laboratory platform for automated protein testing and validation. Use when designing proteins and needing experimental validation including binding assays, expression testing, thermostability measurements, enzyme activity assays, or protein sequence optimization. Also use for submitting experiments via API, tracking experiment status, downloading results, optimizing protein sequences for better expression using computational tools (NetSolP, SoluProt, SolubleMPNN, ESM), or managing protein design workflows with wet-lab validation.
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Use when the user asks to "amplify influencer content with paid media", "set up whitelisting or Spark Ads", "decide which posts to boost", "repurpose influencer content", "turn one video into multiple ads", or "build a UGC asset library"; produces (paid mode) a content-selection scorecard, a paid amplification strategy (whitelisting/boosting/dark posts), audience targeting, and a budget+optimization plan, or (repurpose mode) a rights-tracked content inventory, a 1-video-to-10+-asset repurposing map, per-format transformation specs, and a 30-day distribution plan. Not for gating whether a deliverable is publishable or FTC-compliant — use creator-content-auditor; not for the always-on brand posting calendar — use social-calendar-builder; not for drafting a net-new idea into platform-native packages — use social-creative-builder. 复用达人内容 / 内容放量.
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Optimize Core Web Vitals (LCP, INP, CLS) for better page experience using field and lab evidence. Use when asked to "improve Core Web Vitals", "fix LCP", "reduce CLS", "optimize INP", "page experience optimization", or "fix layout shifts".
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Run repeated, measured Git experiments toward a numeric target; keep improvements and revert failures. Use for autonomous optimization or managing an autoresearch run, not one-shot edits.
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Auto-activate CCS CLI delegation for deterministic tasks. Parses user input, auto-selects optimal profile (glm/kimi/custom) from ~/.ccs/config.json, enhances prompts with context, executes via `ccs {profile} -p "task"` or `ccs {profile}:continue`, and reports results. Triggers on "use ccs [task]" patterns, typo/test/refactor keywords. Excludes complex architecture, security-critical code, performance optimization, breaking changes.
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Have a fast, conversational analysis with the AWS DevOps Agent. Use for cost optimization, architecture review, topology mapping, knowledge / runbook discovery, security audits, dependency questions, and quick diagnostics — anything that needs a 5-30 second answer rather than a 5-8 minute deep investigation. Trigger words include cost, optimize, review, architecture, topology, what runbooks, show me, compare, audit, what if.
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AWS Startups reference content — Activate FAQ, credits guide, programs, partner offers, sample architectures, and hundreds of learn articles spanning generative AI, cloud architecture, cost optimization, security, fundraising, go-to-market, and real-world startup case studies. Use when the user asks factual questions about AWS Activate (eligibility, credits, programs, providers), wants a sample architecture or solution guide, or needs an AWS-curated learn article on a specific startup topic. For copy-paste AI prompts (RAG chatbot, MVP scaffold, security baseline, GPU quota, etc.), see the prompt-library-for-startups skill. Do not use for: account-specific lookups (credits balance, Activate membership status, application status), real-time event listings beyond the events stub, or content not present in the bundled `references/` tree.
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Launches an EC2 instance with secure, cost-efficient defaults including AMI selection, burstable instance sizing, least-privilege IAM roles, hardened security groups, encrypted EBS volumes, and comprehensive tagging. Use when deploying new EC2 instances following AWS best practices for security and cost optimization.
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Diagnoses and resolves Amazon RDS for Oracle connectivity, authentication, networking, and driver troubleshooting. Applicable to any RDS-for-Oracle question including connecting a Python Lambda to RDS Oracle in a VPC with pooling and cold-start optimization, EKS pods to RDS Oracle via the Secrets Manager CSI driver with IRSA and SecretProviderClass, ORA-12170 cross-VPC timeouts from EC2, DPI-1047 cannot-locate-64-bit-Oracle-Client errors, and Oracle Connection Manager (CMAN) on EC2 as a proxy with HA across two AZs. Covers python-oracledb thin vs thick mode, init_oracle_client, RDS Proxy does NOT support RDS Oracle, port 1521, VPC peering, Transit Gateway, Kerberos with AWS Managed Microsoft AD, SSL/TLS/NNE, SSM port forwarding, EC2/ECS Fargate/EKS/Lambda, SQL Developer/DBeaver/Toad/SQLcl, and Secrets Manager.
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Analyze AWS costs, find savings, manage budgets, evaluate Savings Plans and Reserved Instances, right-size EC2/Lambda/RDS/EBS with Compute Optimizer, look up service pricing, query CUR with Athena, detect cost anomalies, scope costs to billing views, and monitor Free Tier usage. Triggers on: AWS bill, cost analysis, reduce spend, savings plan, reserved instance, right-size, budget alert, cost optimization, pricing, free tier, cost anomaly, CUR, cost audit, billing view, billing view ARN.
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