「rizin」の検索結果

Extracts and assigns COSMIC v3.4 mutational signatures (86 SBS / 11 DBS / 18 ID / 21 CN / 16 SV) from somatic VCFs using SigProfilerSuite, MutationalPatterns, MuSiCal mvNMF, SigNet, or HRDetect. Use when characterizing DNA-damage etiology (BRCA1/2 HRD, MMR-D, POLE, APOBEC3A, UV, tobacco, aflatoxin, 5-FU/SBS17b, platinum, colibactin SBS88), routing PARP inhibitor decisions, or auditing de novo extraction vs refit choice for cohort size.

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Calculates molecular fingerprints (ECFP/Morgan, FCFP, MACCS, RDKit, AtomPair, TopologicalTorsion, Avalon, MAP4, MHFP6) and physicochemical descriptors (Lipinski, QED, TPSA, Crippen LogP, 3D shape) with explicit choice tables, bit vs count semantics, and partial-charge model selection. Use when featurizing molecules for similarity, QSAR, virtual screening, or ML, or selecting the correct fingerprint for a chemotype-aware task.

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Detects allele-specific transcription factor or histone modification binding from heterozygous-variant ChIP-seq using WASP (reference-bias filter; mandatory upstream), RASQUAL (joint QTL + bias-corrected testing), BaalChIP (Bayesian beta-binomial with copy-number-aware overdispersion), and AlleleSeq (personalized diploid genome). Handles imprinted-locus awareness, X-inactivation artifacts, cancer copy-number imbalance, and integration with downstream caQTL / bQTL mapping. Use when identifying variants with allelic effects on TF binding, fine-mapping causal regulatory variants, validating deep-learning variant predictions, or characterizing cis-acting regulatory effects.

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Segments the genome into chromatin states from combinatorial histone modification and chromatin factor ChIP-seq data. Uses ChromHMM (multivariate HMM on binarized signal, v1.27), Segway (Dynamic Bayesian Network on continuous signal), EpiSegMix (flexible-distribution HMM with duration modeling, 2024), EpiLogos (multi-biosample visualization), IDEAS (cell-type-aware joint), and full-stack ChromHMM (Vu Ernst 2022) for cross-cell-type segmentations. Handles state-count selection (15 vs 18 vs 25 states), binarization choice, OverlapEnrichment / NeighborhoodEnrichment downstream analysis, and cross-biosample integration. Use when learning chromatin states from a histone mark panel, characterizing learned states by genomic feature enrichment, or comparing chromatin landscapes across cell types.

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Map nucleosome center positions, occupancy, and fuzziness from ATAC-seq fragment-size patterns using NucleoATAC, ATACseqQC, DANPOS3, or scprinter. Use when characterizing nucleosome organization at promoters and enhancers, calling +1/-1 nucleosomes flanking NFRs, generating V-plots for chromatin structure visualization, or comparing nucleosome positioning between conditions.

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Generate and structure MATLAB unit tests using matlab.unittest and matlab.uitest features, including class-based tests, parameterized testing, fixtures, mocking, and app testing with gestures. Use when writing, generating, or adding tests, creating test classes, adding test methods, parameterizing tests, setting up fixtures, mocking dependencies, or testing App Designer apps. Do NOT use for running tests, collecting coverage, or CI/CD configuration.

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Automatically creates user-facing changelogs from git commits by analyzing commit history, categorizing changes, and transforming technical commits into clear, customer-friendly release notes. Turns hours of manual changelog writing into minutes of automated generation.

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Walk a Claude Code session transcript turn-by-turn from Agent Monitor data, summarizing each user, assistant, and tool message in order so a long conversation can be reviewed quickly. Anchors the recap to the session header (model, cost, turn_count). Use when reviewing what was actually said and done in a conversation.

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Roll up Claude Code sessions by working directory (project) from Agent Monitor data — session count, total cost, total tokens, and last-active timestamp per cwd — so per-project activity can be compared at a glance. Use when summarizing where effort and spend went across projects.

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Generate a comprehensive session report with per-model token usage (input, output, cache_read, cache_write including compaction baselines), cost breakdown via the pricing engine, tool invocations, agent hierarchy, compaction events, API errors, turn durations, and thinking block counts. Use when reviewing a specific session or summarizing activity over a date range.

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Route any website you need to visit through markdown.new by prefixing the URL. **WHEN TO USE:** - You would normally open a website link to read content (docs, blog posts, changelogs, GitHub issues, etc.) - You need a cleaner, Markdown-friendly view for copying notes or summarizing

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Integrates Power Pages generative-AI summarization APIs (PREVIEW) into a Single Page Application (SPA) site — the Search Summary API and the Data Summarization API — on any record-detail or list page. Generates per-target service code (CSRF-handled) and AI site settings; delegates Web API settings, table permissions, and web roles to `/integrate-webapi` and `/create-webroles`. Use whenever a user wants AI/Copilot output that condenses Dataverse content on a Power Pages site — an AI summary, AI-generated overview or "key insights" across a record or list, a search-results summary, a case/incident summary, or recommendation-chip refinement — even when phrased as "AI-generated paragraph", "insights", or "overview". Do NOT use for: generative pages in model-driven apps (use the model-apps `genpage` skill), Copilot Studio agents/chatbots, summarizing documents or PDFs, Power BI dashboards, plain keyword search with no AI summary, or plain Dataverse CRUD (use `/integrate-webapi`).

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DevOps for CI/CD, containers, Kubernetes, and Terraform. Use when building pipelines, containerizing apps, managing clusters, provisioning cloud infra, deploying with blue- green/canary, or handling infrastructure incidents.

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Use this skill whenever a lawyer or mediator needs help analyzing a dispute for mediation purposes. This includes: reviewing case materials (pleadings, contracts, correspondence, evidence) to identify issues in dispute, summarizing each party's position and interests, conducting legal analysis of the key issues, proposing mediation strategies or settlement directions, and preparing for mediation sessions. Trigger this skill when the user mentions 'mediation', 'dispute analysis', 'settlement', 'dispute resolution', 'identify issues in dispute', 'party positions', 'mediation brief', 'case analysis for mediation', 'ADR', 'mediation preparation', 'caucus strategy', 'settlement options', or any request to analyze a conflict between two or more parties with the goal of finding resolution. Also trigger when the user uploads case files and asks for a structured breakdown of who wants what, what the core disagreements are, or how the case might settle. Even if the user doesn't explicitly say 'mediation', trigger when the context involves analyzing opposing positions in a dispute with a resolution-oriented (rather than litigation-oriented) goal.

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This tool fetches microarray data directly from GEO database, based on the GEOQuery R package. Given a GSE accession ID, it returns an Rdata object containing the data and a text file (.cond file) summarizing the conditions of the experimen

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Use this skill when the user wants an evidence-based research memo, literature review, market/policy/technical landscape, or a multi-source decision brief with citations, trade-offs, and a clear conclusion. Best for tasks that need synthesis across multiple external sources, iterative follow-up research, or a reusable written artifact. Do not use for quick factual lookups, single-source summaries, simple Q&A, summarizing one document the user already provided, plan-only requests where the user explicitly defers the actual research, or when the user wants a short answer with no need for cited evidence (a short but evidence-backed conclusion is still a brief memo, which this skill covers). Chinese trigger examples: "帮我调研", "深度研究", "综述报告", "技术选型分析", "竞品研究", "政策分析".

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Writing optimized, secure, multi-stage Dockerfiles with language-specific patterns (Python, Node.js, Go, Rust), BuildKit features, and distroless images. Use when containerizing applications, optimizing existing Dockerfiles, or reducing image sizes.

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Classifies existing tests by standard traits and reports their distribution. USE FOR: tagging all tests with category attributes, categorizing/tagging/ labeling each test, compare happy vs error paths, audit the test mix, describe coverage shape by test type, or tag then verify the project builds. Read bodies when names mislead. Apply canonical attributes; otherwise report only. DO NOT USE FOR: requests owned by test-anti-patterns, coverage-analysis, crap-score, test-gap-analysis, code-testing, or migration skills.

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Design, implement, optimize, and review SIMD code in .NET. USE FOR: vectorizing scalar loops with TensorPrimitives, Vector64/128/256/512, or platform hardware intrinsics; reviewing existing SIMD code, including the generic Vector type, for contract equivalence, tail handling, memory safety, portability, fallbacks, and measured performance. DO NOT USE FOR: performance work unrelated to SIMD or vectorization.

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Compare independent opinions from several models or contexts without inflating agreement. Use when: wanting a second opinion or debate, or summarizing several reviewers' results.

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Organize, categorize, track, and manage invoices systematically with automated extraction of invoice data, payment tracking, and financial organization. Use when processing invoice uploads, extracting invoice details (date, amount, vendor), categorizing expenses, tracking payment status, organizing receipts, generating financial reports, or building accounting and bookkeeping systems.

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Automatically creates user-facing changelogs from git commits by analyzing commit history, categorizing changes, and transforming technical commits into clear, customer-friendly release notes. Turns hours of manual changelog writing into minutes of automated generation.

日本語の概要は準備中です。原文の説明を表示しています。

Best practices for Docker-based ROS2 development including multi-stage Dockerfiles, docker-compose for multi-container robotic systems, DDS discovery across containers, GPU passthrough for perception, and dev-vs-deploy container patterns. Use this skill when containerizing ROS2 workspaces, setting up docker-compose for robot software stacks, debugging DDS communication between containers, configuring NVIDIA Container Toolkit for GPU workloads, forwarding X11/Wayland for rviz2 and GUI tools, or managing USB device passthrough for cameras and serial devices. Trigger whenever the user mentions Docker with ROS2, docker-compose for robots, Dockerfile for colcon workspaces, container networking for DDS, devcontainer for ROS2, multi-stage builds for ROS2, or deploying ROS2 in containers. Also trigger for CI/CD with Docker-based ROS2 builds, CycloneDDS or FastDDS configuration in containers, or shared memory in Docker. Covers Humble, Jazzy, and Rolling distributions across Ubuntu 22.04 and 24.04 base images.

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Use when processing, summarizing, or extracting insights from meeting notes in the Obsidian vault. Triggers on "summarize meetings", "process meetings", "meeting summaries", "extract from meetings", "meeting insights".

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