「ising model」の検索結果

Create pitch decks, one-pagers, memos, financial models, and fundraising materials. Use when the user needs investor-facing docs.

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Write essays, articles, and blog posts in Paul Graham's voice — plain, spoken prose that reasons out loud and lands surprising true claims, not AI filler. Use when asked to write or rewrite something "like Paul Graham", "in PG's style", or to make a piece read like a person thinking on the page rather than generated text. Built from a stylistic model of 18 of his essays (see SOURCES.md).

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Classify the information-need of a query and dispatch it to the appropriate retrieval or reasoning strategy. Use before read-side memory access, before multi-strategy retrieval, or any time you'd otherwise default to "one retriever for everything". Returns a strategy label, a token budget, and a retrieval depth so downstream handlers can be specialised. Backed by Pre-Route (arxiv 2605.10235v2) and MemFlow (arxiv 2605.03312v1), which together show LLMs possess latent routing ability elicitable via a structured prompt — and that externalising the routing decision improves small-model performance by ~2x. Triggers: "route this", "what strategy", "before retrieving", "intent classification", or any query whose ideal handling depends on what KIND of question it is.

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Designs publication tables for social-science manuscripts. Covers whether a result belongs in a table at all, column order, row grouping and panels, decimal precision, standard-error and confidence-interval conventions, self-contained titles and notes, and code-generated output. Use when building or revising a regression, balance, descriptive, or robustness table, or when working with modelsummary, stargazer, gt, esttab, or booktabs. Finished tables go to figure-table-audit for end-stage QA.

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Generates 3-5 conceptually distinct approaches labeled Novel, Surprising, Diverse, or Conventional, and holds for the user's selection before implementing. The --codex mode runs the brainstorm on GPT-6 Astra via codex exec, then has Codex implement the selected approach. Use before committing to an approach when a creative, architectural, or analytical task has more than one non-obvious solution; use --codex when another model family should widen the range.

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Use when developing in packages/agent-core-v2 (the DI × Scope agent engine) — adding or modifying a domain Service, choosing a LifecycleScope, wiring DI dependencies, splitting a domain across scopes, owning or migrating a config section, gating behavior behind an experimental flag, raising coded errors, working on the permission system, writing DI/Scope tests, porting business logic from agent-core (v1) to v2, triaging a main-branch commit against v2, or exposing a v2 domain over server-v2 while keeping the /api/v1 wire contract compatible with released clients. Self-contained guide organized by development stage (orient → design → implement → test → verify) plus align workflows for v1→v2 migration, main-branch commit triage, and server-v2 wire exposure; each file carries the rules, examples, and red lines for its step.

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Creates demand generation campaigns, optimizes paid ad spend across LinkedIn, Google, and Meta, develops SEO strategies, and structures partnership programs for Series A+ startups scaling internationally. Use when planning marketing strategy, growth marketing, advertising campaigns, PPC optimization, lead generation, pipeline generation, or startup marketing budgets. Covers multi-channel acquisition (Google Ads, LinkedIn Ads, Meta Ads), CAC analysis, MQL/SQL workflows, attribution modeling, technical SEO, and co-marketing partnerships for hybrid PLG/Sales-Led motions in EU/US/Canada markets.

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Configure and manage NPSP Enhanced Recurring Donations (ERD): enable ERD mode, define schedule objects, configure installment behavior, set status automation thresholds, and interpret the Upcoming Installments UI. NOT for NPSP object and field reference — use data/npsp-data-model. NOT for payment gateways — use architect/fundraising-integration-patterns.

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Use this skill when adding external users to an Experience Cloud site, configuring self-registration, managing external user licenses, or customising the login and registration pages. Trigger keywords: add members to community, external user license, self-registration, customer portal login, partner user onboarding, ConfigurableSelfRegHandler. NOT for choosing which external user license to buy — use architect/experience-cloud-licensing-model. Also covers the networkMemberGroups membership block, NetworkMemberGroup assignment status, external-user creation from contacts, offboarding, and LoginHistory diagnosis for site logins. NOT for what records external users can see — use security/experience-cloud-security.

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Generate professional advertising images from product URLs using the Ad-Ready pipeline on ComfyDeploy. Use when the user wants to create ads for any product by providing a URL, optionally with a brand profile (70+ brands) and funnel stage targeting. Supports model/talent integration, brand-aware creative direction, and multi-format output. Differs from Morpheus (manual fashion photography) — Ad-Ready is URL-driven, brand-intelligent, and funnel-stage aware.

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Normalize read-depth copy-ratio profiles and segment them into copy-number regions using circular binary segmentation (CBS, DNAcopy), hidden Markov models, HaarSeg, and fused-lasso methods. Covers GC-content, mappability, and replication-timing (wave-artifact) bias correction, panel-of-normals/PCA denoising, diploid-baseline centering, and algorithm selection by sequencing depth and event size. Use when choosing a segmentation algorithm, correcting depth bias, diagnosing oversegmentation or a mis-centered baseline, tuning CBS or HMM parameters, or understanding why a downstream CNV caller produced fragmented or shifted segments.

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Performs gene-level association from GWAS summary statistics via genetically predicted tissue expression using FUSION, PrediXcan, S-PrediXcan, S-MultiXcan, UTMOST, MOSTWAS, kTWAS, EpiXcan, TIGAR-V2, and probabilistic fine-mapping with FOCUS and MA-FOCUS. Use when running TWAS from GWAS sumstats, prioritising candidate causal genes from a GWAS lead locus, picking single-tissue vs cross-tissue models, identifying LD-induced TWAS false positives, choosing ancestry-matched prediction weights, fine-mapping co-regulated TWAS hits, or triangulating TWAS with cis-eQTL Mendelian randomization and colocalization to nominate a causal gene.

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Kelly's market-intelligence desk (Busabase App-in-Skill). Merges passive competitor monitoring (Radar), agent-run deep research with approved briefs and cited reports (Research), and keyword/topic demand signals (Trends) over one Busabase-backed snapshot, watchlist, and review model. Use when the user invokes $kelly-radar or /kelly-radar, or asks for competitor monitoring, market intelligence, market research, research reports, trends, rising keywords, pricing changes, product launches, changelog diffs, competitor reviews, funding or hiring news, or opportunity triage.

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Normalize read-depth copy-ratio profiles and segment them into copy-number regions using circular binary segmentation (CBS, DNAcopy), hidden Markov models, HaarSeg, and fused-lasso methods. Covers GC-content, mappability, and replication-timing (wave-artifact) bias correction, panel-of-normals/PCA denoising, diploid-baseline centering, and algorithm selection by sequencing depth and event size. Use when choosing a segmentation algorithm, correcting depth bias, diagnosing oversegmentation or a mis-centered baseline, tuning CBS or HMM parameters, or understanding why a downstream CNV caller produced fragmented or shifted segments.

日本語の概要は準備中です。原文の説明を表示しています。

Performs gene-level association from GWAS summary statistics via genetically predicted tissue expression using FUSION, PrediXcan, S-PrediXcan, S-MultiXcan, UTMOST, MOSTWAS, kTWAS, EpiXcan, TIGAR-V2, and probabilistic fine-mapping with FOCUS and MA-FOCUS. Use when running TWAS from GWAS sumstats, prioritising candidate causal genes from a GWAS lead locus, picking single-tissue vs cross-tissue models, identifying LD-induced TWAS false positives, choosing ancestry-matched prediction weights, fine-mapping co-regulated TWAS hits, or triangulating TWAS with cis-eQTL Mendelian randomization and colocalization to nominate a causal gene.

日本語の概要は準備中です。原文の説明を表示しています。

Detects aberrant splicing in single rare-disease patients vs a control panel using FRASER 2.0 (Bioconductor; Beta-binomial autoencoder on Intron Jaccard Index, default delta cutoff 0.1, q hyperparameter), OUTRIDER (gene-level outlier expression via autoencoder denoising), LeafcutterMD (Dirichlet-multinomial outlier mode of LeafCutter for annotation-free junctions), and DROP (Snakemake pipeline integrating FRASER2 + OUTRIDER + monoallelic expression for clinical diagnostics). The statistical model is fundamentally different from differential splicing — single-sample-vs-cohort outlier detection rather than two-group comparison. Standard tool in EU rare-disease (Solve-RD) and NIH UDN programs. Use when applying RNA-seq to undiagnosed Mendelian disease, validating predicted splice variants in clinical samples, or detecting cryptic splicing in disease tissue.

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Think through the consequences of consequences — not just what happens immediately, but what happens next, and next after that, across time. Load when a decision looks obviously good or obviously bad on initial read, when the user is optimising for a short-term outcome that might create a long-term problem, when unintended consequences are a concern, or when deep-thinking diagnoses a second-order frame. Triggers on "what are the downstream effects", "what happens after that", "unintended consequences", "think ahead on this", "long-term vs short-term", or "what comes after that". Based on Howard Marks second-level thinking and Farnam Street mental models. Most powerful for decisions with delayed consequences or systemic effects.

日本語の概要は準備中です。原文の説明を表示しています。

Normalize read-depth copy-ratio profiles and segment them into copy-number regions using circular binary segmentation (CBS, DNAcopy), hidden Markov models, HaarSeg, and fused-lasso methods. Covers GC-content, mappability, and replication-timing (wave-artifact) bias correction, panel-of-normals/PCA denoising, diploid-baseline centering, and algorithm selection by sequencing depth and event size. Use when choosing a segmentation algorithm, correcting depth bias, diagnosing oversegmentation or a mis-centered baseline, tuning CBS or HMM parameters, or understanding why a downstream CNV caller produced fragmented or shifted segments.

日本語の概要は準備中です。原文の説明を表示しています。

Performs gene-level association from GWAS summary statistics via genetically predicted tissue expression using FUSION, PrediXcan, S-PrediXcan, S-MultiXcan, UTMOST, MOSTWAS, kTWAS, EpiXcan, TIGAR-V2, and probabilistic fine-mapping with FOCUS and MA-FOCUS. Use when running TWAS from GWAS sumstats, prioritising candidate causal genes from a GWAS lead locus, picking single-tissue vs cross-tissue models, identifying LD-induced TWAS false positives, choosing ancestry-matched prediction weights, fine-mapping co-regulated TWAS hits, or triangulating TWAS with cis-eQTL Mendelian randomization and colocalization to nominate a causal gene.

日本語の概要は準備中です。原文の説明を表示しています。

Detects aberrant splicing in single rare-disease patients vs a control panel using FRASER 2.0 (Bioconductor; Beta-binomial autoencoder on Intron Jaccard Index, default delta cutoff 0.1, q hyperparameter), OUTRIDER (gene-level outlier expression via autoencoder denoising), LeafcutterMD (Dirichlet-multinomial outlier mode of LeafCutter for annotation-free junctions), and DROP (Snakemake pipeline integrating FRASER2 + OUTRIDER + monoallelic expression for clinical diagnostics). The statistical model is fundamentally different from differential splicing — single-sample-vs-cohort outlier detection rather than two-group comparison. Standard tool in EU rare-disease (Solve-RD) and NIH UDN programs. Use when applying RNA-seq to undiagnosed Mendelian disease, validating predicted splice variants in clinical samples, or detecting cryptic splicing in disease tissue.

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Reimagine UI posture — bold from-scratch reinvention of a screen. Use when asked to rethink or reinvent a UI, merge screens, change its core interaction model, break the frame rather than polish, or generate surprising new concepts.

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Model cap tables, dilution scenarios, and vesting schedules for startups. Use when planning fundraising, pricing options, or tracking equity.

日本語の概要は準備中です。原文の説明を表示しています。