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Builds QSAR / QSPR models using chemprop D-MPNN, MolFormer, Uni-Mol, ChemBERTa, random forest baselines, and Gaussian processes with explicit handling of OECD 5 principles, applicability domain (kNN, leverage, conformal prediction, Mahalanobis), scaffold-balanced splits, ensemble uncertainty, calibration (Platt, isotonic), feature importance (SHAP, atomic attribution), and prospective validation. Use when building target-specific predictive models from in-house bioassay data, ADMET endpoints, or selectivity profiles.

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Trains and applies base-resolution deep learning models on ChIP-seq / ChIP-nexus / CUT&RUN data. Uses BPNet (Avsec 2021 Nat Genet 53:354; soft motif syntax from ChIP-nexus), chromBPNet (Pampari A et al 2024 bioRxiv; bias-factorized base-resolution profiles), EnFormer (Avsec 2021 Nat Methods 18:1196; 196 kb input, ~100 kb effective receptive field), DeepSEA (Zhou 2015; multi-task CNN), and JASPAR 2026 deep-learning collection (1259 BPNet ChIP models). Performs in silico mutagenesis for variant-effect prediction, DeepLIFT/Grad attribution, and TF-MoDISco motif discovery from attribution scores. Use when predicting variant effects on TF binding, discovering soft motif syntax / cooperativity, integrating ChIP-seq with sequence-only predictions, or applying precomputed JASPAR Deep Learning models to new variants.

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Use when the user mentions Foundation Models review, on-device AI audit, LanguageModelSession issues, or @Generable/guardrail problems — including missing availability checks, manual JSON parsing, and guardrail handling.

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Use when implementing, testing, or evaluating ANY Apple Intelligence, on-device AI, or speech-to-text feature. Covers Foundation Models, @Generable, LanguageModelSession, Tool protocol, eval suites, model-as-judge scoring, SpeechTranscriber, CoreML.

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Use when the user wants to modernize iOS code to iOS 17/18 patterns, migrate from ObservableObject to @Observable, update @StateObject to @State, or adopt modern SwiftUI APIs.

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Apply modern Swift language patterns and idioms for non-concurrency, non-SwiftUI code. Covers if/switch expressions (Swift 5.9+), typed throws (Swift 6+), result builders, property wrappers, opaque and existential types (some vs any), guard patterns, Never type, Regex builders (Swift 5.7+), basic Codable shaping (CodingKeys, custom decoding, nested containers), modern collection APIs (count(where:), contains(where:), replacing()), basic FormatStyle usage, and string interpolation patterns. Use when writing core Swift code involving generics, protocols, enums, closures, or modern language features; route deep Codable to swift-codable, detailed formatting/localization to swift-formatstyle, and API naming to swift-api-design-guidelines.

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Implement computer vision features including text recognition (OCR), face detection, barcode scanning, image segmentation, object tracking, and document scanning in iOS apps. Covers both the modern Swift-native Vision API (iOS 18+) and legacy VNRequest patterns, VisionKit DataScannerViewController for live camera scanning, and CoreMLRequest/VNCoreMLRequest for custom model inference. Use when adding OCR, barcode scanning, face detection, or custom Core ML model inference with Vision.

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Build private, on-device AI features on iPhone, iPad, and Mac with Foundation Models, Core ML, MLX Swift, or llama.cpp. Use when choosing an Apple-local model runtime, building an Apple Intelligence chatbot or tool-calling feature, running an LLM on Apple Silicon, converting or compressing a Python model for Core ML, or comparing on-device inference backends. For Swift Core ML loading and prediction code, use the coreml skill.

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This skill should be used when user asks to "upload my model to Ultralytics Platform", "push this run to the platform", "upload a dataset to platform", "download a dataset from platform", "search platform datasets", "start cloud training", "train on platform GPUs", "export a model on platform", "deploy a model endpoint", "run Moondream on Platform", "auto-annotate a Platform dataset", "run hosted AI inference", "why is my run not showing on platform", or mentions platform.ultralytics.com, ul:// URIs, ultralytics-platform, or ULTRALYTICS_API_KEY.

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Port MATLAB Data Acquisition Toolbox code from the discouraged (legacy) session-based interface (daq.createSession, addAnalogInputChannel, startBackground, DataAvailable listeners, queueOutputData, wait) to the recommended DataAcquisition interface (daq("ni"), addinput, start, ScansAvailableFcn, write, preload). Use when migrating legacy DAQ scripts, converting session-API calls, working with DataAcquisition objects, writing multi-feature DAQ scripts that combine triggers, callbacks, continuous acquisition, or analog output. Also use when a user says their DAQ script "used to work" or "errors on R20XX", since modernizing legacy session-API code is a frequent fix for those failures. Trigger keywords: daq, DAQ, NI, session interface, addtrigger, addclock, ScansAvailableFcn, ScansRequiredFcn, daq.createSession, addAnalogInputChannel, startBackground, queueOutputData, DataAvailable, evt.Data, evt.TimeStamps, wait(d), preload, discouraged, legacy, modernize, R2020a.

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Via modeling: pads, antipads, ground return vias, GRV placement, and signal integrity for high-speed layer transitions. TRIGGER: user asks to model a via, design a via transition, place ground return vias, analyze via performance, or check signal integrity through layer transitions. Invoke BEFORE writing code — only viaSingleEnded exists (no viaDifferential), and the location format is non-obvious. SKIP: general signal integrity without vias (use matlab-analyze-em), transmission line design (use matlab-design-pcb-transmission-line), PDN analysis (use matlab-analyze-pcb-pdn), material/stackup setup only (use matlab-manage-pcb-material).

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Discover OPC UA servers, connect MATLAB clients, and browse/navigate server nodes using opcuaserverinfo, the Local Discovery Service (LDS), opcua, connect, setSecurityModel, certificate-trust functions, findNodeById, opcuanode, and Namespace/Children traversal. Use when finding OPC UA servers on the network, querying endpoints and security policies, connecting to a server, authenticating with username/password or certificates, configuring security modes, handling certificate-trust or hostname-mismatch errors, troubleshooting failed connections or empty discovery, inspecting an OPC UA certificate (.der/.pem), browsing an address space, finding nodes by name or NodeId, navigating node hierarchies, invoking method nodes, or batch-processing large namespaces. Trigger on: opcuaserverinfo, LDS, opcua, opc.ua.Client, setSecurityModel, opc.ua.trustServerCertificate, OPC UA certificate, findNodeById, opcuanode, browse OPC UA, find node, OPC UA namespace, OPC UA method node, Industrial Communication Toolbox.

日本語の概要は準備中です。原文の説明を表示しています。

Style MATLAB charts and figures. colororder palettes for chart series colors, colormap selection, brand color organization, and the R2025a Theme API for uifigure apps (dark mode with fliplightness, ThemeChangedFcn, uistyle, component colors). Use when customizing chart colors, applying a color palette, organizing brand colors, implementing dark mode, or importing an external color scheme. Triggers: theme, dark mode, brand colors, colororder, colormap, palette, fliplightness, color scheme, styling, chart colors.

日本語の概要は準備中です。原文の説明を表示しています。

Build, modify, and diagram SimBiology models — API reference, helper functions, and layout patterns. Use when constructing or editing models programmatically or visually.

日本語の概要は準備中です。原文の説明を表示しています。

AWS Bedrock foundation models for generative AI. Use when invoking foundation models, building AI applications, creating embeddings, configuring model access, or implementing RAG patterns.

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Secure the AI model supply chain with artifact signing, provenance attestation, SBOM workflows, dependency controls, and trusted model promotion.

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Run an independent code review using the OpenAI Codex CLI in headless mode. Gets a second opinion from a different model family (the current Codex models) on recent changes, a PR, a commit, or the whole app — covering bugs, regressions, security, data consistency, UX/state bugs, performance risks, and testing gaps. Saves a severity-prioritised report to .jez/reviews/. Triggers: 'codex review', 'review with codex', 'independent code review', 'what does codex think', 'get codex to review'.

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Set up Tailwind v4 + shadcn/ui themed UI with dark mode. Install deps, configure CSS variables via @theme inline, wire dark mode toggle, verify. Use whenever the user mentions Tailwind v4, setting up Tailwind theming, shadcn/ui colours, dark mode, or troubleshooting colours not working, tw-animate-css errors, @theme inline conflicts, @apply breaking after upgrade, or v3 → v4 migration issues.

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Modern web design trends, principles, and implementation patterns for 2024-2025. Use this skill when designing websites, creating interactive experiences, implementing design systems, ensuring accessibility, or building performance-first interfaces. Triggers on tasks involving modern design trends, micro-interactions, scrollytelling, bold minimalism, cursor UX, glassmorphism, accessibility compliance, performance optimization, or design system architecture. References animation skills (GSAP, Framer Motion, React Spring), 3D skills (Three.js, R3F, Babylon.js), and component libraries for implementation guidance.

日本語の概要は準備中です。原文の説明を表示しています。

Generate and run minimal reproducible Python modeling code for the human-approved main method and usable baseline, saving compact experiment artifacts and a canonical run summary.

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Faithfully append a human modeler's choice and rationale to one canonical per-subquestion JSONL decision ledger. Use after a choice card is answered or when migrating legacy decision artifacts; never originate or improve the decision.

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Build and risk-screen a compact role-based method shortlist for a mathematical-modeling subquestion. Use after problem framing and data profiling, before model code generation, to propose a main candidate, a usable baseline, and at most one conditional fallback without padding the pool.

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TOM and ADOMD.NET guidance via PowerShell for connecting to Power BI Desktop's local Analysis Services instance. Covers model enumeration, DAX queries, metadata modification, annotations, calendar definitions, field parameters, query tracing, DAX library package management (daxlib.org), and the Desktop Bridge for reloading and screenshotting the report canvas. Automatically invoke when the user mentions "Power BI Desktop", "Analysis Services port", "TOM", "ADOMD", "daxlib", "DAX library", "DAX UDF package", or asks to "connect to PBI Desktop", "query PBI Desktop with DAX", "modify PBI Desktop model", "add a measure to PBI", "capture visual queries", "create a field parameter", "validate DAX", "intercept DAX queries", "install daxlib", "add DAX SVG", "add IBCS", "reload the report canvas", "screenshot a report page", "Desktop Bridge", or to work with the model and report in Power BI Desktop together.

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Trace relationships between semantic models and downstream reports across Fabric workspaces. Automatically invoke when the user asks to "find downstream reports", "show report lineage", "impact analysis", "what depends on this dataset", "cross-workspace lineage", "which reports are connected", "get model dependencies", or mentions model-to-report dependency tracing.

日本語の概要は準備中です。原文の説明を表示しています。