「acm」の検索結果

Operate ArvanCloud (arvancloud.ir) through its REST APIs, including CDN and DNS records, domains, cache purge, WAF and rate limits, Cloud Server (IaaS v3, v1 and the undocumented v2 backups), Object Storage, Edge Computing, Cloud Container, VOD, Live and Video Ads, plus Let's Encrypt DNS-01 certificates via acme.sh dns_arvan. Use when the user wants to list, create, change or delete anything on ArvanCloud, take an account inventory, find out which account a key belongs to, check quota or usage, or debug an ArvanCloud API error. Also trigger on hosts like napi.arvancloud.ir, ecc.{region}.arvanapis.ir, storage.arvanapis.ir, dejban.arvancloud.ir, an "Apikey" Authorization header, the dns_arvan plugin, or one of the user's ArvanCloud-hosted domains.

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USB and CAN connectivity for Zephyr RTOS. Covers USB device stack configuration (CDC ACM, HID, MSC), CAN controller integration, and professional USB-to-CAN adapter patterns including buffering and protocol packetization. Trigger when adding USB interfaces, implementing CAN bus communication, or building hardware diagnostic tools.

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Personal research-paper radar. Fetches the latest papers and code repos for the user's keyword subscriptions across arXiv, Crossref (IEEE/ACM), Semantic Scholar, GitHub, HuggingFace, Papers with Code and RSS; deduplicates against history; then YOU (the assistant) expand the queries, filter for computer-science relevance, write Chinese summaries, detect hot sub-fields, and emit a Markdown + HTML digest (optionally emailed). Use when the user asks to "run my paper radar / 文献雷达", "check for new papers", "what's new in my topics", "今天有什么新论文 / 最新文献", "today's research digest", or to configure their keyword subscriptions / sources / schedule.

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Apply the Acme house style to any prose - short sentences, no hype, lead with the answer. Shared across agents.

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Queries ClinVar for variant pathogenicity classifications, ClinGen VCEP curations, and somatic-vs-germline interpretations via REST API, weekly VCF, or bulk XML. Use when determining clinical significance, triangulating conflicting interpretations, or aggregating evidence against the ACMG/AMP framework with ClinGen SVI specifications.

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Implements missing-data sensitivity analyses for confirmatory clinical trials including MMRM under MAR (with Kenward-Roger correction), reference-based multiple imputation (J2R, CR, CIR, LMCF per Carpenter-Roger 2013), Permutt delta-adjustment / tipping-point analysis, pattern-mixture identifying restrictions (CCMV, NCMV, ACMV), and the Cro vs Bartlett variance debate. Use when handling missing primary or secondary endpoint data in regulatory submissions following NRC 2010 and ICH E9(R1).

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Queries gnomAD v4 (807k samples), v3, v2.1.1, and constraint metrics with grpmax FAF95, bottleneck-group exclusion, LOEUF interpretation, SV/CNV/mtDNA catalogs, and Whiffin max-credible-AF framework. Use when filtering rare variants, applying ACMG BS1/BA1, ranking genes by LoF intolerance, or selecting between v2 (GRCh37 + chrX/Y constraint) and v4 (GRCh38 + 807k samples).

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Temporal interval algebra for reasoning about time relationships in planning and knowledge representation

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Send a box of Krispy Kreme donuts (doughnuts) to someone by mail, paid with your own credit card via Stripe Link — driven entirely from the terminal. Use when the user wants to send donuts, doughnuts, treats, or a thank-you gift to a lead, prospect, customer, colleague, or friend — e.g. "send donuts to Jane at Acme", "mail a dozen glazed to our new customer", "send a thank-you gift to the team". Orders are placed and shipped through the Zinc API; payment is a Stripe Link Shared Payment Token via the create-payment-credential (link-cli) skill.

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Send a box of Krispy Kreme donuts (doughnuts) to someone by mail, paid with your own credit card via Stripe Link — driven entirely from the terminal. Use when the user wants to send donuts, doughnuts, treats, or a thank-you gift to a lead, prospect, customer, colleague, or friend — e.g. "send donuts to Jane at Acme", "mail a dozen glazed to our new customer", "send a thank-you gift to the team". Orders are placed and shipped through the Zinc API; payment is a Stripe Link Shared Payment Token via the create-payment-credential (link-cli) skill.

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Implements missing-data sensitivity analyses for confirmatory clinical trials including MMRM under MAR (with Kenward-Roger correction), reference-based multiple imputation (J2R, CR, CIR, LMCF per Carpenter-Roger 2013), Permutt delta-adjustment / tipping-point analysis, pattern-mixture identifying restrictions (CCMV, NCMV, ACMV), and the Cro vs Bartlett variance debate. Use when handling missing primary or secondary endpoint data in regulatory submissions following NRC 2010 and ICH E9(R1).

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Chains a somatic (tumor-normal) SNV/indel and structural-variant pipeline end to end with GATK Mutect2 (or Strelka2), wiring the somatic-specific machinery - panel-of-normals and gnomAD germline-resource priors, GetPileupSummaries/CalculateContamination, and LearnReadOrientationModel FFPE/oxoG orientation-bias filtering fed into FilterMutectCalls. Use when calling somatic mutations from a tumor-normal pair (or tumor-only with PoN caveats), deciding which artifact filter removes which class of false positive, reasoning about VAF/purity/ploidy and clonal-vs-subclonal detection, adding somatic SV/CNV or TMB/MSI/signatures, or routing variants to AMP/ASCO/CAP tier and oncogenicity interpretation (never germline ACMG).

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Queries gnomAD v4 (807k samples), v3, v2.1.1, and constraint metrics with grpmax FAF95, bottleneck-group exclusion, LOEUF interpretation, SV/CNV/mtDNA catalogs, and Whiffin max-credible-AF framework. Use when filtering rare variants, applying ACMG BS1/BA1, ranking genes by LoF intolerance, or selecting between v2 (GRCh37 + chrX/Y constraint) and v4 (GRCh38 + 807k samples).

日本語の概要は準備中です。原文の説明を表示しています。

Queries ClinVar for variant pathogenicity classifications, ClinGen VCEP curations, and somatic-vs-germline interpretations via REST API, weekly VCF, or bulk XML. Use when determining clinical significance, triangulating conflicting interpretations, or aggregating evidence against the ACMG/AMP framework with ClinGen SVI specifications.

日本語の概要は準備中です。原文の説明を表示しています。

Implements missing-data sensitivity analyses for confirmatory clinical trials including MMRM under MAR (with Kenward-Roger correction), reference-based multiple imputation (J2R, CR, CIR, LMCF per Carpenter-Roger 2013), Permutt delta-adjustment / tipping-point analysis, pattern-mixture identifying restrictions (CCMV, NCMV, ACMV), and the Cro vs Bartlett variance debate. Use when handling missing primary or secondary endpoint data in regulatory submissions following NRC 2010 and ICH E9(R1).

日本語の概要は準備中です。原文の説明を表示しています。

Predicts whether a DNA variant alters mRNA splicing using sequence-based deep-learning tools — SpliceAI (10kb context dilated CNN, clinical default), Pangolin (multi-tissue), MMSplice (modular per-region CNN with calibrated ΔPSI), SpliceTransformer/TrASPr (tissue-aware transformers), SpliceVault (empirical 300K-RNA lookup of likely mis-splicing outcomes), CADD-Splice (composite score). Applies the ClinGen SVI 2023 framework for ACMG/AMP variant interpretation (PVS1, PP3, BP4 evidence codes), HGVS splicing nomenclature (c.123+1G>A, c.123-3T>G, r.spl?), extended-window scoring for deep-intronic pseudoexons, tissue-specific predictions, branchpoint variant detection (BPHunter, LaBranchoR), and splice-switching ASO design. Use when interpreting splice impact of clinical variants, prioritizing VUS, identifying deep-intronic pathogenic variants, or designing ASOs.

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Retro arcade-inspired design with pixel fonts, dotted borders, playful high-contrast colors, and 8-bit game aesthetics.

日本語の概要は準備中です。原文の説明を表示しています。

Queries ClinVar for variant pathogenicity classifications, ClinGen VCEP curations, and somatic-vs-germline interpretations via REST API, weekly VCF, or bulk XML. Use when determining clinical significance, triangulating conflicting interpretations, or aggregating evidence against the ACMG/AMP framework with ClinGen SVI specifications.

日本語の概要は準備中です。原文の説明を表示しています。

Queries gnomAD v4 (807k samples), v3, v2.1.1, and constraint metrics with grpmax FAF95, bottleneck-group exclusion, LOEUF interpretation, SV/CNV/mtDNA catalogs, and Whiffin max-credible-AF framework. Use when filtering rare variants, applying ACMG BS1/BA1, ranking genes by LoF intolerance, or selecting between v2 (GRCh37 + chrX/Y constraint) and v4 (GRCh38 + 807k samples).

日本語の概要は準備中です。原文の説明を表示しています。

Implements missing-data sensitivity analyses for confirmatory clinical trials including MMRM under MAR (with Kenward-Roger correction), reference-based multiple imputation (J2R, CR, CIR, LMCF per Carpenter-Roger 2013), Permutt delta-adjustment / tipping-point analysis, pattern-mixture identifying restrictions (CCMV, NCMV, ACMV), and the Cro vs Bartlett variance debate. Use when handling missing primary or secondary endpoint data in regulatory submissions following NRC 2010 and ICH E9(R1).

日本語の概要は準備中です。原文の説明を表示しています。

Predicts whether a DNA variant alters mRNA splicing using sequence-based deep-learning tools — SpliceAI (10kb context dilated CNN, clinical default), Pangolin (multi-tissue), MMSplice (modular per-region CNN with calibrated ΔPSI), SpliceTransformer/TrASPr (tissue-aware transformers), SpliceVault (empirical 300K-RNA lookup of likely mis-splicing outcomes), CADD-Splice (composite score). Applies the ClinGen SVI 2023 framework for ACMG/AMP variant interpretation (PVS1, PP3, BP4 evidence codes), HGVS splicing nomenclature (c.123+1G>A, c.123-3T>G, r.spl?), extended-window scoring for deep-intronic pseudoexons, tissue-specific predictions, branchpoint variant detection (BPHunter, LaBranchoR), and splice-switching ASO design. Use when interpreting splice impact of clinical variants, prioritizing VUS, identifying deep-intronic pathogenic variants, or designing ASOs.

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Use when writing CS research papers (conference, journal, thesis), reviewing scientific manuscripts, improving academic writing clarity, or preparing IEEE/ACM submissions. Invoke when user mentions paper, manuscript, research writing, journal submission, or needs help with academic structure, formatting, or revision.

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Comprehensive MCP tool reference for Proxmox Virtual Environment management - 92 tools across 14 domains including QEMU VMs, LXC containers, cluster operations, storage, networking, Ceph, certificates, ACME, and notifications

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Triage and resolve Arch Linux issues with pacman, systemd, and rolling-release best practices.

日本語の概要は準備中です。原文の説明を表示しています。