「signatures」の検索結果

Core building blocks of Suricata signatures and multi-condition DPI logic

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Expert C4 Code-level documentation specialist. Analyzes code directories to create comprehensive C4 code-level documentation including function signatures, arguments, dependencies, and code structure. Use when documenting code at the lowest C4 level for individual directories and code modules.

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Sketch types, signatures, and module structure before code, then stay in the loop while implementation fills in. Use for /architect, 'architect this', 'design this', or non-trivial work where jumping to code would lock in the wrong shape.

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Lookup documented AKS fixes only when the prompt includes an exact catalog signature and all of its qualifiers: VMCannotFitEphemeralOSDisk; NodePoolMcVersionIncompatible; 'NodeImageVersion is not accepted'; AKS SkuNotAvailable with size, location, and zone; ZonalAllocationFailed with insufficient zone capacity; OverconstrainedAllocationRequest with listed constraints; nested AKS vmssCSE/CSE VMExtensionError_OutboundConnFail, VMExtensionError_K8SAPIServerConnFail, or VMExtensionError_K8SAPIServerDNSLookupFail; or AllocationFailed with the full cataloged internal-error or insufficient-regional-capacity message. Never use for quota errors, code-only or bare wrappers, generic symptoms, incomplete signatures, or failures outside AKS; use aks-troubleshooting or azure-diagnostics.

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Write idiomatic GDScript for Godot 4.7: static typing, the node lifecycle (_ready/_process/_physics_process), @export/@onready/@tool annotations, signals, and await for asynchronous flow. Use when editing .gd scripts in a Godot project (project.godot), writing or debugging GDScript, or porting 3.x GDScript to 4.x (function signatures, yield to await, export to @export).

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Assigns GO terms, Pfam/InterPro domains, KEGG orthologs, EC numbers, and product names to predicted proteins using eggNOG-mapper (orthology), InterProScan (domain signatures), and KofamScan (KEGG), routing specialized functions to dbCAN/antiSMASH/AMRFinderPlus/SignalP. Covers the orthology-vs-domain-vs-homology paradigms, the annotation-error percolation cascade, domain-presence-is-not-function, GO IEA circularity in enrichment, evidence tiering, and bit-score/coverage thresholds. Use when adding functional annotation to predicted genes, choosing between eggNOG-mapper and InterProScan, or judging how much to trust a functional label.

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Quality control for pooled CRISPR screens covering library representation, Gini index, log-skew, replicate Pearson and Spearman concordance, essentialome precision-recall AUC against CEGv2 (Hart 2017), Cas9 cut-toxicity diagnostics, copy-number amplicon detection (Aguirre 2016 / Munoz 2016), bottleneck propagation through plasmid pool, infection, selection, and endpoint stages, MOI verification, and DepMap-style screen-quality scoring. Use when assessing screen quality before hit calling, deciding whether to repeat or rescue a screen, diagnosing low-confidence hits, choosing between MAGeCK / BAGEL2 / Chronos based on quality grade, picking a normalization strategy from QC signatures, or evaluating whether an in-vivo screen retained adequate library complexity.

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Analyzes pooled CRISPR screens with MAGeCK (Li et al 2014), covering count generation (mageck count), the RRA two-condition workflow (mageck test using alpha-RRA over per-sgRNA negative-binomial p-values), the MLE multi-condition workflow (mageck mle with explicit design matrix and beta-score output), normalization choice (median vs total vs control-sgRNA vs spike-in), sgRNA efficiency injection, paired-sample testing, time-course design, drug-screen versus dropout-screen design matrices, MAGeCKFlute and MAGeCK-VISPR downstream visualization, and decision logic for when to use MAGeCK vs JACKS / BAGEL2 / drugZ / Chronos. Use when running a fresh CRISPR screen analysis, picking RRA vs MLE for the experimental design, choosing a normalization method from QC signatures, debugging MLE convergence failure or NaN beta scores, comparing MAGeCK output across tools, or building a batch-aware multi-cell-line / multi-condition MLE design matrix.

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Calls microsatellite instability from WES/WGS/targeted-panel with MSIsensor, MSIsensor-pro, MSIsensor-ct (panel-aware), mSINGS, and MANTIS for FDA pembrolizumab MSI-H pan-tumor / Lynch syndrome / dMMR ICI biomarker. Use when stratifying ICI eligibility (Le 2015), pairing MSI with TMB-H (Sha 2020 / Salem 2018), screening Lynch syndrome (universal IHC + MSI), or distinguishing MSI-H tumors from POLE-exo hypermutator with overlapping signatures.

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Analyzes CUT&RUN (Skene Henikoff 2017) and CUT&Tag (Kaya-Okur 2019) chromatin profiling data. Handles SEACR vs MACS2 peak calling (with the btaf375 2025 benchmark guidance), pA-MNase vs pA-Tn5 vs pAG-Tn5 chimera differences, E. coli spike-in carryover normalization, IgG-only control logic (no input), characteristic fragment-size signatures (25-75 bp for CUT&Tag), and lower depth requirements (5M reads typical vs 25M for ChIP). Use when calling peaks from CUT&RUN/CUT&Tag, scaling by E. coli spike-in carryover, choosing SEACR norm mode, or comparing CUT&RUN/Tag results to traditional ChIP.

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Looks up current LiveKit facts (API signatures, CLI flags, config options, model and provider support, SDK changelogs, pricing) from the docs instead of answering from memory. Use whenever a question touches LiveKit specifics: "does LiveKit support X", "what changed in agents 1.8", "what are the arguments to Y", "how much does LiveKit cost", "find an example of Z in the LiveKit repos", or before writing any LiveKit code. Other LiveKit skills load this one first. Covers the LiveKit Docs MCP server and the `lk docs` CLI.

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Translate NI-DAQmx C function signatures into correct calldaqlib MATLAB calls. Use when the user mentions calldaqlib, any DAQmx* C function name (DAQmxCfgSampClkTiming, DAQmxExportSignal, DAQmxSetStartTrigRetriggerable, DAQmxGetSampClkRate, etc.), or needs NI-DAQmx functionality not exposed by the daq object. Covers: projection rules (taskHandle implicit, output pointers become return values, buffer-size args, enum-as-string), multi-task semantics, start() clobber, device-level empty-daq workaround, dictionary returns, string getter placeholder, array getter placeholder. Trigger contexts: low-level DAQ, escape hatch, retriggerable acquisition, shared timebase, export signal, connect terminals, external sample clock, trigger configuration, NI driver, C function translation.

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Use when writing MATLAB functions with arguments blocks — repeating arguments (arguments (Repeating)), .?ClassName property import in constructors, name-value forwarding with namedargs2cell, or migrating from inputParser or validateattributes. Also when reviewing signatures for implicit-conversion pitfalls (size reshaping, class coercion, computed defaults), or when restricting, constraining, or validating function inputs — scalar vs vector enforcement, type rejection, size checking. Also when asked to harden inputs, make a function more robust, tighten input checking, or rewrite for safer input acceptance — even without "validation" or "arguments block" wording. Triggers on: arguments block, mustBe validators, name-value arguments, varargin, inputParser, nargin/narginchk, restrict input, type checking, scalar constraint, harden inputs, defensive programming. Not for: App Designer callbacks, Simulink mask parameters, class inheritance, or runtime validation outside function or property declarations.

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Document control for medical device QMS, covering numbering, version control, change management, and 21 CFR Part 11 compliance. Use for document control procedures, change control workflows, and electronic signature compliance.

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mastR is an R package designed for automated screening of signatures of interest for specific research questions. The package is developed for generating refined lists of signature genes from multiple group comparisons based on the results from edgeR and limma differential expression (DE) analysis workflow. It also takes into account the background noise of tissue-specificity, which is often ignored by other marker generation tools. This package is particularly useful for the identification of g

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AUCell allows to identify cells with active gene sets (e.g. signatures, gene modules...) in single-cell RNA-seq data. AUCell uses the "Area Under the Curve" (AUC) to calculate whether a critical subset of the input gene set is enriched with

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Retrieves up-to-date documentation, API references, and code examples for any developer technology. Use this skill whenever the user asks about a specific library, framework, SDK, CLI tool, or cloud service — even for well-known ones like React, Next.js, Prisma, Express, Tailwind, Django, or Spring Boot. Your training data may not reflect recent API changes or version updates. Always use for: API syntax questions, configuration options, version migration issues, "how do I" questions mentioning a library name, debugging that involves library-specific behavior, setup instructions, and CLI tool usage. Use even when you think you know the answer — do not rely on training data for API details, signatures, or configuration options as they are frequently outdated. Always verify against current docs. Prefer this over web search for library documentation and API details.

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ALWAYS USE when asked to migrate, replace, or make testable existing C# static calls with a named wrapper or built-in abstraction: DateTime.UtcNow/Now or DateTimeOffset.UtcNow to TimeProvider/IClock, File.* to IFileSystem or an existing store such as ITextFileStore, and Environment.* to an existing reader such as IEnvironmentReader. Covers scoped files/projects, constructor injection, replacing temp-file or process-environment tests with fakes, "already registered" abstractions, and static classes whose callers/signatures must stay unchanged. Preserves DateTimeKind and call count. DO NOT USE for finding statics (detect-static-dependencies), choosing/designing a new wrapper (generate-testability-wrappers), behavior tests with no chosen seam (testability-obstacle), or test-framework migration.

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Correctly call native (C/C++) libraries from .NET using P/Invoke and LibraryImport. Covers function signatures, string marshalling, memory lifetime, SafeHandle, and cross-platform patterns. USE FOR: writing new P/Invoke or LibraryImport declarations, reviewing or debugging existing native interop code, wrapping a C or C++ library for use in .NET, diagnosing crashes, memory leaks, or corruption at the managed/native boundary. DO NOT USE FOR: COM interop, C++/CLI mixed-mode assemblies, or pure managed code with no native dependencies.

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Symbol-level code context for LLM coder-agents: tree-sitter extracts symbols, PageRank ranks them over the cross-file reference graph, and the top class/function signatures are fed to the LLM as a token-budgeted read-only map (not RAG, no vector index, human-auditable). Use when an agent must locate the right files in a large/multi-file repo, when builds/refreshes/scopes a repo-map, or when "model edits the wrong file" needs fixing.

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Operating SOP for DSPy (Stanford NLP) — the declarative framework for "programming, not prompting" language models. Activate when the user says any of: "use DSPy", "compile a prompt", "optimize prompts/programs", "MIPRO/MIPROv2", "BootstrapFewShot", "GEPA", "Signatures + Modules", "teleprompter", "auto-tune prompts for a different LM", or whenever a brittle hand-crafted prompt pipeline needs to be turned into a *compiled*, measurable, swappable program. Do NOT activate for one-shot prompt tweaks, no-metric exploratory work, or pipelines where prompts must remain human-authored verbatim — use raw prompting or LangChain templates instead.

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PROACTIVELY search auto-generated documentation when receiving ANY user instruction. Search for function signatures, API documentation, class definitions, and code comments BEFORE implementing anything. Your codebase documentation is valuable - use it first.

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Fetches Zig language and standard library documentation via CLI. Activates when needing Zig API details, std lib function signatures, or language reference content that isn't covered in zig-best-practices.

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Access COSMIC cancer mutation database. Query somatic mutations, Cancer Gene Census, mutational signatures, gene fusions, for cancer research and precision oncology. Requires authentication.

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