「protocol」の検索結果

Computes sample size and power for clinical trials including continuous, binary, and time-to-event endpoints; superiority, non-inferiority, and equivalence designs; FDA 2016 non-inferiority margin selection with M1/M2 framework; Schoenfeld 1981 and Lakatos 1988 for survival; Schuirmann TOST and 80-125% bioequivalence; minimum clinically important difference (MCID) vs δ distinction. Use when justifying trial size in protocol or SAP per CONSORT 2025 item 16a.

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End-to-end binder design using BindCraft hallucination. Use this skill when: (1) Designing protein binders with built-in AF2 validation, (2) Running production-quality binder campaigns, (3) Using different design protocols (fast, default, slow), (4) Need joint backbone and sequence optimization, (5) Want high experimental success rate. For backbone-only generation, use rfdiffusion. For QC thresholds, use protein-qc. For tool selection guidance, use binder-design.

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Manage BAP (Bitcoin Attestation Protocol) identity files using bap-cli. This skill should be used when users need to create, decrypt, list, or extract BAP identity backups, work with .bep encrypted files, or generate test fixtures for Playwright tests involving BAP identities.

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Plan, execute, and document validation, verification, and transfer of analytical procedures under the governing framework - ICH Q2(R2) and Q14, USP <1220>/<1225>/<1226>, ICH M10 bioanalytical, CLSI EP, or ISO/IEC 17025. Use for HPLC, LC-MS/MS, GC, CE, ICP-MS, dissolution, qNMR, qPCR, NIR, and ligand binding or cell-based assays whenever the question is whether a procedure is fit for its intended purpose. Triggers include "method validation", "analytical method validation", "AMV", "validation protocol", "acceptance criteria", "linearity", "reportable range", "accuracy and precision", "repeatability", "intermediate precision", "recovery", "LOD", "LOQ", "detection limit", "quantitation limit", "specificity", "robustness", "method transfer", "method comparison", "Deming", "Passing-Bablok", "Bland-Altman", "equivalence testing", "OOS investigation", "ICH Q2", "Q2(R2)", "Q14", "USP 1225", "ICH M10", "incurred sample reanalysis", "ISR", "CLSI EP", and any request to show that an assay works.

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Determines unilateral vs bilateral aldosterone excess based on cortisol-corrected aldosterone ratios from adrenal venous sampling, with ratio >4:1 indicating unilateral excess, ratio 3:1 suggestive of bilateral hypersecretion, and interpretation dependent on cosyntropin stimulation protocol used during sampling. Use when analyzing AVS results to guide surgical vs medical treatment decisions; triggers include 'AVS lateralization ratio', 'cosyntropin-stimulated AVS', 'aldosterone-to-cortisol ratio >4:1', and 'ratio 3:1 suggestive of bilateral disease'.

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Core skill activation protocol - establishes mandatory workflows for finding and applying skills before any task

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Debug Node.js via --inspect + Chrome DevTools Protocol CLI.

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Setup and optimize cryptocurrency mining operations — AI-powered mining (soul.md protocol), parallel agent deployment, accumulation strategies, and performance optimization.

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The official combat protocol for the BRAWLNET autonomous agent arena.

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OMC agent catalog, available tools, team pipeline routing, commit protocol, and skills registry. Auto-loads when delegating to agents, using OMC tools, orchestrating teams, making commits, or invoking skills.

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Map existing materials into a first knowledge record, or investigate a subject's history in depth. Use whenever the user asks to map, survey, go through, reconstruct or investigate what already exists - folders of documents, decision records, meeting notes, emails, exports, code - or wants a starting record built from existing materials, even when the word 'record' is never said: consult this before listing or reading the files yourself, because a map has an agreed scope, a protocol and a report. Also, once, at a suitable moment, to offer the starting choices where a workspace has no record and the work is clearly ongoing - never on a greeting. Learning while working needs no map. Requests come in any language.

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Use when a cross-workspace import will not resolve — cannot find module @org/*, TS2307 — to link the packages properly with the workspace: protocol instead of patching tsconfig paths.

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Use when working with MCP (Model Context Protocol) servers — their tools, capabilities, and best practices for effective agent workflows.

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Use when configuring Laravel Reverb — the first-party WebSocket server with Pusher protocol compatibility, horizontal scaling, and Pulse monitoring.

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Envie e receba mensagens criptograficamente assinadas entre agentes de IA usando o Agent Messaging Protocol (AMP). Use quando o usuário pedir para "enviar uma mensagem para um agente", "verificar caixa de entrada do agente", "mensagear outro agente", "responder a uma mensagem", "notificar um agente" ou qualquer tarefa de comunicação entre agentes.

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Guide for creating high-quality MCP (Model Context Protocol) servers that enable LLMs to interact with external services through well-designed tools. Use when building MCP servers to integrate external APIs or services, whether in Python (FastMCP) or Node/TypeScript (MCP SDK).

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[Debugging] Use when analyzing or optimizing performance bottlenecks: database queries, N+1 fan-out, indexing, API latency, memory/GC, concurrency and pool saturation, algorithmic complexity (O(n²)), network/protocol round trips, frontend rendering and Core Web Vitals, caching, and distributed/resilience paths. Calibration constants and domain laws (latency ladder, Little's Law, utilization knee, CWV thresholds, symptom→cause triage) live in references/performance-knowledge.md.

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Maintain stewardship protocol continuity and tool/personality boundaries. Use when a repo agent needs steward-mode threshold checks, self-model update decisions, delegation hygiene, boundary violation review, or handoff-safe continuity context without overclaiming steward personality.

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Test APIs against OWASP API Security Top 10 including discovery, auth abuse, and protocol-specific checks.

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Validate Commodore 1540/1541/1541C/1541-II compatible disk-drive behavior in EMULATORS, including IEC serial bus protocol, device numbers, KERNAL traps, CBM DOS commands/status, D64 image parsing, BAM/directory/file chains, PETSCII filenames, 6502 drive CPU/ROM/RAM expectations, 6522 VIA wiring, GCR/track/sector geometry, motor/head timing, and compatibility boundaries for 1541-like devices. Use when Codex reviews or edits C64, VIC-20, C264, COMMODORE disk, serial I/O, D64, CBM DOS, IEC, VIA, GCR, or 1541 drive code.

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Implement machine input/output, I/O port decoding, external buses, host input adapters, storage and media devices, and peripherals in EMULATORS. Use when adding keyboard matrices, joysticks, controllers, cassette, cartridge, disk, printer, serial or parallel interfaces, protocol state machines, PortManager behavior, or deterministic host-to-emulated-device integration.

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Protocol for auditing API surface coherence and type safety. Trigger when: - Evaluating API designs, interface type safety, or design elegance. - Prompt contains: /api-audit, API surface, API coherence, type safety.

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SOP for locating, auditing, and importing production-tested reference patterns and peer-reviewed literature. Trigger when: - Designing or implementing non-trivial algorithms, system protocols, design patterns, or major library integrations. - Prompt contains: prior art, reference implementation, research patterns, standard implementation, arXiv, RFC.

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Runnable driver for the deterministic campaign-execution protocol — the automaton that takes a validated campaign DAG to a correctly merged branch. Trigger when: - A campaign has a validated DAG + worker IBCs and the composer (or a cheap-tier runner) must DRIVE dispatch ⇄ reconcile as a loop rather than by hand. - Resuming a partially-executed campaign from its git history + sketch checkpoint after a halt or crash. - Prompt contains: /orchestrate, orchestration, drive the DAG, run the campaign, layer schedule, reconcile-and-merge, resume campaign.

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