「quant」の検索結果

Prepares bulk RNA-seq FASTQ, Salmon, STAR or featureCounts output for gene-level differential expression. Covers nf-core/rnaseq and standalone quantification, biological replication, strandedness, reference provenance, validated count assembly and a PyDESeq2 handoff. Use for FASTQ-to-counts analysis, nf-core/rnaseq configuration, STAR/Salmon quantification, or building a counts matrix for DESeq2. For single-cell data use scanpy; for statistical fitting alone use pydeseq2.

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Develop AxonX research plugins and operate quantitative research tasks through CLI or MCP, inspecting execution status, logs, artifacts, and lineage.

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Export a promoted fine-tuned model in the right deployment format — merged safetensors, LoRA-only, GGUF with imatrix, or FP8. Use after a checkpoint passes promotion, when choosing a quantization format for a target device, or when an exported model fails its smoke test.

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Use when quantizing a diffusion DiT with NVIDIA ModelOpt and making the resulting FP8 or NVFP4 checkpoint loadable, verifiable, and benchmarkable in SGLang Diffusion.

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Workflow for upgrading/integrating cache-dit in SGLang diffusion (multimodal_gen): DBCache, DMD calibrator, TaylorSeer, SVDQuant DQ; porting upstream PRs and resolving conflicts against the per-request knob system; adding new cache knobs; building the sglang generate CLI test matrix; precision validation (PSNR / log evidence); troubleshooting environment issues (wheel ABI, svdq extension, flashinfer conflicts). Use when upgrading or integrating cache-dit in sglang diffusion, porting cache-dit PRs with conflicts, adding cache knobs, running the sglang generate CLI test matrix, or validating precision (PSNR) for DBCache/DMD/SVDQuant(DQ) paths.

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Quantitative statistical methods: ADF unit-root / cointegration tests, GARCH volatility modeling, regression diagnostics (heteroskedasticity / autocorrelation), Bootstrap, and hypothesis testing.

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Find opportunities to add metrics and estimate numbers when exact data is unavailable. Use when the user wants to quantify achievements, add numbers, percentages, or impact metrics to a resume.

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Serves LLMs with high throughput using vLLM's PagedAttention and continuous batching. Use when deploying production LLM APIs, optimizing inference latency/throughput, or serving models with limited GPU memory. Supports OpenAI-compatible endpoints, quantization (GPTQ/AWQ/FP8), and tensor parallelism.

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Runs LLM inference on CPU, Apple Silicon, and consumer GPUs without NVIDIA hardware. Use for edge deployment, M1/M2/M3 Macs, AMD/Intel GPUs, or when CUDA is unavailable. Supports GGUF quantization (1.5-8 bit) for reduced memory and 4-10× speedup vs PyTorch on CPU.

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Serves LLMs with high throughput using vLLM's PagedAttention and continuous batching. Use when deploying production LLM APIs, optimizing inference latency/throughput, or serving models with limited GPU memory. Supports OpenAI-compatible endpoints, quantization (GPTQ/AWQ/FP8), and tensor parallelism.

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Runs LLM inference on CPU, Apple Silicon, and consumer GPUs without NVIDIA hardware. Use for edge deployment, M1/M2/M3 Macs, AMD/Intel GPUs, or when CUDA is unavailable. Supports GGUF quantization (1.5-8 bit) for reduced memory and 4-10× speedup vs PyTorch on CPU.

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Cloud-based quantum chemistry platform with Python API. Preferred for computational chemistry workflows including pKa prediction, geometry optimization, conformer searching, molecular property calculations, protein-ligand docking (AutoDock Vina), and AI protein cofolding (Chai-1, Boltz-1/2). Use when tasks involve quantum chemistry calculations, molecular property prediction, DFT or semiempirical methods, neural network potentials (AIMNet2), protein-ligand binding predictions, or automated computational chemistry pipelines. Provides cloud compute resources with no local setup required.

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Use when porting circuits from another framework (e.g. Qiskit) into CUDA-Q kernels while preserving the source algorithm and validation fidelity.

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Use for CUDA-Q setup, simulation targets, QPU access, and @cudaq.kernel authoring guidance.

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Protein quantification from mass spectrometry data including label-free (LFQ, intensity-based), isobaric labeling (TMT, iTRAQ), and metabolic labeling (SILAC) approaches. Use when extracting protein abundances from MS data for differential analysis.

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Load and parse mass spectrometry data formats including mzML, mzXML, and quantification tool outputs like MaxQuant proteinGroups.txt. Use when starting a proteomics analysis with raw or processed MS data. Handles contaminant filtering and missing value assessment.

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Targeted metabolomics analysis using MRM/SRM with standard curves. Covers absolute quantification, method validation, and quality assessment. Use when quantifying specific metabolites using calibration curves and internal standards.

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Use when evaluating Jim Simons / Renaissance-style quantitative strategies: many weak signals, statistical validation, signal decay, portfolio construction, execution cost, and model risk.

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Use this skill for setting up vector similarity search with pgvector for AI/ML embeddings, RAG applications, or semantic search. **Trigger when user asks to:** - Store or search vector embeddings in PostgreSQL - Set up semantic search, similarity search, or nearest neighbor search - Create HNSW or IVFFlat indexes for vectors - Implement RAG (Retrieval Augmented Generation) with PostgreSQL - Optimize pgvector performance, recall, or memory usage - Use binary quantization for large vector datasets **Keywords:** pgvector, embeddings, semantic search, vector similarity, HNSW, IVFFlat, halfvec, cosine distance, nearest neighbor, RAG, LLM, AI search Covers: halfvec storage, HNSW index configuration (m, ef_construction, ef_search), quantization strategies, filtered search, bulk loading, and performance tuning.

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Build financial models, backtest trading strategies, and analyze market data. Implements risk metrics, portfolio optimization, and statistical arbitrage. Use PROACTIVELY for quantitative finance, trading algorithms, or risk analysis.

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End-to-end user research assistant — qualitative and quantitative. Use this skill whenever the user mentions user research, user interviews, discussion guides, interview guides, research plans, qualitative research, quantitative research, user surveys, survey design, usability studies, participant recruitment, research synthesis, interview transcripts, research reports, running studies with AI, or explicitly mentions Cookiy AI. Also trigger when users want to talk to customers, conduct discovery research, create a study or survey, analyze interview data, run AI-moderated interviews, or collect survey responses. Covers the full lifecycle: planning studies, creating discussion guides, running AI-moderated interviews (real or synthetic) via Cookiy, designing and distributing surveys, and synthesizing results into reports.

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Use when targeting Earth and Planetary Science Letters (EPSL) or deciding whether a quantitative solid-earth or planetary-science manuscript fits this venue. Encodes the journal's broad-interest process-science fit, the quantitative geochemistry/geophysics evidence bar, Elsevier house style, official-submission re-check, and desk-reject heuristics.

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Estimates tumor fraction (the genome-wide proportion of cfDNA molecules that are tumor-derived, the cfDNA analogue of bulk-tumor purity) from shallow whole-genome sequencing with ichorCNA, an HMM over 1 Mb bins that jointly EM-estimates tumor fraction, ploidy, and subclonal prevalence over a normal/ploidy grid. Encodes the load-bearing reframes: tumor fraction is the quantity that travels across assays and is NOT mutation VAF (clonal-het VAF approximately TF/2), CNA-based estimation has a hard ~3 percent limit-of-detection floor, and near-diploid or copy-neutral-LOH genomes return a falsely low value. Selects the estimator by data type (sWGS to ichorCNA, deep panel to max-VAF, methylation to deconvolution, sub-3 percent to fragmentomics or methylation). Use when quantifying tumor burden from a liquid biopsy, picking a tumor-fraction estimator for a given assay, or reconciling a TF estimate against a panel VAF.

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Bead-based signal normalization and cross-batch harmonization for CyTOF and high-parameter cytometry - EQ four-element bead normalization of instrument sensitivity drift (CATALYST normCytof, premessa), and reference-anchor cross-batch normalization (CytoNorm, per-cluster quantile splines). Covers the distinction between within-run drift correction and between-batch correction, the mandatory anchor/reference sample, why normalization is per-cluster with many quantiles, and the over-correction risk. Use when correcting CyTOF signal drift, harmonizing multi-batch or multi-site studies, or deciding whether to normalize data versus model batch in the design.

日本語の概要は準備中です。原文の説明を表示しています。