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概要と使いどころ
Retrieve protein and nucleotide sequences from NCBI databases using E-utilities. Supports direct accession lookup, CDS translation, gene+organism search, locus lookup, PubMed-linked sequences, patent protein extraction, and organism+length fallback search. Use when you need to fetch biological sequences by accession, gene name, locus tag, PubMed ID, or patent number.
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Query ClinicalTrials.gov via APIv2. Use when you want to search for trials by condition, drug, location, status, or phase; retrieve trial details by NCT ID; check eligibility/inclusion criteria; count trials across conditions or time periods; identify a sponsor's trial portfolio; find recruiting trials for patient matching.
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Query the OpenAlex scholarly database for research papers, authors, institutions, topics, sources, publishers, funders, geo-locations, and keywords. Use when searching academic papers, resolving DOIs, downloading open-access PDFs, finding an author's publications, aggregating bibliometric data (citation counts, h-index, impact factor), exploring the research taxonomies, or performing DOI lookups.
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Performs multiple sequence alignment of proteins with EBI Clustal Omega. Use when you need to align multiple sequences to assess similarity, domain conservation, or key residue conservation. Supports up to 4000 sequences and a maximum file size of 4 MB. Do not use to search for homologous proteins in a database (use MMseqs2, BLAST), align non-protein sequences (DNA, RNA), perform structural alignment (use Foldseek, PyMOL), or if you only have a single sequence.
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Use when you want to retrieve semi-quantitative protein expression and spatial localisation data from the Human Protein Atlas (HPA).
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Query the QuickGO and Evidence & Conclusion Ontology (ECO) REST API. Use this when you need to map genes to biological processes, molecular functions, or cellular components, find genes associated with a specific pathway/GO term, or explore the Gene Ontology hierarchy. Do not use for querying drug targets (use OpenTargets) or mechanistic signaling pathway diagrams (use KEGG).
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Query and analyze data in Azure Data Explorer (Kusto/ADX) using KQL for log analytics, telemetry, and time series analysis. WHEN: KQL queries, Kusto database queries, Azure Data Explorer, ADX clusters, log analytics, time series data, IoT telemetry, anomaly detection.
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Azure Storage Services including Blob Storage, File Shares, Queue Storage, Table Storage, and Data Lake. Answers questions about storage access tiers (hot, cool, cold, archive), when to use each tier, and tier comparison. Provides object storage, SMB file shares, async messaging, NoSQL key-value, and big data analytics. Includes lifecycle management. USE FOR: blob storage, file shares, queue storage, table storage, data lake, upload files, download blobs, storage accounts, access tiers, storage tiers, hot cool cold archive, storage tier comparison, when to use storage tiers, lifecycle management, Azure Storage concepts. DO NOT USE FOR: SQL databases, Cosmos DB (use azure-prepare), messaging with Event Hubs or Service Bus (use azure-messaging).
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Connect to Azure Database for PostgreSQL Flexible Server from Node.js/TypeScript using the pg (node-postgres) package. Use for PostgreSQL queries, connection pooling, transactions, and Microsoft Entra ID (passwordless) authentication. Triggers: "PostgreSQL", "postgres", "pg client", "node-postgres", "Azure PostgreSQL connection", "PostgreSQL TypeScript", "pg Pool", "passwordless postgres".
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Create Pydantic models following the multi-model pattern with Base, Create, Update, Response, and InDB variants. Use when defining API request/response schemas, database models, or data validation in Python applications using Pydantic v2.
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Review and create distinctive, production-grade frontend interfaces with high design quality and design system compliance. Evaluates using three pillars: frictionless insight-to-action, quality craft, and trustworthy building. USE FOR: PR reviews, design reviews, accessibility audits, design system compliance checks, creative frontend design, UI code review, component reviews, responsive design checks, theme testing, and creating memorable UI. DO NOT USE FOR: Backend API reviews, database schema reviews, infrastructure or DevOps work, pure business logic without UI, or non-frontend code.
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Manage MongoDB Atlas Organizations as Azure ARM resources using Azure.ResourceManager.MongoDBAtlas SDK. Use when creating, updating, listing, or deleting MongoDB Atlas organizations through Azure Marketplace integration. This SDK manages the Azure-side organization resource, not Atlas clusters/databases directly.
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Azure Resource Manager SDK for Cosmos DB in .NET. Use for MANAGEMENT PLANE operations: creating/managing Cosmos DB accounts, databases, containers, throughput settings, and RBAC via Azure Resource Manager. NOT for data plane operations (CRUD on documents) - use Microsoft.Azure.Cosmos for that. Triggers: "Cosmos DB account", "create Cosmos account", "manage Cosmos resources", "ARM Cosmos", "CosmosDBAccountResource", "provision Cosmos DB".
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Peptide-spectrum matching and protein identification from MS/MS data. Use when identifying peptides from tandem mass spectra. Covers database searching, spectral library matching, and FDR estimation using target-decoy approaches.
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Reactome pathway enrichment using ReactomePA package. Use when analyzing gene lists against Reactome's curated peer-reviewed pathway database. Performs over-representation analysis and GSEA with visualization and pathway hierarchy exploration.
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KEGG pathway and module enrichment analysis using clusterProfiler enrichKEGG and enrichMKEGG. Use when identifying metabolic and signaling pathways over-represented in a gene list. Supports 4000+ organisms via KEGG online database.
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Taxonomic classification of ASVs using reference databases like SILVA, GTDB, or UNITE. Covers naive Bayes classifiers (DADA2, IDTAXA) and exact matching approaches. Use when assigning taxonomy to ASVs after DADA2 amplicon processing.
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Metabolite identification from m/z and retention time. Covers database matching, MS/MS spectral matching, and confidence level assignment. Use when assigning compound identities to detected features in untargeted metabolomics.
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Taxonomic classification of metagenomic reads using Kraken2. Fast k-mer based classification against RefSeq database. Use when performing initial taxonomic classification of shotgun metagenomic reads before abundance estimation with Bracken.
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Filter and prioritize variants by pathogenicity, population frequency, and clinical evidence for rare disease analysis. Use when identifying candidate disease-causing variants from exome or genome sequencing.
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Calculate tumor mutational burden from panel or WES data with proper normalization and clinical thresholds. Use when assessing immunotherapy eligibility or characterizing tumor immunogenicity.
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Call HLA alleles from NGS data using OptiType, HLA-HD, or arcasHLA for immunogenomics applications. Use when determining HLA genotype for transplant matching, neoantigen prediction, or pharmacogenomic screening.
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Access AlphaFold's 200M+ AI-predicted protein structures. Retrieve structures by UniProt ID, download PDB/mmCIF files, analyze confidence metrics (pLDDT, PAE), for drug discovery and structural biology.
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Query PharmGKB and CPIC for drug-gene interactions, pharmacogenomic annotations, and dosing guidelines. Use when predicting drug response from genetic variants or implementing clinical pharmacogenomics.
日本語の概要は準備中です。原文の説明を表示しています。