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概要と使いどころ
Expert-level genetics covering Mendelian inheritance, molecular genetics, mutations, linkage analysis, population genetics, epigenetics, and GWAS. Covers classical and modern approaches from Mendel to CRISPR.
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Use when modeling CAC, LTV, payback, contribution margin, or burn-multiple per customer — SaaS, marketplace, or transactional. Triggers on 'are we unit-economic', 'what is our LTV/CAC'.
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Evidence-grounded AI research workflow for turning supplied economics, finance, management, and social-science papers or structured records into versioned PaperReading artifacts. Use when Codex must ingest text, Markdown, or a text-based PDF; separate source-grounded claims from researcher analysis; bind findings to evidence IDs and locators; review extraction candidates; migrate v0.2 PaperRecord JSON; validate or verify a v0.3 PaperPackage; generate research extensions; export reviewable JSON or Markdown; or safely update a compatible 13-field literature workbook.
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Search, summarize, and synthesize economics literature. find research gaps, position your contribution.
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Draft economics papers with proper structure and academic style
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Knowledge base from the FAA Human Factors Design Standard (HF-STD-001B, 2016) — the FAA's consolidated human-factors / human-systems-integration design criteria for systems it manages, operates, or maintains. Use for requirement-level design rules on: general human-factors design principles; automation and function allocation; designing equipment for maintenance; displays, controls, and visual indicators; alarms, audio, and voice communications; the computer-human interface (information presentation, coding, interaction styles, windows, dialogue); keyboards, input devices, and workstation/workplace ergonomics; system security, personnel safety, environment, anthropometry, and user documentation; plus intended-use and tailoring guidance. It is a quantified, source-attributed synthesis (heavily citing MIL-STD-1472G, MIL-HDBK-759C, DOD-HFDG-ATCCS, NUREG-0700, NASA-STD-3000, ANSI, OSHA, ISO 9241). Complements nasa-hsi as a parallel HSI tradition from the civil-aviation domain. Scope limits: it is design criteria, NOT an HSI lifecycle/process model (use nasa-hsi, nasa-npr-7123, or dau-se-guidebook for process); it does NOT reproduce the third-party standards it cites; it is FAA-acquisition-oriented (ATC, towers, TRACONs, airway facilities), not a general consumer-UX guide; and it is thin on modern touchscreen/mobile, web, and AI-driven interface patterns and on quantitative human-reliability analysis.
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Reviews a proposal, business case, deck or plan in character as a Chief Marketing Officer archetype and returns a DRAFT review in the chat with a verdict, findings cited to specific passages, marketing risks, what would change the verdict and five interrogation questions. Use when the user asks to "run a CMO review", "pressure-test the positioning", "what would a CMO say about this", "challenge the launch plan" or "check the messaging and audience". Do not use for price economics, margins or payback, use cfo-reviewer instead; for sales pipeline mechanics, use cro-reviewer. Drafts for human review; never approves, authorises or signs off.
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Use when the user asks to "plan launch pricing", "design pricing tiers / packaging", or "set up a launch discount / early-bird offer"; produces a launch pricing and packaging plan — tier structure and naming, a value-to-price map aligned to the message house, a launch-offer ladder with a true deadline reason, beta / early-adopter pricing with a post-launch graduation path, and guarantee / refund terms — with every price claim and offer term submitted to memory/events/claims.ndjson. Not for the canonical offer / claim record — use offer-claims-registry; not for paid-newsletter subscription economics — use newsletter-monetization-planner; not for ad bidding — use bid-strategy-planner. 发布定价/梯度打包/早鸟优惠/保证设计
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Design or evaluate pricing and packaging using customer value, willingness-to-pay evidence, competitive context, unit economics and experiment design.
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Calculate and model paid-media CPA, CPL, CPC, CPM, ROAS, MER, break-even targets, contribution margin, LTV:CAC, impression-share opportunity, budgets, forecasts, and experiment economics. Use for PPC math, ad calculator, break-even analysis, ROAS calculator, CPA calculator, budget forecast, LTV CAC, or MER.
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Create a professional paid-advertising strategy covering objectives, economics, platform selection, campaign architecture, audiences, budget, creative, measurement, experiments, governance, rollout, and reporting. Use for ad plan, media plan, PPC strategy, paid-social strategy, campaign architecture, advertising roadmap, or channel planning.
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Knowledge comics (知识漫画): educational, biography, tutorial.
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Annotated matrices for single-cell genomics. Stores X with obs/var metadata, layers, embeddings (obsm/varm), graphs (obsp/varp), uns. Use for .h5ad/.zarr I/O, concatenation, scverse integration. For analysis use scanpy; for probabilistic models use scvi-tools.
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Search and retrieve preprints from arXiv via the Atom API. Use this skill when searching for papers in physics, mathematics, computer science, quantitative biology, quantitative finance, statistics, electrical engineering, or economics by keywords, authors, arXiv IDs, date ranges, or categories.
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Infer gene regulatory networks (GRNs) from gene expression data using scalable algorithms (GRNBoost2, GENIE3). Use when analyzing transcriptomics data (bulk RNA-seq, single-cell RNA-seq) to identify transcription factor-target gene relationships and regulatory interactions. Supports distributed computation for large-scale datasets.
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Expert en optimisation des coûts cloud (AWS cost, reserved instances, spot, rightsizing, FinOps)
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Token budgeting discipline for all agents. Treats tokens as a resource from session start — not just when the buffer hits 60%. Covers prompt compression, context hygiene, handoff packing, and HOT memory pruning.
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Knowledge comics (知识漫画): educational, biography, tutorial.
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Build, analyze, repair, and audit finance three-statement models and operating forecasts. Use when the user invokes $kelly-finance, asks for 财务三表, 三表模型, income statement, balance sheet, cash flow statement, forecast model, budget model, financial projections, FP&A model, SaaS/unit economics forecast, fundraising model, board finance pack, investor model, model checks, balance-sheet balancing, cash runway, working capital, capex/depreciation schedules, debt schedules, scenario/sensitivity cases, or Excel/Sheets-ready finance outputs.
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Investigate LLM spend in PostHog — total cost over time, cost by model, provider, user, trace, or custom dimension, token and cache-hit economics, and cost regressions. Use when the user asks "how much are we spending on LLMs?", "which model / user / feature is most expensive?", "why did cost spike?", wants to build a cost dashboard or alert, or pastes a trace URL and asks about its cost.
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Designs genomics experiments so technical nuisance variation (batch, lane, plate, flow cell, operator, reagent lot, processing day) is balanced against the biological variable of interest and therefore estimable rather than confounded, using constrained sample-to-batch assignment (designit, OSAT), the confounder/mediator/collider distinction, and the principle that no post-hoc correction recovers a fully confounded design. Covers detecting hidden batches with surrogate variable analysis, a decision table for downstream correction (ComBat-seq, RUVSeq, SVA) whose execution is deferred to differential-expression/batch-correction, and reproducibility metadata. Use when assigning samples to sequencing batches/lanes/plates, avoiding batch-condition confounding, deciding whether a design is salvageable by correction, choosing a correction method, or estimating the number of hidden batches. For the experimental unit, randomization, and blocking concepts see experimental-design/randomization-blocking.
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Estimates the minimum biological replicates (or cells/events) for a target power at a target FDR in genomics experiments using ssizeRNA, PROPER, powsimR for scRNA-seq, and pilot-data dispersion estimation from DESeq2/edgeR. Covers the biological-versus-technical replication distinction (technical replicates do not add degrees of freedom for biological inference), replicate-number-versus-sequencing-depth budgeting, scRNA-seq sample-versus-cell allocation under a pseudobulk model, and the critique that "n=3" is a publication convention rather than a power calculation. Use when budgeting a sequencing experiment, writing the sample-size justification in a grant, estimating replicates from pilot data, allocating a fixed budget between samples and depth, or planning scRNA-seq cohort size. For clinical-trial sample size see clinical-biostatistics/power-and-sample-size; for the power-given-n direction see experimental-design/power-analysis.
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Structures biological experiments so inference is valid by construction, covering Fisher's principles (randomization, replication, local control), the experimental-vs-observational unit distinction and pseudoreplication (Hurlbert 1984; Lazic 2018), randomization mechanics (complete, restricted, stratified, rerandomization, run-order), blocking layouts (randomized complete block, Latin square, incomplete block), factorial designs and interactions, and the split-plot/nested error strata hidden inside multi-batch genomics. Use when deciding the experimental unit and what counts as a replicate, planning randomization and run order, choosing a blocked/factorial/split-plot/nested layout, avoiding pseudoreplication in cell-culture or animal studies, or specifying the random-effects structure of the analysis model. For assigning samples to sequencing batches/lanes/plates and batch-effect correction see experimental-design/batch-design; for regulated clinical-trial randomization see clinical-biostatistics.
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Controls error rates across thousands of simultaneous tests in genomics discovery using false-discovery-rate methods (Benjamini-Hochberg 1995; Benjamini-Yekutieli 2001 for arbitrary dependence; Storey q-value with pi0 estimation; local FDR; independent filtering Bourgon 2010; covariate-weighted FDR via IHW Ignatiadis 2016), plus family-wise error control (Bonferroni, Holm) and the GWAS genome-wide threshold. Covers the FDR-versus-FWER choice as the discovery-versus-confirmatory distinction, the dependence assumptions behind BH (PRDS) versus BY, pi0 estimation, the independent-filtering and false-coverage-rate traps, and reproducibility ranking via IDR (Li 2011). Use when correcting p-values from genome-wide tests, choosing between BH/BY/q-value/Bonferroni, setting an FDR threshold, applying IHW or independent filtering, or interpreting q-values. For confirmatory trials with few pre-specified endpoints (closed testing, graphical/gatekeeping), see clinical-biostatistics/multiplicity-graphical.
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