2,136 件 ・ 関連度順
概要と使いどころ
Analyze a website's SEO visibility, keyword rankings, traffic estimates, and competitive positioning. Uses web search probes, SimilarWeb (free tier via web), and site: queries to build an SEO profile without requiring paid tool subscriptions. Useful for competitive intel, gap analysis, and reverse-engineering a company's organic acquisition strategy.
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Pull real SEO metrics for any domain using Apify scrapers for Semrush and Ahrefs data. Gets domain authority, organic traffic estimates, keyword rankings, backlink profiles, top performing pages, and auto-discovers competitors from keyword overlap. No Semrush/Ahrefs subscription needed — uses Apify actors that scrape public pages.
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Find quick-win SEO content opportunities by comparing your site's existing content against competitor keyword rankings. Chains site-content-catalog and seo-domain-analyzer to build a content inventory, then identifies gaps — topics competitors rank for that you don't cover yet. Outputs a prioritized list of posts to write or update. Use when a seed/Series A team wants to start winning organic traffic without guessing.
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Generate 3-5 messaging variants for a value proposition, design structured A/B tests, and analyze results to determine which framing resonates most with ICP. Tests can run via LinkedIn organic posts, cold email subject line splits, or both. Pure reasoning for variant generation and analysis — the user deploys the tests through their own tools. Use when a team can't decide between messaging angles and needs data, not opinions.
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Organize DI registrations using IServiceCollection extension methods. Group related services into composable Add* methods for clean Program.cs and reusable configuration in tests.
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Predict peptide-MHC class I binding and natural presentation with MHCflurry, NetMHCpan-4.1, and MixMHCpred to nominate candidate CD8 T-cell epitopes. Covers the binding-affinity (BA) vs eluted-ligand (EL/presentation) distinction, why %Rank beats raw nM for cross-allele work, the MS abundance bias that misranks low-expression neoantigens, allele-coverage inequity, and length bias. Use when scanning a protein or peptide set for class I epitopes, scoring neoantigen candidates, or choosing a binding predictor. For CD4/HLA class II see mhc-class-ii-prediction.
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Defines cell populations in flow and spectral cytometry through manual gates (rectangle, polygon, quadrant, boolean) and reproducible automated gating (openCyto gating templates, flowDensity data-driven thresholds, flowClust model-based gates), organized as a hierarchical GatingSet (flowWorkspace) and round-tripped with FlowJo via CytoML. Covers the canonical gate order (time -> debris -> singlets -> live -> lineage), FMO-vs-isotype boundary setting, gate-order dependence and recompute semantics, rare-event/MRD gating, and per-population statistics. Use when building a gating strategy, automating a manual FlowJo scheme across samples, choosing manual vs data-driven gates, or extracting population frequencies.
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Build interactive HTML/web visualizations with plotly (Python/R), bokeh (Python), and gganimate/plotly frames for animation, with awareness of current Kaleido static-export model (post-orca-EOL), HTML file-size bloat, and the limits of interactive-only output for journal submission. Use when producing zoomable/hoverable plots for notebook EDA, supplementary HTML, dashboards, or animated time-course / iteration visualizations.
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Run remote BLAST searches against NCBI servers using Biopython Bio.Blast.NCBIWWW. Use when identifying unknown sequences, finding homologs, picking the correct BLAST program (blastn/blastp/blastx/tblastn/tblastx/psiblast/megablast/dc-megablast), interpreting Karlin-Altschul E-values, avoiding the max_target_seqs trap (Shah 2019), choosing composition-based statistics, or limiting searches by organism. Covers RID lifecycle, database choice (nt/nr/refseq_select/swissprot), word-size and CBS taxonomy.
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Designs and analyzes in vivo CRISPR screens in animal tumor models, organoids, and immune-cell adoptive transfers. Covers bottleneck math (250x cells/sgRNA requires ~25M cells implanted; impossible for most syngeneic models, forcing focused libraries), focused library design (Manguso 2017 Nature 547:413 immune screen; Chen 2015 tumor screens), CRISPR-StAR intrinsic-control screening (Uijttewaal 2025 Nat Biotechnol 43:1848), clonal-dynamics-limited detection, tumor-explant DNA recovery, syngeneic vs xenograft vs PDX considerations, and the relationship to downstream MAGeCK / drugZ analysis. Use when designing in vivo CRISPR screens for tumor / immune / metastasis biology, choosing focused vs genome-wide for animal models, addressing bottleneck-induced clonal collapse, picking the syngeneic / xenograft / PDX model, integrating in vivo with in vitro results, or applying CRISPR-StAR for animal experiments.
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Validates docked / generated protein-ligand poses using PoseBusters physical-validity tests, strain energy quantification, geometric checks (planarity, vdW overlap, bond/angle distortion), and pose-energy reasonableness. Use when QC-ing docking results, comparing classical vs ML docking outputs, or filtering pose lists before SAR analysis.
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Calls HLA class I and class II alleles at 2/4/6/8-field resolution from WGS/WES/RNA-seq/long-read data using OptiType, HLA-LA, T1K, Polysolver, HLA-HD, arcasHLA, StarPhase, or HIBAG imputation. Use when typing for HSCT, solid-organ transplant, neoantigen prediction, PGx screening (B*57:01, B*15:02, etc.), or disease-association studies, with reconciliation across tools and IPD-IMGT/HLA version mismatch handling.
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Generates 3D conformer ensembles using RDKit ETKDGv3 with knowledge-enhanced distance geometry, MMFF94/UFF force-field optimization, CREST + GFN2-xTB semi-empirical refinement, and macrocycle-aware torsion preferences. Provides explicit decision rules for single vs ensemble conformer use, RMSD pruning, energy windows, conformer count, and force-field choice. Use when preparing 3D ligands for docking, generating descriptor input for 3D QSAR, or sampling macrocycle/peptide conformational ensembles.
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Performs structure-based virtual screening using AutoDock Vina, SMINA, GNINA (CNN scoring), and DiffDock-L hybrid workflows with explicit choice rules across rigid vs flexible docking, cross-docking vs self-docking, binding-site detection (P2Rank, fpocket), receptor preparation (PDB2PQR, PROPKA), ligand preparation (meeko, OpenBabel), and ultralarge-library screening (ZINC22, Enamine REAL). Use when screening chemical libraries against a protein target to find candidate binders, ranking docking poses, or selecting a docking workflow for a specific scenario.
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Builds and applies 3D pharmacophore models using RDKit Pharm3D, the apo2ph4 receptor-based workflow (Heider et al. 2023), Pharmer / Pharmit for search, and PharmacoForge for protein-pocket-conditioned pharmacophore generation (Flynn et al. 2025), covering ligand-based pharmacophores from active-set alignment and receptor-based pharmacophores from binding-pocket geometry. Explicitly handles feature types, geometric tolerances, partial matching, and pharmacophore-based virtual screening. Use when identifying scaffold-hopping candidates, building shape-and-feature search queries, or transferring SAR across chemotypes.
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Normalizes ChIP-seq data using exogenous spike-in (ChIP-Rx with Drosophila chromatin per Orlando 2014 / Egan 2016; E. coli carryover for CUT&RUN/CUT&Tag). Distinguishes RRPM from Rx-Input scaling, integrates with DiffBind / DESeq2 / edgeR / csaw via sizeFactors and DiffBind library-size vectors, applies the Patel et al 2024 *Nat Biotechnol* failure-mode framework, and validates that normalization is applied at the read level (not peak counts). Use when global signal shifts are expected (HDACi, BETi, EZH2i, dosage, target knockdown), when ChIPseqSpikeInFree detects post-hoc shifts, or when validating internal-control regions before publication.
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Calculates molecular fingerprints (ECFP/Morgan, FCFP, MACCS, RDKit, AtomPair, TopologicalTorsion, Avalon, MAP4, MHFP6) and physicochemical descriptors (Lipinski, QED, TPSA, Crippen LogP, 3D shape) with explicit choice tables, bit vs count semantics, and partial-charge model selection. Use when featurizing molecules for similarity, QSAR, virtual screening, or ML, or selecting the correct fingerprint for a chemotype-aware task.
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Map nucleosome center positions, occupancy, and fuzziness from ATAC-seq fragment-size patterns using NucleoATAC, ATACseqQC, DANPOS3, or scprinter. Use when characterizing nucleosome organization at promoters and enhancers, calling +1/-1 nucleosomes flanking NFRs, generating V-plots for chromatin structure visualization, or comparing nucleosome positioning between conditions.
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Implement, review, or improve data visualizations using Swift Charts. Use when building bar, line, area, point, pie, donut, or iOS 26 3D charts; when adding chart selection, scrolling, annotations, axes, scales, legends, or foregroundStyle grouping; when plotting functions with BarPlot, LinePlot, AreaPlot, PointPlot, Chart3D, or SurfacePlot; or when creating heat maps, Gantt charts, grouped bars, sparklines, threshold lines, or spatial visualizations.
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Writes and migrates Swift Testing framework tests with @Test, @Suite, #expect, #require, confirmation, traits, withKnownIssue, Attachment.record, processExitsWith exit tests and capture lists, Test.cancel, Issue.record warnings/manual failures, XCTest-to-Swift Testing migration, Xcode 27 interoperability modes, XCUITest UI-test boundaries, performance/snapshot boundaries, mocking, async patterns, and test organization. Use when writing tests, converting XCTest assertions such as XCTUnwrap or XCTFail, reviewing advanced Swift Testing API availability, or deciding when to keep XCTest/XCUITest.
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Creates and maintains the scenarios a LiveKit agent simulation runs, and wires the agent to consume them. Use when the user asks "what should I test", "generate simulation scenarios", "write scenarios for my agent", "add a scenario for X", "organize my scenario files", "my simulations are flaky", "the scenario hits my real database", "seed state per scenario", "it passed but booked the wrong thing", "grade the final state", or wants to stress-test a flow before shipping. Covers generating a baseline with the LiveKit scenario generator and refining it, writing the cases generation misses, phrasing simulated-user instructions so they steer reliably, splitting scenarios into sets across files, and the agent-side code that seeds deterministic state from a scenario and fails a run on its final state. To run them use running-livekit-simulations.
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Use when adding, fixing, or reviewing structured data: JSON-LD for articles, products, FAQs, breadcrumbs, organizations, and local businesses, and what to do when markup doesn't earn a rich result.
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Use when reviewing a page or site for organic search, or diagnosing why something isn't ranking: crawl and index signals, on-page elements, content quality, and how to order the fixes.
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Use this skill whenever the user wants to create, read, edit, or manipulate Word documents (.docx files) or Word templates (.dotx files). Triggers include: any mention of 'Word doc', 'word document', '.docx', '.dotx', or requests to produce professional documents with formatting like tables of contents, headings, page numbers, or letterheads. Also use when extracting or reorganizing content from .docx or .dotx files, inserting or replacing images in documents, performing find-and-replace in Word files, working with tracked changes or comments, or converting content into a polished Word document. If the user asks for a 'report', 'memo', 'letter', 'template', or similar deliverable as a Word or .docx file, use this skill. Do NOT use for PDFs, spreadsheets, Google Docs, or general coding tasks unrelated to document generation.
日本語の概要は準備中です。原文の説明を表示しています。